CN101397270B - 多奈哌齐盐的多晶型物及其制备和应用 - Google Patents

多奈哌齐盐的多晶型物及其制备和应用 Download PDF

Info

Publication number
CN101397270B
CN101397270B CN2008102117315A CN200810211731A CN101397270B CN 101397270 B CN101397270 B CN 101397270B CN 2008102117315 A CN2008102117315 A CN 2008102117315A CN 200810211731 A CN200810211731 A CN 200810211731A CN 101397270 B CN101397270 B CN 101397270B
Authority
CN
China
Prior art keywords
donepezil
acid
formula
solution
tablet
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN2008102117315A
Other languages
English (en)
Chinese (zh)
Other versions
CN101397270A (zh
Inventor
张和胜
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
HAINAN HAILING CHEMICAL PHARMACEUTICAL CO Ltd
TIANJIN HEMEI BIOTECHNOLOGY CO Ltd
Original Assignee
HAINAN HAILING CHEMICAL PHARMACEUTICAL CO Ltd
Tianjin Hemay Biotechnology Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to EP08800639A priority Critical patent/EP2204364B1/en
Priority to HK11100149.7A priority patent/HK1146047B/en
Priority to JP2010526129A priority patent/JP5426554B2/ja
Priority to ES08800639T priority patent/ES2415166T3/es
Priority to CN2008102117315A priority patent/CN101397270B/zh
Priority to PCT/CN2008/001646 priority patent/WO2009049479A1/zh
Priority to DK08800639.0T priority patent/DK2204364T3/da
Application filed by HAINAN HAILING CHEMICAL PHARMACEUTICAL CO Ltd, Tianjin Hemay Biotechnology Co Ltd filed Critical HAINAN HAILING CHEMICAL PHARMACEUTICAL CO Ltd
Publication of CN101397270A publication Critical patent/CN101397270A/zh
Priority to US12/748,248 priority patent/US8501779B2/en
Application granted granted Critical
Publication of CN101397270B publication Critical patent/CN101397270B/zh
Priority to US13/935,927 priority patent/US20130296283A1/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
    • C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
    • C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
    • C07C57/13—Dicarboxylic acids
    • C07C57/145—Maleic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
    • C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
    • C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
    • C07C65/10—Salicylic acid

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Hospice & Palliative Care (AREA)
  • Anesthesiology (AREA)
  • Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN2008102117315A 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用 Active CN101397270B (zh)

Priority Applications (9)

Application Number Priority Date Filing Date Title
JP2010526129A JP5426554B2 (ja) 2007-09-28 2008-09-24 ドネペジル塩、その多形体、その製造方法、応用方法および組成物
ES08800639T ES2415166T3 (es) 2007-09-28 2008-09-24 Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos
CN2008102117315A CN101397270B (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用
PCT/CN2008/001646 WO2009049479A1 (en) 2007-09-28 2008-09-24 Polymorphs of donepezil salts, preparation methods and uses thereof
EP08800639A EP2204364B1 (en) 2007-09-28 2008-09-24 Polymorphs of donepezil salts, preparation methods and uses thereof
HK11100149.7A HK1146047B (en) 2007-09-28 2008-09-24 Polymorphs of donepezil salts, preparation methods and uses thereof
DK08800639.0T DK2204364T3 (da) 2007-09-28 2008-09-24 Polymorfer af donepezil-salte, fremgangsmåder til fremstilling og anvendelser deraf
US12/748,248 US8501779B2 (en) 2007-09-28 2010-03-26 Polymorphs of donepezil salts, preparation methods and uses thereof
US13/935,927 US20130296283A1 (en) 2007-09-28 2013-07-05 Polymorphs of donepezil salts, preparation methods and uses thereof

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
CN200710061212.0 2007-09-28
CN200710061212 2007-09-28
CN200810052067.4 2008-01-15
CN200810052067 2008-01-15
CN2008102117315A CN101397270B (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN2012100165448A Division CN102603612A (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用

Publications (2)

Publication Number Publication Date
CN101397270A CN101397270A (zh) 2009-04-01
CN101397270B true CN101397270B (zh) 2012-03-28

Family

ID=40566980

Family Applications (2)

Application Number Title Priority Date Filing Date
CN2008102117315A Active CN101397270B (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用
CN2012100165448A Pending CN102603612A (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN2012100165448A Pending CN102603612A (zh) 2007-09-28 2008-09-24 多奈哌齐盐的多晶型物及其制备和应用

Country Status (7)

Country Link
US (2) US8501779B2 (enExample)
EP (1) EP2204364B1 (enExample)
JP (1) JP5426554B2 (enExample)
CN (2) CN101397270B (enExample)
DK (1) DK2204364T3 (enExample)
ES (1) ES2415166T3 (enExample)
WO (1) WO2009049479A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100113793A1 (en) * 2006-03-20 2010-05-06 Ind-Swift Laboratories Limited Process for the Preparation of Highly Pure Donepezil
JP5563841B2 (ja) * 2010-02-05 2014-07-30 沢井製薬株式会社 薬物の不快な味をマスキングした経口医薬組成物
GB201411802D0 (en) * 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
CN104958254A (zh) * 2015-06-27 2015-10-07 万特制药(海南)有限公司 一种盐酸多奈哌齐口服溶液及其制备方法
EP3888636A4 (en) * 2018-11-26 2022-08-17 Ebabio Inc. EUTECTIC MIXTURE OF DONEPEZIL AND ITS USE
KR102318249B1 (ko) * 2018-11-26 2021-10-27 에바바이오 주식회사 도네페질 이온성 액체 및 이의 용도
EP4087395A4 (en) * 2020-01-10 2023-12-27 President And Fellows Of Harvard College METHOD FOR BIOSTASIS INDUCTION IN A CELL, TISSUE OR ORGAN

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1759836A (zh) * 2004-10-12 2006-04-19 天津和美生物技术有限公司 多奈哌齐及其衍生物的舌下含片

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI95572C (fi) 1987-06-22 1996-02-26 Eisai Co Ltd Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi
JPH1053576A (ja) * 1996-06-07 1998-02-24 Eisai Co Ltd 塩酸ドネペジルの多形結晶およびその製造法
SI9720038B (sl) * 1996-06-07 2010-06-30 Eisai Co Ltd Polimorfi donepezil hidroklorida in postopek izdelave
US20050288330A1 (en) * 2004-06-29 2005-12-29 Avinash Naidu Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride)
US7439365B2 (en) 2003-11-17 2008-10-21 Usv, Ltd. Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil)
HUP0401850A3 (en) * 2004-09-15 2008-03-28 Egis Gyogyszergyar Nyilvanosan Donepezil salts for producing pharmaceutical composition
DE102004046497A1 (de) * 2004-09-23 2006-04-06 Helm Ag Donepezil-Salze
CA2581926A1 (en) * 2004-09-29 2006-04-06 Chemagis Ltd. Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride
WO2007010910A1 (en) * 2005-07-15 2007-01-25 Eisai R & D Management Co., Ltd. 1-benzyl-4-[(5, 6-dimethoxy-1-indanon)-2-yl]-methyl piperidine p-toluenesulfonate or crystal thereof
HU227474B1 (en) * 2005-12-20 2011-07-28 Richter Gedeon Nyrt Process for industrial scale production of high purity donepezil hydrochloride polymorph i.

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1759836A (zh) * 2004-10-12 2006-04-19 天津和美生物技术有限公司 多奈哌齐及其衍生物的舌下含片

Also Published As

Publication number Publication date
EP2204364A4 (en) 2011-08-10
CN101397270A (zh) 2009-04-01
HK1146047A1 (en) 2011-05-13
US20130296283A1 (en) 2013-11-07
US20100311793A1 (en) 2010-12-09
EP2204364A1 (en) 2010-07-07
JP5426554B2 (ja) 2014-02-26
CN102603612A (zh) 2012-07-25
US8501779B2 (en) 2013-08-06
WO2009049479A1 (en) 2009-04-23
JP2010540470A (ja) 2010-12-24
EP2204364B1 (en) 2013-03-20
DK2204364T3 (da) 2013-06-03
ES2415166T3 (es) 2013-07-24

Similar Documents

Publication Publication Date Title
CN101397270B (zh) 多奈哌齐盐的多晶型物及其制备和应用
AU731282B2 (en) Polymorphs of donepezil hydrochloride and process for production
ES2652187T3 (es) Fenilacetato de l-ornitina y métodos para elaborar el mismo
JP2005015486A (ja) 塩酸ドネペジルの多形結晶およびその製造法
TWI446903B (zh) 含（-）-ｏ-去甲基泛拉弗辛（ｖｅｎｌａｆａｘｉｎｅ）之固體形式及其用途
PT1678139E (pt) Montelucaste em estado sólido
WO2018019300A1 (zh) 一种口服固体制剂及其应用
JP4427900B2 (ja) シアル酸誘導体を含む固体分散体
US20090136570A1 (en) Taste-Masked Tablets and Granules
CN101423537A (zh) 灯盏乙素酯及其医疗用途
EP2626347A1 (en) Dalfampridine polymorph, preparation therefor, and application thereof
CN116262698A (zh) 一种新的2-(1-羟基戊基)苯甲酸环烷胺盐
HK1146047B (en) Polymorphs of donepezil salts, preparation methods and uses thereof
JP7359769B2 (ja) ピラノース置換複素環式化合物の塩、その調製方法および用途
TWI267511B (en) Process for preparing 10,11-methanobenzosuberane derivatives
KR102509190B1 (ko) 트리메부틴 말레산염의 다형체 및 이의 사용방법
US20240174598A1 (en) Compounds for the treatment of disorders and salts and polymorphs thereof
TWI898321B (zh) 用於治療或預防高尿酸血症或痛風的化合物的固體晶型
CN102126973A (zh) 一种二元酯酸的葡甲胺盐化合物,其制备方法和药物应用
RU2802964C2 (ru) Твердые формы 2-(5-(4-(2-морфолиноэтокси)фенил)пиридин-2-ил)-n-бензилацетамида
KR20250081156A (ko) L-세린 염산염의 제조 방법 및 이의 용도
WO2015043404A1 (zh) (-)-石杉碱甲盐
TW202434612A (zh) 一種二肽類化合物的鹽、其製備方法和用途
CN107586293A (zh) 含硫二苯并噻嗪生物碱类化合物及其用途
ES2380799T3 (es) Sal de ácido fumárico y 3-(2-dimetilamino)metil- (cicloex-1-il))-fenol y sus formas cristalinas

Legal Events

Date Code Title Description
C06 Publication
PB01 Publication
C10 Entry into substantive examination
SE01 Entry into force of request for substantive examination
ASS Succession or assignment of patent right

Owner name: HAINAN HAILING CHEMICAL PHARMACEUTICAL CO., LTD.

C41 Transfer of patent application or patent right or utility model
TA01 Transfer of patent application right

Effective date of registration: 20110118

Address after: 300457 Tianjin City, Tianjin economic and Technological Development Zone Xiaoyuan village 31-101

Applicant after: Tianjin Hemei Biotechnology Co., Ltd.

Co-applicant after: Hainan Hailing Chemical Pharmaceutical Co., Ltd.

Address before: 300457 Tianjin City, Tianjin economic and Technological Development Zone Xiaoyuan village 31-101

Applicant before: Tianjin Hemei Biotechnology Co., Ltd.

C14 Grant of patent or utility model
GR01 Patent grant