JP2010518236A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010518236A5 JP2010518236A5 JP2009549253A JP2009549253A JP2010518236A5 JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5 JP 2009549253 A JP2009549253 A JP 2009549253A JP 2009549253 A JP2009549253 A JP 2009549253A JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- disease
- composition
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000007850 fluorescent dye Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- -1 N- hydroxy sulfosuccinimide ester Chemical class 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 238000012634 optical imaging Methods 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
- 238000002659 cell therapy Methods 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 208000016361 genetic disease Diseases 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000008300 phosphoramidites Chemical class 0.000 claims description 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 2
- NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical compound NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000007762 localization of cell Effects 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88906607P | 2007-02-09 | 2007-02-09 | |
| US60/889,066 | 2007-02-09 | ||
| PCT/US2008/053399 WO2008100817A2 (en) | 2007-02-09 | 2008-02-08 | Polycyclo dyes and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Division JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518236A JP2010518236A (ja) | 2010-05-27 |
| JP2010518236A5 true JP2010518236A5 (enExample) | 2012-03-22 |
| JP5643514B2 JP5643514B2 (ja) | 2014-12-17 |
Family
ID=39690741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549253A Active JP5643514B2 (ja) | 2007-02-09 | 2008-02-08 | ポリシクロ染料およびその使用 |
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8221721B2 (enExample) |
| EP (1) | EP2118206B9 (enExample) |
| JP (2) | JP5643514B2 (enExample) |
| DK (1) | DK2118206T3 (enExample) |
| ES (1) | ES2670852T3 (enExample) |
| WO (1) | WO2008100817A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002038190A2 (en) * | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| ES2612738T3 (es) * | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| DK1934211T3 (en) | 2005-09-02 | 2017-04-10 | Visen Medical Inc | Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| JP5643514B2 (ja) | 2007-02-09 | 2014-12-17 | ビセン メディカル， インコーポレイテッド | ポリシクロ染料およびその使用 |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| SG10201706428XA (en) * | 2009-02-06 | 2017-09-28 | Beth Israel Deaconess Medical Ct Inc | Charge-balanced imaging agents |
| EP2707102B1 (en) | 2011-05-09 | 2019-11-13 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| WO2013148319A1 (en) | 2012-03-30 | 2013-10-03 | Visen Medical, Inc. | Bacterial imaging agents and methods of using same |
| CA2882019C (en) | 2012-08-15 | 2021-02-09 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| IL221489A0 (en) * | 2012-08-15 | 2012-12-31 | Aspect Imaging Ltd | Imaging system for generating a rendered image |
| US20140051973A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd | Mri imaging system for generating a rendered image |
| US20140051975A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd. | Multiple heterogeneous imaging systems for clinical and preclinical diagnosis |
| AU2014228504C1 (en) | 2013-03-15 | 2019-10-03 | Visen Medical, Inc. | Substituted silaxanthenium red to near-infrared fluorochromes for in vitro and in vivo imaging and detection |
| CN105339436B (zh) | 2013-03-15 | 2018-05-25 | 文森医学公司 | 4,4-二取代环己基桥连七甲川花菁染料及其应用 |
| EP3165153A1 (en) * | 2015-11-05 | 2017-05-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | System for fluorescence aided surgery |
| WO2019067180A1 (en) | 2017-09-29 | 2019-04-04 | Perkinelmer Health Sciences, Inc. | NIR-SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION |
| EA202092228A1 (ru) * | 2018-03-21 | 2021-07-19 | Эколь Политекник Федераль Де Лозанн (Эпфл) | Азацианиновые красители и их применение |
| US10633542B2 (en) | 2018-03-21 | 2020-04-28 | Ecole polytechnique fédérale de Lausanne (EPFL) | Azacyanine dyes and use thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219335A (en) | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5164297A (en) | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
| US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| JPH08501097A (ja) | 1992-09-04 | 1996-02-06 | ザ ゼネラル ホスピタル コーポレーション | 臨床診断及び治療用部分を含む生体適合性ポリマー |
| DE69434016T2 (de) | 1993-03-04 | 2005-02-10 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Photographisches Silberhalogenidmaterial |
| JPH0862763A (ja) | 1994-08-17 | 1996-03-08 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| JP3794793B2 (ja) * | 1996-07-24 | 2006-07-12 | アグフア−ゲヴエルト，ナームローゼ・フエンノートシヤツプ | 増感色素を含むフオトサーモグラフイ記録材料及びそのための記録法 |
| US5876915A (en) * | 1996-07-24 | 1999-03-02 | Agfa-Gevaert | Photothermographic recording material comprising sensitizing dyes and a recording process therefor |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6046585A (en) | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US6214533B1 (en) | 1998-04-10 | 2001-04-10 | Konica Corporation | Thermally developable photosensitive material |
| US6083486A (en) | 1998-05-14 | 2000-07-04 | The General Hospital Corporation | Intramolecularly-quenched near infrared fluorescent probes |
| US6592847B1 (en) | 1998-05-14 | 2003-07-15 | The General Hospital Corporation | Intramolecularly-quenched near infrared flourescent probes |
| US6120351A (en) * | 1998-08-31 | 2000-09-19 | Ingersoll-Rand Company | Automatic machinability measuring and machining methods and apparatus therefor |
| JP3918369B2 (ja) | 1999-03-05 | 2007-05-23 | コニカミノルタホールディングス株式会社 | ハロゲン化銀乳剤、ハロゲン化銀感光材料、熱現像感光材料及びこれを用いた画像記録方法及び画像形成方法、並びに熱現像感光材料の製造方法 |
| ATE284433T1 (de) | 1999-07-02 | 2004-12-15 | Visen Medical Inc | Fluorescierende cyaninlabels mit einem sulphamidobrückenglied |
| US6395257B1 (en) | 2000-01-18 | 2002-05-28 | Mallinckrodt Inc. | Dendrimer precursor dyes for imaging |
| US6183726B1 (en) | 2000-01-18 | 2001-02-06 | Mallinckrodt Inc. | Versatile hydrophilic dyes |
| US6180086B1 (en) | 2000-01-18 | 2001-01-30 | Mallinckrodt Inc. | Hydrophilic cyanine dyes |
| US7597878B2 (en) | 2000-09-19 | 2009-10-06 | Li-Cor, Inc. | Optical fluorescent imaging |
| JP4989013B2 (ja) * | 2000-09-19 | 2012-08-01 | リ−コール インコーポレーティッド | シアニン色素 |
| EP2325263B1 (en) | 2000-09-29 | 2013-01-23 | Life Technologies Corporation | Modified carbocyanine dyes and their conjugates |
| WO2002038190A2 (en) | 2000-10-27 | 2002-05-16 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| US6615063B1 (en) | 2000-11-27 | 2003-09-02 | The General Hospital Corporation | Fluorescence-mediated molecular tomography |
| EP1209205A1 (en) | 2000-11-28 | 2002-05-29 | Innosense S.r.l. | Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds |
| EP1221465A1 (en) | 2001-01-03 | 2002-07-10 | Innosense S.r.l. | Symmetric, monofunctionalised polymethine dyes labelling reagents |
| US20030044353A1 (en) | 2001-01-05 | 2003-03-06 | Ralph Weissleder | Activatable imaging probes |
| TNSN03146A1 (fr) | 2001-06-28 | 2005-12-23 | Pfizer Prod Inc | Indoles, benzofurannes et benzothiophenes a substituant triamide, utiles comme inhibiteurs de secretion de la proteine de transfert des triglycerides microsomaux et/ou de l'apolipo-proteine b (apo b). |
| AU2003207438A1 (en) | 2002-01-02 | 2003-07-24 | Visen Medical, Inc. | Amine functionalized superparamagnetic nanoparticles for the synthesis of bioconjugates and uses therefor |
| WO2003061711A2 (en) | 2002-01-16 | 2003-07-31 | Visen Medical, Inc. | Chromophore probes for optical imaging |
| AU2003225763A1 (en) | 2002-03-11 | 2003-09-29 | Visen Medical, Inc. | Optical imaging probes |
| EP2410315B1 (en) | 2002-06-04 | 2020-04-01 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in contact and non-contact tomography |
| AU2003303954A1 (en) | 2002-10-25 | 2004-10-11 | Emory University | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
| JP2006513293A (ja) | 2003-01-24 | 2006-04-20 | シエーリング アクチエンゲゼルシャフト | 親水性チオール−反応性シアニン色素及び蛍光診断のための生物分子との接合体 |
| EP1462854A1 (en) | 2003-03-24 | 2004-09-29 | Konica Minolta Medical & Graphic Inc. | Photothermographic imaging material |
| WO2004108902A2 (en) | 2003-06-04 | 2004-12-16 | Visen Medical, Inc. | Biocompatible fluorescent silicon nanoparticles |
| US7332257B2 (en) | 2003-07-11 | 2008-02-19 | Asahi Glass Company, Limited | Composition for optical film, and optical film |
| WO2005017539A2 (en) | 2003-08-14 | 2005-02-24 | The General Hospital Corporation | Imaging pathology |
| WO2006034260A2 (en) | 2004-09-21 | 2006-03-30 | Engineered Support Systems, Inc. | Method and apparatus for improving the energy conversion efficiency of electrical power generators |
| US20060239916A1 (en) | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
| DK1934211T3 (en) | 2005-09-02 | 2017-04-10 | Visen Medical Inc | Biocompatible N, N-disubstituted sulfonamide-containing fluorescent color markers |
| ES2612738T3 (es) | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| WO2007028118A2 (en) | 2005-09-02 | 2007-03-08 | Visen Medical, Inc. | Nicotinic acid and picolinic acid derived near-infrared fluorophores |
| US9913917B2 (en) | 2005-12-22 | 2018-03-13 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| WO2007109364A2 (en) | 2006-03-20 | 2007-09-27 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| JP5643514B2 (ja) | 2007-02-09 | 2014-12-17 | ビセン メディカル， インコーポレイテッド | ポリシクロ染料およびその使用 |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US20090037114A1 (en) | 2007-07-30 | 2009-02-05 | Chengbin Peng | 4d+ prestack seismic data structure, and methods and apparatus for processing 4d+ prestack seismic data |
| EP2732826B1 (en) | 2008-01-18 | 2017-11-08 | Visen Medical, Inc. | Fluorescent imaging agents |
| CA2715034C (en) | 2008-03-14 | 2016-12-06 | Visen Medical, Inc. | Integrin targeting agents and in-vivo and in-vitro imaging methods using the same |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2008
- 2008-02-08 JP JP2009549253A patent/JP5643514B2/ja active Active
- 2008-02-08 DK DK08729371.8T patent/DK2118206T3/en active
- 2008-02-08 WO PCT/US2008/053399 patent/WO2008100817A2/en not_active Ceased
- 2008-02-08 EP EP08729371.8A patent/EP2118206B9/en active Active
- 2008-02-08 US US12/028,209 patent/US8221721B2/en not_active Expired - Fee Related
- 2008-02-08 ES ES08729371.8T patent/ES2670852T3/es active Active
-
2012
- 2012-07-13 US US13/548,451 patent/US9365721B2/en active Active
-
2014
- 2014-03-31 JP JP2014071365A patent/JP2014167119A/ja not_active Withdrawn
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010518236A5 (enExample) | ||
| JP2016521254A5 (enExample) | ||
| JP2016519080A5 (enExample) | ||
| CN106977628B (zh) | 吲哚菁化合物、其合成及精制法、诊断用组合物、生物体内动态测定装置及循环可视化装置 | |
| JP2009507035A5 (enExample) | ||
| JP5643514B2 (ja) | ポリシクロ染料およびその使用 | |
| JP5500875B2 (ja) | 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤 | |
| JP2015532641A5 (enExample) | ||
| ES2963120T3 (es) | Molécula fluorescente en el infrarrojo cercano de reconocimiento activo para el reconocimiento del receptor de folato y procedimiento de preparación de la misma | |
| JP2009507108A5 (enExample) | ||
| CN113015482B (zh) | 用于治疗、成像和治疗诊断应用的较小高度均匀的纳米药物组合物 | |
| WO2011077751A1 (ja) | 中枢神経系組織標識用組成物、中枢神経系組織の標識方法、及び中枢神経系組織標識用組成物を用いたスクリーニング方法 | |
| JP2010169678A (ja) | 生物試料用標識剤並びに該標識剤を用いた標識方法及びスクリーニング方法 | |
| JP2012510499A5 (enExample) | ||
| JPH0797340A (ja) | Ｍｒｉ造影剤組成物 | |
| WO2011077733A1 (ja) | 経鼻中枢神経系組織標識用組成物、経鼻中枢神経系組織標識用組成物を用いた標識方法及びスクリーニング方法 | |
| WO2020066881A1 (ja) | バイオイメージング剤 | |
| KR102174196B1 (ko) | 소수성기가 도입된 실리콘-로다민 형광 프로브 및 이의 용도 | |
| KR20230058122A (ko) | 종양 조영 화합물, 이의 제조 방법 및 종양 진단 이미징에서의 응용 | |
| US9498546B2 (en) | Synthesis and application of novel imaging agents conjugated to DPA 713 analogs for imaging inflammation | |
| US12306194B2 (en) | Reagent for fluorescence imaging of lipid droplets in cell and tissue | |
| US9409923B2 (en) | Drug-fluorophore complex for specific detection of tumor cells | |
| JP2010501544A (ja) | 光学的なイメージング用のＴｍ２＋を含有する発光性の物質を含む造影剤 | |
| CN111875667B (zh) | 有机金属螯合物及其制备方法与应用、探针 | |
| WO2005061456A1 (ja) | 近赤外蛍光造影剤 |