DE60140748D1 - Thiazol-derivate zur verwendung als entzündungshemmende mittel - Google Patents

Thiazol-derivate zur verwendung als entzündungshemmende mittel

Info

Publication number
DE60140748D1
DE60140748D1 DE60140748T DE60140748T DE60140748D1 DE 60140748 D1 DE60140748 D1 DE 60140748D1 DE 60140748 T DE60140748 T DE 60140748T DE 60140748 T DE60140748 T DE 60140748T DE 60140748 D1 DE60140748 D1 DE 60140748D1
Authority
DE
Germany
Prior art keywords
substituted
unsubstituted
hydrogen
inflammatory agents
unsubstituted alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60140748T
Other languages
English (en)
Inventor
Norio Fujiwara
Hitoshi Fujita
Fujio Antoku
Toshinari Sugasawa
Hajime Kawakami
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Pharma Co Ltd
Original Assignee
Sumitomo Dainippon Pharma Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sumitomo Dainippon Pharma Co Ltd filed Critical Sumitomo Dainippon Pharma Co Ltd
Application granted granted Critical
Publication of DE60140748D1 publication Critical patent/DE60140748D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Transplantation (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
DE60140748T 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel Expired - Lifetime DE60140748D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2000198074 2000-06-30
PCT/JP2001/005540 WO2002002542A1 (en) 2000-06-30 2001-06-28 Five-membered-ring compound

Publications (1)

Publication Number Publication Date
DE60140748D1 true DE60140748D1 (de) 2010-01-21

Family

ID=18696291

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60140748T Expired - Lifetime DE60140748D1 (de) 2000-06-30 2001-06-28 Thiazol-derivate zur verwendung als entzündungshemmende mittel

Country Status (15)

Country Link
US (2) US6919361B2 (de)
EP (2) EP1300401B1 (de)
JP (1) JP3785397B2 (de)
KR (2) KR100758775B1 (de)
CN (2) CN100369903C (de)
AT (1) ATE451102T1 (de)
AU (2) AU2001266345B2 (de)
CA (1) CA2413000C (de)
CY (1) CY1109863T1 (de)
DE (1) DE60140748D1 (de)
DK (1) DK1300401T3 (de)
ES (1) ES2336425T3 (de)
PT (1) PT1300401E (de)
TW (1) TWI313266B (de)
WO (1) WO2002002542A1 (de)

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AU2002361117A1 (en) * 2001-12-28 2003-07-24 Sumitomo Pharmaceuticals Co., Ltd. 5-membered cyclic compounds
EP1348433A1 (de) * 2002-03-28 2003-10-01 Warner-Lambert Company LLC Thiazol-5-yl-imine als PDE7-Inhibitoren
DE10254336A1 (de) * 2002-11-21 2004-06-03 Merck Patent Gmbh Carbonsäureamide
US20070105908A1 (en) * 2003-06-27 2007-05-10 Dainippon Sumitomo Pharma Co., Ltd. Thiazolimine compound and oxazolimine compound
KR100844705B1 (ko) * 2003-10-10 2008-07-07 샤프 가부시키가이샤 재생 장치, 비디오 데이터의 재생 방법, 콘텐츠 기록 매체,및 컴퓨터 판독 가능한 기록 매체
MY162179A (en) * 2004-04-01 2017-05-31 Elan Pharm Inc Steroid sparing agents and methods of using same
RU2007122351A (ru) * 2004-11-15 2008-12-20 Тайсо Фармасьютикал Ко. Иминовое соединение
US8012971B2 (en) * 2005-04-28 2011-09-06 Dainippon Sumitomo Pharma Co., Ltd. Therapeutic agent for chronic obstructive pulmonary disease
JP2007015999A (ja) * 2005-07-11 2007-01-25 Sumitomo Chemical Co Ltd イミノチアゾール化合物の製造方法
US20090124622A1 (en) * 2006-05-11 2009-05-14 Toshinari Sugasawa Medicament Containing a Thiazole Derivative as an Active Ingredient
EP2024349B1 (de) 2006-05-31 2017-08-02 AbbVie Inc. Verbindungen als cannabinoid-rezeptorliganden und ihre verwendung
US8841334B2 (en) 2006-05-31 2014-09-23 Abbvie Inc. Compounds as cannabinoid receptor ligands and uses thereof
MX2009010363A (es) 2007-03-28 2009-12-04 Abbott Lab Compuestos de 1,3-tiazol-2(3h)-ilideno como ligandos del receptor canabinoide.
US7872033B2 (en) 2007-04-17 2011-01-18 Abbott Laboratories Compounds as cannabinoid receptor ligands
JP2010527929A (ja) 2007-05-18 2010-08-19 アボット・ラボラトリーズ カンナビノイド受容体リガンドとしての新規な化合物
KR100863239B1 (ko) * 2007-05-23 2008-10-15 한국과학기술연구원 신규한 2-이미노-1,3-티아졸린계 화합물 및 이를 함유하는ｔ-형 칼슘 채널 저해제
US9193713B2 (en) 2007-10-12 2015-11-24 Abbvie Inc. Compounds as cannabinoid receptor ligands
JPWO2009131171A1 (ja) 2008-04-25 2011-08-18 大日本住友製薬株式会社 新規５員環化合物
CA2722007A1 (en) 2008-04-25 2009-10-29 Dainippon Sumitomo Pharma Co., Ltd. Five-membered ring compound
US8846730B2 (en) 2008-09-08 2014-09-30 Abbvie Inc. Compounds as cannabinoid receptor ligands
WO2010033543A2 (en) 2008-09-16 2010-03-25 Abbott Laboratories Novel compounds as cannabinoid receptor ligands
PA8854001A1 (es) 2008-12-16 2010-07-27 Abbott Lab Compuestos novedosos como ligandos de receptores de canabinoides
CA2756178A1 (en) 2009-03-27 2010-09-30 Abbott Laboratories Compounds as cannabinoid receptor ligands
WO2014052831A1 (en) * 2012-09-28 2014-04-03 Xavier University Of Louisiana Anti-migration and anti-invasion thiazole analogs for treatment of cellular proliferative disease

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DE941288C (de) * 1950-10-31 1956-04-05 Goodrich Co B F Verfahren zur Herstellung substituierter 2-Imino-4-thiazoline oder von Salzen derselben bzw. von substituierten 2-Aminothiazolen
EP0848059A1 (de) 1996-12-12 1998-06-17 Vetigen ICYP (Iodocyanopindolol) Rezeptor von Säugetieren und dessen Anwendungen
US7076307B2 (en) * 2002-05-09 2006-07-11 Boveja Birinder R Method and system for modulating the vagus nerve (10th cranial nerve) with electrical pulses using implanted and external components, to provide therapy neurological and neuropsychiatric disorders
FR2796643B1 (fr) * 1999-07-22 2005-04-29 Sod Conseils Rech Applic Derives de 2-arylimino-2, 3-dihydrothiazoles, leurs procedes de preparation et leur utilisation therapeutique
WO2001032604A1 (en) * 1999-11-05 2001-05-10 University College London Activators of soluble guanylate cyclase
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Also Published As

Publication number Publication date
EP1300401A4 (de) 2004-07-21
AU2001266345B2 (en) 2006-03-02
PT1300401E (pt) 2010-01-25
KR20030011377A (ko) 2003-02-07
KR100824156B1 (ko) 2008-04-21
CN1620442A (zh) 2005-05-25
US6919361B2 (en) 2005-07-19
AU6634501A (en) 2002-01-14
EP1300401A1 (de) 2003-04-09
CA2413000C (en) 2010-01-19
WO2002002542A1 (en) 2002-01-10
US20040072827A1 (en) 2004-04-15
ES2336425T3 (es) 2010-04-13
US20050222226A1 (en) 2005-10-06
CN100369903C (zh) 2008-02-20
CA2413000A1 (en) 2002-01-10
KR100758775B1 (ko) 2007-09-14
JP3785397B2 (ja) 2006-06-14
US7396842B2 (en) 2008-07-08
EP1669070A3 (de) 2007-05-23
TWI313266B (en) 2009-08-11
CN1944417A (zh) 2007-04-11
DK1300401T3 (da) 2010-02-01
ATE451102T1 (de) 2009-12-15
CY1109863T1 (el) 2014-09-10
EP1669070A2 (de) 2006-06-14
KR20070086998A (ko) 2007-08-27
EP1300401B1 (de) 2009-12-09

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