ATE451102T1 - Thiazol-derivate zur verwendung als entzündungshemmende mittel - Google Patents

Thiazol-derivate zur verwendung als entzündungshemmende mittel

Info

Publication number
ATE451102T1
ATE451102T1 AT01943850T AT01943850T ATE451102T1 AT E451102 T1 ATE451102 T1 AT E451102T1 AT 01943850 T AT01943850 T AT 01943850T AT 01943850 T AT01943850 T AT 01943850T AT E451102 T1 ATE451102 T1 AT E451102T1
Authority
AT
Austria
Prior art keywords
substituted
unsubstituted
hydrogen
inflammatory agents
thiazole derivatives
Prior art date
Application number
AT01943850T
Other languages
English (en)
Inventor
Norio Fujiwara
Hitoshi Fujita
Fujio Antoku
Toshinari Sugasawa
Hajime Kawakami
Original Assignee
Dainippon Sumitomo Pharma Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dainippon Sumitomo Pharma Co filed Critical Dainippon Sumitomo Pharma Co
Application granted granted Critical
Publication of ATE451102T1 publication Critical patent/ATE451102T1/de

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D231/00Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D233/00Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D249/00Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D277/00Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38Nitrogen atoms
    • C07D277/42Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT01943850T 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel ATE451102T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000198074 2000-06-30
PCT/JP2001/005540 WO2002002542A1 (fr) 2000-06-30 2001-06-28 Compose annulaire a cinq chainons

Publications (1)

Publication Number Publication Date
ATE451102T1 true ATE451102T1 (de) 2009-12-15

Family

ID=18696291

Family Applications (1)

Application Number Title Priority Date Filing Date
AT01943850T ATE451102T1 (de) 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel

Country Status (15)

Country Link
US (2) US6919361B2 (de)
EP (2) EP1300401B1 (de)
JP (1) JP3785397B2 (de)
KR (2) KR100758775B1 (de)
CN (2) CN1944417A (de)
AT (1) ATE451102T1 (de)
AU (2) AU6634501A (de)
CA (1) CA2413000C (de)
CY (1) CY1109863T1 (de)
DE (1) DE60140748D1 (de)
DK (1) DK1300401T3 (de)
ES (1) ES2336425T3 (de)
PT (1) PT1300401E (de)
TW (1) TWI313266B (de)
WO (1) WO2002002542A1 (de)

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EP1348433A1 (de) * 2002-03-28 2003-10-01 Warner-Lambert Company LLC Thiazol-5-yl-imine als PDE7-Inhibitoren
DE10254336A1 (de) * 2002-11-21 2004-06-03 Merck Patent Gmbh Carbonsäureamide
JPWO2005000825A1 (ja) * 2003-06-27 2006-08-03 住友製薬株式会社 チアゾールイミン類およびオキサゾールイミン類
CN101777364B (zh) * 2003-10-10 2012-07-04 夏普株式会社 再现装置及视频数据的再现方法
MY162179A (en) * 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
US20080312435A1 (en) * 2004-11-15 2008-12-18 Taisho Pharmaceutical Co., Ltd. Imine Compound
AU2006241774B2 (en) * 2005-04-28 2011-09-15 Sumitomo Dainippon Pharma Co., Ltd. Therapeutic agent for chronic obstructive pulmonary disease
JP2007015999A (ja) * 2005-07-11 2007-01-25 Sumitomo Chemical Co Ltd イミノチアゾール化合物の製造方法
AU2006343735A1 (en) * 2006-05-11 2007-11-22 Dainippon Sumitomo Pharma Co., Ltd. A medicament containing a thiazole derivative as an active ingredient
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
US7875639B2 (en) 2006-05-31 2011-01-25 Abbott Laboratories Compounds as cannabinoid receptor ligands and uses thereof
WO2008121558A1 (en) 2007-03-28 2008-10-09 Abbott Laboratories 1, 3-thiazol-2 (3h) -ylidene compounds as cannabinoid receptor ligands
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
JP2010527929A (ja) 2007-05-18 2010-08-19 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての新規な化合物
KR100863239B1 (ko) * 2007-05-23 2008-10-15 한국과학기술연구원 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는t-형 칼슘 채널 저해제
US9193713B2 (en) * 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
JPWO2009131171A1 (ja) 2008-04-25 2011-08-18 大日本住友製薬株式会社 新規5員環化合物
CN102076682A (zh) * 2008-04-25 2011-05-25 大日本住友制药株式会社 五元环化合物
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
AU2009293319A1 (en) 2008-09-16 2010-03-25 Abbott Laboratories Substituted benzamides as cannabinoid receptor ligands
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CN102448957A (zh) 2009-03-27 2012-05-09 雅培制药有限公司 作为大麻素受体配体的化合物
WO2014052831A1 (en) * 2012-09-28 2014-04-03 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease

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US7076307B2 (en) * 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
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Also Published As

Publication number Publication date
EP1669070A3 (de) 2007-05-23
WO2002002542A1 (fr) 2002-01-10
CA2413000A1 (en) 2002-01-10
JP3785397B2 (ja) 2006-06-14
CN100369903C (zh) 2008-02-20
EP1669070A2 (de) 2006-06-14
KR20030011377A (ko) 2003-02-07
KR100758775B1 (ko) 2007-09-14
EP1300401A4 (de) 2004-07-21
US20050222226A1 (en) 2005-10-06
CN1944417A (zh) 2007-04-11
DE60140748D1 (de) 2010-01-21
ES2336425T3 (es) 2010-04-13
KR20070086998A (ko) 2007-08-27
CN1620442A (zh) 2005-05-25
KR100824156B1 (ko) 2008-04-21
AU6634501A (en) 2002-01-14
DK1300401T3 (da) 2010-02-01
CY1109863T1 (el) 2014-09-10
PT1300401E (pt) 2010-01-25
US6919361B2 (en) 2005-07-19
CA2413000C (en) 2010-01-19
EP1300401A1 (de) 2003-04-09
US20040072827A1 (en) 2004-04-15
TWI313266B (en) 2009-08-11
US7396842B2 (en) 2008-07-08
EP1300401B1 (de) 2009-12-09
AU2001266345B2 (en) 2006-03-02

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