JP2009502963A5 - - Google Patents
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- Publication number
- JP2009502963A5 JP2009502963A5 JP2008524227A JP2008524227A JP2009502963A5 JP 2009502963 A5 JP2009502963 A5 JP 2009502963A5 JP 2008524227 A JP2008524227 A JP 2008524227A JP 2008524227 A JP2008524227 A JP 2008524227A JP 2009502963 A5 JP2009502963 A5 JP 2009502963A5
- Authority
- JP
- Japan
- Prior art keywords
- prodrug
- compound
- deuterium
- salt
- hydrogen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229940002612 prodrug Drugs 0.000 claims 8
- 239000000651 prodrug Substances 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 8
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical compound [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims 7
- 150000001875 compounds Chemical class 0.000 claims 7
- 229910052805 deuterium Inorganic materials 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 201000010099 disease Diseases 0.000 claims 3
- 229910052739 hydrogen Inorganic materials 0.000 claims 3
- 239000001257 hydrogen Substances 0.000 claims 3
- 208000007848 Alcoholism Diseases 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 201000007930 alcohol dependence Diseases 0.000 claims 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 2
- 208000024714 major depressive disease Diseases 0.000 claims 2
- -1 or a hydrate Substances 0.000 claims 2
- 239000012453 solvate Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 241000282472 Canis lupus familiaris Species 0.000 claims 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 206010012335 Dependence Diseases 0.000 claims 1
- 201000004624 Dermatitis Diseases 0.000 claims 1
- 206010013954 Dysphoria Diseases 0.000 claims 1
- 208000011688 Generalised anxiety disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 206010062501 Non-cardiac chest pain Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 206010034912 Phobia Diseases 0.000 claims 1
- 206010036618 Premenstrual syndrome Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002996 emotional effect Effects 0.000 claims 1
- 208000029364 generalized anxiety disease Diseases 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 150000002431 hydrogen Chemical class 0.000 claims 1
- 230000029849 luteinization Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 208000019906 panic disease Diseases 0.000 claims 1
- 208000019899 phobic disease Diseases 0.000 claims 1
- 230000010118 platelet activation Effects 0.000 claims 1
- 230000002028 premature Effects 0.000 claims 1
- 206010036596 premature ejaculation Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000002062 proliferating effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 230000005586 smoking cessation Effects 0.000 claims 1
- 230000000391 smoking effect Effects 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 208000011580 syndromic disease Diseases 0.000 claims 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US70407305P | 2005-07-29 | 2005-07-29 | |
| US60/704,073 | 2005-07-29 | ||
| PCT/US2006/029599 WO2007016431A2 (en) | 2005-07-29 | 2006-07-28 | Novel benzo [d] [1,3]-dioxol derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502963A JP2009502963A (ja) | 2009-01-29 |
| JP2009502963A5 true JP2009502963A5 (enExample) | 2009-09-17 |
| JP5301991B2 JP5301991B2 (ja) | 2013-09-25 |
Family
ID=37709249
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008524227A Expired - Fee Related JP5301991B2 (ja) | 2005-07-29 | 2006-07-28 | 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US20080287495A1 (enExample) |
| EP (1) | EP1910322B1 (enExample) |
| JP (1) | JP5301991B2 (enExample) |
| KR (1) | KR101380190B1 (enExample) |
| CN (1) | CN101273024A (enExample) |
| AU (1) | AU2006275595B2 (enExample) |
| BR (1) | BRPI0615973A2 (enExample) |
| CA (1) | CA2616383C (enExample) |
| EA (1) | EA014432B1 (enExample) |
| ES (1) | ES2396365T3 (enExample) |
| WO (1) | WO2007016431A2 (enExample) |
| ZA (1) | ZA200800785B (enExample) |
Families Citing this family (51)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5301991B2 (ja) * | 2005-07-29 | 2013-09-25 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体 |
| EP1948646A2 (en) * | 2005-11-14 | 2008-07-30 | Auspex Pharmaceuticals Inc. | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| KR101087805B1 (ko) * | 2006-04-03 | 2011-11-29 | 에프. 호프만-라 로슈 아게 | 거울상이성체-풍부한 환형 베타-아릴 또는 헤테로아릴 카르복시산의 제조방법 |
| EP2099299A4 (en) * | 2006-10-23 | 2011-11-30 | Concert Pharmaceuticals Inc | OXAZOLIDINONE DERIVATIVES AND METHOD FOR THEIR USE |
| ATE509015T1 (de) * | 2007-03-07 | 2011-05-15 | Concert Pharmaceuticals Inc | Deuterierte piperazinderivate als verbindungen gegen angina |
| US7608737B2 (en) * | 2007-05-01 | 2009-10-27 | Concert Pharmaceuticasl Inc. | Naphthyl(ethyl)acetamides |
| ES2401892T3 (es) * | 2007-05-01 | 2013-04-25 | Concert Pharmaceuticals Inc. | Compuestos morfinanos |
| EP3093290B1 (en) | 2007-05-01 | 2018-01-24 | Concert Pharmaceuticals Inc. | Morphinan compounds |
| CA2690379A1 (en) * | 2007-06-13 | 2008-12-24 | Auspex Pharmaceuticals, Inc. | Substituted piperazines |
| AU2008299921B2 (en) * | 2007-09-13 | 2012-03-01 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
| US9061060B2 (en) * | 2008-07-15 | 2015-06-23 | Theracos Inc. | Deuterated benzylbenzene derivatives and methods of use |
| WO2010010141A1 (en) * | 2008-07-25 | 2010-01-28 | Boehringer Ingelheim International Gmbh | Pramipexole for treating cardiomyopathy |
| US20100093721A1 (en) * | 2008-10-13 | 2010-04-15 | Barbay J Kent | PHENYL AND HETEROARYL SUBSTITUTED THIENO[2,3-d]PYRIMIDINES AND THEIR USE AS ADENOSINE A2a RECEPTOR ANTAGONISTS |
| US9045453B2 (en) | 2008-11-14 | 2015-06-02 | Concert Pharmaceuticals, Inc. | Substituted dioxopiperidinyl phthalimide derivatives |
| MX2011005112A (es) * | 2008-11-14 | 2011-06-16 | Concert Pharmaceuticals Inc | Derivados de dioxopiperidinil-ftalimida sustituida. |
| WO2010077730A2 (en) * | 2008-12-09 | 2010-07-08 | Auspex Pharmaceutical, Inc | Indanone inhibitors of acetylcholinesterase |
| WO2010075086A2 (en) * | 2008-12-15 | 2010-07-01 | Auspex Pharmaceuticals, Inc. | Pyrrolidinone inhibitors of pde-4 |
| KR20120092139A (ko) * | 2009-10-26 | 2012-08-20 | 오츠카 세이야쿠 가부시키가이샤 | 벤즈아제핀 화합물 |
| WO2011159920A1 (en) * | 2010-06-17 | 2011-12-22 | Concert Pharmaceuticals, Inc. | [5,6]-dihydro-2h-pyran-2-one derivatives |
| ES2719145T3 (es) | 2011-06-20 | 2019-07-08 | H Lundbeck As | 1-Piperazino-3-fenil-indanos deuterados para el tratamiento de la esquizofrenia |
| MX355654B (es) * | 2012-01-31 | 2018-04-26 | Eisai R&D Man Co Ltd | Derivado de paroxetina. |
| EP2847203A1 (en) | 2012-02-03 | 2015-03-18 | Selectx Pharmaceuticals, Inc. | 4,6-substituted 2,5-dideoxystreptamine aminoglycoside antibiotics |
| EP2687854A1 (en) * | 2012-07-19 | 2014-01-22 | Chiron AS | Test kit for the quantitative determination of narcotic drugs |
| WO2014066243A1 (en) | 2012-10-22 | 2014-05-01 | Concert Pharmaceuticals, Inc. | Solid forms of {s-3-(4-amino-1-oxo-isoindolin-2yl)(piperidine-3,4,4,5,5-d5)-2,6-dione} |
| AR094054A1 (es) * | 2012-12-19 | 2015-07-08 | H Lundbeck As | 6-cloro-3-(fenil-d₅)-inden-1-ona y uso de la misma |
| AU2014243869A1 (en) | 2013-03-13 | 2015-09-24 | Boston Biomedical, Inc. | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
| CA2916653C (en) * | 2013-06-27 | 2017-07-18 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine d1 ligands |
| CN104059030B (zh) | 2014-05-30 | 2016-05-04 | 镇江圣安医药有限公司 | [(苯硫烷基)-苯基]哌嗪的衍生物及其药物组合物和用途 |
| NZ728488A (en) | 2014-07-29 | 2023-03-31 | Shenzhen Hightide Biopharmaceutical Ltd | Berberine salts, ursodeoxycholic salts and combinations, methods of preparation and application thereof |
| US10089505B1 (en) | 2015-09-29 | 2018-10-02 | Amazon Technologies, Inc. | Inventory tracking using RFID |
| US10037449B1 (en) | 2015-09-29 | 2018-07-31 | Amazon Technologies, Inc. | Inventory tracking using RFID |
| US10577362B2 (en) | 2016-05-04 | 2020-03-03 | Genoscience Pharma | Substituted 2, 4-diamino-quinoline derivatives for use in the treatment of proliferative diseases |
| CA3023648C (en) | 2016-05-10 | 2023-11-28 | Shenzhen Hightide Biopharmaceutical, Ltd. | Pharmaceutical composition of berberine with epa and dha |
| CN109328018A (zh) | 2016-12-15 | 2019-02-12 | 雀巢产品技术援助有限公司 | 调节伴侣动物体内的磷或酶的组合物和方法 |
| CN108864077B (zh) | 2017-05-12 | 2020-05-22 | 深圳君圣泰生物技术有限公司 | 小檗碱有机酸盐的固体形式及其制备方法 |
| CN109134432B (zh) * | 2017-06-15 | 2021-06-11 | 北京君科华元医药科技有限公司 | 氘代抗抑郁药物 |
| US11440904B2 (en) | 2017-08-28 | 2022-09-13 | Zhihong Chen | Substituted pyrimidines, pharmaceutical compositions and therapeutic methods thereof |
| CN107970243B (zh) * | 2017-10-30 | 2020-07-28 | 江苏理工学院 | 一种去甲氯氮平的新用途 |
| TW202519270A (zh) | 2018-06-07 | 2025-05-16 | 美商思進公司 | 喜樹鹼結合物 |
| MX2021004517A (es) | 2018-11-01 | 2021-11-04 | Lynk Pharmaceuticals Co Ltd | Inhibidores de cinasa de janus 1 triciclicos y composiciones y metodos de los mismos. |
| US11535600B2 (en) | 2018-12-03 | 2022-12-27 | H. Lundbeck A/S | Prodrugs of 4-((1R,3S)-6-chloro-3-phenyl-2,3-dihydro-1H-inden-1-yl)-1,2,2-trimethylpiperazine and 4-((1R,3S)-6-chloro-3-(phenyl-d5)-2,3-dihydro-1H-inden-1-yl)-2,2-dimethyl-1-(methyl-d3)piperazine |
| WO2020146845A1 (en) | 2019-01-11 | 2020-07-16 | University Of Rochester | Compositions and methods for treating prostate cancer with enzalutamide and an inhibitor of monoamin oxidase a |
| JP7538803B6 (ja) | 2019-02-01 | 2024-09-10 | ユー，ニンフイ | イミダゾキノリンアミン誘導体、医薬組成物、その使用 |
| WO2020163118A1 (en) | 2019-02-07 | 2020-08-13 | Canwell Biotech Limited | Phosphorus imidazoquinoline amine derivatives, pharmaceutical compositions and therapeutic methods thereof |
| CN110283156B (zh) * | 2019-07-29 | 2020-06-30 | 河北省农林科学院经济作物研究所 | 从刺五加中提取的新型降血脂化合物 |
| CA3152316A1 (en) | 2019-10-04 | 2021-04-08 | Scott C. Jeffrey | Camptothecin peptide conjugates |
| EP4138840A1 (en) | 2020-04-22 | 2023-03-01 | University of Rochester | Compositions and methods for treating metabolic and cardiovascular diseases |
| JP2022100060A (ja) * | 2020-12-23 | 2022-07-05 | 大陽日酸株式会社 | モノ重水素化ジハロゲン化メタン、重水素化シクロプロパン化合物及びそれらの製造方法 |
| AU2022218110A1 (en) | 2021-02-02 | 2023-08-17 | Yanping Kong | Composition and methods for treating cancer |
| AU2022297453A1 (en) | 2021-06-22 | 2024-01-04 | Crimson Biopharm Inc. | (1h-pyrrolo[2,3-b]pyridin-1-yl)pyrimidin-2-yl-amino-phenyl--acrylamide inhibitors of egfr for use in the treatment of brain tumors |
| WO2025126109A1 (en) | 2023-12-15 | 2025-06-19 | Ensem Therapeutics, Inc. | Anilino-pyrazole derivatives, compositions and methods thereof |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1422263A (en) * | 1973-01-30 | 1976-01-21 | Ferrosan As | 4-phenyl-piperidine compounds |
| GB8430581D0 (en) | 1984-12-04 | 1985-01-09 | Ferrosan As | Treatment |
| WO1989001342A2 (en) * | 1987-08-07 | 1989-02-23 | Mallinckrodt, Inc. | Diagnostic or radiotherapeutic composition comprising a hydrogen containing compound |
| US6221335B1 (en) | 1994-03-25 | 2001-04-24 | Isotechnika, Inc. | Method of using deuterated calcium channel blockers |
| JP3696884B2 (ja) * | 1994-03-25 | 2005-09-21 | アイソテクニカ、インコーポレーテッド | ジュウテリウム化による薬物の効能の増強 |
| US5597826A (en) * | 1994-09-14 | 1997-01-28 | Pfizer Inc. | Compositions containing sertraline and a 5-HT1D receptor agonist or antagonist |
| ES2155995T3 (es) * | 1997-06-10 | 2001-06-01 | Synthon Bv | Compuestos de 4-fenilpiperidina. |
| US6440710B1 (en) | 1998-12-10 | 2002-08-27 | The Scripps Research Institute | Antibody-catalyzed deuteration, tritiation, dedeuteration or detritiation of carbonyl compounds |
| EP1104760B1 (en) | 1999-12-03 | 2003-03-12 | Pfizer Products Inc. | Sulfamoylheteroaryl pyrazole compounds as anti-inflammatory/analgesic agents |
| EP1134290A3 (en) * | 2000-03-14 | 2004-01-02 | Pfizer Products Inc. | Pharmacophore models for the identification of the CYP2D6 inhibitory potency of selective serotonin reuptake inhibitors |
| US6436938B1 (en) * | 2001-01-22 | 2002-08-20 | Pfizer Inc. | Combination treatment for depression |
| US6720003B2 (en) * | 2001-02-16 | 2004-04-13 | Andrx Corporation | Serotonin reuptake inhibitor formulations |
| TW200413273A (en) | 2002-11-15 | 2004-08-01 | Wako Pure Chem Ind Ltd | Heavy hydrogenation method of heterocyclic rings |
| JP5301991B2 (ja) * | 2005-07-29 | 2013-09-25 | コンサート ファーマシューティカルズ インコーポレイテッド | 新規なベンゾ［ｄ］［１，３］−ジオキソール誘導体 |
| US20080033011A1 (en) * | 2005-07-29 | 2008-02-07 | Concert Pharmaceuticals Inc. | Novel benzo[d][1,3]-dioxol derivatives |
| CA2624179A1 (en) | 2005-10-06 | 2007-04-12 | Auspex Pharmaceuticals, Inc. | Deuterated inhibitors of gastric h+, k+-atpase with enhanced therapeutic properties |
| EP1948646A2 (en) * | 2005-11-14 | 2008-07-30 | Auspex Pharmaceuticals Inc. | Substituted phenylpiperidines with serotoninergic activity and enhanced therapeutic properties |
| US7750168B2 (en) | 2006-02-10 | 2010-07-06 | Sigma-Aldrich Co. | Stabilized deuteroborane-tetrahydrofuran complex |
| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
| CA2661404A1 (en) | 2006-09-05 | 2008-03-13 | Schering Corporation | Pharmaceutical combinations for lipid management and in the treatment of atherosclerosis and hepatic steatosis |
| AU2008299921B2 (en) * | 2007-09-13 | 2012-03-01 | Concert Pharmaceuticals, Inc. | Synthesis of deuterated catechols and benzo[d][1,3] dioxoles and derivatives thereof |
-
2006
- 2006-07-28 JP JP2008524227A patent/JP5301991B2/ja not_active Expired - Fee Related
- 2006-07-28 EP EP06813250A patent/EP1910322B1/en active Active
- 2006-07-28 CN CNA2006800351923A patent/CN101273024A/zh active Pending
- 2006-07-28 EA EA200800490A patent/EA014432B1/ru not_active IP Right Cessation
- 2006-07-28 KR KR1020087004867A patent/KR101380190B1/ko not_active Expired - Fee Related
- 2006-07-28 AU AU2006275595A patent/AU2006275595B2/en not_active Ceased
- 2006-07-28 BR BRPI0615973-7A patent/BRPI0615973A2/pt not_active IP Right Cessation
- 2006-07-28 ES ES06813250T patent/ES2396365T3/es active Active
- 2006-07-28 WO PCT/US2006/029599 patent/WO2007016431A2/en not_active Ceased
- 2006-07-28 CA CA2616383A patent/CA2616383C/en active Active
- 2006-07-31 US US11/498,334 patent/US20080287495A1/en not_active Abandoned
-
2007
- 2007-02-08 US US11/704,554 patent/US7678914B2/en not_active Expired - Fee Related
-
2008
- 2008-01-25 ZA ZA200800785A patent/ZA200800785B/xx unknown
-
2010
- 2010-01-15 US US12/688,466 patent/US8450492B2/en not_active Expired - Fee Related
-
2013
- 2013-05-24 US US13/901,651 patent/US20140018390A1/en not_active Abandoned
-
2015
- 2015-03-10 US US14/644,012 patent/US20150196544A1/en not_active Abandoned
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