CA2616799C - Improved methods and compositions for increasing longevity and protein yield from a cell culture - Google Patents
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4747—Apoptosis related proteins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3007—Carcino-embryonic Antigens
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N5/06—Animal cells or tissues; Human cells or tissues
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- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
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- C—CHEMISTRY; METALLURGY
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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- C12N2500/00—Specific components of cell culture medium
- C12N2500/90—Serum-free medium, which may still contain naturally-sourced components
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- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/40—Regulators of development
- C12N2501/48—Regulators of apoptosis
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
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- Life Sciences & Earth Sciences (AREA)
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- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
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- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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| US11/187,863 US7531327B2 (en) | 2004-07-23 | 2005-07-25 | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US11/187,863 | 2005-07-25 | ||
| PCT/US2006/027820 WO2007015848A2 (en) | 2005-07-25 | 2006-07-14 | Improved methods and compositions for increasing longevity and protein yield from a cell culture |
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| CA2616799A1 CA2616799A1 (en) | 2007-02-08 |
| CA2616799C true CA2616799C (en) | 2015-11-24 |
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| CA (1) | CA2616799C (enExample) |
| WO (1) | WO2007015848A2 (enExample) |
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| US7537930B2 (en) * | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| US7531327B2 (en) | 2004-07-23 | 2009-05-12 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| US7608425B2 (en) * | 2004-07-23 | 2009-10-27 | Immunomedics, Inc. | Methods for protein expression in mammalian cells in serum-free medium |
| US20070092947A1 (en) * | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
| KR101794638B1 (ko) * | 2008-06-10 | 2017-12-04 | 상가모 테라퓨틱스, 인코포레이티드 | Ｂａｘ- 및 ｂａｋ-결함 세포주들의 제조 방법 및 조성물 |
| SI2331678T1 (sl) * | 2008-06-13 | 2015-12-31 | Janssen Biotech, Inc. | Postopki za dobivanje visoke gostote viabilnih celic v sesalski celični kulturi |
| DE102008051574A1 (de) * | 2008-10-14 | 2010-04-15 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Verfahren zur Herstellung von Interferon-beta und deren Varianten |
| SG173469A1 (en) | 2009-02-20 | 2011-09-29 | Ventria Bioscience | Cell culture media containing combinations of proteins |
| CN101899471B (zh) * | 2009-05-26 | 2014-06-11 | 中国医学科学院基础医学研究所 | 同时表达抗原特异性受体和外源基因的重组逆转录病毒载体、用其修饰的b-淋巴细胞及其用途 |
| CN102482701B (zh) | 2009-09-16 | 2015-05-13 | 免疫医疗公司 | I类抗-cea抗体及其使用 |
| CA2782194C (en) | 2009-12-02 | 2018-01-16 | Immunomedics, Inc. | Combination of radiolabelled antibodies (rait) and antibody-drug conjugates (adc) for treatment of pancreatic cancer |
| US20120028933A1 (en) | 2010-07-28 | 2012-02-02 | Baust John M | Cell Culture Media Supplement and Method of Molecular Stress Control |
| JP5665065B2 (ja) | 2011-04-28 | 2015-02-04 | 国立大学法人大阪大学 | リソソーム病治療用医薬組成物 |
| JP6024025B2 (ja) | 2011-05-02 | 2016-11-09 | イミューノメディクス、インコーポレイテッドＩｍｍｕｎｏｍｅｄｉｃｓ， Ｉｎｃ． | 少容量投与用のアロタイプ選択抗体の限外濾過濃縮 |
| CN103031277B (zh) * | 2011-09-29 | 2015-07-15 | 重庆大学 | 力生长因子在制备无血清培养耐受型哺乳动物工程细胞中的应用 |
| AU2013302696B9 (en) | 2012-08-14 | 2018-08-09 | Ibc Pharmaceuticals, Inc. | T-cell redirecting bispecific antibodies for treatment of disease |
| WO2014127200A1 (en) * | 2013-02-15 | 2014-08-21 | Immunomedics, Inc. | Chimeric and humanized anti-histone antibodies |
| EP2970915B1 (en) * | 2013-03-15 | 2019-08-14 | Maxcyte, Inc. | Methods and compositions for generating stable transfected cells |
| US11390663B2 (en) | 2013-10-11 | 2022-07-19 | Regeneron Pharmaceuticals, Inc. | Metabolically optimized cell culture |
| ES2833471T3 (es) * | 2013-10-11 | 2021-06-15 | Regeneron Pharma | Cultivo celular metabólicamente optimizado |
| JP6447933B2 (ja) | 2014-02-21 | 2019-01-09 | アイビーシー ファーマスーティカルズ，インコーポレイテッド | Ｔｒｏｐ−２発現細胞に対する免疫応答を誘発することによる疾患治療 |
| US9139649B2 (en) | 2014-02-25 | 2015-09-22 | Immunomedics, Inc. | Humanized anti-CD22 antibody |
| WO2015200260A1 (en) | 2014-06-24 | 2015-12-30 | Immunomedics, Inc. | Anti-histone therapy for vascular necrosis in severe glomerulonephritis |
| AU2015328370B2 (en) | 2014-10-07 | 2021-08-05 | Immunomedics, Inc. | Neoadjuvant use of antibody-drug conjugates |
| KR20170135966A (ko) | 2015-04-13 | 2017-12-08 | 맥스시티 인코포레이티드 | 게놈 dna를 변형시키기 위한 방법 및 조성물 |
| CA2981543A1 (en) | 2015-04-22 | 2016-10-27 | Immunomedics, Inc. | Isolation, detection, diagnosis and/or characterization of circulating trop-2-positive cancer cells |
| PL3316885T3 (pl) | 2015-07-01 | 2021-12-06 | Immunomedics, Inc. | Immunokoniugaty przeciwciało-sn-38 z linkerem cl2a |
| JP6835815B2 (ja) * | 2015-07-17 | 2021-02-24 | アレス トレーディング ソシエテ アノニム | 組み換えタンパク質の産生プロファイルを修飾する方法 |
| TWI784063B (zh) * | 2017-12-27 | 2022-11-21 | 財團法人生物技術開發中心 | 具有增進蛋白質表現功效的宿主細胞及其用途 |
| CN120174006A (zh) * | 2018-07-13 | 2025-06-20 | 隆萨有限公司 | 用于通过降低内源性蛋白质的水平来改善生物产物的生产的方法 |
| CN111349615B (zh) * | 2018-12-24 | 2024-08-13 | 上海细胞治疗集团股份有限公司 | 制备过表达外源基因的细胞的方法 |
| US20250073349A1 (en) | 2021-05-10 | 2025-03-06 | Kawasaki Institute Of Industrial Promotion | Antibody having reduced binding affinity for antigen |
| WO2023096380A1 (ko) * | 2021-11-26 | 2023-06-01 | 한양대학교 산학협력단 | 유전자 과발현을 이용해 조건부 성숙이 가능한 적혈구 전구세포주 확립 |
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| US5550019A (en) | 1993-05-26 | 1996-08-27 | La Jolla Cancer Research Foundation | Methods of identifying compounds which alter apoptosis |
| US6492169B1 (en) | 1999-05-18 | 2002-12-10 | Crucell Holland, B.V. | Complementing cell lines |
| AU7614600A (en) * | 1999-09-27 | 2001-04-30 | Genentech Inc. | Methods for making recombinant proteins using apoptosis inhibitors |
| AU2001294520A1 (en) | 2000-08-21 | 2002-03-04 | Clonex Development, Inc. | Methods and compositions for increasing protein yield from a cell culture |
| US7604989B2 (en) | 2001-07-10 | 2009-10-20 | Johns Hopkins University | Inhibition of apoptosis process and improvement of cell performance |
| WO2003040374A1 (en) | 2001-11-02 | 2003-05-15 | Centocor, Inc. | METHODS AND COMPOSITIONS FOR ENHANCED PROTEIN EXPRESSION AND/OR GROWTH OF CULTURED CELLS USING CO-TRANSCRIPTION OF A Bcl2 ENCODING NUCLEIC ACID |
| US6964199B2 (en) | 2001-11-02 | 2005-11-15 | Cantocor, Inc. | Methods and compositions for enhanced protein expression and/or growth of cultured cells using co-transcription of a Bcl2 encoding nucleic acid |
| EP1490481A4 (en) * | 2001-12-14 | 2005-12-07 | Centocor Inc | CLONAL CELL LINES OF MYELOMES FOR PRODUCING PROTEINS IN A CHEMICALLY DEFINED ENVIRONMENT |
| US20030219871A1 (en) | 2002-03-28 | 2003-11-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Host cells having improved cell survival properties and methods to generate such cells |
| EP1348758A1 (en) | 2002-03-28 | 2003-10-01 | Boehringer Ingelheim Pharma GmbH & Co.KG | Host cells having improved cell survival properties and methods to generate such cells |
| EP1563073A4 (en) * | 2002-06-26 | 2007-09-19 | Biogen Idec Inc | PROTEIN PRODUCTION METHODS AND MODIFIED CELLS FOR USE IN SUCH METHODS |
| CA2542121A1 (en) * | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | Genomically modified cell neutralized to serum-free system |
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| US7537930B2 (en) | 2004-07-23 | 2009-05-26 | Immunomedics, Inc. | Mammalian cell lines for increasing longevity and protein yield from a cell culture |
| CN1287862C (zh) * | 2004-09-29 | 2006-12-06 | 中国人民解放军第四军医大学 | MG7－Ag模拟表位构建胃癌特异性多表位基因疫苗的方法 |
| US20070092947A1 (en) | 2005-10-20 | 2007-04-26 | Immunomedics, Inc. | Methods and compositions for increasing longevity and protein yield from a cell culture |
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| US7531327B2 (en) | 2009-05-12 |
| EP1910515A4 (en) | 2009-03-11 |
| JP5301990B2 (ja) | 2013-09-25 |
| CA2616799A1 (en) | 2007-02-08 |
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