JP2010518236A5 - - Google Patents
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- JP2010518236A5 JP2010518236A5 JP2009549253A JP2009549253A JP2010518236A5 JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5 JP 2009549253 A JP2009549253 A JP 2009549253A JP 2009549253 A JP2009549253 A JP 2009549253A JP 2010518236 A5 JP2010518236 A5 JP 2010518236A5
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- 150000001875 compounds Chemical class 0.000 claims description 63
- 239000007850 fluorescent dye Substances 0.000 claims description 24
- 238000000034 method Methods 0.000 claims description 23
- 125000000217 alkyl group Chemical group 0.000 claims description 19
- 201000010099 disease Diseases 0.000 claims description 16
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 16
- -1 N- hydroxy sulfosuccinimide ester Chemical class 0.000 claims description 15
- 125000003118 aryl group Chemical group 0.000 claims description 12
- 229910052739 hydrogen Inorganic materials 0.000 claims description 12
- 229910052799 carbon Inorganic materials 0.000 claims description 10
- 125000002877 alkyl aryl group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 239000000523 sample Substances 0.000 claims description 8
- 229910052717 sulfur Inorganic materials 0.000 claims description 8
- 238000012634 optical imaging Methods 0.000 claims description 7
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 6
- 150000003839 salts Chemical class 0.000 claims description 6
- 208000024172 Cardiovascular disease Diseases 0.000 claims description 4
- 206010028980 Neoplasm Diseases 0.000 claims description 4
- 238000010521 absorption reaction Methods 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 201000011510 cancer Diseases 0.000 claims description 4
- 229910052736 halogen Inorganic materials 0.000 claims description 4
- 150000002367 halogens Chemical class 0.000 claims description 4
- 125000005647 linker group Chemical group 0.000 claims description 4
- 230000003287 optical effect Effects 0.000 claims description 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
- 230000003213 activating effect Effects 0.000 claims description 3
- 239000012472 biological sample Substances 0.000 claims description 3
- 238000000338 in vitro Methods 0.000 claims description 3
- HFHFGHLXUCOHLN-UHFFFAOYSA-N 2-fluorophenol Chemical class OC1=CC=CC=C1F HFHFGHLXUCOHLN-UHFFFAOYSA-N 0.000 claims description 2
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 2
- 208000020084 Bone disease Diseases 0.000 claims description 2
- 208000035473 Communicable disease Diseases 0.000 claims description 2
- 208000026350 Inborn Genetic disease Diseases 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 claims description 2
- NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims description 2
- 150000001408 amides Chemical class 0.000 claims description 2
- 150000001412 amines Chemical class 0.000 claims description 2
- 150000001540 azides Chemical class 0.000 claims description 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims description 2
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 2
- 150000007942 carboxylates Chemical class 0.000 claims description 2
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 2
- 150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
- 238000002659 cell therapy Methods 0.000 claims description 2
- 238000002591 computed tomography Methods 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 208000016097 disease of metabolism Diseases 0.000 claims description 2
- 208000030533 eye disease Diseases 0.000 claims description 2
- 208000016361 genetic disease Diseases 0.000 claims description 2
- 125000000623 heterocyclic group Chemical group 0.000 claims description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 2
- 238000003384 imaging method Methods 0.000 claims description 2
- 208000026278 immune system disease Diseases 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims description 2
- 208000027866 inflammatory disease Diseases 0.000 claims description 2
- 230000004054 inflammatory process Effects 0.000 claims description 2
- 208000030159 metabolic disease Diseases 0.000 claims description 2
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
- 238000012544 monitoring process Methods 0.000 claims description 2
- 230000004770 neurodegeneration Effects 0.000 claims description 2
- 208000015122 neurodegenerative disease Diseases 0.000 claims description 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
- 150000007523 nucleic acids Chemical class 0.000 claims description 2
- 102000039446 nucleic acids Human genes 0.000 claims description 2
- 108020004707 nucleic acids Proteins 0.000 claims description 2
- 150000008300 phosphoramidites Chemical class 0.000 claims description 2
- LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 2
- NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical compound NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 claims description 2
- 125000003367 polycyclic group Chemical group 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 208000023504 respiratory system disease Diseases 0.000 claims description 2
- 229920006395 saturated elastomer Polymers 0.000 claims description 2
- 229910052711 selenium Inorganic materials 0.000 claims description 2
- 208000017520 skin disease Diseases 0.000 claims description 2
- 229940124530 sulfonamide Drugs 0.000 claims description 2
- 150000003456 sulfonamides Chemical class 0.000 claims description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 2
- 238000003325 tomography Methods 0.000 claims description 2
- 238000001514 detection method Methods 0.000 claims 2
- 230000007762 localization of cell Effects 0.000 claims 1
- PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 description 1
- 125000000753 cycloalkyl group Chemical group 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 230000004807 localization Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88906607P | 2007-02-09 | 2007-02-09 | |
| US60/889,066 | 2007-02-09 | ||
| PCT/US2008/053399 WO2008100817A2 (en) | 2007-02-09 | 2008-02-08 | Polycyclo dyes and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Division JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010518236A JP2010518236A (ja) | 2010-05-27 |
| JP2010518236A5 true JP2010518236A5 (enExample) | 2012-03-22 |
| JP5643514B2 JP5643514B2 (ja) | 2014-12-17 |
Family
ID=39690741
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009549253A Active JP5643514B2 (ja) | 2007-02-09 | 2008-02-08 | ポリシクロ染料およびその使用 |
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014071365A Withdrawn JP2014167119A (ja) | 2007-02-09 | 2014-03-31 | ポリシクロ染料およびその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8221721B2 (enExample) |
| EP (1) | EP2118206B9 (enExample) |
| JP (2) | JP5643514B2 (enExample) |
| DK (1) | DK2118206T3 (enExample) |
| ES (1) | ES2670852T3 (enExample) |
| WO (1) | WO2008100817A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1341557A2 (en) * | 2000-10-27 | 2003-09-10 | Beth Israel Deaconess Medical Center | Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates |
| ES2612738T3 (es) * | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| JP5106397B2 (ja) | 2005-09-02 | 2012-12-26 | ビセン メディカル， インコーポレイテッド | 生体適合性ｎ，ｎ−二置換スルホンアミド含有蛍光色素標識 |
| EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| EP2118206B9 (en) | 2007-02-09 | 2018-08-29 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) * | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| EP2244741B1 (en) | 2008-01-18 | 2015-03-25 | VisEn Medical, Inc. | Fluorescent imaging agents |
| SG2014009146A (en) * | 2009-02-06 | 2014-05-29 | Beth Israel Hospital | Charge-balanced imaging agents |
| EP2707102B1 (en) | 2011-05-09 | 2019-11-13 | Visen Medical, Inc. | Carbonic anhydrase targeting agents and methods of using same |
| EP2831264B1 (en) | 2012-03-30 | 2019-07-10 | VisEn Medical, Inc. | Bacterial imaging agents and methods of using same |
| IL221489A0 (en) * | 2012-08-15 | 2012-12-31 | Aspect Imaging Ltd | Imaging system for generating a rendered image |
| US20140051975A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd. | Multiple heterogeneous imaging systems for clinical and preclinical diagnosis |
| US20140051973A1 (en) * | 2012-08-15 | 2014-02-20 | Aspect Imaging Ltd | Mri imaging system for generating a rendered image |
| WO2014028057A1 (en) | 2012-08-15 | 2014-02-20 | Visen Medical, Inc. | Prostate specific antigen agents and methods of using same for prostate cancer imaging |
| EP2970674B1 (en) | 2013-03-15 | 2018-12-12 | VisEn Medical, Inc. | 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof |
| CN105073761B (zh) | 2013-03-15 | 2020-10-20 | 文森医学公司 | 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料 |
| EP3165153A1 (en) * | 2015-11-05 | 2017-05-10 | Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts | System for fluorescence aided surgery |
| WO2019067180A1 (en) | 2017-09-29 | 2019-04-04 | Perkinelmer Health Sciences, Inc. | NIR-SWIR FLUORESCENT COMPOUNDS FOR IMAGING AND DETECTION |
| US10633542B2 (en) | 2018-03-21 | 2020-04-28 | Ecole polytechnique fédérale de Lausanne (EPFL) | Azacyanine dyes and use thereof |
| CA3094902A1 (en) * | 2018-03-21 | 2019-09-26 | Ecole Polytechnique Federale De Lausanne (Epfl) | Azacyanine dyes and use thereof |
Family Cites Families (55)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4219335A (en) | 1978-09-18 | 1980-08-26 | E. I. Du Pont De Nemours And Company | Immunochemical testing using tagged reagents |
| US6086737A (en) | 1984-03-29 | 2000-07-11 | Li-Cor, Inc. | Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor |
| US6048982A (en) | 1986-04-18 | 2000-04-11 | Carnegie Mellon University | Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods |
| US5164297A (en) | 1990-05-03 | 1992-11-17 | Advanced Magnetics Inc. | Solvent mediated relaxation assay system |
| US5445970A (en) | 1992-03-20 | 1995-08-29 | Abbott Laboratories | Magnetically assisted binding assays using magnetically labeled binding members |
| JPH08501097A (ja) | 1992-09-04 | 1996-02-06 | ザ ゼネラル ホスピタル コーポレーション | 臨床診断及び治療用部分を含む生体適合性ポリマー |
| DE69434016T2 (de) | 1993-03-04 | 2005-02-10 | Fuji Photo Film Co., Ltd., Minami-Ashigara | Photographisches Silberhalogenidmaterial |
| JPH0862763A (ja) | 1994-08-17 | 1996-03-08 | Fuji Photo Film Co Ltd | ハロゲン化銀写真感光材料 |
| DE4445065A1 (de) | 1994-12-07 | 1996-06-13 | Diagnostikforschung Inst | Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung |
| IT1276833B1 (it) | 1995-10-09 | 1997-11-03 | Sorin Biomedica Cardio Spa | Coloranti fluorescenti della famiglia della solfo benz e indocianina |
| US5876915A (en) * | 1996-07-24 | 1999-03-02 | Agfa-Gevaert | Photothermographic recording material comprising sensitizing dyes and a recording process therefor |
| JP3794793B2 (ja) * | 1996-07-24 | 2006-07-12 | アグフア−ゲヴエルト，ナームローゼ・フエンノートシヤツプ | 増感色素を含むフオトサーモグラフイ記録材料及びそのための記録法 |
| DE19717904A1 (de) | 1997-04-23 | 1998-10-29 | Diagnostikforschung Inst | Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie |
| US6046585A (en) | 1997-11-21 | 2000-04-04 | Quantum Design, Inc. | Method and apparatus for making quantitative measurements of localized accumulations of target particles having magnetic particles bound thereto |
| US6214533B1 (en) | 1998-04-10 | 2001-04-10 | Konica Corporation | Thermally developable photosensitive material |
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| ATE536993T1 (de) | 2002-01-02 | 2011-12-15 | Visen Medical Inc | Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten |
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| EP2410315B1 (en) | 2002-06-04 | 2020-04-01 | Visen Medical, Inc. | Imaging volumes with arbitrary geometries in contact and non-contact tomography |
| WO2004083902A2 (en) | 2002-10-25 | 2004-09-30 | Georgia Tech Research Corporation | Multifunctional magnetic nanoparticle probes for intracellular molecular imaging and monitoring |
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| EP1462854A1 (en) | 2003-03-24 | 2004-09-29 | Konica Minolta Medical & Graphic Inc. | Photothermographic imaging material |
| WO2004108902A2 (en) | 2003-06-04 | 2004-12-16 | Visen Medical, Inc. | Biocompatible fluorescent silicon nanoparticles |
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| US20060239916A1 (en) | 2005-01-07 | 2006-10-26 | Kai Licha | Use of cyanine dyes for the diagnosis of proliferative diseases |
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| US8173819B2 (en) | 2005-09-02 | 2012-05-08 | Visen Medical, Inc. | Nicotinic and picolinic acid derived near-infrared fluorophores |
| ES2612738T3 (es) | 2005-09-02 | 2017-05-18 | Visen Medical, Inc. | Agentes de formación de imágenes fluorescentes biocompatibles |
| EP1973575B1 (en) | 2005-12-22 | 2019-07-24 | Visen Medical, Inc. | Biocompatible fluorescent metal oxide nanoparticles |
| WO2007109364A2 (en) | 2006-03-20 | 2007-09-27 | The General Hospital Corporation | Intramolecularly quenched fluorochrome conjugates and methods of use |
| EP2118206B9 (en) | 2007-02-09 | 2018-08-29 | Visen Medical, Inc. | Polycyclo dyes and use thereof |
| WO2008109832A2 (en) | 2007-03-08 | 2008-09-12 | Visen Medical, Inc. | Viable near-infrared fluorochrome labeled cells and methods of making and using same |
| US20090037114A1 (en) | 2007-07-30 | 2009-02-05 | Chengbin Peng | 4d+ prestack seismic data structure, and methods and apparatus for processing 4d+ prestack seismic data |
| EP2244741B1 (en) | 2008-01-18 | 2015-03-25 | VisEn Medical, Inc. | Fluorescent imaging agents |
| EP3673922A1 (en) | 2008-03-14 | 2020-07-01 | VisEn Medical, Inc. | Integrin targeting agents and methods of using same |
| US8864821B2 (en) | 2008-11-26 | 2014-10-21 | Visen Medical, Inc. | Methods and compositions for identifying subjects at risk of developing stent thrombosis |
-
2008
- 2008-02-08 EP EP08729371.8A patent/EP2118206B9/en active Active
- 2008-02-08 US US12/028,209 patent/US8221721B2/en not_active Expired - Fee Related
- 2008-02-08 JP JP2009549253A patent/JP5643514B2/ja active Active
- 2008-02-08 ES ES08729371.8T patent/ES2670852T3/es active Active
- 2008-02-08 DK DK08729371.8T patent/DK2118206T3/en active
- 2008-02-08 WO PCT/US2008/053399 patent/WO2008100817A2/en not_active Ceased
-
2012
- 2012-07-13 US US13/548,451 patent/US9365721B2/en active Active
-
2014
- 2014-03-31 JP JP2014071365A patent/JP2014167119A/ja not_active Withdrawn
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