JP2010540470A5 - - Google Patents
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- Publication number
- JP2010540470A5 JP2010540470A5 JP2010526129A JP2010526129A JP2010540470A5 JP 2010540470 A5 JP2010540470 A5 JP 2010540470A5 JP 2010526129 A JP2010526129 A JP 2010526129A JP 2010526129 A JP2010526129 A JP 2010526129A JP 2010540470 A5 JP2010540470 A5 JP 2010540470A5
- Authority
- JP
- Japan
- Prior art keywords
- solution
- formula
- compound represented
- polymorph
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 20
- 239000000243 solution Substances 0.000 claims 18
- 239000002904 solvent Substances 0.000 claims 7
- ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 230000003247 decreasing effect Effects 0.000 claims 5
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims 4
- 229910017604 nitric acid Inorganic materials 0.000 claims 4
- 238000001816 cooling Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- OIPILFWXSMYKGL-UHFFFAOYSA-N acetylcholine Chemical compound CC(=O)OCC[N+](C)(C)C OIPILFWXSMYKGL-UHFFFAOYSA-N 0.000 claims 2
- 229960004373 acetylcholine Drugs 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 229960003530 donepezil Drugs 0.000 claims 2
- 239000011259 mixed solution Substances 0.000 claims 2
- 239000006191 orally-disintegrating tablet Substances 0.000 claims 2
- 230000035790 physiological processes and functions Effects 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- 206010012218 Delirium Diseases 0.000 claims 1
- 201000010374 Down Syndrome Diseases 0.000 claims 1
- 208000023105 Huntington disease Diseases 0.000 claims 1
- 208000019022 Mood disease Diseases 0.000 claims 1
- 208000002193 Pain Diseases 0.000 claims 1
- 206010039966 Senile dementia Diseases 0.000 claims 1
- 206010044688 Trisomy 21 Diseases 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 208000029028 brain injury Diseases 0.000 claims 1
- 239000007910 chewable tablet Substances 0.000 claims 1
- 229940068682 chewable tablet Drugs 0.000 claims 1
- 239000003086 colorant Substances 0.000 claims 1
- 239000007884 disintegrant Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 239000007938 effervescent tablet Substances 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 230000000366 juvenile effect Effects 0.000 claims 1
- 239000000314 lubricant Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 229940100688 oral solution Drugs 0.000 claims 1
- 239000007935 oral tablet Substances 0.000 claims 1
- 229940096978 oral tablet Drugs 0.000 claims 1
- 230000036407 pain Effects 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000000634 powder X-ray diffraction Methods 0.000 claims 1
- 208000019116 sleep disease Diseases 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 239000007787 solid Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710061212.0 | 2007-09-28 | ||
| CN200710061212 | 2007-09-28 | ||
| CN200810052067.4 | 2008-01-15 | ||
| CN200810052067 | 2008-01-15 | ||
| CN200810211731.5 | 2008-09-24 | ||
| PCT/CN2008/001646 WO2009049479A1 (en) | 2007-09-28 | 2008-09-24 | Polymorphs of donepezil salts, preparation methods and uses thereof |
| CN2008102117315A CN101397270B (zh) | 2007-09-28 | 2008-09-24 | 多奈哌齐盐的多晶型物及其制备和应用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010540470A JP2010540470A (ja) | 2010-12-24 |
| JP2010540470A5 true JP2010540470A5 (enExample) | 2013-12-05 |
| JP5426554B2 JP5426554B2 (ja) | 2014-02-26 |
Family
ID=40566980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010526129A Expired - Fee Related JP5426554B2 (ja) | 2007-09-28 | 2008-09-24 | ドネペジル塩、その多形体、その製造方法、応用方法および組成物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8501779B2 (enExample) |
| EP (1) | EP2204364B1 (enExample) |
| JP (1) | JP5426554B2 (enExample) |
| CN (2) | CN102603612A (enExample) |
| DK (1) | DK2204364T3 (enExample) |
| ES (1) | ES2415166T3 (enExample) |
| WO (1) | WO2009049479A1 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100113793A1 (en) * | 2006-03-20 | 2010-05-06 | Ind-Swift Laboratories Limited | Process for the Preparation of Highly Pure Donepezil |
| JP5563841B2 (ja) * | 2010-02-05 | 2014-07-30 | 沢井製薬株式会社 | 薬物の不快な味をマスキングした経口医薬組成物 |
| GB201411802D0 (en) * | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| CN104958254A (zh) * | 2015-06-27 | 2015-10-07 | 万特制药(海南)有限公司 | 一种盐酸多奈哌齐口服溶液及其制备方法 |
| KR102318249B1 (ko) * | 2018-11-26 | 2021-10-27 | 에바바이오 주식회사 | 도네페질 이온성 액체 및 이의 용도 |
| WO2020111719A2 (ko) * | 2018-11-26 | 2020-06-04 | 연세대학교 산학협력단 | 도네페질 공융혼합물 및 이의 용도 |
| US20230054895A1 (en) * | 2020-01-10 | 2023-02-23 | President And Fellows Of Harvard College | Methods for inducing biostasis in a cell, tissue or organ |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| NZ333197A (en) * | 1996-06-07 | 2001-03-30 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
| JPH1053576A (ja) * | 1996-06-07 | 1998-02-24 | Eisai Co Ltd | 塩酸ドネペジルの多形結晶およびその製造法 |
| US7439365B2 (en) | 2003-11-17 | 2008-10-21 | Usv, Ltd. | Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil) |
| US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
| HUP0401850A3 (en) | 2004-09-15 | 2008-03-28 | Egis Gyogyszergyar Nyilvanosan | Donepezil salts for producing pharmaceutical composition |
| DE102004046497A1 (de) * | 2004-09-23 | 2006-04-06 | Helm Ag | Donepezil-Salze |
| CA2581926A1 (en) * | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| CN1759836A (zh) * | 2004-10-12 | 2006-04-19 | 天津和美生物技术有限公司 | 多奈哌齐及其衍生物的舌下含片 |
| WO2007010910A1 (en) * | 2005-07-15 | 2007-01-25 | Eisai R & D Management Co., Ltd. | 1-benzyl-4-[(5, 6-dimethoxy-1-indanon)-2-yl]-methyl piperidine p-toluenesulfonate or crystal thereof |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
-
2008
- 2008-09-24 JP JP2010526129A patent/JP5426554B2/ja not_active Expired - Fee Related
- 2008-09-24 WO PCT/CN2008/001646 patent/WO2009049479A1/zh not_active Ceased
- 2008-09-24 CN CN2012100165448A patent/CN102603612A/zh active Pending
- 2008-09-24 DK DK08800639.0T patent/DK2204364T3/da active
- 2008-09-24 CN CN2008102117315A patent/CN101397270B/zh active Active
- 2008-09-24 ES ES08800639T patent/ES2415166T3/es active Active
- 2008-09-24 EP EP08800639A patent/EP2204364B1/en not_active Not-in-force
-
2010
- 2010-03-26 US US12/748,248 patent/US8501779B2/en not_active Expired - Fee Related
-
2013
- 2013-07-05 US US13/935,927 patent/US20130296283A1/en not_active Abandoned
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