JP5483403B2 - リボヌクレオチド標識核酸検出 - Google Patents

リボヌクレオチド標識核酸検出 Download PDF

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Publication number
JP5483403B2
JP5483403B2 JP2009101953A JP2009101953A JP5483403B2 JP 5483403 B2 JP5483403 B2 JP 5483403B2 JP 2009101953 A JP2009101953 A JP 2009101953A JP 2009101953 A JP2009101953 A JP 2009101953A JP 5483403 B2 JP5483403 B2 JP 5483403B2
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sequence
nucleic acid
polynucleotide
target nucleic
nucleotide
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Japanese (ja)
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JP2009261392A (ja
JP2009261392A5 (https=
Inventor
エー．バウアー キース
エイチ．ゲルファント デイビッド
グリンヌ ギュ イボ
フロランス，モージェ
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/686—Polymerase chain reaction [PCR]

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2009101953A 2008-04-21 2009-04-20 リボヌクレオチド標識核酸検出 Active JP5483403B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US4672008P 2008-04-21 2008-04-21
US61/046,720 2008-04-21

Publications (3)

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JP2009261392A JP2009261392A (ja) 2009-11-12
JP2009261392A5 JP2009261392A5 (https=) 2012-04-12
JP5483403B2 true JP5483403B2 (ja) 2014-05-07

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JP2009101953A Active JP5483403B2 (ja) 2008-04-21 2009-04-20 リボヌクレオチド標識核酸検出

Country Status (6)

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US (2) US10150990B2 (https=)
EP (1) EP2112230B1 (https=)
JP (1) JP5483403B2 (https=)
CN (1) CN101649354B (https=)
CA (1) CA2663302C (https=)
ES (1) ES2392783T3 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2180065A1 (en) * 2008-10-24 2010-04-28 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. Method of reducing the molecular weight of at least one PCR product for its detection while maintaining its identity
DE112013004650T5 (de) * 2012-09-24 2015-06-18 Cb Biotechnologies, Inc. Multiplexpyrosequenzierung unter Verwendung nichtinterferierender, rauschbeendender Polynukleotididentifikationstags
US10106842B2 (en) 2013-03-15 2018-10-23 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
US9828629B2 (en) 2013-03-15 2017-11-28 Roche Molecular Systems, Inc. Nucleic acid target identification by structure based probe cleavage
US9637791B2 (en) 2013-12-20 2017-05-02 Roche Molecular Systems, Inc. Multiplexed nucleic acid target identification by strucutre based probe cleavage
WO2016041591A1 (en) * 2014-09-17 2016-03-24 Roche Diagnostics Gmbh Nucleic acid target identification by structure based probe cleavage
US11034997B2 (en) 2016-09-15 2021-06-15 Roche Molecular Systems, Inc. Methods for performing multiplexed real-time PCR
WO2023212662A2 (en) * 2022-04-28 2023-11-02 Oregon Health & Science University Compositions and methods for modulating antigen binding activity

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US4683202A (en) 1985-03-28 1987-07-28 Cetus Corporation Process for amplifying nucleic acid sequences
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US5374553A (en) 1986-08-22 1994-12-20 Hoffmann-La Roche Inc. DNA encoding a thermostable nucleic acid polymerase enzyme from thermotoga maritima
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US5466591A (en) 1986-08-22 1995-11-14 Hoffmann-La Roche Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
WO1992006200A1 (en) 1990-09-28 1992-04-16 F. Hoffmann-La-Roche Ag 5' to 3' exonuclease mutations of thermostable dna polymerases
US4889818A (en) 1986-08-22 1989-12-26 Cetus Corporation Purified thermostable enzyme
US5795762A (en) 1986-08-22 1998-08-18 Roche Molecular Systems, Inc. 5' to 3' exonuclease mutations of thermostable DNA polymerases
US5216141A (en) 1988-06-06 1993-06-01 Benner Steven A Oligonucleotide analogs containing sulfur linkages
US5386023A (en) 1990-07-27 1995-01-31 Isis Pharmaceuticals Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
US5602240A (en) 1990-07-27 1997-02-11 Ciba Geigy Ag. Backbone modified oligonucleotide analogs
AU3222793A (en) 1991-11-26 1993-06-28 Gilead Sciences, Inc. Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
US5484908A (en) 1991-11-26 1996-01-16 Gilead Sciences, Inc. Oligonucleotides containing 5-propynyl pyrimidines
TW393513B (en) 1991-11-26 2000-06-11 Isis Pharmaceuticals Inc Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
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US5637684A (en) 1994-02-23 1997-06-10 Isis Pharmaceuticals, Inc. Phosphoramidate and phosphorothioamidate oligomeric compounds
CZ293215B6 (cs) 1996-08-06 2004-03-17 F. Hoffmann-La Roche Ag Rekombinantní tepelně stálá DNA polymeráza, způsob její přípravy a prostředek, který ji obsahuje
ATE314488T1 (de) 1999-03-18 2006-01-15 Exiqon As Einstufige probezubereitung und bestimmung von nukleinsäure in biologischen proben
US6734291B2 (en) 1999-03-24 2004-05-11 Exiqon A/S Synthesis of [2.2.1]bicyclo nucleosides
JP4768132B2 (ja) 1999-03-24 2011-09-07 エクシコン エ／エス ［２．２．１］ビシクロヌクレオシドの改良された製法
ATE298004T1 (de) * 1999-04-30 2005-07-15 Methexis Genomics N V Diagnostische sequenzierung durch eine kombination von spezifischer spaltung und massenspektrometrie
AU2001250572A1 (en) 2000-04-07 2001-10-23 Epigenomics Ag Detection of single nucleotide polymorphisms (snp's) and cytosine-methylations
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US7148049B2 (en) 2002-04-02 2006-12-12 Roche Molecular Systems, Inc. Thermostable or thermoactive DNA polymerase molecules with attenuated 3′-5′ exonuclease activity
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US7745125B2 (en) 2004-06-28 2010-06-29 Roche Molecular Systems, Inc. 2′-terminator related pyrophosphorolysis activated polymerization
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Also Published As

Publication number Publication date
CN101649354B (zh) 2015-04-29
US20090263813A1 (en) 2009-10-22
EP2112230A3 (en) 2009-12-30
ES2392783T3 (es) 2012-12-13
CN101649354A (zh) 2010-02-17
US10150990B2 (en) 2018-12-11
US20130096027A1 (en) 2013-04-18
JP2009261392A (ja) 2009-11-12
EP2112230A2 (en) 2009-10-28
CA2663302C (en) 2014-09-09
EP2112230B1 (en) 2012-08-22
CA2663302A1 (en) 2009-10-21
HK1141559A1 (en) 2010-11-12

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