JP2010520304A5 - - Google Patents
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- JP2010520304A5 JP2010520304A5 JP2009552872A JP2009552872A JP2010520304A5 JP 2010520304 A5 JP2010520304 A5 JP 2010520304A5 JP 2009552872 A JP2009552872 A JP 2009552872A JP 2009552872 A JP2009552872 A JP 2009552872A JP 2010520304 A5 JP2010520304 A5 JP 2010520304A5
- Authority
- JP
- Japan
- Prior art keywords
- composition according
- lipid
- membrane
- surfactant layer
- composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000002632 lipids Chemical class 0.000 claims 6
- 239000004094 surface-active agent Substances 0.000 claims 6
- 108090000765 processed proteins & peptides Proteins 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 230000002209 hydrophobic effect Effects 0.000 claims 3
- 150000001413 amino acids Chemical class 0.000 claims 2
- 239000000032 diagnostic agent Substances 0.000 claims 2
- 229940039227 diagnostic agent Drugs 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 230000001225 therapeutic effect Effects 0.000 claims 2
- 108010036176 Melitten Proteins 0.000 claims 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 1
- 150000001722 carbon compounds Chemical class 0.000 claims 1
- 230000003013 cytotoxicity Effects 0.000 claims 1
- 231100000135 cytotoxicity Toxicity 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 230000009036 growth inhibition Effects 0.000 claims 1
- 239000003446 ligand Substances 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- VDXZNPDIRNWWCW-JFTDCZMZSA-N melittin Chemical group NCC(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(N)=O)CC1=CNC2=CC=CC=C12 VDXZNPDIRNWWCW-JFTDCZMZSA-N 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- 102000004196 processed proteins & peptides Human genes 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US90522707P | 2007-03-05 | 2007-03-05 | |
| US60/905,227 | 2007-03-05 | ||
| US99165407P | 2007-11-30 | 2007-11-30 | |
| US60/991,654 | 2007-11-30 | ||
| PCT/US2008/055969 WO2008109712A2 (en) | 2007-03-05 | 2008-03-05 | Nanoparticle delivery systems for membrane-integrating peptides |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010520304A JP2010520304A (ja) | 2010-06-10 |
| JP2010520304A5 true JP2010520304A5 (enExample) | 2011-04-21 |
| JP5249248B2 JP5249248B2 (ja) | 2013-07-31 |
Family
ID=39739102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009552872A Expired - Fee Related JP5249248B2 (ja) | 2007-03-05 | 2008-03-05 | 膜組み込みペプチドのためのナノ粒子輸送システム |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US7943168B2 (enExample) |
| EP (1) | EP2120876B1 (enExample) |
| JP (1) | JP5249248B2 (enExample) |
| AU (1) | AU2008222822A1 (enExample) |
| CA (1) | CA2680206C (enExample) |
| WO (1) | WO2008109712A2 (enExample) |
Families Citing this family (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101868180A (zh) | 2007-10-09 | 2010-10-20 | 圣路易斯华盛顿州立大学 | 成像粒子 |
| WO2009049089A1 (en) | 2007-10-09 | 2009-04-16 | Washington University In St. Louis | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| WO2009151788A2 (en) * | 2008-04-22 | 2009-12-17 | The Washington University | Universal anchor peptide for nanoparticles |
| CN106362171A (zh) | 2009-02-13 | 2017-02-01 | 华盛顿大学 | 用于磁共振成像的钆表现脂质纳米颗粒 |
| AU2010339809B2 (en) | 2009-12-17 | 2016-05-05 | The Washington University | Antithrombotic nanoparticle |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| AU2011239414A1 (en) | 2010-04-15 | 2012-11-08 | The Washington University | Prodrug compositions, prodrug nanoparticles, and methods of use thereof |
| US8822663B2 (en) | 2010-08-06 | 2014-09-02 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| DK4108671T3 (da) | 2010-10-01 | 2025-01-06 | Modernatx Inc | Modificerede nukleosider, nukleotider og nukleinsyrer samt anvendelser deraf |
| US20120100186A1 (en) * | 2010-10-20 | 2012-04-26 | Washington University | Nanoparticulate-based contraceptive/anti-hiv composition and methods |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
| US9464124B2 (en) | 2011-09-12 | 2016-10-11 | Moderna Therapeutics, Inc. | Engineered nucleic acids and methods of use thereof |
| JP6113737B2 (ja) | 2011-10-03 | 2017-04-12 | モデルナティエックス インコーポレイテッドＭｏｄｅｒｎａＴＸ，Ｉｎｃ． | 修飾型のヌクレオシド、ヌクレオチドおよび核酸、ならびにそれらの使用方法 |
| WO2013082304A1 (en) * | 2011-11-29 | 2013-06-06 | The Regents Of The University Of California | Photonic nanoantenna mediated gene circuit reconfiguration |
| KR20140102759A (ko) | 2011-12-16 | 2014-08-22 | 모더나 세라퓨틱스, 인코포레이티드 | 변형된 뉴클레오사이드, 뉴클레오타이드 및 핵산 조성물 |
| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9254311B2 (en) | 2012-04-02 | 2016-02-09 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| EP2834259A4 (en) | 2012-04-02 | 2016-08-24 | Moderna Therapeutics Inc | MODIFIED POLYNUCLEOTIDES |
| US9597380B2 (en) | 2012-11-26 | 2017-03-21 | Modernatx, Inc. | Terminally modified RNA |
| US10258698B2 (en) | 2013-03-14 | 2019-04-16 | Modernatx, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| US8980864B2 (en) | 2013-03-15 | 2015-03-17 | Moderna Therapeutics, Inc. | Compositions and methods of altering cholesterol levels |
| AU2014315287A1 (en) | 2013-09-03 | 2015-03-12 | Moderna Therapeutics, Inc. | Chimeric polynucleotides |
| EP3041938A1 (en) | 2013-09-03 | 2016-07-13 | Moderna Therapeutics, Inc. | Circular polynucleotides |
| US10023626B2 (en) | 2013-09-30 | 2018-07-17 | Modernatx, Inc. | Polynucleotides encoding immune modulating polypeptides |
| EP3052521A1 (en) | 2013-10-03 | 2016-08-10 | Moderna Therapeutics, Inc. | Polynucleotides encoding low density lipoprotein receptor |
| RU2021109685A (ru) | 2014-04-23 | 2021-04-13 | МОДЕРНАТиЭкс, ИНК. | Вакцины на основе нуклеиновых кислот |
| US20160296628A1 (en) * | 2015-01-23 | 2016-10-13 | Washington University | Nanoparticle delivery systems for cytolytic peptide prodrugs |
| WO2017031232A1 (en) | 2015-08-17 | 2017-02-23 | Modernatx, Inc. | Methods for preparing particles and related compositions |
| EP3350157B1 (en) | 2015-09-17 | 2022-01-05 | Modernatx, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| ES2924407T3 (es) | 2015-12-10 | 2022-10-06 | Modernatx Inc | Composiciones y procedimientos para el suministro de agentes terapéuticos |
| SI3394030T1 (sl) | 2015-12-22 | 2022-04-29 | Modernatx, Inc. | Sestave za doziranje sredstev v celice |
| LT3394093T (lt) | 2015-12-23 | 2022-04-25 | Modernatx, Inc. | Ox40 ligandus koduojančių polinukleotidų naudojimo būdai |
| EP3400023A1 (en) | 2016-01-10 | 2018-11-14 | ModernaTX, Inc. | Therapeutic mrnas encoding anti ctla-4 antibodies |
| US11583504B2 (en) | 2016-11-08 | 2023-02-21 | Modernatx, Inc. | Stabilized formulations of lipid nanoparticles |
| JP7332478B2 (ja) | 2017-03-15 | 2023-08-23 | モデルナティエックス インコーポレイテッド | 脂質ナノ粒子製剤 |
| ES2911186T3 (es) | 2017-03-15 | 2022-05-18 | Modernatx Inc | Formas cristalinas de aminolípidos |
| FI3596041T3 (fi) | 2017-03-15 | 2023-01-31 | Yhdiste ja koostumuksia terapeuttisten aineiden antamiseen solun sisään | |
| US11421011B2 (en) | 2017-05-18 | 2022-08-23 | Modernatx, Inc. | Polynucleotides encoding tethered interleukin-12 (IL12) polypeptides and uses thereof |
| EP3638678B1 (en) | 2017-06-14 | 2025-12-03 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of agents |
| EP3853202A1 (en) | 2018-09-19 | 2021-07-28 | ModernaTX, Inc. | Compounds and compositions for intracellular delivery of therapeutic agents |
| WO2020061284A1 (en) | 2018-09-19 | 2020-03-26 | Modernatx, Inc. | Peg lipids and uses thereof |
| EP4509118A3 (en) | 2018-09-19 | 2025-05-14 | ModernaTX, Inc. | High-purity peg lipids and uses thereof |
| BR112022004759A2 (pt) | 2019-09-19 | 2022-06-21 | Modernatx Inc | Composições e compostos lipídicos com cauda ramificada para entrega intracelular de agentes terapêuticos |
| US11524023B2 (en) | 2021-02-19 | 2022-12-13 | Modernatx, Inc. | Lipid nanoparticle compositions and methods of formulating the same |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5576016A (en) * | 1993-05-18 | 1996-11-19 | Pharmos Corporation | Solid fat nanoemulsions as drug delivery vehicles |
| US5645996A (en) | 1994-08-24 | 1997-07-08 | Torrey Pines Institute For Molecular Studies | Melittin-related polypeptides, mixture sets and libraries thereof |
| JP3450318B2 (ja) | 1994-11-21 | 2003-09-22 | 株式会社ワイ・ワイ・エル | 熱電冷却型パワーリード |
| US6821506B2 (en) * | 1995-06-08 | 2004-11-23 | Barnes-Jewish Hospital | Site specific binding system, imaging compositions and methods |
| US20050119470A1 (en) * | 1996-06-06 | 2005-06-02 | Muthiah Manoharan | Conjugated oligomeric compounds and their use in gene modulation |
| US6248353B1 (en) * | 1999-12-10 | 2001-06-19 | Dade Behring Inc. | Reconstitution of purified membrane proteins into preformed liposomes |
| US6780416B1 (en) * | 2000-02-18 | 2004-08-24 | Ecole Polytechnique Federale De Lausanne | Bee venom polypeptides and methods of use thereof |
| US6676963B1 (en) | 2000-10-27 | 2004-01-13 | Barnes-Jewish Hospital | Ligand-targeted emulsions carrying bioactive agents |
| NZ534500A (en) | 2002-01-24 | 2007-07-27 | Barnes Jewish Hospital | Nanoparticle-based emulsions specifically targeted to integrins |
| WO2005051305A2 (en) | 2003-11-19 | 2005-06-09 | Barnes-Jewish Hospital | Enhanced drug delivery |
| US20050177541A1 (en) * | 2004-02-04 | 2005-08-11 | Zorch, Inc. | Method and system for dynamically updating a process library |
| US20070140973A1 (en) | 2005-12-15 | 2007-06-21 | Bristol-Myers Squibb Pharma Company | Contrast agents for myocardium perfusion imaging |
| WO2009151788A2 (en) * | 2008-04-22 | 2009-12-17 | The Washington University | Universal anchor peptide for nanoparticles |
-
2008
- 2008-03-05 CA CA2680206A patent/CA2680206C/en not_active Expired - Fee Related
- 2008-03-05 EP EP08731481.1A patent/EP2120876B1/en not_active Not-in-force
- 2008-03-05 WO PCT/US2008/055969 patent/WO2008109712A2/en not_active Ceased
- 2008-03-05 US US12/043,063 patent/US7943168B2/en not_active Expired - Fee Related
- 2008-03-05 AU AU2008222822A patent/AU2008222822A1/en not_active Abandoned
- 2008-03-05 JP JP2009552872A patent/JP5249248B2/ja not_active Expired - Fee Related
-
2011
- 2011-05-17 US US13/109,873 patent/US8496945B2/en not_active Expired - Fee Related
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