JP2009507035A5 - - Google Patents

Download PDF

Info

Publication number
JP2009507035A5
JP2009507035A5 JP2008529356A JP2008529356A JP2009507035A5 JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5 JP 2008529356 A JP2008529356 A JP 2008529356A JP 2008529356 A JP2008529356 A JP 2008529356A JP 2009507035 A5 JP2009507035 A5 JP 2009507035A5
Authority
JP
Japan
Prior art keywords
group
composition
disease
independently selected
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2008529356A
Other languages
English (en)
Japanese (ja)
Other versions
JP5416970B2 (ja
JP2009507035A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2006/034406 external-priority patent/WO2007028118A2/en
Publication of JP2009507035A publication Critical patent/JP2009507035A/ja
Publication of JP2009507035A5 publication Critical patent/JP2009507035A5/ja
Application granted granted Critical
Publication of JP5416970B2 publication Critical patent/JP5416970B2/ja
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

JP2008529356A 2005-09-02 2006-09-01 ニコチン酸及びピコリン酸誘導近赤外線蛍光団 Expired - Fee Related JP5416970B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US71407405P 2005-09-02 2005-09-02
US60/714,074 2005-09-02
PCT/US2006/034406 WO2007028118A2 (en) 2005-09-02 2006-09-01 Nicotinic acid and picolinic acid derived near-infrared fluorophores

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2012232544A Division JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Publications (3)

Publication Number Publication Date
JP2009507035A JP2009507035A (ja) 2009-02-19
JP2009507035A5 true JP2009507035A5 (cg-RX-API-DMAC10.html) 2009-12-24
JP5416970B2 JP5416970B2 (ja) 2014-02-12

Family

ID=37653212

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2008529356A Expired - Fee Related JP5416970B2 (ja) 2005-09-02 2006-09-01 ニコチン酸及びピコリン酸誘導近赤外線蛍光団
JP2012232544A Withdrawn JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2012232544A Withdrawn JP2013014625A (ja) 2005-09-02 2012-10-22 ニコチン酸及びピコリン酸誘導近赤外線蛍光団

Country Status (4)

Country Link
US (3) US8173819B2 (cg-RX-API-DMAC10.html)
EP (1) EP1934202B1 (cg-RX-API-DMAC10.html)
JP (2) JP5416970B2 (cg-RX-API-DMAC10.html)
WO (1) WO2007028118A2 (cg-RX-API-DMAC10.html)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE536993T1 (de) 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
US8227621B2 (en) 2005-06-30 2012-07-24 Li-Cor, Inc. Cyanine dyes and methods of use
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル, インコーポレイテッド 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識
ES2612738T3 (es) * 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
EP2118206B9 (en) 2007-02-09 2018-08-29 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) * 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
EP2244741B1 (en) * 2008-01-18 2015-03-25 VisEn Medical, Inc. Fluorescent imaging agents
WO2010057944A1 (en) * 2008-11-20 2010-05-27 Ge Healthcare As Dye conjugate imaging agents
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis
EP2419478B1 (en) 2009-04-17 2018-02-28 Li-Cor, Inc. Fluorescent imaging with substituted cyanine dyes
JP2011046663A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
JP2011046662A (ja) * 2009-08-28 2011-03-10 Fujifilm Corp 近赤外蛍光造影剤
GB201010878D0 (en) * 2010-06-29 2010-08-11 Ge Healthcare As Dye compositiion and dye syntheses
US9610367B2 (en) * 2010-08-24 2017-04-04 Canon Kabushiki Kaisha Particle and contrast agent having the particle
US8669374B2 (en) * 2010-08-25 2014-03-11 Gene Shen Functionalized cyanine dyes (PEG)
EP2630196B1 (en) 2010-10-20 2017-09-06 Li-Cor, Inc. Cyanine dyes and their conjugates
EP2707102B1 (en) * 2011-05-09 2019-11-13 Visen Medical, Inc. Carbonic anhydrase targeting agents and methods of using same
CZ304094B6 (cs) * 2011-12-01 2013-10-16 Vysoká skola chemicko-technologická v Praze Vyuzití polymethiniových solí jako mitochondriálních sond
EP2831264B1 (en) 2012-03-30 2019-07-10 VisEn Medical, Inc. Bacterial imaging agents and methods of using same
WO2013173844A1 (en) 2012-05-18 2013-11-21 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes
US9315864B2 (en) 2012-05-18 2016-04-19 Pacific Biosciences Of California, Inc. Heteroarylcyanine dyes with sulfonic acid substituents
WO2014028057A1 (en) 2012-08-15 2014-02-20 Visen Medical, Inc. Prostate specific antigen agents and methods of using same for prostate cancer imaging
CN105073761B (zh) 2013-03-15 2020-10-20 文森医学公司 用于体外和体内成像和检测的取代的硅杂蒽阳离子红至近红外荧光染料
EP2970674B1 (en) * 2013-03-15 2018-12-12 VisEn Medical, Inc. 4,4-disubstituted cyclohexyl bridged heptamethine cyanine dyes and uses thereof
US11077210B2 (en) * 2013-10-31 2021-08-03 Beth Israel Deaconess Medical Center Near-infrared fluorescent contrast bioimaging agents and methods of use thereof
US11001562B2 (en) 2013-10-31 2021-05-11 Beth Israel Deaconess Medical Center Near-infrared fluorescent nerve contrast agents and methods of use thereof
CZ306320B6 (cs) * 2014-04-01 2016-11-30 Vysoká škola chemicko - technologická v Praze Využití nových typů pentamethiniových solí s expandovanou chinoxalinovou jednotkou v protinádorové terapii
GB2567124A (en) * 2017-05-08 2019-04-10 Vysoka Akola Chemicko Tech V Praze Imaging agents and methods
JP7032969B2 (ja) * 2018-03-28 2022-03-09 日本化薬株式会社 シアニン化合物
US12440585B2 (en) 2023-09-12 2025-10-14 Curadel Surgical Innovations, Inc. Zwitterionic metal chelators

Family Cites Families (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3864644A (en) 1971-03-22 1975-02-04 Eastman Kodak Co Dye lasers including rigidized carbocyanine dyes
DE2121014A1 (de) * 1971-04-29 1972-11-02 Agfa-Gevaert Ag, 5090 Leverkusen Sensibilisierte elektrophotographische Schichten
US4011086A (en) 1975-10-14 1977-03-08 Eastman Kodak Company Photographic emulsions and elements containing rigidized carbocyanine dyes
JPS6025781B2 (ja) * 1977-03-11 1985-06-20 富士ゼロックス株式会社 電子写真用感光材料
US4370401A (en) * 1979-12-07 1983-01-25 Minnesota Mining And Manufacturing Company Light sensitive, thermally developable imaging system
US6086737A (en) 1984-03-29 2000-07-11 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting using laser diodes and suitable labels therefor
US5366603A (en) 1984-03-29 1994-11-22 Li-Cor, Inc. Sequencing near infrared and infrared fluorescence labeled DNA for detecting useing laser diodes
US6048982A (en) 1986-04-18 2000-04-11 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
US5268486A (en) 1986-04-18 1993-12-07 Carnegie-Mellon Unversity Method for labeling and detecting materials employing arylsulfonate cyanine dyes
US5569587A (en) 1986-04-18 1996-10-29 Carnegie Mellon University Method for labeling and detecting materials employing luminescent arysulfonate cyanine dyes
US5627027A (en) 1986-04-18 1997-05-06 Carnegie Mellon University Cyanine dyes as labeling reagents for detection of biological and other materials by luminescence methods
DE3912046B4 (de) * 1988-09-02 2004-03-25 Carnegie Mellon University Verfahren zum Markieren einer Komponente einer wäßrigen Flüssigkeit und lumineszenzphotostabiles Reaktionsprodukt
US5073171A (en) 1989-01-12 1991-12-17 Eaton John W Biocompatible materials comprising albumin-binding dyes
US4981977A (en) 1989-06-09 1991-01-01 Carnegie-Mellon University Intermediate for and fluorescent cyanine dyes containing carboxylic acid groups
JP2824917B2 (ja) * 1989-08-30 1998-11-18 株式会社林原生物化学研究所 抗腫瘍剤
US5831098A (en) 1992-03-16 1998-11-03 Minnesota Mining And Manufacturing Company 2-methyl-4,4a-dihydro-3H-carbazolium salts and dyes derived therefrom
JPH08501097A (ja) 1992-09-04 1996-02-06 ザ ゼネラル ホスピタル コーポレーション 臨床診断及び治療用部分を含む生体適合性ポリマー
US5808044A (en) 1993-01-22 1998-09-15 Pharmacia Biotech Inc. Indocarbocyanine and benzindocarbocyanine phosphoramidites
US5453505A (en) 1994-06-30 1995-09-26 Biometric Imaging, Inc. N-heteroaromatic ion and iminium ion substituted cyanine dyes for use as fluorescence labels
US5605809A (en) 1994-10-28 1997-02-25 Oncoimmunin, Inc. Compositions for the detection of proteases in biological samples and methods of use thereof
DE4445065A1 (de) 1994-12-07 1996-06-13 Diagnostikforschung Inst Verfahren zur In-vivo-Diagnostik mittels NIR-Strahlung
US6127134A (en) 1995-04-20 2000-10-03 Carnegie Mellon University Difference gel electrophoresis using matched multiple dyes
US6008373A (en) 1995-06-07 1999-12-28 Carnegie Mellon University Fluorescent labeling complexes with large stokes shift formed by coupling together cyanine and other fluorochromes capable of resonance energy transfer
IT1276833B1 (it) 1995-10-09 1997-11-03 Sorin Biomedica Cardio Spa Coloranti fluorescenti della famiglia della solfo benz e indocianina
US6004536A (en) 1995-11-14 1999-12-21 Molecular Probes, Inc. Lipophilic cyanine dyes with enchanced aqueous solubilty
CA2251985A1 (en) 1996-04-19 1997-10-30 Alan Lewis Hamilton Squarate dyes and their use in fluorescent sequencing method
JPH1071766A (ja) * 1996-06-25 1998-03-17 Fuji Photo Film Co Ltd 情報記録媒体及び色素化合物
JP3840301B2 (ja) 1996-07-18 2006-11-01 富士写真フイルム株式会社 情報記録媒体
US6027709A (en) 1997-01-10 2000-02-22 Li-Cor Inc. Fluorescent cyanine dyes
DE19717904A1 (de) 1997-04-23 1998-10-29 Diagnostikforschung Inst Säurelabile und enzymatisch spaltbare Farbstoffkonstrukte zur Diagnostik mit Nahinfrarotlicht und zur Therapie
US5877310A (en) 1997-04-25 1999-03-02 Carnegie Mellon University Glycoconjugated fluorescent labeling reagents
US6133445A (en) 1997-12-17 2000-10-17 Carnegie Mellon University Rigidized trimethine cyanine dyes
EP1042407B1 (en) 1997-12-17 2001-09-12 Carnegie-Mellon University Rigidized trimethine cyanine dyes
AU3386399A (en) 1998-04-08 1999-10-25 Ewald A. Terpetschnig Luminescent compounds
US6002003A (en) 1998-04-14 1999-12-14 Beckman Instruments, Inc. Cyanine dye activating group with improved coupling selectivity
US6083486A (en) 1998-05-14 2000-07-04 The General Hospital Corporation Intramolecularly-quenched near infrared fluorescent probes
US6592847B1 (en) 1998-05-14 2003-07-15 The General Hospital Corporation Intramolecularly-quenched near infrared flourescent probes
EP1100520B1 (en) 1998-07-21 2004-09-22 Cytovia, Inc. Novel fluorescence dyes and their applications for whole cell fluorescence screening assays for caspases, peptidases, proteases and other enzymes and the use thereof
JP2000095758A (ja) 1998-09-18 2000-04-04 Schering Ag 近赤外蛍光造影剤および蛍光造影方法
ATE284433T1 (de) 1999-07-02 2004-12-15 Visen Medical Inc Fluorescierende cyaninlabels mit einem sulphamidobrückenglied
DE60020584T2 (de) * 1999-09-20 2006-04-27 Fuji Photo Film Co., Ltd., Minami-Ashigara Verbindungen zur fluoreszenz-kennzeichnung
JP2001323179A (ja) 1999-10-06 2001-11-20 Hayashibara Biochem Lab Inc シアニン色素
EP1341557A2 (en) 2000-10-27 2003-09-10 Beth Israel Deaconess Medical Center Non-isotopic detection of osteoblastic activity in vivo using modified bisphosphonates
US6615063B1 (en) 2000-11-27 2003-09-02 The General Hospital Corporation Fluorescence-mediated molecular tomography
EP1209205A1 (en) 2000-11-28 2002-05-29 Innosense S.r.l. Improved process and method for the preparation of asymetric monofunctionalised indocyanine labelling reagents and obtained compounds
EP1221465A1 (en) * 2001-01-03 2002-07-10 Innosense S.r.l. Symmetric, monofunctionalised polymethine dyes labelling reagents
US20030044353A1 (en) 2001-01-05 2003-03-06 Ralph Weissleder Activatable imaging probes
ATE536993T1 (de) 2002-01-02 2011-12-15 Visen Medical Inc Aminfunktionalisierte superparamagnetisierte nanoteilchen für die synthese von biokonjugaten
WO2003061711A2 (en) 2002-01-16 2003-07-31 Visen Medical, Inc. Chromophore probes for optical imaging
AU2003225763A1 (en) 2002-03-11 2003-09-29 Visen Medical, Inc. Optical imaging probes
EP2410315B1 (en) 2002-06-04 2020-04-01 Visen Medical, Inc. Imaging volumes with arbitrary geometries in contact and non-contact tomography
WO2004072906A1 (en) 2003-02-05 2004-08-26 The General Hospital Corporation Method and system for free space optical tomography of diffuse media
WO2004108902A2 (en) 2003-06-04 2004-12-16 Visen Medical, Inc. Biocompatible fluorescent silicon nanoparticles
EP2610315B1 (en) * 2003-12-05 2016-08-31 Life Technologies Corporation Methine-substituted cyanine dye compounds
US20060099712A1 (en) 2004-11-08 2006-05-11 Eastman Kodak Company Correlation of anti-cancer activity of dyes with redox potentials
US20080312540A1 (en) 2004-12-08 2008-12-18 Vasilis Ntziachristos System and Method for Normalized Flourescence or Bioluminescence Imaging
US20060239916A1 (en) 2005-01-07 2006-10-26 Kai Licha Use of cyanine dyes for the diagnosis of proliferative diseases
JP5106397B2 (ja) 2005-09-02 2012-12-26 ビセン メディカル, インコーポレイテッド 生体適合性n,n−二置換スルホンアミド含有蛍光色素標識
US8173819B2 (en) 2005-09-02 2012-05-08 Visen Medical, Inc. Nicotinic and picolinic acid derived near-infrared fluorophores
ES2612738T3 (es) 2005-09-02 2017-05-18 Visen Medical, Inc. Agentes de formación de imágenes fluorescentes biocompatibles
CN101262817B (zh) 2005-09-13 2011-09-07 皇家飞利浦电子股份有限公司 用于成像的多次造影剂注射
EP1973575B1 (en) 2005-12-22 2019-07-24 Visen Medical, Inc. Biocompatible fluorescent metal oxide nanoparticles
WO2007109364A2 (en) 2006-03-20 2007-09-27 The General Hospital Corporation Intramolecularly quenched fluorochrome conjugates and methods of use
EP2118206B9 (en) 2007-02-09 2018-08-29 Visen Medical, Inc. Polycyclo dyes and use thereof
WO2008109832A2 (en) 2007-03-08 2008-09-12 Visen Medical, Inc. Viable near-infrared fluorochrome labeled cells and methods of making and using same
US8314406B2 (en) 2007-04-06 2012-11-20 The General Hospital Corporation Systems and methods for optical imaging using early arriving photons
EP2244741B1 (en) 2008-01-18 2015-03-25 VisEn Medical, Inc. Fluorescent imaging agents
EP3673922A1 (en) 2008-03-14 2020-07-01 VisEn Medical, Inc. Integrin targeting agents and methods of using same
US8864821B2 (en) 2008-11-26 2014-10-21 Visen Medical, Inc. Methods and compositions for identifying subjects at risk of developing stent thrombosis

Similar Documents

Publication Publication Date Title
AU2022203395B2 (en) Fluorescent compound comprising a fluorophore conjugated to a pH -triggered polypeptide
Usama et al. On the mechanisms of uptake of tumor-seeking cyanine dyes
JP2009507108A5 (cg-RX-API-DMAC10.html)
Teunissen et al. Investigating supramolecular systems using Förster resonance energy transfer
JP2010518236A5 (cg-RX-API-DMAC10.html)
Du et al. Highly stable and bright NIR-II AIE dots for intraoperative identification of ureter
JP5500875B2 (ja) 新規化合物、該新規化合物を用いたプローブ及び該新規化合物もしくは該プローブを用いた蛍光イメージング用造影剤
ES2254042T3 (es) Microesferas para embolizacion activa.
AU2018258581A1 (en) RAF-degrading conjugate compounds
JP2016521254A5 (cg-RX-API-DMAC10.html)
Plunkett et al. In vivo deep-tissue microscopy with UCNP/Janus-dendrimers as imaging probes: resolution at depth and feasibility of ratiometric sensing
JP2007500192A (ja) 高度放射性プローブを組合わせたポリマーソーム
Nam et al. A Pressure‐Sensitive, repositionable bioadhesive for instant, atraumatic surgical application on internal organs
CN102770460A (zh) 新吲哚菁化合物、其合成法及其精制法、使用该吲哚菁化合物的诊断用组合物、使用该诊断用组合物的生物体内动态测定装置以及循环可视化装置
WO2004002476B1 (en) Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
KR20140058438A (ko) 타이로신 키나아제 저해제
Xu et al. Utilization of aggregation‐induced emission materials in urinary system diseases
JP2022506062A (ja) 置換されたインダンを含む固体分散体及び医薬組成物並びにそれの製造方法及び使用
Chen et al. Targeted cyclo [8] pyrrole-Based NIR-II photoacoustic tomography probe for suppression of orthotopic pancreatic tumor growth and intra-abdominal metastases
Oh et al. Thoracoscopic color and fluorescence imaging system for sentinel lymph node mapping in porcine lung using indocyanine green-neomannosyl human serum albumin: intraoperative image-guided sentinel nodes navigation
KR20230058122A (ko) 종양 조영 화합물, 이의 제조 방법 및 종양 진단 이미징에서의 응용
US20190275175A1 (en) Carbon Nanotubes for Imaging and Drug Delivery
Zhang et al. Rapid tumor bioimaging and photothermal treatment based on GSH-capped red fluorescent gold nanoclusters
WO2026036843A1 (zh) 靶向叶酸受体的小分子化合物及制备方法、组合物和应用
CN112641958A (zh) Met靶向分子探针及其制备方法