JP2009500348A5 - - Google Patents
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- Publication number
- JP2009500348A5 JP2009500348A5 JP2008519635A JP2008519635A JP2009500348A5 JP 2009500348 A5 JP2009500348 A5 JP 2009500348A5 JP 2008519635 A JP2008519635 A JP 2008519635A JP 2008519635 A JP2008519635 A JP 2008519635A JP 2009500348 A5 JP2009500348 A5 JP 2009500348A5
- Authority
- JP
- Japan
- Prior art keywords
- methyl
- pyrimidin
- benzimidazol
- phenyl
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 C*C*C=*CN* Chemical compound C*C*C=*CN* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69617405P | 2005-07-01 | 2005-07-01 | |
| US60/696,174 | 2005-07-01 | ||
| PCT/US2006/025706 WO2007005673A1 (en) | 2005-07-01 | 2006-06-30 | Pyrimidine-substituted benzimidazole derivatives as protein kinase inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009500348A JP2009500348A (ja) | 2009-01-08 |
| JP2009500348A5 true JP2009500348A5 (enExample) | 2009-07-30 |
| JP5054004B2 JP5054004B2 (ja) | 2012-10-24 |
Family
ID=37110309
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008519635A Expired - Fee Related JP5054004B2 (ja) | 2005-07-01 | 2006-06-30 | タンパク質キナーゼ阻害剤としてのピリミジン置換ベンゾイミダゾール誘導体 |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8426404B2 (enExample) |
| EP (1) | EP1899329B1 (enExample) |
| JP (1) | JP5054004B2 (enExample) |
| KR (1) | KR20080015475A (enExample) |
| CN (1) | CN101213192B (enExample) |
| AT (1) | ATE527253T1 (enExample) |
| AU (1) | AU2006265840B2 (enExample) |
| BR (1) | BRPI0613501A2 (enExample) |
| CA (1) | CA2614148A1 (enExample) |
| ES (1) | ES2375151T3 (enExample) |
| MX (1) | MX2007016066A (enExample) |
| PL (1) | PL1899329T3 (enExample) |
| PT (1) | PT1899329E (enExample) |
| RU (1) | RU2386630C2 (enExample) |
| WO (1) | WO2007005673A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RS20050532A (sr) | 2003-01-14 | 2007-12-31 | Arena Pharmaceuticals Inc., | Derivati 1,2,3-trisupstituisanog arila i heteroarila kao modulatori metabolizma za profilaksu i tretman poremećaja povezanih sa njim, kao što su dijebetes i hiperglikemija |
| AR045047A1 (es) * | 2003-07-11 | 2005-10-12 | Arena Pharm Inc | Derivados arilo y heteroarilo trisustituidos como moduladores del metabolismo y de la profilaxis y tratamiento de desordenes relacionados con los mismos |
| KR20060056944A (ko) | 2003-07-14 | 2006-05-25 | 아레나 파마슈티칼스, 인크. | 대사 조절제로서 융합된 아릴 및 헤테로아릴 유도체 및이에 관련된 장애의 예방 또는 치료 |
| MY148521A (en) | 2005-01-10 | 2013-04-30 | Arena Pharm Inc | Substituted pyridinyl and pyrimidinyl derivatives as modulators of metabolism and the treatment of disorders related thereto |
| WO2008023159A1 (en) | 2006-08-24 | 2008-02-28 | Astrazeneca Ab | Morpholino pyrimidine derivatives useful in the treatment of proliferative disorders |
| WO2008153701A1 (en) * | 2007-05-24 | 2008-12-18 | Schering Corporation | Compounds for inhibiting ksp kinesin activity |
| WO2009007750A1 (en) | 2007-07-09 | 2009-01-15 | Astrazeneca Ab | Morpholino pyrimidine derivatives used in diseases linked to mtor kinase and/or pi3k |
| US9273077B2 (en) | 2008-05-21 | 2016-03-01 | Ariad Pharmaceuticals, Inc. | Phosphorus derivatives as kinase inhibitors |
| JP2011523646A (ja) | 2008-05-21 | 2011-08-18 | アリアド・ファーマシューティカルズ・インコーポレイテッド | キナーゼ阻害剤としてのリン誘導体 |
| WO2009158432A2 (en) | 2008-06-27 | 2009-12-30 | Amgen Inc. | Ang-2 inhibition to treat multiple sclerosis |
| PA8851101A1 (es) * | 2008-12-16 | 2010-07-27 | Lilly Co Eli | Compuesto amino pirazol |
| MX2011008674A (es) * | 2009-02-18 | 2011-11-04 | Amgen Inc | Compuestos de indol/bencimidazol como inhibidores de quinasa mtor. |
| WO2010100127A1 (en) * | 2009-03-04 | 2010-09-10 | Novartis Ag | Disubstituted imidazole derivatives as modulators of raf kinase |
| SA111320519B1 (ar) | 2010-06-11 | 2014-07-02 | Astrazeneca Ab | مركبات بيريميدينيل للاستخدام كمثبطات atr |
| CN102947274A (zh) * | 2010-06-17 | 2013-02-27 | 诺瓦提斯公司 | 联苯基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物 |
| CN103221410B (zh) | 2010-09-22 | 2017-09-15 | 艾尼纳制药公司 | Gpr119受体调节剂和对与其相关的障碍的治疗 |
| AU2012250517B2 (en) | 2011-05-04 | 2016-05-19 | Takeda Pharmaceutical Company Limited | Compounds for inhibiting cell proliferation in EGFR-driven cancers |
| US9061028B2 (en) | 2012-02-15 | 2015-06-23 | Natco Pharma Limited | Process for the preparation of Nilotinib |
| JP6469567B2 (ja) | 2012-05-05 | 2019-02-13 | アリアド・ファーマシューティカルズ・インコーポレイテッド | Ｅｇｆｒ発動性がんの細胞増殖阻害用化合物 |
| KR101469127B1 (ko) * | 2013-03-11 | 2014-12-04 | 한양대학교 에리카산학협력단 | 신규 벤즈이미다졸 유도체, 이의 이성질체 또는 이의 약학적으로 허용 가능한 염, 및 이를 포함하는 약학 조성물 |
| US9611283B1 (en) | 2013-04-10 | 2017-04-04 | Ariad Pharmaceuticals, Inc. | Methods for inhibiting cell proliferation in ALK-driven cancers |
| CA2954186A1 (en) * | 2014-07-21 | 2016-01-28 | Dana-Farber Cancer Institute, Inc. | Imidazolyl kinase inhibitors and uses thereof |
| KR101850282B1 (ko) * | 2014-11-26 | 2018-05-31 | 한국과학기술연구원 | 단백질 키나아제 저해제로 유용한 헤테로아릴아민 유도체 |
| CA3002540C (en) | 2015-01-06 | 2023-11-07 | Arena Pharmaceuticals, Inc. | Use of (r)-2-(7-(4-cyclopentyl-3-(trifluoromethyl)benzyloxy)-1,2,3,4-tetrahydrocyclopenta[b]indol-3-yl)acetic acid for treating conditions related to the s1p1 receptor |
| JP6838744B2 (ja) | 2015-06-22 | 2021-03-03 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１Ｐ１レセプター関連障害における使用のための（Ｒ）−２−（７−（４−シクロペンチル−３−（トリフルオロメチル）ベンジルオキシ）−１，２，３，４−テトラヒドロシクロペンタ［ｂ］インドール−３−イル）酢酸（化合物１）の結晶性Ｌ−アルギニン塩 |
| WO2017066193A1 (en) | 2015-10-15 | 2017-04-20 | Princeton Drug Discovery, Llc | Novel inhibitors of protein kinases |
| CN110520124A (zh) | 2017-02-16 | 2019-11-29 | 艾尼纳制药公司 | 用于治疗原发性胆汁性胆管炎的化合物和方法 |
| KR101840674B1 (ko) | 2017-02-20 | 2018-03-21 | 한양대학교 에리카산학협력단 | Jnk 저해 활성을 갖는 신규한 벤즈이미다졸 유도체 및 이의 용도 |
| WO2019028308A1 (en) * | 2017-08-04 | 2019-02-07 | Goldfinch Bio, Inc. | BENZIMIDAZOLES AND AZA-BENZIMIDAZOLES AND METHODS OF USE |
| JP7397011B2 (ja) | 2018-06-06 | 2023-12-12 | アリーナ ファーマシューティカルズ， インコーポレイテッド | Ｓ１ｐ１受容体に関連する状態を治療する方法 |
| WO2023101505A1 (ko) * | 2021-12-03 | 2023-06-08 | 연세대학교 산학협력단 | Wnk3 억제제를 유효성분으로 포함하는 면역관문 억제용 조성물 |
| KR20250130162A (ko) * | 2024-04-17 | 2025-09-01 | 한양대학교 에리카산학협력단 | 단백질 인산화 효소 저해 활성을 갖는 신규한 벤조이미다졸 유도체 및 이의 용도 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE305465T1 (de) | 1998-11-17 | 2005-10-15 | Kumiai Chemical Industry Co | Pyrimidinylbenzimidazol- und triazinylbenzimidazol-derivate und agrikulte/hortikulte fungizide |
| KR20030024659A (ko) | 2000-02-17 | 2003-03-26 | 암겐 인코포레이티드 | 키나제 억제제 |
| KR100833371B1 (ko) * | 2001-04-27 | 2008-05-28 | 젠야쿠코교가부시키가이샤 | 헤테로시클릭 화합물 및 이를 유효 성분으로 하는 항종양제 |
-
2006
- 2006-06-30 BR BRPI0613501-3A patent/BRPI0613501A2/pt not_active IP Right Cessation
- 2006-06-30 MX MX2007016066A patent/MX2007016066A/es not_active Application Discontinuation
- 2006-06-30 AT AT06774386T patent/ATE527253T1/de active
- 2006-06-30 US US11/915,148 patent/US8426404B2/en not_active Expired - Fee Related
- 2006-06-30 PL PL06774386T patent/PL1899329T3/pl unknown
- 2006-06-30 CA CA002614148A patent/CA2614148A1/en not_active Abandoned
- 2006-06-30 KR KR1020077030728A patent/KR20080015475A/ko not_active Abandoned
- 2006-06-30 PT PT06774386T patent/PT1899329E/pt unknown
- 2006-06-30 CN CN2006800242273A patent/CN101213192B/zh not_active Expired - Fee Related
- 2006-06-30 WO PCT/US2006/025706 patent/WO2007005673A1/en not_active Ceased
- 2006-06-30 ES ES06774386T patent/ES2375151T3/es not_active Expired - Lifetime
- 2006-06-30 EP EP06774386A patent/EP1899329B1/en not_active Expired - Lifetime
- 2006-06-30 JP JP2008519635A patent/JP5054004B2/ja not_active Expired - Fee Related
- 2006-06-30 AU AU2006265840A patent/AU2006265840B2/en not_active Expired - Fee Related
- 2006-06-30 RU RU2008103143/04A patent/RU2386630C2/ru not_active IP Right Cessation
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