JP2009508507A5 - - Google Patents
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- JP2009508507A5 JP2009508507A5 JP2008531620A JP2008531620A JP2009508507A5 JP 2009508507 A5 JP2009508507 A5 JP 2009508507A5 JP 2008531620 A JP2008531620 A JP 2008531620A JP 2008531620 A JP2008531620 A JP 2008531620A JP 2009508507 A5 JP2009508507 A5 JP 2009508507A5
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- JP
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- Prior art keywords
- cell population
- cells
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- cell
- treg
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 210000004027 cell Anatomy 0.000 claims 50
- 102100037850 Interferon gamma Human genes 0.000 claims 13
- 108010074328 Interferon-gamma Proteins 0.000 claims 13
- 210000003289 regulatory T cell Anatomy 0.000 claims 11
- 238000000034 method Methods 0.000 claims 9
- 239000000427 antigen Substances 0.000 claims 8
- 102000036639 antigens Human genes 0.000 claims 8
- 108091007433 antigens Proteins 0.000 claims 8
- 102000006639 indoleamine 2,3-dioxygenase Human genes 0.000 claims 6
- 108020004201 indoleamine 2,3-dioxygenase Proteins 0.000 claims 6
- 239000007787 solid Substances 0.000 claims 4
- 210000000612 antigen-presenting cell Anatomy 0.000 claims 3
- 210000002808 connective tissue Anatomy 0.000 claims 3
- 210000000265 leukocyte Anatomy 0.000 claims 3
- 210000005259 peripheral blood Anatomy 0.000 claims 3
- 239000011886 peripheral blood Substances 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- -1 CD11c Proteins 0.000 claims 2
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 2
- 239000006285 cell suspension Substances 0.000 claims 2
- 208000027866 inflammatory disease Diseases 0.000 claims 2
- 229960003130 interferon gamma Drugs 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 102100032912 CD44 antigen Human genes 0.000 claims 1
- 102100037904 CD9 antigen Human genes 0.000 claims 1
- 102100037241 Endoglin Human genes 0.000 claims 1
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims 1
- 101000868273 Homo sapiens CD44 antigen Proteins 0.000 claims 1
- 101000738354 Homo sapiens CD9 antigen Proteins 0.000 claims 1
- 101000881679 Homo sapiens Endoglin Proteins 0.000 claims 1
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims 1
- 101001046686 Homo sapiens Integrin alpha-M Proteins 0.000 claims 1
- 101000599852 Homo sapiens Intercellular adhesion molecule 1 Proteins 0.000 claims 1
- 101000946889 Homo sapiens Monocyte differentiation antigen CD14 Proteins 0.000 claims 1
- 101000610551 Homo sapiens Prominin-1 Proteins 0.000 claims 1
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 1
- 101000800116 Homo sapiens Thy-1 membrane glycoprotein Proteins 0.000 claims 1
- 102100022338 Integrin alpha-M Human genes 0.000 claims 1
- 102100022297 Integrin alpha-X Human genes 0.000 claims 1
- 102100037877 Intercellular adhesion molecule 1 Human genes 0.000 claims 1
- 102100035877 Monocyte differentiation antigen CD14 Human genes 0.000 claims 1
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims 1
- 102100040120 Prominin-1 Human genes 0.000 claims 1
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 1
- 102100033523 Thy-1 membrane glycoprotein Human genes 0.000 claims 1
- 230000001464 adherent effect Effects 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 208000037979 autoimmune inflammatory disease Diseases 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037765 diseases and disorders Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000011534 incubation Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 230000005865 ionizing radiation Effects 0.000 claims 1
- 230000007774 longterm Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000005855 radiation Effects 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
- 238000002054 transplantation Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP05077186.4 | 2005-09-23 | ||
| EP05077186 | 2005-09-23 | ||
| PCT/EP2006/009244 WO2007039150A2 (en) | 2005-09-23 | 2006-09-22 | Cell populations having immunoregulatory activity, method for isolation and uses |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014118859A Division JP6089004B2 (ja) | 2005-09-23 | 2014-06-09 | 免疫調節活性を有する細胞集団、単離方法および使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009508507A JP2009508507A (ja) | 2009-03-05 |
| JP2009508507A5 true JP2009508507A5 (enExample) | 2009-09-24 |
| JP5925408B2 JP5925408B2 (ja) | 2016-05-25 |
Family
ID=37708240
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008531620A Active JP5925408B2 (ja) | 2005-09-23 | 2006-09-22 | 免疫調節活性を有する細胞集団、単離方法および使用 |
| JP2014118859A Active JP6089004B2 (ja) | 2005-09-23 | 2014-06-09 | 免疫調節活性を有する細胞集団、単離方法および使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014118859A Active JP6089004B2 (ja) | 2005-09-23 | 2014-06-09 | 免疫調節活性を有する細胞集団、単離方法および使用 |
Country Status (19)
| Country | Link |
|---|---|
| US (5) | US20090130067A1 (enExample) |
| EP (4) | EP3184631B1 (enExample) |
| JP (2) | JP5925408B2 (enExample) |
| KR (2) | KR101536239B1 (enExample) |
| CN (2) | CN101313062A (enExample) |
| AU (1) | AU2006299144A1 (enExample) |
| CA (2) | CA2623353C (enExample) |
| CY (1) | CY1117972T1 (enExample) |
| DK (1) | DK1926813T4 (enExample) |
| ES (2) | ES2751692T3 (enExample) |
| HU (1) | HUE030503T2 (enExample) |
| IL (3) | IL190363A0 (enExample) |
| LT (1) | LT1926813T (enExample) |
| MX (1) | MX342474B (enExample) |
| PL (1) | PL1926813T5 (enExample) |
| PT (1) | PT1926813T (enExample) |
| SG (3) | SG165418A1 (enExample) |
| SI (1) | SI1926813T2 (enExample) |
| WO (1) | WO2007039150A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20060045872A1 (en) | 2004-08-25 | 2006-03-02 | Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco | Use of adipose tissue-derived stromal stem cells in treating fistula |
| JP5925408B2 (ja) | 2005-09-23 | 2016-05-25 | タイジェニックス、ソシエダッド、アノニマ、ウニペルソナルＴｉｇｅｎｉｘ Ｓ．Ａ．Ｕ． | 免疫調節活性を有する細胞集団、単離方法および使用 |
| DK2347775T3 (da) | 2005-12-13 | 2020-07-13 | Harvard College | Skabeloner til celletransplantation |
| US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
| US10328133B2 (en) | 2008-02-13 | 2019-06-25 | President And Fellows Of Harvard College | Continuous cell programming devices |
| EP2282748B1 (en) | 2008-03-28 | 2016-11-09 | Stemcyte, Inc. | Treatment of brain damage using umbilical cord blood cells |
| HUE037973T2 (hu) * | 2008-04-17 | 2018-09-28 | Io Biotech Aps | Indolamin-2,3-dioxigenáz-alapú immunterápia |
| GB0814249D0 (en) * | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| AU2009201915C1 (en) | 2008-08-22 | 2015-02-26 | Regeneus Ltd | Therapeutic methods |
| EP2204442A1 (en) * | 2008-10-01 | 2010-07-07 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method of enriching stem cells in culture |
| GB0820397D0 (en) | 2008-11-07 | 2008-12-17 | Cellerix Sa | Cells, nucleic acid constructs, cells comprising said constructs and methods utilizing said cells in the treatment of diseases |
| KR101788885B1 (ko) | 2009-07-09 | 2017-10-20 | 타이제닉스, 에스.에이.유. | 세포 요법에 사용하기 위한 방법 및 조성물 |
| WO2011014871A1 (en) * | 2009-07-31 | 2011-02-03 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
| US9005616B2 (en) | 2009-08-31 | 2015-04-14 | Amplimmune, Inc. | Methods and compositions for the inhibition of transplant rejection |
| GB0918615D0 (en) * | 2009-10-23 | 2009-12-09 | Cellerix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| CN107648668B (zh) | 2010-10-06 | 2021-06-18 | 哈佛学院董事会 | 用于基于材料的细胞疗法的可注射的成孔水凝胶 |
| EP2663316A2 (en) | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| JP2014508527A (ja) * | 2011-03-11 | 2014-04-10 | ティゲニクス、エセ、ア、ウ | 免疫調節活性を有する細胞集団、単離方法および使用 |
| CN109432502A (zh) * | 2011-04-25 | 2019-03-08 | 南加州大学 | 一种用于修复头盖缺陷的植入物 |
| US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
| US8834928B1 (en) | 2011-05-16 | 2014-09-16 | Musculoskeletal Transplant Foundation | Tissue-derived tissugenic implants, and methods of fabricating and using same |
| WO2012156522A1 (en) | 2011-05-19 | 2012-11-22 | Tigenix Sa | Cell populations having immunoregulatory activity, methods for the preparation and uses thereof |
| CN104244929B (zh) | 2012-04-16 | 2017-04-05 | 哈佛学院董事会 | 用于调节免疫反应的介孔二氧化硅组合物 |
| JP6412933B2 (ja) * | 2013-06-25 | 2018-10-24 | ティジェニクス エス．エー．ユー． | 免疫調節活性を有する細胞集団、その調製方法および使用 |
| US20150037436A1 (en) | 2013-07-30 | 2015-02-05 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| JP6702866B2 (ja) | 2013-11-18 | 2020-06-03 | ルビウス セラピューティクス， インコーポレイテッド | 合成膜−レシーバー複合体 |
| WO2015153102A1 (en) | 2014-04-01 | 2015-10-08 | Rubius Therapeutics, Inc. | Methods and compositions for immunomodulation |
| US10682400B2 (en) | 2014-04-30 | 2020-06-16 | President And Fellows Of Harvard College | Combination vaccine devices and methods of killing cancer cells |
| SG11201610844PA (en) | 2014-06-30 | 2017-01-27 | Tigenix S A U | Mesenchymal stromal cells for treating sepsis |
| JP6722598B2 (ja) | 2014-06-30 | 2020-07-15 | ティジェニクス エス．エー．ユー． | 関節リウマチ治療のための間葉系間質細胞 |
| JP2016017068A (ja) * | 2014-07-10 | 2016-02-01 | 国立大学法人金沢大学 | 脂肪組織由来間質細胞群を含む消化管炎症治療剤 |
| KR101675521B1 (ko) * | 2014-07-11 | 2016-11-17 | 대한민국 | 인돌아민 2,3-디옥시게나아제를 이용하여 인터페론-감마의 발현을 조절하는 방법 |
| EP3250250A4 (en) | 2015-01-30 | 2019-05-22 | President and Fellows of Harvard College | PERITUMORAL AND INTRATUMORAL MATERIALS FOR CANCER THERAPY |
| JP7094533B2 (ja) | 2015-04-10 | 2022-07-04 | プレジデント アンド フェローズ オブ ハーバード カレッジ | 免疫細胞捕捉デバイスおよびその製造および使用方法 |
| EP3297694A1 (en) | 2015-05-21 | 2018-03-28 | Musculoskeletal Transplant Foundation | Modified demineralized cortical bone fibers |
| US10912864B2 (en) | 2015-07-24 | 2021-02-09 | Musculoskeletal Transplant Foundation | Acellular soft tissue-derived matrices and methods for preparing same |
| US11052175B2 (en) | 2015-08-19 | 2021-07-06 | Musculoskeletal Transplant Foundation | Cartilage-derived implants and methods of making and using same |
| EP3411475B1 (en) | 2016-02-06 | 2025-08-27 | President and Fellows of Harvard College | Recapitulating the hematopoietic niche to reconstitute immunity |
| EP3419635B1 (en) | 2016-02-22 | 2022-01-05 | Centauri Biotech, S.L. | Pharmaceutical or veterinary cell compositions comprising mesenchymal stromal cells (mscs) and dimethyl sulfoxide (dmso) |
| GB201604304D0 (en) | 2016-03-14 | 2016-04-27 | Tigenix S A U | Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease |
| CN115537372A (zh) | 2016-07-13 | 2022-12-30 | 哈佛学院院长等 | 抗原呈递细胞模拟支架及其制备和使用方法 |
| EP3493842A4 (en) | 2016-08-02 | 2020-07-29 | President and Fellows of Harvard College | BIOMATERIALS TO MODULATE IMMUNE RESPONSES |
| AU2018234827B2 (en) | 2017-03-15 | 2024-04-04 | Orca Biosystems Inc. | Compositions and methods for hematopoietic stem cell transplants |
| US20210008120A1 (en) | 2018-03-13 | 2021-01-14 | Oxacell Ag | Cell products with improved stability and uses thereof |
| CA3103043A1 (en) | 2018-06-15 | 2019-12-19 | Luis Marinas Pardo | Pharmaceutical composition for dermatology and uses thereof |
| WO2020061129A1 (en) | 2018-09-19 | 2020-03-26 | President And Fellows Of Harvard College | Compositions and methods for labeling and modulation of cells in vitro and in vivo |
| KR20210149148A (ko) * | 2019-05-21 | 2021-12-08 | 이엠오 바이오메디슨 코퍼레이션 | 면역-관련 질환 치료에서의 중간엽 줄기 세포의 용도 |
| JP2023512072A (ja) * | 2020-01-30 | 2023-03-23 | モデルナティエックス インコーポレイテッド | 代謝リプログラミングポリペプチドをコードするｍＲＮＡ及びその使用 |
| KR102438419B1 (ko) * | 2021-12-01 | 2022-09-01 | 메디포스트(주) | Cd47 과발현 중간엽 줄기세포를 포함하는 폐 질환 예방 또는 치료용 조성물 |
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| GB0814249D0 (en) | 2008-08-04 | 2008-09-10 | Cellerix Sa | Uses of mesenchymal stem cells |
| ES2345867B1 (es) | 2009-04-03 | 2011-07-28 | Fundacion Instituto Mediterraneo Para La Biotecnologia Y La Investigacion Sanitaria (Imabis) | Celulas madre multipotentes derivadas de estroma de mesenterio. |
| KR101788885B1 (ko) | 2009-07-09 | 2017-10-20 | 타이제닉스, 에스.에이.유. | 세포 요법에 사용하기 위한 방법 및 조성물 |
| EP2663316A2 (en) | 2011-01-12 | 2013-11-20 | TiGenix, S.A.U. | Adipose-derived mesenchymal stem cells for intralymphatic administration in autoimmune and inflammatory diseases |
| JP2014508527A (ja) | 2011-03-11 | 2014-04-10 | ティゲニクス、エセ、ア、ウ | 免疫調節活性を有する細胞集団、単離方法および使用 |
| US20140134140A1 (en) | 2012-11-09 | 2014-05-15 | Case Western Reserve University | Mesenchymal stem cell compositions for the treatment of microbial infections |
| AU2014230014B2 (en) | 2013-03-15 | 2019-11-14 | Tigenix, S.A.U. | Lymphocyte biomarkers for determining the clinical response to therapy with mesenschymal stromal cells(MSC) |
| JP6412933B2 (ja) | 2013-06-25 | 2018-10-24 | ティジェニクス エス．エー．ユー． | 免疫調節活性を有する細胞集団、その調製方法および使用 |
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