JP2009503095A5 - - Google Patents
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- Publication number
- JP2009503095A5 JP2009503095A5 JP2008525141A JP2008525141A JP2009503095A5 JP 2009503095 A5 JP2009503095 A5 JP 2009503095A5 JP 2008525141 A JP2008525141 A JP 2008525141A JP 2008525141 A JP2008525141 A JP 2008525141A JP 2009503095 A5 JP2009503095 A5 JP 2009503095A5
- Authority
- JP
- Japan
- Prior art keywords
- sevoflurane
- crude
- hfip
- multiphase mixture
- formaldehyde
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- DFEYYRMXOJXZRJ-UHFFFAOYSA-N sevoflurane Chemical compound FCOC(C(F)(F)F)C(F)(F)F DFEYYRMXOJXZRJ-UHFFFAOYSA-N 0.000 claims 33
- 229960002078 sevoflurane Drugs 0.000 claims 33
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 24
- 238000000034 method Methods 0.000 claims 18
- 239000000203 mixture Substances 0.000 claims 10
- 239000012535 impurity Substances 0.000 claims 7
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 claims 6
- 238000009835 boiling Methods 0.000 claims 6
- 239000012043 crude product Substances 0.000 claims 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- VNXYDFNVQBICRO-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoro-2-methoxypropane Chemical compound COC(C(F)(F)F)C(F)(F)F VNXYDFNVQBICRO-UHFFFAOYSA-N 0.000 claims 4
- SGAMQLNREKTWEK-UHFFFAOYSA-N fluoro(fluoromethoxy)methane Chemical compound FCOCF SGAMQLNREKTWEK-UHFFFAOYSA-N 0.000 claims 4
- 229910000040 hydrogen fluoride Inorganic materials 0.000 claims 4
- 239000000047 product Substances 0.000 claims 3
- OOKYWAXNZYBZER-UHFFFAOYSA-N 3-amino-3-(4-ethoxy-3-methoxyphenyl)propanoic acid Chemical compound CCOC1=CC=C(C(N)CC(O)=O)C=C1OC OOKYWAXNZYBZER-UHFFFAOYSA-N 0.000 claims 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Natural products CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- -1 methyl 2,2,2-trifluoro-1- (trifluoromethyl) ethyl Chemical group 0.000 claims 2
- 229920000570 polyether Polymers 0.000 claims 2
- BYEAHWXPCBROCE-UHFFFAOYSA-N 1,1,1,3,3,3-hexafluoropropan-2-ol Chemical compound FC(F)(F)C(O)C(F)(F)F BYEAHWXPCBROCE-UHFFFAOYSA-N 0.000 claims 1
- 238000003795 desorption Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70540805P | 2005-08-04 | 2005-08-04 | |
| US60/705,408 | 2005-08-04 | ||
| PCT/US2006/030046 WO2007019161A2 (en) | 2005-08-04 | 2006-08-02 | Purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009503095A JP2009503095A (ja) | 2009-01-29 |
| JP2009503095A5 true JP2009503095A5 (enExample) | 2009-08-13 |
| JP5069236B2 JP5069236B2 (ja) | 2012-11-07 |
Family
ID=37727866
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008525141A Expired - Fee Related JP5069236B2 (ja) | 2005-08-04 | 2006-08-02 | フルオロメチル１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテル（セボフルラン）の精製方法 |
Country Status (14)
| Country | Link |
|---|---|
| US (1) | US7750192B2 (enExample) |
| EP (1) | EP1910258B1 (enExample) |
| JP (1) | JP5069236B2 (enExample) |
| KR (1) | KR100997836B1 (enExample) |
| CN (1) | CN101263102B (enExample) |
| AT (1) | ATE540914T1 (enExample) |
| BR (1) | BRPI0614298A2 (enExample) |
| CA (1) | CA2618345C (enExample) |
| DK (1) | DK1910258T3 (enExample) |
| ES (1) | ES2381573T3 (enExample) |
| IL (1) | IL189243A (enExample) |
| MX (1) | MX2008001654A (enExample) |
| WO (1) | WO2007019161A2 (enExample) |
| ZA (1) | ZA200801327B (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7732647B2 (en) * | 2007-12-27 | 2010-06-08 | Halocarbon Products Corporation | Process for the purification of fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether (sevoflurane) |
| KR101455449B1 (ko) * | 2009-06-15 | 2014-10-27 | 다이킨 고교 가부시키가이샤 | 고순도 불소 함유 에테르의 제조 방법 |
| CN105664883B (zh) * | 2009-09-01 | 2020-09-08 | 蓝区技术有限公司 | 用于气体处理的系统和方法 |
| EP2889355B1 (en) * | 2013-12-26 | 2017-04-19 | Central Glass Company, Limited | Azeotropic mixture-like composition, heat transfer composition, cleaner, high-temperature heat pump device, and heat transfer method |
| CN105566074A (zh) * | 2014-10-08 | 2016-05-11 | 浙江化工院科技有限公司 | 一种纯化六氟异丙基甲醚的方法 |
| CN105523903B (zh) * | 2016-01-30 | 2017-07-18 | 华东医药（西安）博华制药有限公司 | 一种七氟烷的纯化方法 |
| JP6299905B1 (ja) | 2017-02-06 | 2018-03-28 | セントラル硝子株式会社 | セボフルランの製造方法 |
| CN107698430B (zh) * | 2017-11-01 | 2021-01-08 | 华东医药（西安）博华制药有限公司 | 一种七氟烷反应液的后处理方法 |
| CN114560758B (zh) * | 2022-02-22 | 2023-08-18 | 中船(邯郸)派瑞特种气体股份有限公司 | 一种电子级九氟丁基甲醚的纯化方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4250331A (en) | 1979-10-09 | 1981-02-10 | E. I. Du Pont De Nemours And Company | Removal of organic acids from dilute aqueous solutions of salts of organic acids by supercritical fluids |
| US4250334A (en) * | 1979-12-26 | 1981-02-10 | Baxter Travenol Laboratories, Inc. | Method of synthesizing fluoromethylhexafluoroisopropyl ether |
| JP2865554B2 (ja) * | 1994-04-08 | 1999-03-08 | セントラル硝子株式会社 | フルオロメチル−１，１，１，３，３，３−ヘキサフルオロイソプロピルエーテルのガスクロマトグラフ分析 |
| US5969193A (en) * | 1997-08-18 | 1999-10-19 | Medeva Pharmaceuticals Pa, Inc. | Method for the preparation of sevoflurane |
| US6469219B1 (en) * | 2000-03-16 | 2002-10-22 | Halocarbon Products Corporation | Production of fluoromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether |
-
2006
- 2006-08-02 CA CA2618345A patent/CA2618345C/en not_active Expired - Lifetime
- 2006-08-02 ES ES06800644T patent/ES2381573T3/es not_active Expired - Lifetime
- 2006-08-02 CN CN2006800335846A patent/CN101263102B/zh not_active Expired - Fee Related
- 2006-08-02 AT AT06800644T patent/ATE540914T1/de active
- 2006-08-02 US US11/997,435 patent/US7750192B2/en not_active Expired - Fee Related
- 2006-08-02 BR BRPI0614298-2A patent/BRPI0614298A2/pt not_active IP Right Cessation
- 2006-08-02 DK DK06800644.4T patent/DK1910258T3/da active
- 2006-08-02 MX MX2008001654A patent/MX2008001654A/es active IP Right Grant
- 2006-08-02 EP EP06800644A patent/EP1910258B1/en not_active Expired - Lifetime
- 2006-08-02 WO PCT/US2006/030046 patent/WO2007019161A2/en not_active Ceased
- 2006-08-02 JP JP2008525141A patent/JP5069236B2/ja not_active Expired - Fee Related
- 2006-08-02 KR KR1020087004828A patent/KR100997836B1/ko not_active Expired - Fee Related
-
2008
- 2008-02-04 IL IL189243A patent/IL189243A/en not_active IP Right Cessation
- 2008-02-07 ZA ZA200801327A patent/ZA200801327B/xx unknown
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