DK2118206T3

DK2118206T3 - POLYCYCLOF COLORS AND APPLICATION THEREOF

POLYCYCLOF COLORS AND APPLICATION THEREOF Download PDF

Info

Publication number: DK2118206T3
Authority: DK; Denmark
Prior art keywords: compound; group; disease; alkyl; biomolecule
Prior art date: 2007-02-09

Application number

DK08729371.8T

Other languages

Danish (da)

English (en)

Inventor

Nara Narayanan

Original Assignee

Visen Medical Inc

Priority date

2007-02-09

Filing date

2008-02-08

Publication date

2018-06-18

2008-02-08 Application filed by Visen Medical Inc filed Critical Visen Medical Inc

2018-06-18 Application granted granted Critical

2018-06-18 Publication of DK2118206T3 publication Critical patent/DK2118206T3/en

Links

239000003086 colorant Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims description 64
-1 Fluorochrome compound Chemical class 0.000 claims description 56
238000003384 imaging method Methods 0.000 claims description 46
125000000217 alkyl group Chemical group 0.000 claims description 44
229910052739 hydrogen Inorganic materials 0.000 claims description 36
239000000523 sample Substances 0.000 claims description 36
125000003118 aryl group Chemical group 0.000 claims description 32
201000010099 disease Diseases 0.000 claims description 32
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 32
238000012634 optical imaging Methods 0.000 claims description 22
230000003287 optical effect Effects 0.000 claims description 20
108020004707 nucleic acids Proteins 0.000 claims description 16
102000039446 nucleic acids Human genes 0.000 claims description 16
150000003839 salts Chemical class 0.000 claims description 16
238000001727 in vivo Methods 0.000 claims description 15
150000007523 nucleic acids Chemical class 0.000 claims description 15
206010028980 Neoplasm Diseases 0.000 claims description 14
125000000753 cycloalkyl group Chemical group 0.000 claims description 14
229910052760 oxygen Inorganic materials 0.000 claims description 14
229910052717 sulfur Inorganic materials 0.000 claims description 14
238000000338 in vitro Methods 0.000 claims description 13
201000011510 cancer Diseases 0.000 claims description 10
229910052736 halogen Inorganic materials 0.000 claims description 10
150000002367 halogens Chemical class 0.000 claims description 10
125000002877 alkyl aryl group Chemical group 0.000 claims description 9
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 9
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims description 9
238000002591 computed tomography Methods 0.000 claims description 9
125000003710 aryl alkyl group Chemical group 0.000 claims description 8
238000010521 absorption reaction Methods 0.000 claims description 7
125000002887 hydroxy group Chemical group [H]O* 0.000 claims description 7
229910006069 SO3H Inorganic materials 0.000 claims description 6
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 6
BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 claims description 6
125000003837 (C1-C20) alkyl group Chemical group 0.000 claims description 5
206010061218 Inflammation Diseases 0.000 claims description 5
150000001412 amines Chemical class 0.000 claims description 5
229910052799 carbon Inorganic materials 0.000 claims description 5
125000004122 cyclic group Chemical group 0.000 claims description 5
230000004054 inflammatory process Effects 0.000 claims description 5
230000004770 neurodegeneration Effects 0.000 claims description 5
208000015122 neurodegenerative disease Diseases 0.000 claims description 5
LFGREXWGYUGZLY-UHFFFAOYSA-N phosphoryl Chemical group [P]=O LFGREXWGYUGZLY-UHFFFAOYSA-N 0.000 claims description 5
102000004169 proteins and genes Human genes 0.000 claims description 5
108090000623 proteins and genes Proteins 0.000 claims description 5
208000024172 Cardiovascular disease Diseases 0.000 claims description 4
125000005647 linker group Chemical group 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 4
125000000020 sulfo group Chemical group O=S(=O)([*])O[H] 0.000 claims description 4
LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims description 3
208000035473 Communicable disease Diseases 0.000 claims description 3
208000028782 Hereditary disease Diseases 0.000 claims description 3
150000001408 amides Chemical class 0.000 claims description 3
150000001540 azides Chemical class 0.000 claims description 3
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150000001732 carboxylic acid derivatives Chemical class 0.000 claims description 3
230000007613 environmental effect Effects 0.000 claims description 3
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208000015181 infectious disease Diseases 0.000 claims description 3
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229910052711 selenium Inorganic materials 0.000 claims description 3
208000020084 Bone disease Diseases 0.000 claims description 2
PEEHTFAAVSWFBL-UHFFFAOYSA-N Maleimide Chemical compound O=C1NC(=O)C=C1 PEEHTFAAVSWFBL-UHFFFAOYSA-N 0.000 claims description 2
208000024556 Mendelian disease Diseases 0.000 claims description 2
239000012472 biological sample Substances 0.000 claims description 2
150000001733 carboxylic acid esters Chemical class 0.000 claims description 2
208000016097 disease of metabolism Diseases 0.000 claims description 2
125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims description 2
229910052755 nonmetal Inorganic materials 0.000 claims description 2
208000023504 respiratory system disease Diseases 0.000 claims description 2
229920006395 saturated elastomer Polymers 0.000 claims description 2
229940124530 sulfonamide Drugs 0.000 claims description 2
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GVJXGCIPWAVXJP-UHFFFAOYSA-N 2,5-dioxo-1-oxoniopyrrolidine-3-sulfonate Chemical class ON1C(=O)CC(S(O)(=O)=O)C1=O GVJXGCIPWAVXJP-UHFFFAOYSA-N 0.000 claims 1
208000026350 Inborn Genetic disease Diseases 0.000 claims 1
NQTADLQHYWFPDB-UHFFFAOYSA-N N-Hydroxysuccinimide Chemical class ON1C(=O)CCC1=O NQTADLQHYWFPDB-UHFFFAOYSA-N 0.000 claims 1
208000027866 inflammatory disease Diseases 0.000 claims 1
NAYYNDKKHOIIOD-UHFFFAOYSA-N phthalamide Chemical compound NC(=O)C1=CC=CC=C1C(N)=O NAYYNDKKHOIIOD-UHFFFAOYSA-N 0.000 claims 1
210000004027 cell Anatomy 0.000 description 55
238000000034 method Methods 0.000 description 43
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BFMYDTVEBKDAKJ-UHFFFAOYSA-L disodium;(2',7'-dibromo-3',6'-dioxido-3-oxospiro[2-benzofuran-1,9'-xanthene]-4'-yl)mercury;hydrate Chemical class O.[Na+].[Na+].O1C(=O)C2=CC=CC=C2C21C1=CC(Br)=C([O-])C([Hg])=C1OC1=C2C=C(Br)C([O-])=C1 BFMYDTVEBKDAKJ-UHFFFAOYSA-L 0.000 description 33
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125000001424 substituent group Chemical group 0.000 description 15
RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical group CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 14
238000002360 preparation method Methods 0.000 description 14
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238000001514 detection method Methods 0.000 description 13
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125000004414 alkyl thio group Chemical group 0.000 description 9
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125000003545 alkoxy group Chemical group 0.000 description 7
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125000004429 atom Chemical group 0.000 description 7
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OJRUSAPKCPIVBY-KQYNXXCUSA-N C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N Chemical compound C1=NC2=C(N=C(N=C2N1[C@H]3[C@@H]([C@@H]([C@H](O3)COP(=O)(CP(=O)(O)O)O)O)O)I)N OJRUSAPKCPIVBY-KQYNXXCUSA-N 0.000 description 6
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