|
US4331647A
(en)
*
|
1980-03-03 |
1982-05-25 |
Goldenberg Milton David |
Tumor localization and therapy with labeled antibody fragments specific to tumor-associated markers
|
|
DK368882A
(da)
*
|
1981-08-25 |
1983-02-26 |
Alan John Kingsman |
Expessions vektorer
|
|
US4579821A
(en)
*
|
1981-11-23 |
1986-04-01 |
University Patents, Inc. |
Control of DNA sequence transcription
|
|
US4656134A
(en)
*
|
1982-01-11 |
1987-04-07 |
Board Of Trustees Of Leland Stanford Jr. University |
Gene amplification in eukaryotic cells
|
|
US4486533A
(en)
*
|
1982-09-02 |
1984-12-04 |
St. Louis University |
Filamentous fungi functional replicating extrachromosomal element
|
|
US4599311A
(en)
*
|
1982-08-13 |
1986-07-08 |
Kawasaki Glenn H |
Glycolytic promotersfor regulated protein expression: protease inhibitor
|
|
US4977092A
(en)
*
|
1985-06-26 |
1990-12-11 |
Amgen |
Expression of exogenous polypeptides and polypeptide products including hepatitis B surface antigen in yeast cells
|
|
US4601978A
(en)
*
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4713339A
(en)
*
|
1983-01-19 |
1987-12-15 |
Genentech, Inc. |
Polycistronic expression vector construction
|
|
US4661454A
(en)
*
|
1983-02-28 |
1987-04-28 |
Collaborative Research, Inc. |
GAL1 yeast promoter linked to non galactokinase gene
|
|
US5139936A
(en)
*
|
1983-02-28 |
1992-08-18 |
Collaborative Research, Inc. |
Use of the GAL1 yeast promoter
|
|
US4870008A
(en)
*
|
1983-08-12 |
1989-09-26 |
Chiron Corporation |
Secretory expression in eukaryotes
|
|
US4931373A
(en)
*
|
1984-05-25 |
1990-06-05 |
Zymogenetics, Inc. |
Stable DNA constructs for expression of α-1 antitrypsin
|
|
US4766073A
(en)
*
|
1985-02-25 |
1988-08-23 |
Zymogenetics Inc. |
Expression of biologically active PDGF analogs in eucaryotic cells
|
|
CA1280080C
(en)
*
|
1984-12-06 |
1991-02-12 |
Jacques Oberto |
Promoters for the expression of foreign genes in yeast, plasmids comprising them, and uses thereof for the production of polypeptides
|
|
US4751181A
(en)
*
|
1984-12-31 |
1988-06-14 |
Duke University |
Methods and compositions useful in the diagnosis and treatment of autoimmune diseases
|
|
GR860984B
(en)
*
|
1985-04-17 |
1986-08-18 |
Zymogenetics Inc |
Expression of factor vii and ix activities in mammalian cells
|
|
US4882279A
(en)
*
|
1985-10-25 |
1989-11-21 |
Phillips Petroleum Company |
Site selective genomic modification of yeast of the genus pichia
|
|
US4935349A
(en)
*
|
1986-01-17 |
1990-06-19 |
Zymogenetics, Inc. |
Expression of higher eucaryotic genes in aspergillus
|
|
GB8611832D0
(en)
*
|
1986-05-15 |
1986-06-25 |
Holland I B |
Polypeptide
|
|
US4946778A
(en)
*
|
1987-09-21 |
1990-08-07 |
Genex Corporation |
Single polypeptide chain binding molecules
|
|
US5063154A
(en)
*
|
1987-06-24 |
1991-11-05 |
Whitehead Institute For Biomedical Research |
Pheromone - inducible yeast promoter
|
|
US5637677A
(en)
*
|
1987-07-16 |
1997-06-10 |
The Trustees Of The University Of Pennsylvania |
Biologically active compounds and methods of constructing and using the same
|
|
ES2092468T3
(es)
*
|
1988-01-22 |
1996-12-01 |
Zymogenetics Inc |
Metodos para producir analogos de receptores secretados.
|
|
US5567584A
(en)
*
|
1988-01-22 |
1996-10-22 |
Zymogenetics, Inc. |
Methods of using biologically active dimerized polypeptide fusions to detect PDGF
|
|
US4956288A
(en)
*
|
1988-04-22 |
1990-09-11 |
Biogen, Inc. |
Method for producing cells containing stably integrated foreign DNA at a high copy number, the cells produced by this method, and the use of these cells to produce the polypeptides coded for by the foreign DNA
|
|
US5037743A
(en)
*
|
1988-08-05 |
1991-08-06 |
Zymogenetics, Inc. |
BAR1 secretion signal
|
|
US5223409A
(en)
*
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5530101A
(en)
*
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
US5162228A
(en)
*
|
1988-12-28 |
1992-11-10 |
Takeda Chemical Industries, Ltd. |
Gylceraldehyde-3-phosphate dehydrogenase gene and promoter
|
|
US5162222A
(en)
*
|
1989-07-07 |
1992-11-10 |
Guarino Linda A |
Use of baculovirus early promoters for expression of foreign genes in stably transformed insect cells or recombinant baculoviruses
|
|
DE69030172T2
(de)
|
1990-01-26 |
1997-06-19 |
Immunomedics Inc |
Impfstoffe gegen Krebs und Infektionskrankheiten
|
|
ES2152920T3
(es)
|
1990-02-09 |
2001-02-16 |
Salk Inst For Biological Studi |
Composiciones receptoras de retinoides y metodos.
|
|
US5208146A
(en)
*
|
1990-11-05 |
1993-05-04 |
The Regents Of The University Of California |
Murine monoclonal anti-idiotype antibodies
|
|
WO1994006463A1
(en)
|
1992-09-14 |
1994-03-31 |
Pfizer Inc |
Immortalized cells and uses therefor
|
|
WO1994009137A1
(en)
|
1992-10-15 |
1994-04-28 |
Genentech, Inc. |
Antibodies against type 2 tumor necrosis factor receptor
|
|
US5595721A
(en)
*
|
1993-09-16 |
1997-01-21 |
Coulter Pharmaceutical, Inc. |
Radioimmunotherapy of lymphoma using anti-CD20
|
|
US5650550A
(en)
*
|
1993-10-01 |
1997-07-22 |
The United States Of America As Represented By The Department Of Health And Human Services |
Mutant mice having a deficit of functional estrogen receptors
|
|
US5523227A
(en)
*
|
1994-06-17 |
1996-06-04 |
The Board Of Trustees Of The Leland Stanford Junior Univ. |
DNA encoding calcium-signal modulating cyclophilin ligand
|
|
DK0871645T3
(da)
|
1994-12-15 |
2007-12-03 |
Yeda Res & Dev |
Modulationer af FAS/APO1-receptorers funktion
|
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
|
US5739277A
(en)
*
|
1995-04-14 |
1998-04-14 |
Genentech Inc. |
Altered polypeptides with increased half-life
|
|
DE19533447C1
(de)
|
1995-09-09 |
1996-12-05 |
Bbs Kraftfahrzeugtechnik |
Verfahren und Vorrichtung zum Befüllen eines Gießwerkzeugs mit einer Metallschmelze
|
|
US5716808A
(en)
*
|
1995-11-09 |
1998-02-10 |
Zymogenetics, Inc. |
Genetic engineering of pichia methanolica
|
|
WO1997017451A2
(en)
|
1995-11-09 |
1997-05-15 |
Zymogenetics, Inc. |
Production of gad65 in methylotrophic yeast
|
|
DE69630710T2
(de)
|
1996-03-14 |
2004-09-23 |
Human Genome Sciences Inc. |
Humaner tumornekrosefaktor delta und epsilon
|
|
IL128073A0
(en)
|
1996-07-17 |
1999-11-30 |
Zymogenetics Inc |
Transformation of pichia methanolica
|
|
US5736383A
(en)
*
|
1996-08-26 |
1998-04-07 |
Zymogenetics, Inc. |
Preparation of Pichia methanolica auxotrophic mutants
|
|
JP2002514049A
(ja)
|
1996-07-17 |
2002-05-14 |
ザイモジェネティクス，インコーポレイティド |
ピヒア・メタノリカの栄養要求性突然変異体の製造
|
|
US6689579B1
(en)
*
|
1996-10-25 |
2004-02-10 |
Human Genome Sciences, Inc. |
Polynucleotides encoding neutrokine-α
|
|
NZ334309A
(en)
|
1996-10-25 |
2000-08-25 |
Human Genome Sciences Inc |
Neutrokine alpha protein, a member of the TNF family, and its use in treating and/or detecting immune disorders
|
|
AU5705898A
(en)
|
1996-12-17 |
1998-07-15 |
Schering Corporation |
Mammalian cell surface antigens; related reagents
|
|
US5969102A
(en)
*
|
1997-03-03 |
1999-10-19 |
St. Jude Children's Research Hospital |
Lymphocyte surface receptor that binds CAML, nucleic acids encoding the same and methods of use thereof
|
|
CA2232743A1
(en)
|
1997-04-02 |
1998-10-02 |
Smithkline Beecham Corporation |
A tnf homologue, tl5
|
|
EP0991759A1
(en)
|
1997-06-06 |
2000-04-12 |
Regeneron Pharmaceuticals, Inc. |
Ntn-2 member of tnf ligand family
|
|
EP1012292A1
(en)
|
1997-06-06 |
2000-06-28 |
Regeneron Pharmaceuticals, Inc. |
Ntn-2 member of tnf ligand family
|
|
WO1999004001A1
(en)
|
1997-07-21 |
1999-01-28 |
Zymogenetics, Inc. |
Tumor necrosis factor receptor ztnfr-5
|
|
US6015801A
(en)
*
|
1997-07-22 |
2000-01-18 |
Merck & Co., Inc. |
Method for inhibiting bone resorption
|
|
AU9376498A
(en)
|
1997-09-05 |
1999-03-22 |
University Of Washington |
Tumor necrosis factor family receptors and ligands, encoding nucleic acids and related binding agents
|
|
PL339463A1
(en)
|
1997-09-12 |
2000-12-18 |
Biogen |
April - novel protein of growth promoting action
|
|
TR200000654T2
(tr)
|
1997-09-12 |
2000-07-21 |
Apotech R & D Sa |
KAY-Yeni bir bağışıklık sistemi proteini.
|
|
WO2001060397A1
(en)
*
|
2000-02-16 |
2001-08-23 |
Genentech, Inc. |
Uses of agonists and antagonists to modulate activity of tnf-related molecules
|
|
DE19831987A1
(de)
|
1998-07-16 |
2000-01-20 |
Bayer Ag |
Diphenylimidazoline
|
|
GB9828628D0
(en)
|
1998-12-23 |
1999-02-17 |
Glaxo Group Ltd |
Novel ligand
|
|
WO2000040714A2
(en)
|
1998-12-30 |
2000-07-13 |
Oligos Etc. Inc. |
Therapeutic phosphodiesterase inhibitors
|
|
US7833529B1
(en)
|
1999-01-07 |
2010-11-16 |
Zymogenetics, Inc. |
Methods for inhibiting B lymphocyte proliferation with soluble ztnf4 receptor
|
|
US20060067933A1
(en)
|
1999-01-07 |
2006-03-30 |
Gross Jane A |
Soluble receptor BR43x2 and methods of using
|
|
CZ303272B6
(cs)
|
1999-01-07 |
2012-07-11 |
Zymogenetics, Inc. |
Farmaceutický prostredek obsahující fúzní protein, izolovaná molekula polynukleotidu, expresní vektor, kultivovaná bunka, zpusob prípravy polypeptidu a izolovaný polypeptid
|
|
CZ299819B6
(cs)
|
1999-01-25 |
2008-12-03 |
Biogen Idec Ma Inc. |
Farmaceutické kompozice obsahující protilátky specifické pro rozpustný BAFF
|
|
EP1860190A3
(en)
|
1999-02-23 |
2008-03-12 |
Human Genome Sciences, Inc. |
Neutrokine-alpha and neutrokine-alpha splice variants
|
|
CA2366785C
(en)
|
1999-04-19 |
2012-02-07 |
Immunex Corporation |
Soluble tumor necrosis factor receptor treatment of medical disorders
|
|
US20030022233A1
(en)
|
1999-04-30 |
2003-01-30 |
Raymond G. Goodwin |
Methods of use of the taci/taci-l interaction
|
|
US6537540B1
(en)
*
|
1999-05-28 |
2003-03-25 |
Targeted Genetics Corporation |
Methods and composition for lowering the level of tumor necrosis factor (TNF) in TNF-associated disorders
|
|
HK1043608B
(en)
|
1999-08-17 |
2007-12-07 |
Biogen Ma Inc. |
Baff receptor (bcma), an immunoregulatory agent
|
|
UA74798C2
(uk)
|
1999-10-06 |
2006-02-15 |
Байоджен Айдек Ма Інк. |
Спосіб лікування раку у ссавця за допомогою поліпептиду, що протидіє взаємодії april з його рецепторами
|
|
AU2006201471B2
(en)
|
2000-02-16 |
2009-07-23 |
Genentech, Inc. |
Uses of agonists and antagonists to modulate activity of TNF-related molecules
|
|
PT2857516T
(pt)
|
2000-04-11 |
2017-08-28 |
Genentech Inc |
Anticorpos multivalentes e utilizações dos mesmos
|
|
US20040013674A1
(en)
|
2001-04-27 |
2004-01-22 |
Christine Ambrose |
Taci as an anti-tumor agent
|
|
NZ521629A
(en)
|
2000-04-27 |
2004-05-28 |
Biogen Inc |
TACI as an anti-tumor agent
|
|
AU2001263114A1
(en)
*
|
2000-05-12 |
2001-11-26 |
Amgen Inc |
Methods and compositions of matter concerning april/g70, bcma, blys/agp-3, and taci
|
|
CN101275136A
(zh)
|
2000-08-11 |
2008-10-01 |
麒麟医药株式会社 |
调节磷酸代谢,钙代谢,钙化和维生素d代谢的多肽及其编码dna
|
|
DK1407017T3
(en)
|
2000-11-07 |
2009-09-21 |
Zymogenetics Inc |
Human receptor for tumor nekrose faktor
|
|
PL403488A1
(pl)
*
|
2001-05-24 |
2013-07-08 |
Zymogenetics, Inc. |
Zastosowanie bialka fuzyjnego TACI-immunoglobulina, bialko fuzyjne, czasteczka kwasu nukleinowego kodujaca bialko fuzyjne, kompozycja farmaceutyczna i sposób wytwarzania bialka fuzyjnego TACI-immunoglobulina
|
|
KR20040019105A
(ko)
|
2001-08-03 |
2004-03-04 |
제넨테크, 인크. |
ＴＡＣＩｓ 및 ＢＲ3 폴리펩티드 및 이의 용도
|
|
US20050163775A1
(en)
|
2003-06-05 |
2005-07-28 |
Genentech, Inc. |
Combination therapy for B cell disorders
|
|
WO2005042009A1
(en)
|
2003-10-20 |
2005-05-12 |
Biogen Idec Ma Inc. |
Therapeutic regimens for baff antagonists
|
|
US8808696B2
(en)
|
2005-08-09 |
2014-08-19 |
Ares Trading S.A. |
Methods for the treatment and prevention of abnormal cell proliferation using TACI-fusion molecules
|
|
KR20080056714A
(ko)
|
2005-08-09 |
2008-06-23 |
지모제넥틱스, 인코포레이티드 |
ＴＡＣＩ―Ｉｇ 융합 분자를 사용하여 Ｂ―세포 악성종양을치료하는 방법
|