JP2009502167A5 - - Google Patents
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- JP2009502167A5 JP2009502167A5 JP2008523951A JP2008523951A JP2009502167A5 JP 2009502167 A5 JP2009502167 A5 JP 2009502167A5 JP 2008523951 A JP2008523951 A JP 2008523951A JP 2008523951 A JP2008523951 A JP 2008523951A JP 2009502167 A5 JP2009502167 A5 JP 2009502167A5
- Authority
- JP
- Japan
- Prior art keywords
- cell line
- antibody
- protein
- inhibitor
- caspase
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11/187,863 US7531327B2 (en) | 2004-07-23 | 2005-07-25 | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US11/187,863 | 2005-07-25 | ||
| PCT/US2006/027820 WO2007015848A2 (en) | 2005-07-25 | 2006-07-14 | Improved methods and compositions for increasing longevity and protein yield from a cell culture |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Division JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009502167A JP2009502167A (ja) | 2009-01-29 |
| JP2009502167A5 true JP2009502167A5 (enExample) | 2009-08-27 |
| JP5301990B2 JP5301990B2 (ja) | 2013-09-25 |
Family
ID=37709058
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008523951A Active JP5301990B2 (ja) | 2005-07-25 | 2006-07-14 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013084178A Pending JP2013172722A (ja) | 2005-07-25 | 2013-04-12 | 細胞の培養寿命の延長および培養細胞からのタンパク質収量を増加させるための改良された方法および組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US7531327B2 (enExample) |
| EP (1) | EP1910515B1 (enExample) |
| JP (2) | JP5301990B2 (enExample) |
| KR (2) | KR20130027579A (enExample) |
| CN (1) | CN101273121B (enExample) |
| AU (1) | AU2006276182B2 (enExample) |
| CA (1) | CA2616799C (enExample) |
| WO (1) | WO2007015848A2 (enExample) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7537930B2 (en) * | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| KR101794638B1 (ko) * | 2008-06-10 | 2017-12-04 | 상가모 테라퓨틱스, 인코포레이티드 | Ｂａｘ- 및 ｂａｋ-결함 세포주들의 제조 방법 및 조성물 |
| SI2331678T1 (sl) * | 2008-06-13 | 2015-12-31 | Janssen Biotech, Inc. | Postopki za dobivanje visoke gostote viabilnih celic v sesalski celični kulturi |
| DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| SG173469A1 (en) | 2009-02-20 | 2011-09-29 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| CN101899471B (zh) * | 2009-05-26 | 2014-06-11 | 中国医学科学院基础医学研究所 | 同时表达抗原特异性受体和外源基因的重组逆转录病毒载体、用其修饰的b-淋巴细胞及其用途 |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| US20120028933A1 (en) | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| JP5665065B2 (ja) | 2011-04-28 | 2015-02-04 | 国立大学法人大阪大学 | リソソーム病治療用医薬組成物 |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| CN103031277B (zh) * | 2011-09-29 | 2015-07-15 | 重庆大学 | 力生长因子在制备无血清培养耐受型哺乳动物工程细胞中的应用 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| WO2014127200A1 (en) * | 2013-02-15 | 2014-08-21 | Immunomedics, Inc. | Chimeric and humanized anti-histone antibodies |
| EP2970915B1 (en) * | 2013-03-15 | 2019-08-14 | Maxcyte, Inc. | Methods and compositions for generating stable transfected cells |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| ES2833471T3 (es) * | 2013-10-11 | 2021-06-15 | Regeneron Pharma | Cultivo celular metabólicamente optimizado |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ，インコーポレイテッド | Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療 |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| AU2015328370B2 (en) | 2014-10-07 | 2021-08-05 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| KR20170135966A (ko) | 2015-04-13 | 2017-12-08 | 맥스시티 인코포레이티드 | 게놈 dna를 변형시키기 위한 방법 및 조성물 |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| JP6835815B2 (ja) * | 2015-07-17 | 2021-02-24 | アレス トレーディング ソシエテ アノニム | 組み換えタンパク質の産生プロファイルを修飾する方法 |
| TWI784063B (zh) * | 2017-12-27 | 2022-11-21 | 財團法人生物技術開發中心 | 具有增進蛋白質表現功效的宿主細胞及其用途 |
| CN120174006A (zh) * | 2018-07-13 | 2025-06-20 | 隆萨有限公司 | 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| WO2023096380A1 (ko) * | 2021-11-26 | 2023-06-01 | 한양대학교 산학협력단 | 유전자 과발현을 이용해 조건부 성숙이 가능한 적혈구 전구세포주 확립 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0471484A (ja) * | 1990-07-11 | 1992-03-06 | Teijin Ltd | 低凝集性細胞及びその培養方法 |
| US5550019A (en) | 1993-05-26 | 1996-08-27 | La Jolla Cancer Research Foundation | Methods of identifying compounds which alter apoptosis |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| AU7614600A (en) * | 1999-09-27 | 2001-04-30 | Genentech Inc. | Methods for making recombinant proteins using apoptosis inhibitors |
| AU2001294520A1 (en) | 2000-08-21 | 2002-03-04 | Clonex Development, Inc. | Methods and compositions for increasing protein yield from a cell culture |
| US7604989B2 (en) | 2001-07-10 | 2009-10-20 | Johns Hopkins University | Inhibition of apoptosis process and improvement of cell performance |
| WO2003040374A1 (en) | 2001-11-02 | 2003-05-15 | Centocor, Inc. | METHODS AND COMPOSITIONS FOR ENHANCED PROTEIN EXPRESSION AND/OR GROWTH OF CULTURED CELLS USING CO-TRANSCRIPTION OF A Bcl2 ENCODING NUCLEIC ACID |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| EP1490481A4 (en) * | 2001-12-14 | 2005-12-07 | Centocor Inc | CLONAL CELL LINES OF MYELOMES FOR PRODUCING PROTEINS IN A CHEMICALLY DEFINED ENVIRONMENT |
| US20030219871A1 (en) | 2002-03-28 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Host cells having improved cell survival properties and methods to generate such cells |
| EP1348758A1 (en) | 2002-03-28 | 2003-10-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Host cells having improved cell survival properties and methods to generate such cells |
| EP1563073A4 (en) * | 2002-06-26 | 2007-09-19 | Biogen Idec Inc | PROTEIN PRODUCTION METHODS AND MODIFIED CELLS FOR USE IN SUCH METHODS |
| CA2542121A1 (en) * | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Genomically modified cell neutralized to serum-free system |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| CN1287862C (zh) * | 2004-09-29 | 2006-12-06 | 中国人民解放军第四军医大学 | MG7－Ag模拟表位构建胃癌特异性多表位基因疫苗的方法 |
| US20070092947A1 (en) | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
-
2005
- 2005-07-25 US US11/187,863 patent/US7531327B2/en active Active
-
2006
- 2006-07-14 CN CN2006800352269A patent/CN101273121B/zh active Active
- 2006-07-14 AU AU2006276182A patent/AU2006276182B2/en active Active
- 2006-07-14 JP JP2008523951A patent/JP5301990B2/ja active Active
- 2006-07-14 KR KR1020137004422A patent/KR20130027579A/ko not_active Ceased
- 2006-07-14 EP EP06787690.4A patent/EP1910515B1/en active Active
- 2006-07-14 KR KR1020087002132A patent/KR101518062B1/ko active Active
- 2006-07-14 CA CA2616799A patent/CA2616799C/en active Active
- 2006-07-14 WO PCT/US2006/027820 patent/WO2007015848A2/en not_active Ceased
-
2013
- 2013-04-12 JP JP2013084178A patent/JP2013172722A/ja active Pending
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