JP2009507035A5 - - Google Patents
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- JP2009507035A5 JP2009507035A5 JP2008529356A JP2008529356A JP2009507035A5 JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5 JP 2008529356 A JP2008529356 A JP 2008529356A JP 2008529356 A JP2008529356 A JP 2008529356A JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5
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- Prior art keywords
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- composition
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- independently selected
- compound
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 17
- 229910052799 carbon Inorganic materials 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 125000001931 aliphatic group Chemical group 0.000 claims 7
- 125000001072 heteroaryl group Chemical group 0.000 claims 6
- 229910052717 sulfur Inorganic materials 0.000 claims 6
- -1 carbonyl halide Chemical class 0.000 claims 5
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 125000000542 sulfonic acid group Chemical group 0.000 claims 4
- 125000003545 alkoxy group Chemical group 0.000 claims 3
- 150000001408 amides Chemical class 0.000 claims 3
- 150000001412 amines Chemical class 0.000 claims 3
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 3
- 150000007942 carboxylates Chemical class 0.000 claims 3
- 150000001733 carboxylic acid esters Chemical class 0.000 claims 3
- 150000001735 carboxylic acids Chemical class 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 3
- 238000012634 optical imaging Methods 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- 229910052711 selenium Inorganic materials 0.000 claims 3
- 239000000126 substance Substances 0.000 claims 3
- 229940124530 sulfonamide Drugs 0.000 claims 3
- 150000003456 sulfonamides Chemical class 0.000 claims 3
- 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 claims 3
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims 2
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- TWBYWOBDOCUKOW-UHFFFAOYSA-N isonicotinic acid Chemical compound OC(=O)C1=CC=NC=C1 TWBYWOBDOCUKOW-UHFFFAOYSA-N 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 230000003287 optical effect Effects 0.000 claims 2
- SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 claims 2
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims 1
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical group OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims 1
- 208000024172 Cardiovascular disease Diseases 0.000 claims 1
- 208000035473 Communicable disease Diseases 0.000 claims 1
- 208000026350 Inborn Genetic disease Diseases 0.000 claims 1
- 208000029534 Infectious Bone disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 238000002659 cell therapy Methods 0.000 claims 1
- 230000030570 cellular localization Effects 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- 208000016097 disease of metabolism Diseases 0.000 claims 1
- 230000007613 environmental effect Effects 0.000 claims 1
- 208000016361 genetic disease Diseases 0.000 claims 1
- 125000000623 heterocyclic group Chemical group 0.000 claims 1
- 125000002883 imidazolyl group Chemical group 0.000 claims 1
- 208000026278 immune system disease Diseases 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000003993 interaction Effects 0.000 claims 1
- 230000010189 intracellular transport Effects 0.000 claims 1
- 230000001678 irradiating effect Effects 0.000 claims 1
- 208000030159 metabolic disease Diseases 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 230000004770 neurodegeneration Effects 0.000 claims 1
- 208000015122 neurodegenerative disease Diseases 0.000 claims 1
- 229960003512 nicotinic acid Drugs 0.000 claims 1
- 235000001968 nicotinic acid Nutrition 0.000 claims 1
- 239000011664 nicotinic acid Substances 0.000 claims 1
- 125000000538 pentafluorophenyl group Chemical group FC1=C(F)C(F)=C(*)C(F)=C1F 0.000 claims 1
- 229940081066 picolinic acid Drugs 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical compound C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- VTGOHKSTWXHQJK-UHFFFAOYSA-N pyrimidin-2-ol Chemical compound OC1=NC=CC=N1 VTGOHKSTWXHQJK-UHFFFAOYSA-N 0.000 claims 1
- 208000023504 respiratory system disease Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71407405P | 2005-09-02 | 2005-09-02 | |
| US60/714,074 | 2005-09-02 | ||
| PCT/US2006/034406 WO2007028118A2 (en) | 2005-09-02 | 2006-09-01 | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232544A Division JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009507035A JP2009507035A (ja) | 2009-02-19 |
| JP2009507035A5 true JP2009507035A5 (enExample) | 2009-12-24 |
| JP5416970B2 JP5416970B2 (ja) | 2014-02-12 |
Family
ID=37653212
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008529356A Active JP5416970B2 (ja) | 2005-09-02 | 2006-09-01 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
| JP2012232544A Withdrawn JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012232544A Withdrawn JP2013014625A (ja) | 2005-09-02 | 2012-10-22 | ニコチン酸及びピコリン酸誘導近赤外線蛍光団 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US8173819B2 (enExample) |
| EP (1) | EP1934202B1 (enExample) |
| JP (2) | JP5416970B2 (enExample) |
| WO (1) | WO2007028118A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2003207438A1 (en) | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| US8227621B2 (en) | 2005-06-30 | 2012-07-24 | Li-Cor, Inc. | Cyanine dyes and methods of use |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| ES2612738T3 (es) * | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| DK1934211T3 (en) | 2005-09-02 | 2017-04-10 | Visen Medical Inc | Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| JP5643514B2 (ja) | 2007-02-09 | 2014-12-17 | ビセン メディカル， インコーポレイテッド | ポリシクロ染料およびその使用 |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| EP2732826B1 (en) * | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| CN102281904A (zh) * | 2008-11-20 | 2011-12-14 | 通用电气医疗集团股份有限公司 | 染料缀合物成像剂 |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
| WO2010121163A2 (en) * | 2009-04-17 | 2010-10-21 | Li-Cor, Inc. | Fluorescent imaging with substituted cyanine dyes |
| JP2011046663A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| JP2011046662A (ja) * | 2009-08-28 | 2011-03-10 | Fujifilm Corp | 近赤外蛍光造影剤 |
| GB201010878D0 (en) * | 2010-06-29 | 2010-08-11 | Ge Healthcare As | Dye compositiion and dye syntheses |
| US9610367B2 (en) * | 2010-08-24 | 2017-04-04 | Canon Kabushiki Kaisha | Particle and contrast agent having the particle |
| WO2012027623A2 (en) | 2010-08-25 | 2012-03-01 | Pacific Biosciences Of California, Inc. | Cyanine dyes |
| EP2630196B1 (en) | 2010-10-20 | 2017-09-06 | Li-Cor, Inc. | Cyanine dyes and their conjugates |
| EP2707102B1 (en) | 2011-05-09 | 2019-11-13 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| CZ304094B6 (cs) * | 2011-12-01 | 2013-10-16 | Vysoká skola chemicko-technologická v Praze | Vyuzití polymethiniových solí jako mitochondriálních sond |
| WO2013148319A1 (en) | 2012-03-30 | 2013-10-03 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| US9315864B2 (en) | 2012-05-18 | 2016-04-19 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes with sulfonic acid substituents |
| US10458915B2 (en) | 2012-05-18 | 2019-10-29 | Pacific Biosciences Of California, Inc. | Heteroarylcyanine dyes |
| CA2882019C (en) | 2012-08-15 | 2021-02-09 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| CN105339436B (zh) * | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| WO2015066296A1 (en) | 2013-10-31 | 2015-05-07 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent nerve contrast agents and methods of use thereof |
| EP4147724A1 (en) * | 2013-10-31 | 2023-03-15 | Beth Israel Deaconess Medical Center | Near-infrared fluorescent contrast bioimaging agents and methods of use thereof |
| CZ306320B6 (cs) * | 2014-04-01 | 2016-11-30 | Vysoká škola chemicko - technologická v Praze | Využití nových typů pentamethiniových solí s expandovanou chinoxalinovou jednotkou v protinádorové terapii |
| GB2567124A (en) * | 2017-05-08 | 2019-04-10 | Vysoka Akola Chemicko Tech V Praze | Imaging agents and methods |
| JP7032969B2 (ja) * | 2018-03-28 | 2022-03-09 | 日本化薬株式会社 | シアニン化合物 |
| US20250082795A1 (en) | 2023-09-12 | 2025-03-13 | Curadel Surgical Innovations, Inc. | Combinations of imaging agent conjugates and application thereof |
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| JP5643514B2 (ja) | 2007-02-09 | 2014-12-17 | ビセン メディカル， インコーポレイテッド | ポリシクロ染料およびその使用 |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US8314406B2 (en) | 2007-04-06 | 2012-11-20 | The General Hospital Corporation | Systems and methods for optical imaging using early arriving photons |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| CA2715034C (en) | 2008-03-14 | 2016-12-06 | Visen Medical, Inc. | Integrin targeting agents and in-vivo and in-vitro imaging methods using the same |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2006
- 2006-09-01 WO PCT/US2006/034406 patent/WO2007028118A2/en not_active Ceased
- 2006-09-01 EP EP06802888.5A patent/EP1934202B1/en active Active
- 2006-09-01 JP JP2008529356A patent/JP5416970B2/ja active Active
- 2006-09-01 US US12/065,391 patent/US8173819B2/en active Active
-
2012
- 2012-04-18 US US13/450,003 patent/US8455651B2/en active Active
- 2012-10-22 JP JP2012232544A patent/JP2013014625A/ja not_active Withdrawn
-
2013
- 2013-03-14 US US13/828,648 patent/US8771646B2/en active Active
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