JP5416970B2 - ニコチン酸及びピコリン酸誘導近赤外線蛍光団 - Google Patents

ニコチン酸及びピコリン酸誘導近赤外線蛍光団 Download PDF

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JP5416970B2
JP5416970B2 JP2008529356A JP2008529356A JP5416970B2 JP 5416970 B2 JP5416970 B2 JP 5416970B2 JP 2008529356 A JP2008529356 A JP 2008529356A JP 2008529356 A JP2008529356 A JP 2008529356A JP 5416970 B2 JP5416970 B2 JP 5416970B2
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group
compound
composition
substituted
fluorescent
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JP2009507035A5 (enExample
JP2009507035A (ja
Inventor
ミリンド ラジョパディー，
ナラシムハチャリ ナラヤナン，
ジェフリー ディー． ピーターソン，
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ビセン メディカル， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • A61K49/0032—Methine dyes, e.g. cyanine dyes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/001—Preparation for luminescence or biological staining
    • A61K49/0013—Luminescence
    • A61K49/0017—Fluorescence in vivo
    • A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
    • A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/0008—Methine or polymethine dyes, e.g. cyanine dyes substituted on the polymethine chain
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00—Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083—Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Pyridine Compounds (AREA)
JP2008529356A 2005-09-02 2006-09-01 ニコチン酸及びピコリン酸誘導近赤外線蛍光団 Active JP5416970B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71407405P 2005-09-02 2005-09-02
US60/714,074 2005-09-02
PCT/US2006/034406 WO2007028118A2 (en) 2005-09-02 2006-09-01 Nicotinic acid and picolinic acid derived near-infrared fluorophores

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012232544A Division JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Publications (3)

Publication Number Publication Date
JP2009507035A JP2009507035A (ja) 2009-02-19
JP2009507035A5 JP2009507035A5 (enExample) 2009-12-24
JP5416970B2 true JP5416970B2 (ja) 2014-02-12

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Family Applications (2)

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JP2008529356A Active JP5416970B2 (ja) 2005-09-02 2006-09-01 ニコチン酸及びピコリン酸誘導近赤外線蛍光団
JP2012232544A Withdrawn JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

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JP2012232544A Withdrawn JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Country Status (4)

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US (3) US8173819B2 (enExample)
EP (1) EP1934202B1 (enExample)
JP (2) JP5416970B2 (enExample)
WO (1) WO2007028118A2 (enExample)

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Also Published As

Publication number Publication date
US8173819B2 (en) 2012-05-08
WO2007028118A2 (en) 2007-03-08
WO2007028118A3 (en) 2007-04-26
EP1934202A2 (en) 2008-06-25
US20130272967A1 (en) 2013-10-17
EP1934202B1 (en) 2019-01-09
US8455651B2 (en) 2013-06-04
US20120321562A1 (en) 2012-12-20
US20080267883A1 (en) 2008-10-30
JP2009507035A (ja) 2009-02-19
US8771646B2 (en) 2014-07-08
JP2013014625A (ja) 2013-01-24

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