JP2009261392A5 - - Google Patents
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- Publication number
- JP2009261392A5 JP2009261392A5 JP2009101953A JP2009101953A JP2009261392A5 JP 2009261392 A5 JP2009261392 A5 JP 2009261392A5 JP 2009101953 A JP2009101953 A JP 2009101953A JP 2009101953 A JP2009101953 A JP 2009101953A JP 2009261392 A5 JP2009261392 A5 JP 2009261392A5
- Authority
- JP
- Japan
- Prior art keywords
- polynucleotide
- nucleic acid
- sequence
- target nucleic
- nucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108091033319 polynucleotide Proteins 0.000 claims description 56
- 239000002157 polynucleotide Substances 0.000 claims description 56
- 102000040430 polynucleotide Human genes 0.000 claims description 56
- 239000002773 nucleotide Substances 0.000 claims description 53
- 125000003729 nucleotide group Chemical group 0.000 claims description 53
- 150000007523 nucleic acids Chemical class 0.000 claims description 31
- 238000000034 method Methods 0.000 claims description 17
- 230000000295 complement effect Effects 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 14
- 102000039446 nucleic acids Human genes 0.000 claims description 14
- 108020004707 nucleic acids Proteins 0.000 claims description 14
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 13
- 108091028664 Ribonucleotide Proteins 0.000 claims description 12
- 239000002336 ribonucleotide Substances 0.000 claims description 12
- 125000002652 ribonucleotide group Chemical group 0.000 claims description 12
- 230000003321 amplification Effects 0.000 claims description 10
- 238000010348 incorporation Methods 0.000 claims description 10
- 238000003199 nucleic acid amplification method Methods 0.000 claims description 10
- 108091093088 Amplicon Proteins 0.000 claims description 8
- 108090000790 Enzymes Proteins 0.000 claims description 8
- 102000004190 Enzymes Human genes 0.000 claims description 8
- 239000011942 biocatalyst Substances 0.000 claims description 8
- 239000005547 deoxyribonucleotide Substances 0.000 claims description 8
- 125000002637 deoxyribonucleotide group Chemical group 0.000 claims description 8
- 238000001514 detection method Methods 0.000 claims description 8
- 230000000694 effects Effects 0.000 claims description 5
- 108700028369 Alleles Proteins 0.000 claims description 4
- 108091028733 RNTP Proteins 0.000 claims description 4
- 230000000903 blocking effect Effects 0.000 claims description 4
- 238000012705 nitroxide-mediated radical polymerization Methods 0.000 claims description 2
- 239000002777 nucleoside Substances 0.000 claims description 2
- -1 nucleoside monophosphate Chemical class 0.000 claims description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- 239000011541 reaction mixture Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 239000013641 positive control Substances 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4672008P | 2008-04-21 | 2008-04-21 | |
| US61/046,720 | 2008-04-21 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009261392A JP2009261392A (ja) | 2009-11-12 |
| JP2009261392A5 true JP2009261392A5 (https=) | 2012-04-12 |
| JP5483403B2 JP5483403B2 (ja) | 2014-05-07 |
Family
ID=40810047
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009101953A Active JP5483403B2 (ja) | 2008-04-21 | 2009-04-20 | リボヌクレオチド標識核酸検出 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US10150990B2 (https=) |
| EP (1) | EP2112230B1 (https=) |
| JP (1) | JP5483403B2 (https=) |
| CN (1) | CN101649354B (https=) |
| CA (1) | CA2663302C (https=) |
| ES (1) | ES2392783T3 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2180065A1 (en) * | 2008-10-24 | 2010-04-28 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity |
| DE112013004650T5 (de) * | 2012-09-24 | 2015-06-18 | Cb Biotechnologies, Inc. | Multiplexpyrosequenzierung unter Verwendung nichtinterferierender, rauschbeendender Polynukleotididentifikationstags |
| US10106842B2 (en) | 2013-03-15 | 2018-10-23 | Roche Molecular Systems, Inc. | Nucleic acid target identification by structure based probe cleavage |
| US9828629B2 (en) | 2013-03-15 | 2017-11-28 | Roche Molecular Systems, Inc. | Nucleic acid target identification by structure based probe cleavage |
| US9637791B2 (en) | 2013-12-20 | 2017-05-02 | Roche Molecular Systems, Inc. | Multiplexed nucleic acid target identification by strucutre based probe cleavage |
| WO2016041591A1 (en) * | 2014-09-17 | 2016-03-24 | Roche Diagnostics Gmbh | Nucleic acid target identification by structure based probe cleavage |
| US11034997B2 (en) | 2016-09-15 | 2021-06-15 | Roche Molecular Systems, Inc. | Methods for performing multiplexed real-time PCR |
| WO2023212662A2 (en) * | 2022-04-28 | 2023-11-02 | Oregon Health & Science University | Compositions and methods for modulating antigen binding activity |
Family Cites Families (38)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4469863A (en) | 1980-11-12 | 1984-09-04 | Ts O Paul O P | Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5235033A (en) | 1985-03-15 | 1993-08-10 | Anti-Gene Development Group | Alpha-morpholino ribonucleoside derivatives and polymers thereof |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| DE3529478A1 (de) | 1985-08-16 | 1987-02-19 | Boehringer Mannheim Gmbh | 7-desaza-2'desoxyguanosin-nukleotide, verfahren zu deren herstellung und deren verwendung zur nukleinsaeure-sequenzierung |
| US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
| US5374553A (en) | 1986-08-22 | 1994-12-20 | Hoffmann-La Roche Inc. | DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| WO1992006200A1 (en) | 1990-09-28 | 1992-04-16 | F. Hoffmann-La-Roche Ag | 5' to 3' exonuclease mutations of thermostable dna polymerases |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5795762A (en) | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5216141A (en) | 1988-06-06 | 1993-06-01 | Benner Steven A | Oligonucleotide analogs containing sulfur linkages |
| US5386023A (en) | 1990-07-27 | 1995-01-31 | Isis Pharmaceuticals | Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling |
| US5602240A (en) | 1990-07-27 | 1997-02-11 | Ciba Geigy Ag. | Backbone modified oligonucleotide analogs |
| AU3222793A (en) | 1991-11-26 | 1993-06-28 | Gilead Sciences, Inc. | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5484908A (en) | 1991-11-26 | 1996-01-16 | Gilead Sciences, Inc. | Oligonucleotides containing 5-propynyl pyrimidines |
| TW393513B (en) | 1991-11-26 | 2000-06-11 | Isis Pharmaceuticals Inc | Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines |
| US5644048A (en) | 1992-01-10 | 1997-07-01 | Isis Pharmaceuticals, Inc. | Process for preparing phosphorothioate oligonucleotides |
| US5637684A (en) | 1994-02-23 | 1997-06-10 | Isis Pharmaceuticals, Inc. | Phosphoramidate and phosphorothioamidate oligomeric compounds |
| CZ293215B6 (cs) | 1996-08-06 | 2004-03-17 | F. Hoffmann-La Roche Ag | Rekombinantní tepelně stálá DNA polymeráza, způsob její přípravy a prostředek, který ji obsahuje |
| ATE314488T1 (de) | 1999-03-18 | 2006-01-15 | Exiqon As | Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben |
| US6734291B2 (en) | 1999-03-24 | 2004-05-11 | Exiqon A/S | Synthesis of [2.2.1]bicyclo nucleosides |
| JP4768132B2 (ja) | 1999-03-24 | 2011-09-07 | エクシコン エ／エス | ［２．２．１］ビシクロヌクレオシドの改良された製法 |
| ATE298004T1 (de) * | 1999-04-30 | 2005-07-15 | Methexis Genomics N V | Diagnostische sequenzierung durch eine kombination von spezifischer spaltung und massenspektrometrie |
| AU2001250572A1 (en) | 2000-04-07 | 2001-10-23 | Epigenomics Ag | Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations |
| US7179590B2 (en) | 2000-04-18 | 2007-02-20 | Roche Molecular Systems, Inc | High temperature reverse transcription using mutant DNA polymerases |
| US7148049B2 (en) | 2002-04-02 | 2006-12-12 | Roche Molecular Systems, Inc. | Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity |
| CN1197976C (zh) | 2003-01-31 | 2005-04-20 | 中国人民解放军南京军区联勤部军事医学研究所 | 基因多态性检测方法 |
| EP1493824A1 (en) | 2003-07-02 | 2005-01-05 | Consortium National de Recherche en Genomique (CNRG) | Method for detection of mutations in DNA |
| US7928207B2 (en) | 2004-06-28 | 2011-04-19 | Roche Molecular Systems, Inc | Synthesis and compositions of nucleic acids comprising 2′-terminator nucleotides |
| US7745125B2 (en) | 2004-06-28 | 2010-06-29 | Roche Molecular Systems, Inc. | 2′-terminator related pyrophosphorolysis activated polymerization |
| US7890268B2 (en) * | 2004-12-28 | 2011-02-15 | Roche Molecular Systems, Inc. | De-novo sequencing of nucleic acids |
| WO2007024800A2 (en) * | 2005-08-22 | 2007-03-01 | Applera Corporation | Device and method for making discrete volumes of a first fluid in contact with a second fluid, which are immiscible with each other |
| US8673567B2 (en) * | 2006-03-08 | 2014-03-18 | Atila Biosystems, Inc. | Method and kit for nucleic acid sequence detection |
| US8962293B2 (en) | 2006-10-18 | 2015-02-24 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
| US8026091B2 (en) | 2007-07-13 | 2011-09-27 | Roche Molecular Systems, Inc. | DNA polymerases and related methods |
-
2009
- 2009-04-09 US US12/421,188 patent/US10150990B2/en active Active
- 2009-04-17 ES ES09005451T patent/ES2392783T3/es active Active
- 2009-04-17 EP EP09005451A patent/EP2112230B1/en active Active
- 2009-04-20 CA CA2663302A patent/CA2663302C/en active Active
- 2009-04-20 JP JP2009101953A patent/JP5483403B2/ja active Active
- 2009-04-20 CN CN200910203986.1A patent/CN101649354B/zh active Active
-
2012
- 2012-12-19 US US13/720,881 patent/US20130096027A1/en not_active Abandoned
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