ATE296828T1 - Verbindungen zur floureszenz-kennzeichnung - Google Patents

Verbindungen zur floureszenz-kennzeichnung

Info

Publication number
ATE296828T1
ATE296828T1 AT00961100T AT00961100T ATE296828T1 AT E296828 T1 ATE296828 T1 AT E296828T1 AT 00961100 T AT00961100 T AT 00961100T AT 00961100 T AT00961100 T AT 00961100T AT E296828 T1 ATE296828 T1 AT E296828T1
Authority
AT
Austria
Prior art keywords
group
represent
compounds
alkyl group
bind
Prior art date
Application number
AT00961100T
Other languages
English (en)
Inventor
Junji Nishigaki
Kouki Nakamura
Original Assignee
Fuji Photo Film Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fuji Photo Film Co Ltd filed Critical Fuji Photo Film Co Ltd
Application granted granted Critical
Publication of ATE296828T1 publication Critical patent/ATE296828T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02Phosphorus compounds
    • C07F9/547Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/06Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups three >CH- groups, e.g. carbocyanines
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/083Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines five >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/02Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups
    • C09B23/08Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines
    • C09B23/086Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing an odd number of >CH- or >C[alkyl]- groups more than three >CH- groups, e.g. polycarbocyanines more than five >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10The polymethine chain containing an even number of >CH- groups
    • C09B23/105The polymethine chain containing an even number of >CH- groups two >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/10The polymethine chain containing an even number of >CH- groups
    • C09B23/107The polymethine chain containing an even number of >CH- groups four >CH- groups
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/14Styryl dyes
    • C09B23/145Styryl dyes the ethylene chain carrying an heterocyclic residue, e.g. heterocycle-CH=CH-C6H5
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B23/00Methine or polymethine dyes, e.g. cyanine dyes
    • C09B23/16Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms
    • C09B23/162Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms only nitrogen atoms
    • C09B23/164Methine or polymethine dyes, e.g. cyanine dyes the polymethine chain containing hetero atoms only nitrogen atoms containing one nitrogen atom
    • CCHEMISTRY; METALLURGY
    • C09DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09BORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00Other synthetic dyes of known constitution

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Luminescent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Hydrogenated Pyridines (AREA)
AT00961100T 1999-09-20 2000-09-20 Verbindungen zur floureszenz-kennzeichnung ATE296828T1 (de)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
JP26484499 1999-09-20
JP26484599 1999-09-20
JP29491199 1999-10-18
JP29491099 1999-10-18
JP2000117451 2000-04-19
PCT/JP2000/006401 WO2001021624A1 (en) 1999-09-20 2000-09-20 Compounds for fluorescence labeling

Publications (1)

Publication Number Publication Date
ATE296828T1 true ATE296828T1 (de) 2005-06-15

Family

ID=27530441

Family Applications (1)

Application Number Title Priority Date Filing Date
AT00961100T ATE296828T1 (de) 1999-09-20 2000-09-20 Verbindungen zur floureszenz-kennzeichnung

Country Status (6)

Country Link
US (1) US6794509B1 (de)
EP (1) EP1219626B1 (de)
AT (1) ATE296828T1 (de)
AU (1) AU7316900A (de)
DE (1) DE60020584T2 (de)
WO (1) WO2001021624A1 (de)

Families Citing this family (56)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1106621B1 (de) * 1999-12-07 2003-11-19 Fuji Photo Film Co., Ltd. Fluoreszente materialen
CA2423806C (en) 2000-09-29 2009-12-22 Molecular Probes, Inc. Modified carbocyanine dyes and their conjugates
EP1801165B1 (de) 2000-09-29 2012-08-01 Life Technologies Corporation Modifizierte Carbocyanin-Farbstoffe und ihre Konjugate
JP4676654B2 (ja) * 2001-07-19 2011-04-27 富士フイルム株式会社 蛍光ヌクレオチド及びそれを用いた標識法
US8323903B2 (en) 2001-10-12 2012-12-04 Life Technologies Corporation Antibody complexes and methods for immunolabeling
US20030124194A1 (en) 2002-01-02 2003-07-03 Gaw Debra A. Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor
DE10356130A1 (de) * 2003-11-28 2005-06-23 Dyomics Gmbh Neue Polymethinfarbstoffe auf Cumarin-Basis mit einstellbarem Stokes-Shift
US7282339B2 (en) 2003-09-17 2007-10-16 Invitrogen Corporation Competitive immunoassay
JP2005145921A (ja) * 2003-11-19 2005-06-09 Konica Minolta Medical & Graphic Inc 診断用蛍光造影剤及び蛍光造影診断方法
US7767834B2 (en) * 2004-08-13 2010-08-03 Elitech Holding B.V. Phosphonylated fluorescent dyes and conjugates
DK1934211T3 (en) 2005-09-02 2017-04-10 Visen Medical Inc Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers
EP1934202B1 (de) 2005-09-02 2019-01-09 Visen Medical, Inc. Nah-infrarot-fluorophore, die sich von nicotinsäure und picolinsäure ableiten
ES2612738T3 (es) 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
WO2007047450A1 (en) 2005-10-13 2007-04-26 Aureon Laboratories, Inc. Multiplex in situ immunohistochemical analysis
WO2007136413A2 (en) 2005-12-22 2007-11-29 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
DE602006020618D1 (de) 2005-12-22 2011-04-21 Visen Medical Inc Kombiniertes röntgen- und optisches tomographie-bildgebungssystem
USD580285S1 (en) 2006-01-13 2008-11-11 Invitrogen Corporation Fluorometer
JP2009524832A (ja) 2006-01-24 2009-07-02 ライフ テクノロジーズ コーポレーション 検体を定量するためのデバイスおよび方法
US8114636B2 (en) 2006-02-10 2012-02-14 Life Technologies Corporation Labeling and detection of nucleic acids
EP1987068B1 (de) 2006-02-10 2018-08-08 Life Technologies Corporation Modifizierung von oligosacchariden und etikettierung von proteinen
US8562802B1 (en) 2006-02-13 2013-10-22 Life Technologies Corporation Transilluminator base and scanner for imaging fluorescent gels, charging devices and portable electrophoresis systems
EP2362224A3 (de) 2006-03-23 2012-03-14 Absorber AB Blutgruppenantigene verschiedener Typen für diagnostische und therapeutische Anwendungen
EP2029799B1 (de) 2006-04-20 2012-08-22 Becton, Dickinson and Company Thermisch stabile proteine und verfahren zu ihrer herstellung und verwendung
WO2009055095A1 (en) 2007-10-19 2009-04-30 Visen Medical, Inc. Imaging systems featuring waveguiding compensation
ES2658852T3 (es) 2008-01-18 2018-03-12 Visen Medical, Inc. Agentes de imaginología fluorescentes
EP3673922A1 (de) 2008-03-14 2020-07-01 VisEn Medical, Inc. Auf integrin abzielende mittel und verfahren zur verwendung davon
CN104263816B (zh) 2008-05-16 2018-10-19 生命技术公司 用于测量细胞增殖的双标记法
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
RU2524573C2 (ru) * 2009-03-24 2014-07-27 Эбботт Лэборетриз Способ получения (e)-n-(3-трет-бутил-5-(2,4-диоксо-3,4-дигидропиримидин-1(2н)-ил)-2-метокси-стирил)фенил)метансульфонамида и промежуточные соединения для его получения
WO2011025950A2 (en) 2009-08-28 2011-03-03 Visen Medical, Inc. Systems and methods for tomographic imaging in diffuse media using a hybrid inversion technique
EP2473563B1 (de) 2009-08-31 2019-06-19 Promega Corporation Reaktive cyaninverbindungen
WO2011038006A1 (en) 2009-09-22 2011-03-31 Visen Medical, Inc. Systems and methods for virtual index-matching of diffusive media
US9216952B2 (en) 2010-03-23 2015-12-22 Abbvie Inc. Process for preparing antiviral compound
USD653981S1 (en) 2010-08-06 2012-02-14 Life Technologies Corporation Fluorometer
WO2012022734A2 (en) 2010-08-16 2012-02-23 Medimmune Limited Anti-icam-1 antibodies and methods of use
WO2012054749A1 (en) 2010-10-20 2012-04-26 Li-Cor, Inc. Cyanine dyes and their conjugates
CN103687854A (zh) 2011-05-09 2014-03-26 文森医学公司 碳酸酐酶靶向剂及其使用方法
CN114042171B (zh) 2012-03-30 2024-12-06 文森医学公司 细菌成像剂及其使用方法
CA2882019C (en) 2012-08-15 2021-02-09 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
US10743768B2 (en) 2012-10-15 2020-08-18 Visen Medical, Inc. Systems, methods, and apparatus for imaging of diffuse media featuring cross-modality weighting of fluorescent and bioluminescent sources
CN104704359A (zh) 2012-10-25 2015-06-10 生命科技公司 糖蛋白酶介导位点特异性放射性标记的方法和组合物
WO2015050959A1 (en) 2013-10-01 2015-04-09 Yale University Anti-kit antibodies and methods of use thereof
JP6535675B2 (ja) 2013-10-02 2019-06-26 メディミューン,エルエルシー 抗a型インフルエンザ抗体の中和及びその使用
US9504405B2 (en) 2013-10-23 2016-11-29 Verily Life Sciences Llc Spatial modulation of magnetic particles in vasculature by external magnetic field
US10542918B2 (en) 2013-10-23 2020-01-28 Verily Life Sciences Llc Modulation of a response signal to distinguish between analyte and background signals
AU2014373656B2 (en) 2013-12-31 2019-12-05 Cornell University Systems, methods, and apparatus for multichannel imaging of fluorescent sources in real time
WO2016100340A1 (en) 2014-12-15 2016-06-23 Memorial Sloan Kettering Cancer Center Cyclic peptides with enhanced nerve-binding selectivity, nanoparticles bound with said cyclic peptides, and use of same for real-time in vivo nerve tissue imaging
US9861710B1 (en) 2015-01-16 2018-01-09 Verily Life Sciences Llc Composite particles, methods, and in vivo diagnostic system
US10028659B2 (en) 2015-03-26 2018-07-24 Verily Life Sciences Llc Aptamer-based sensors, implantable devices and detection system
EP3389726A1 (de) 2015-12-15 2018-10-24 Memorial Sloan Kettering Cancer Center Bildgebungssysteme und -verfahren zur differenzierung von gewebe, z.b. zur intraoperativen visualisierung
WO2017181176A1 (en) 2016-04-15 2017-10-19 Lcahn School Of Medicine At Mount Sinai Tissue profiling using multiplexed immunohistochemical consecutive staining
KR20190090394A (ko) 2016-11-30 2019-08-01 메모리얼 슬로안 케터링 캔서 센터 억제제-작용화된 초소형 나노입자 및 이의 방법
US20210108253A1 (en) 2017-03-30 2021-04-15 Life Technologies Corporation Quantification of ngs dna by adapter sequence
CA3095410A1 (en) 2018-03-30 2019-10-03 Perkinelmer Health Sciences, Inc. Systems and methods for 3d reconstruction of anatomical organs and inclusions using short-wave infrared (swir) projection tomography
KR20230034333A (ko) 2020-07-02 2023-03-09 라이프 테크놀로지스 코포레이션 트리뉴클레오티드 캡 유사체, 제조 및 이의 용도
EP4015004A1 (de) 2020-12-18 2022-06-22 Phi Pharma SA Proteoglykanspezifische verzweigte peptide

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB870753A (en) * 1957-07-04 1961-06-21 Ilford Ltd Improvements in or relating to methine dyes
US5268486A (en) * 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5057406A (en) * 1988-05-07 1991-10-15 Konica Corporation Silver halide photographic material
US5246989A (en) * 1990-03-29 1993-09-21 Tokuyama Soda Kabishiki Kaisha Photochromic compound, composition and use thereof
JPH0480747A (ja) * 1990-07-23 1992-03-13 Konica Corp ハロゲン化銀写真感光材料の処理方法
JPH05287209A (ja) * 1992-04-09 1993-11-02 Hitachi Chem Co Ltd 蛍光標識用色素、蛍光標識用色素で標識された生物由来物質、及びそれらを含有する試薬
JPH07145148A (ja) * 1992-06-02 1995-06-06 Bio Sensor Kenkyusho:Kk ポリメチン系化合物およびそれを用いる測定方法
EP1106621B1 (de) 1999-12-07 2003-11-19 Fuji Photo Film Co., Ltd. Fluoreszente materialen

Also Published As

Publication number Publication date
DE60020584D1 (de) 2005-07-07
EP1219626A4 (de) 2003-04-16
US6794509B1 (en) 2004-09-21
WO2001021624A1 (en) 2001-03-29
EP1219626A1 (de) 2002-07-03
AU7316900A (en) 2001-04-24
EP1219626B1 (de) 2005-06-01
DE60020584T2 (de) 2006-04-27

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