ES2415166T3 - Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos - Google Patents
Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos Download PDFInfo
- Publication number
- ES2415166T3 ES2415166T3 ES08800639T ES08800639T ES2415166T3 ES 2415166 T3 ES2415166 T3 ES 2415166T3 ES 08800639 T ES08800639 T ES 08800639T ES 08800639 T ES08800639 T ES 08800639T ES 2415166 T3 ES2415166 T3 ES 2415166T3
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- Prior art keywords
- donepezil
- compound
- formula
- solution
- polymorph
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- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 claims abstract description 30
- 229910017604 nitric acid Inorganic materials 0.000 claims abstract description 30
- 229960003530 donepezil Drugs 0.000 claims description 498
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- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
- C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D211/30—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom
- C07D211/32—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by doubly bound oxygen or sulfur atoms or by two oxygen or sulfur atoms singly bound to the same carbon atom by oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/02—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms with only carbon-to-carbon double bonds as unsaturation
- C07C57/13—Dicarboxylic acids
- C07C57/145—Maleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C65/01—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups
- C07C65/03—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring
- C07C65/05—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing hydroxy or O-metal groups monocyclic and having all hydroxy or O-metal groups bound to the ring o-Hydroxy carboxylic acids
- C07C65/10—Salicylic acid
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Anesthesiology (AREA)
- Psychology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN200710061212 | 2007-09-28 | ||
| CN200710061212 | 2007-09-28 | ||
| CN200810052067 | 2008-01-15 | ||
| CN200810052067 | 2008-01-15 | ||
| PCT/CN2008/001646 WO2009049479A1 (en) | 2007-09-28 | 2008-09-24 | Polymorphs of donepezil salts, preparation methods and uses thereof |
| CN200810211731 | 2008-09-24 | ||
| CN2008102117315A CN101397270B (zh) | 2007-09-28 | 2008-09-24 | 多奈哌齐盐的多晶型物及其制备和应用 |
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| ES2415166T3 true ES2415166T3 (es) | 2013-07-24 |
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| Application Number | Title | Priority Date | Filing Date |
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| ES08800639T Active ES2415166T3 (es) | 2007-09-28 | 2008-09-24 | Polímorfos de sales de Donepezilo, métodos de preparación y usos de los mismos |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8501779B2 (enExample) |
| EP (1) | EP2204364B1 (enExample) |
| JP (1) | JP5426554B2 (enExample) |
| CN (2) | CN102603612A (enExample) |
| DK (1) | DK2204364T3 (enExample) |
| ES (1) | ES2415166T3 (enExample) |
| WO (1) | WO2009049479A1 (enExample) |
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| US20100113793A1 (en) * | 2006-03-20 | 2010-05-06 | Ind-Swift Laboratories Limited | Process for the Preparation of Highly Pure Donepezil |
| JP5563841B2 (ja) * | 2010-02-05 | 2014-07-30 | 沢井製薬株式会社 | 薬物の不快な味をマスキングした経口医薬組成物 |
| GB201411802D0 (en) * | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| CN104958254A (zh) * | 2015-06-27 | 2015-10-07 | 万特制药(海南)有限公司 | 一种盐酸多奈哌齐口服溶液及其制备方法 |
| KR102318249B1 (ko) * | 2018-11-26 | 2021-10-27 | 에바바이오 주식회사 | 도네페질 이온성 액체 및 이의 용도 |
| WO2020111719A2 (ko) * | 2018-11-26 | 2020-06-04 | 연세대학교 산학협력단 | 도네페질 공융혼합물 및 이의 용도 |
| US20230054895A1 (en) * | 2020-01-10 | 2023-02-23 | President And Fellows Of Harvard College | Methods for inducing biostasis in a cell, tissue or organ |
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| FI95572C (fi) | 1987-06-22 | 1996-02-26 | Eisai Co Ltd | Menetelmä lääkeaineena käyttökelpoisen piperidiinijohdannaisten tai sen farmaseuttisen suolan valmistamiseksi |
| NZ333197A (en) * | 1996-06-07 | 2001-03-30 | Eisai Co Ltd | Polymorphs of donepezil hydrochloride |
| JPH1053576A (ja) * | 1996-06-07 | 1998-02-24 | Eisai Co Ltd | 塩酸ドネペジルの多形結晶およびその製造法 |
| US7439365B2 (en) | 2003-11-17 | 2008-10-21 | Usv, Ltd. | Pharmaceutical salt of (1-benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine (Donepezil) |
| US20050288330A1 (en) * | 2004-06-29 | 2005-12-29 | Avinash Naidu | Process for producing a polymorphic form of (1-Benzyl-4-[(5,6-dimethoxy-1-indanone)-2-yl] methyl piperidine hydrochloride (donepezil hydrochloride) |
| HUP0401850A3 (en) | 2004-09-15 | 2008-03-28 | Egis Gyogyszergyar Nyilvanosan | Donepezil salts for producing pharmaceutical composition |
| DE102004046497A1 (de) * | 2004-09-23 | 2006-04-06 | Helm Ag | Donepezil-Salze |
| CA2581926A1 (en) * | 2004-09-29 | 2006-04-06 | Chemagis Ltd. | Use of purified donepezil maleate for preparing pharmaceutically pure amorphous donepezil hydrochloride |
| CN1759836A (zh) * | 2004-10-12 | 2006-04-19 | 天津和美生物技术有限公司 | 多奈哌齐及其衍生物的舌下含片 |
| WO2007010910A1 (en) * | 2005-07-15 | 2007-01-25 | Eisai R & D Management Co., Ltd. | 1-benzyl-4-[(5, 6-dimethoxy-1-indanon)-2-yl]-methyl piperidine p-toluenesulfonate or crystal thereof |
| HU227474B1 (en) * | 2005-12-20 | 2011-07-28 | Richter Gedeon Nyrt | Process for industrial scale production of high purity donepezil hydrochloride polymorph i. |
-
2008
- 2008-09-24 JP JP2010526129A patent/JP5426554B2/ja not_active Expired - Fee Related
- 2008-09-24 WO PCT/CN2008/001646 patent/WO2009049479A1/zh not_active Ceased
- 2008-09-24 CN CN2012100165448A patent/CN102603612A/zh active Pending
- 2008-09-24 DK DK08800639.0T patent/DK2204364T3/da active
- 2008-09-24 CN CN2008102117315A patent/CN101397270B/zh active Active
- 2008-09-24 ES ES08800639T patent/ES2415166T3/es active Active
- 2008-09-24 EP EP08800639A patent/EP2204364B1/en not_active Not-in-force
-
2010
- 2010-03-26 US US12/748,248 patent/US8501779B2/en not_active Expired - Fee Related
-
2013
- 2013-07-05 US US13/935,927 patent/US20130296283A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2010540470A (ja) | 2010-12-24 |
| WO2009049479A1 (en) | 2009-04-23 |
| DK2204364T3 (da) | 2013-06-03 |
| HK1146047A1 (en) | 2011-05-13 |
| EP2204364B1 (en) | 2013-03-20 |
| US20130296283A1 (en) | 2013-11-07 |
| JP5426554B2 (ja) | 2014-02-26 |
| US20100311793A1 (en) | 2010-12-09 |
| CN101397270B (zh) | 2012-03-28 |
| CN101397270A (zh) | 2009-04-01 |
| EP2204364A1 (en) | 2010-07-07 |
| CN102603612A (zh) | 2012-07-25 |
| US8501779B2 (en) | 2013-08-06 |
| EP2204364A4 (en) | 2011-08-10 |
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