JP2011513485A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011513485A5 JP2011513485A5 JP2010550697A JP2010550697A JP2011513485A5 JP 2011513485 A5 JP2011513485 A5 JP 2011513485A5 JP 2010550697 A JP2010550697 A JP 2010550697A JP 2010550697 A JP2010550697 A JP 2010550697A JP 2011513485 A5 JP2011513485 A5 JP 2011513485A5
- Authority
- JP
- Japan
- Prior art keywords
- salt crystal
- ray powder
- powder diffraction
- crystal according
- salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000013078 crystal Substances 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 36
- 238000000634 powder X-ray diffraction Methods 0.000 claims description 12
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 3
- 239000012453 solvate Substances 0.000 claims description 2
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 claims 8
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 4
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims 4
- 229910052802 copper Inorganic materials 0.000 claims 4
- 239000010949 copper Substances 0.000 claims 4
- 229910052759 nickel Inorganic materials 0.000 claims 4
- 239000002904 solvent Substances 0.000 claims 4
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims 3
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 claims 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical group CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 3
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 claims 3
- VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 208000019695 Migraine disease Diseases 0.000 claims 2
- IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000028017 Psychotic disease Diseases 0.000 claims 2
- WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- YKYONYBAUNKHLG-UHFFFAOYSA-N propyl acetate Chemical compound CCCOC(C)=O YKYONYBAUNKHLG-UHFFFAOYSA-N 0.000 claims 2
- 201000000980 schizophrenia Diseases 0.000 claims 2
- 208000012201 sexual and gender identity disease Diseases 0.000 claims 2
- 208000015891 sexual disease Diseases 0.000 claims 2
- 208000019116 sleep disease Diseases 0.000 claims 2
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 claims 2
- HOIIHACBCFLJET-SFTDATJTSA-N 4-((6br,10as)-3-methyl-2,3,6b,9,10,10a-hexahydro-1h-pyrido-[3',4':4,5]-pyrrolo[1,2,3-de]quinoxalin-8-(7h)-yl)-1-(4-fluorophenyl)-1-butanone Chemical compound C([C@@H]1N2CCN(C=3C=CC=C(C2=3)[C@@H]1C1)C)CN1CCCC(=O)C1=CC=C(F)C=C1 HOIIHACBCFLJET-SFTDATJTSA-N 0.000 claims 1
- 208000019901 Anxiety disease Diseases 0.000 claims 1
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 1
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 1
- BSDXEDJUOIHGIU-GUTACTQSSA-N C(C1=CC=CC=C1)S(=O)(=O)O.CN1CCN2C=3C(=CC=CC13)[C@H]1[C@@H]2CCN(C1)CCCC(=O)C1=CC=C(C=C1)F Chemical compound C(C1=CC=CC=C1)S(=O)(=O)O.CN1CCN2C=3C(=CC=CC13)[C@H]1[C@@H]2CCN(C1)CCCC(=O)C1=CC=C(C=C1)F BSDXEDJUOIHGIU-GUTACTQSSA-N 0.000 claims 1
- 208000030814 Eating disease Diseases 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 1
- 238000005033 Fourier transform infrared spectroscopy Methods 0.000 claims 1
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 1
- 206010019233 Headaches Diseases 0.000 claims 1
- 208000008589 Obesity Diseases 0.000 claims 1
- 206010041250 Social phobia Diseases 0.000 claims 1
- 230000036506 anxiety Effects 0.000 claims 1
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 1
- 238000001816 cooling Methods 0.000 claims 1
- 230000006735 deficit Effects 0.000 claims 1
- 238000000113 differential scanning calorimetry Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 235000014632 disordered eating Nutrition 0.000 claims 1
- 230000004064 dysfunction Effects 0.000 claims 1
- 239000012458 free base Substances 0.000 claims 1
- 230000005176 gastrointestinal motility Effects 0.000 claims 1
- 231100000869 headache Toxicity 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 1
- 235000020824 obesity Nutrition 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 208000020685 sleep-wake disease Diseases 0.000 claims 1
- 238000010183 spectrum analysis Methods 0.000 claims 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 1
- 238000002411 thermogravimetry Methods 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000007787 solid Substances 0.000 description 2
- LBLYYCQCTBFVLH-UHFFFAOYSA-N 2-Methylbenzenesulfonic acid Chemical compound CC1=CC=CC=C1S(O)(=O)=O LBLYYCQCTBFVLH-UHFFFAOYSA-N 0.000 description 1
- -1 Pyrrolo [1,2,3-de] quinoxalin-8 (7H) -yl Chemical group 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000012634 fragment Substances 0.000 description 1
- 125000000623 heterocyclic group Chemical group 0.000 description 1
- LHAPOGAFBLSJJQ-GUTACTQSSA-N iti007 Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1.C([C@@H]1N2CCN(C=3C=CC=C(C2=3)[C@@H]1C1)C)CN1CCCC(=O)C1=CC=C(F)C=C1 LHAPOGAFBLSJJQ-GUTACTQSSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3606908P | 2008-03-12 | 2008-03-12 | |
| US61/036,069 | 2008-03-12 | ||
| PCT/US2009/001608 WO2009114181A2 (en) | 2008-03-12 | 2009-03-12 | Substituted heterocycle fused gamma-carbolines solid |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011513485A JP2011513485A (ja) | 2011-04-28 |
| JP2011513485A5 true JP2011513485A5 (enExample) | 2014-05-22 |
| JP5611846B2 JP5611846B2 (ja) | 2014-10-22 |
Family
ID=41065729
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010550697A Active JP5611846B2 (ja) | 2008-03-12 | 2009-03-12 | 置換ヘテロ環縮合ガンマ−カルボリン類固体 |
Country Status (16)
| Country | Link |
|---|---|
| US (4) | US8648077B2 (enExample) |
| EP (1) | EP2262505B1 (enExample) |
| JP (1) | JP5611846B2 (enExample) |
| KR (2) | KR101610977B1 (enExample) |
| CN (2) | CN102046175B (enExample) |
| AU (1) | AU2009223701B2 (enExample) |
| CA (1) | CA2716730C (enExample) |
| DK (1) | DK2262505T3 (enExample) |
| ES (1) | ES2530090T3 (enExample) |
| HR (1) | HRP20141178T1 (enExample) |
| IL (3) | IL207772A0 (enExample) |
| MX (2) | MX2010010024A (enExample) |
| PL (1) | PL2262505T3 (enExample) |
| PT (1) | PT2262505E (enExample) |
| SI (1) | SI2262505T1 (enExample) |
| WO (1) | WO2009114181A2 (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101796051B (zh) | 2007-03-12 | 2013-11-06 | 细胞内治疗公司 | 与取代的杂环稠合的γ-咔啉的合成 |
| WO2009114181A2 (en) | 2008-03-12 | 2009-09-17 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines solid |
| USRE48839E1 (en) | 2008-05-27 | 2021-12-07 | Intra-Cellular Therapies, Inc | Methods and compositions for sleep disorders and other disorders |
| US9107696B2 (en) * | 2008-08-06 | 2015-08-18 | Emory University | Method of embryo transfer that eliminates transferred air while hormonally inducing implantation and apparatus |
| EP2560676B8 (en) | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2836211B1 (en) | 2012-04-14 | 2019-03-20 | Intra-Cellular Therapies, Inc. | Treatment of PTSD and impulse control disorders |
| PT2968320T (pt) | 2013-03-15 | 2021-01-28 | Intra Cellular Therapies Inc | Compostos orgânicos |
| IL321987A (en) * | 2013-12-03 | 2025-09-01 | Intra Cellular Therapies Inc | A long-acting injectable preparation containing polymeric microspheres of modified compressed gamma-carboline heterocyclic compounds or a sustained-release pharmaceutical preparation containing these compounds for use in the treatment of bipolar I and/or bipolar II disorders |
| PE20161573A1 (es) | 2014-02-13 | 2017-01-19 | Incyte Corp | Ciclopropilamina como inhibidor de la lsd1 |
| WO2015154025A1 (en) | 2014-04-04 | 2015-10-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
| CN106456638A (zh) | 2014-04-04 | 2017-02-22 | 细胞内治疗公司 | 有机化合物 |
| PE20180455A1 (es) | 2015-04-03 | 2018-03-05 | Incyte Corp | Compuestos heterociclicos como inhibidores de lsd1 |
| SG10202001219UA (en) | 2015-08-12 | 2020-03-30 | Incyte Corp | Salts of an lsd1 inhibitor |
| CA3011983A1 (en) | 2016-01-26 | 2017-08-03 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines |
| EP3407889B1 (en) | 2016-03-25 | 2021-05-19 | Intra-Cellular Therapies, Inc. | Organic compounds and their use in treating or preventing central nervous system disorders |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| JP2019513143A (ja) * | 2016-03-28 | 2019-05-23 | イントラ−セルラー・セラピーズ・インコーポレイテッドＩｎｔｒａ−Ｃｅｌｌｕｌａｒ Ｔｈｅｒａｐｉｅｓ， Ｉｎｃ． | 新規塩類および結晶 |
| JP6997718B2 (ja) * | 2016-03-28 | 2022-01-18 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規共結晶 |
| WO2018031535A1 (en) | 2016-08-09 | 2018-02-15 | Assia Chemical Industries Ltd. | Solid state forms of lumateperone ditosylate salt |
| US11331316B2 (en) | 2016-10-12 | 2022-05-17 | Intra-Cellular Therapies, Inc. | Amorphous solid dispersions |
| WO2018126143A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2018175969A1 (en) | 2017-03-24 | 2018-09-27 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| US11292793B2 (en) | 2017-04-10 | 2022-04-05 | Dr. Reddy's Laboratories Limited | Solid dispersions of amorphous Lumateperone p-Tosylate |
| KR102899502B1 (ko) | 2017-07-26 | 2025-12-11 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| IL272252B2 (en) | 2017-07-26 | 2024-03-01 | Intra Cellular Therapies Inc | Derivatives of substituted heterocycle fused gamma-carbolines, pharmaceutical compositions comnprising them and their use in treatment |
| MX2020007271A (es) | 2017-09-26 | 2020-08-17 | Intra Cellular Therapies Inc | Sales y cristales novedosos. |
| US11655251B2 (en) | 2017-11-27 | 2023-05-23 | Egis Gyogyszergyar Zrt. | Method for the production of lumateperone and its salts |
| CN109867674A (zh) * | 2017-12-05 | 2019-06-11 | 上海度德医药科技有限公司 | 一种取代的杂环稠合γ-咔啉的新盐及其制备方法和晶型 |
| CA3094204A1 (en) | 2018-03-16 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Novel methods |
| MX2020009929A (es) | 2018-03-23 | 2021-01-08 | Intra Cellular Therapies Inc | Compuestos organicos. |
| MX2020009928A (es) | 2018-03-23 | 2021-01-08 | Intra Cellular Therapies Inc | Compuestos organicos. |
| EP3628007B1 (en) * | 2018-06-06 | 2023-05-03 | Intra-Cellular Therapies, Inc. | Novel salts and crystals |
| WO2019237037A1 (en) | 2018-06-08 | 2019-12-12 | Intra-Cellular Therapies, Inc. | Novel methods |
| EP3609891B1 (en) * | 2018-06-11 | 2026-02-11 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| AU2019288476A1 (en) | 2018-06-21 | 2021-03-18 | Aquestive Therapeutics, Inc. | System and method for making personalized individual unit doses containing pharmaceutical actives |
| WO2020047241A1 (en) | 2018-08-29 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel compositions and methods |
| WO2020047198A1 (en) | 2018-08-31 | 2020-03-05 | Incyte Corporation | Salts of an lsd1 inhibitor and processes for preparing the same |
| WO2020047407A1 (en) * | 2018-08-31 | 2020-03-05 | Intra-Cellular Therapies, Inc. | Novel methods |
| KR20210052472A (ko) * | 2018-08-31 | 2021-05-10 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| CN120789028A (zh) | 2018-09-07 | 2025-10-17 | 阿奎蒂夫疗法公司 | 具有精确的活性物溶出谱的口腔膜组合物和剂型 |
| WO2020112941A2 (en) | 2018-11-27 | 2020-06-04 | Teva Czech Industries S.R.O | Solid state forms of lumateperone salts and processes for preparation of lumateperone and salts thereof |
| KR102901722B1 (ko) | 2018-12-17 | 2025-12-17 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 치환된 헤테로사이클 융합 감마-카르볼린 합성 |
| AU2019403149B2 (en) | 2018-12-17 | 2025-04-03 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines synthesis |
| CN113423568A (zh) | 2018-12-17 | 2021-09-21 | 细胞内治疗公司 | 有机化合物 |
| US12331052B2 (en) | 2018-12-21 | 2025-06-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US12195463B2 (en) | 2018-12-21 | 2025-01-14 | Intra-Cellular Therapies, Inc. | Organic compounds |
| WO2020182978A1 (en) | 2019-03-13 | 2020-09-17 | Sandoz Ag | Crystalline salt of a 5-ht2a receptor antagonist |
| BR112022000231A2 (pt) | 2019-07-07 | 2022-02-22 | Intra Cellular Therapies Inc | Novos métodos |
| US12478623B2 (en) | 2019-09-25 | 2025-11-25 | Intra-Cellular Therapies, Inc. | Methods of treating central nervous system disorders comprising administering lumateperone and a nitric oxide donor |
| AU2020373100A1 (en) | 2019-11-01 | 2022-05-19 | Aquestive Therapeutics, Inc. | Prodrug compositions and methods of treatment |
| KR20220126287A (ko) | 2019-11-14 | 2022-09-15 | 어퀘스티브 테라퓨틱스, 아이엔씨. | 멀티모달 조성물 및 치료 방법 |
| JP7261942B2 (ja) | 2019-12-11 | 2023-04-20 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| WO2021127572A1 (en) | 2019-12-19 | 2021-06-24 | Intra-Cellular Therapies, Inc. | Methods of schizophrenia treatment |
| JP2024505429A (ja) | 2021-01-15 | 2024-02-06 | アクエスティブ セラピューティクス インコーポレイテッド | プロドラッグ組成物及び治療の方法 |
| CA3210706A1 (en) | 2021-03-09 | 2022-09-15 | Alexander Mark Schobel | Dosage forms having equivalent biocomparable profiles |
| CN117425652A (zh) * | 2021-06-07 | 2024-01-19 | 细胞内治疗公司 | 新盐和晶体 |
| EP4525874A1 (en) | 2022-05-18 | 2025-03-26 | Intra-Cellular Therapies, Inc. | Novel methods |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| CN120282964A (zh) * | 2022-10-26 | 2025-07-08 | 上海枢境生物科技有限公司 | 一种杂环取代的稠合γ-咔啉类衍生物的甲磺酸盐、晶型及其制备方法和应用 |
| KR20250123225A (ko) | 2022-12-30 | 2025-08-14 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| WO2024173901A1 (en) | 2023-02-17 | 2024-08-22 | Intra-Cellular Therapies, Inc. | Lumateperone and derivatives thereof for modulating the nervous system |
| WO2025111568A1 (en) | 2023-11-22 | 2025-05-30 | Intra-Cellular Therapies, Inc. | Lumateperone and analogues, as 5-ht2a or 5-ht2a/d2 receptor modulators, for use in the treatment of psychiatric disorders caused by viral, bacterial, or autoimmune encephalitis, and of psychiatric symptoms thereof |
| WO2025240804A1 (en) | 2024-05-16 | 2025-11-20 | Intra-Cellular Therapies, Inc. | Novel compositions, devices and methods |
| WO2026011166A1 (en) | 2024-07-03 | 2026-01-08 | Intra-Cellular Therapies, Inc. | Substituted heterocycles for use in the treatment of diseases involving the 5-ht2a receptor |
| WO2026011136A1 (en) | 2024-07-03 | 2026-01-08 | Intra-Cellular Therapies, Inc. | Organic compounds |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6713471B1 (en) * | 1999-06-15 | 2004-03-30 | Bristol-Myers Squibb Pharma Company | Substituted heterocycle fused gamma-carbolines |
| US7071186B2 (en) * | 1999-06-15 | 2006-07-04 | Bristol-Myers Squibb Pharma Co. | Substituted heterocycle fused gamma-carbolines |
| MXPA01012914A (es) | 1999-06-15 | 2004-04-21 | Bristol Myers Squibb Co | Gama-carbolinas fundidas de heterociclo substituido. |
| FR2796644B1 (fr) * | 1999-07-23 | 2001-09-07 | Adir | Nouveaux derives de beta-carboline, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| WO2005009956A1 (en) * | 2003-07-21 | 2005-02-03 | Smithkline Beecham Corporation | (2s,4s)-4-fluoro-1-[4-fluoro-beta-(4-fluorophenyl)-l-phenylalanyl]-2-pyrrolidinecarbonitrile p-toluenesulfonic acid salt and anhydrous crystalline forms thereof |
| CN101796051B (zh) * | 2007-03-12 | 2013-11-06 | 细胞内治疗公司 | 与取代的杂环稠合的γ-咔啉的合成 |
| WO2009114181A2 (en) | 2008-03-12 | 2009-09-17 | Intra-Cellular Therapies, Inc. | Substituted heterocycle fused gamma-carbolines solid |
| USRE48839E1 (en) | 2008-05-27 | 2021-12-07 | Intra-Cellular Therapies, Inc | Methods and compositions for sleep disorders and other disorders |
| EP2560676B8 (en) | 2010-04-22 | 2016-10-12 | Intra-Cellular Therapies, Inc. | Organic compounds |
| EP2836211B1 (en) | 2012-04-14 | 2019-03-20 | Intra-Cellular Therapies, Inc. | Treatment of PTSD and impulse control disorders |
| PT2968320T (pt) | 2013-03-15 | 2021-01-28 | Intra Cellular Therapies Inc | Compostos orgânicos |
-
2009
- 2009-03-12 WO PCT/US2009/001608 patent/WO2009114181A2/en not_active Ceased
- 2009-03-12 AU AU2009223701A patent/AU2009223701B2/en active Active
- 2009-03-12 HR HRP20141178AT patent/HRP20141178T1/hr unknown
- 2009-03-12 PL PL09718951T patent/PL2262505T3/pl unknown
- 2009-03-12 CN CN200980108387.XA patent/CN102046175B/zh active Active
- 2009-03-12 CN CN201510456013.4A patent/CN105237536A/zh active Pending
- 2009-03-12 US US12/922,056 patent/US8648077B2/en active Active
- 2009-03-12 CA CA2716730A patent/CA2716730C/en active Active
- 2009-03-12 ES ES09718951.8T patent/ES2530090T3/es active Active
- 2009-03-12 MX MX2010010024A patent/MX2010010024A/es active IP Right Grant
- 2009-03-12 EP EP09718951.8A patent/EP2262505B1/en active Active
- 2009-03-12 PT PT97189518T patent/PT2262505E/pt unknown
- 2009-03-12 DK DK09718951.8T patent/DK2262505T3/en active
- 2009-03-12 MX MX2014007104A patent/MX347257B/es unknown
- 2009-03-12 JP JP2010550697A patent/JP5611846B2/ja active Active
- 2009-03-12 KR KR1020107022312A patent/KR101610977B1/ko active Active
- 2009-03-12 KR KR1020157034267A patent/KR20150140418A/ko not_active Withdrawn
- 2009-03-12 SI SI200931092T patent/SI2262505T1/sl unknown
-
2010
- 2010-08-24 IL IL207772A patent/IL207772A0/en unknown
-
2014
- 2014-02-11 US US14/177,689 patent/US9199995B2/en active Active
-
2015
- 2015-11-30 US US14/954,845 patent/US9586960B2/en not_active Ceased
-
2018
- 2018-11-28 IL IL263338A patent/IL263338A/en unknown
-
2019
- 2019-03-06 US US16/294,607 patent/USRE48825E1/en active Active
-
2022
- 2022-01-09 IL IL289706A patent/IL289706A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011513485A5 (enExample) | ||
| JP5714824B2 (ja) | １−４−（５−シアノインドール−３−イル）ブチル−４−（２−カルバモイルベンゾフラン−５−イル）ピペラジン塩酸塩の多形相 | |
| JP6170146B2 (ja) | チロシンキナーゼ阻害剤二マレイン酸塩のｉ型結晶およびその製造法 | |
| CN1227233C (zh) | 纯晶形的5－氯－3－(4－甲磺酰基苯基)－6′－甲基－[2,3′]联吡啶及其合成方法 | |
| HRP20141178T1 (hr) | Äśvrsti gama karbolin kondenziran sa supstituiranim heterociklusom | |
| TWI311559B (en) | 5-substituted quinoline and isoquinoline derivatives, a process for their production and their use as anti-inflammatory agents | |
| JP2010090174A (ja) | 新規ナテグリニド結晶 | |
| JP2007532560A5 (enExample) | ||
| CA2912902A1 (en) | Polymorphic forms of nilotinib hydrochloride | |
| JP2012500819A5 (enExample) | ||
| JP2010514725A5 (enExample) | ||
| JP2016510767A5 (enExample) | ||
| TWI499584B (zh) | ４－｛３－［順－六氫環戊［ｃ］吡咯－２（１ｈ）－基］丙氧基｝苯甲醯胺鹽酸鹽之晶形及其合成方法及含彼之醫藥組合物 | |
| KR20130025857A (ko) | 2-［［［2-［(히드록시아세틸)아미노］-4-피리디닐］메틸］티오］-ｎ-［4-(트리플루오로메톡시)페닐］-3-피리딘카르복사미드의 벤젠술폰산염, 이의 결정, 이의 결정 다형 및 이들의 제조 방법 | |
| JP2013541589A5 (enExample) | ||
| CN105085396B (zh) | 用于制备贝达喹啉的中间体及其制备方法和应用 | |
| JP4820295B2 (ja) | イソインドール誘導体の製造方法 | |
| JP2016503389A (ja) | （１ｓ，４ｓ，５ｓ）−４−ブロモ−６−オキサビシクロ［３．２．１］オクタン−７−オンの調製方法 | |
| JP2020520936A5 (enExample) | ||
| JP6843116B2 (ja) | アンドロゲン受容体阻害剤の結晶型及びその製造方法 | |
| WO2014008640A1 (zh) | 茚达特罗中间体及茚达特罗的合成方法 | |
| WO2014008639A1 (zh) | 制备茚达特罗的方法 | |
| CN103664781B (zh) | 盐酸屈他维林晶型i和晶型ii及制备方法 | |
| KR101589910B1 (ko) | 결정형 α 탈티레린의 제조방법 및 결정형의 변환방법 | |
| RU2019101109A (ru) | Твердые формы ингибитора ttk |