JP2009209069A - 光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物 - Google Patents
光安定性が改善されたニューキノロン系抗菌剤含有医薬組成物 Download PDFInfo
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- JP2009209069A JP2009209069A JP2008052660A JP2008052660A JP2009209069A JP 2009209069 A JP2009209069 A JP 2009209069A JP 2008052660 A JP2008052660 A JP 2008052660A JP 2008052660 A JP2008052660 A JP 2008052660A JP 2009209069 A JP2009209069 A JP 2009209069A
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Images
Abstract
【解決手段】医薬組成物中で、(a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種のニューキノロン系抗菌剤と共に、(b)ビタミンB6類とを共存させることにより、該ニューキノロン系抗菌剤の光安定性が改善され、医薬組成物の光曝露による変色を抑制できる。
【選択図】なし
Description
項1. (a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種と、(b)ビタミンB6類とを含有することを特徴とする、医薬組成物。
項2. 前記(a)成分が、ロメフロキサシン及びその薬理学的に許容される塩よりなる群から選択される少なくとも1種である、項1に記載の医薬組成物。
項3. 前記(a)成分に含まれる薬理学的に許容される塩が、塩酸塩、トシル酸塩、硫酸塩、リン酸塩、酢酸塩、乳酸塩、コハク酸塩、メタンスルホン酸塩、マレイン酸塩、グルコン酸塩、及びアスパラギン酸塩よりなる群から選択される少なくとも1種である、項1又は2に記載の医薬組成物。
項4. 前記(a)成分を0.01〜1w/v%の割合で含有する、項1乃至3のいずれかに記載の医薬組成物。
項5. 前記(b)成分を0.005〜1w/v%の割合で含有する、項1乃至4のいずれかに記載の医薬組成物。
項6. 更に、(c)テルペノイドを含有する、項1乃至5のいずれかに記載の医薬組成物。
項7. 前記(c)成分が、メントール、カンフル、ボルネオール、ゲラニオール、シネオール、リモネン、リナロール、オイゲノール、ゲルガモット油、ハッカ油、ユーカリ油、ウイキョウ油、ローズ油及びクールミント油よりなる群から選択される少なくとも1種である、項6に記載の医薬組成物。
項8. 水性組成物である、項1乃至7のいずれかに記載の医薬組成物。
項9. 点眼剤である、項1乃至8のいずれかに記載の医薬組成物。
項10. 透明部分を有する包装体に、項1乃至9のいずれかに記載の医薬組成物が収容されてなることを特徴とする、医薬製品。
項11. 前記医薬組成物が点眼剤であり、前記包装体が点眼容器である、項10に記載の医薬製品。
項12. 前記包装体の透明部分の可視光線の透過性が40%以上である、項10又は11に記載の医薬製品。
項13. (a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種を含む医薬組成物に、(b)ビタミンB6類を配合することを特徴とする、該医薬組成物の光曝露時の着色抑制方法。
本発明の医薬組成物は、ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種のニューキノロン系抗菌剤(以下、単に(a)成分と表記することもある)を含有する。
抗ヒスタミン剤:例えば、イプロヘプチン、ジフェンヒドラミン、クロルフェニラミン等。
殺菌剤:例えば、アクリノール、セチルピリジニウム、ベンザルコニウム、ベンゼトニウム、クロルヘキシジン等。
消炎剤:例えば、グリチルレチン酸、グリチルリチン酸、プラノプロフェン、サリチル酸メチル、サリチル酸グリコール、アラントイン、アズレン、アズレンスルホン酸、グアイアズレン、トラネキサム酸、ε−アミノカプロン酸、ベルベリン、リゾチーム、甘草等。
収斂剤:例えば、亜鉛華、乳酸亜鉛、硫酸亜鉛等。
その他:例えば、インドメタシン、イブプロフェン、イブプロフェンピコノール、ブフェキサマク、フルフェナム酸ブチル、ベンダザック、ピロキシカム、ケトプロフェン、フェルビナク、紫根、セイヨウトチノキ、及びこれらの塩等。
担体:例えば、水、含水エタノール等の水性担体。
増粘剤:例えば、カルボキシビニルポリマー、ヒドロキシエチルセルロース、ヒドロキシプロピルメチルセルロース、メチルセルロース、アルギン酸、ポリビニルアルコール(完全、又は部分ケン化物)、ポリビニルピロリドン、マクロゴール、コンドロイチン硫酸ナトリウム等。
糖類:例えば、グルコース、シクロデキストリン等。
糖アルコール類:例えば、キシリトール、ソルビトール、マンニトールなど。これらはd体、l体又はdl体のいずれでもよい。
界面活性剤:例えば、ポリオキシエチレン(以下、POEと略す)−ポリオキシプロピレン(以下、POPと略す)ブロックコポリマー(具体的には、ポロクサマー407等)、エチレンジアミンのPOE-POPブロックコポリマー付加物(具体的には、ポロキサミン等)、モノオレイン酸POEソルビタン、POE硬化ヒマシ油(具体的には、POE(60)硬化ヒマシ油等)、ステアリン酸ポリオキシル等の非イオン性界面活性剤;アルキルジアミノエチルグリシン等のグリシン型両性界面活性剤;アルキル4級アンモニウム塩(具体的には、塩化ベンザルコニウム、塩化ベンゼトニウム等の陽イオン界面活性剤等。なお、括弧内の数字は付加モル数を示す。
防腐剤、殺菌剤又は抗菌剤:例えば、塩酸アルキルジアミノエチルグリシン、安息香酸ナトリウム、エタノール、塩化ベンザルコニウム、塩化ベンゼトニウム、グルコン酸クロルヘキシジン、クロロブタノール、ソルビン酸、ソルビン酸カリウム、デヒドロ酢酸ナトリウム、パラオキシ安息香酸メチル、パラオキシ安息香酸エチル、パラオキシ安息香酸プロピル、パラオキシ安息香酸ブチル、硫酸オキシキノリン、フェネチルアルコール、ベンジルアルコール、ビグアニド化合物(具体的には、ポリヘキサメチレンビグアニド等)、グローキル(ローディア社製 商品名)等。
pH調節剤:例えば、塩酸、ホウ酸、アミノエチルスルホン酸、イプシロン−アミノカプロン酸、クエン酸、酢酸、水酸化ナトリウム、水酸化カリウム、水酸化カルシウム、水酸化マグネシウム、炭酸水素ナトリウム、炭酸ナトリウム、ホウ砂、トリエタノールアミン、モノエタノールアミン、ジイソプロパノールアミン、硫酸、リン酸、ポリリン酸、プロピオン酸、シュウ酸、グルコン酸、フマル酸、乳酸、酒石酸、リンゴ酸、コハク酸、グルコノラクトン、酢酸アンモニウム等。
等張化剤:例えば、亜硫酸水素ナトリウム、亜硫酸ナトリウム、塩化カリウム、塩化カルシウム、塩化ナトリウム、塩化マグネシウム、酢酸カリウム、酢酸ナトリウム、炭酸水素ナトリウム、炭酸ナトリウム、チオ硫酸ナトリウム、硫酸マグネシウム、リン酸水素二ナトリウム、リン酸二水素ナトリウム、リン酸二水素カリウム、グリセリン、プロピレングリコール等。
安定化剤:ジブチルヒドロキシトルエン、トロメタモール、ナトリウムホルムアルデヒドスルホキシレート(ロンガリット)、トコフェロール、ピロ亜硫酸ナトリウム、モノエタノールアミン、モノステアリン酸アルミニウム、モノステアリン酸グリセリン等。
基剤:オクチルドデカノール、ゴマ油、酸化チタン、臭化カリウム、ダイズ油、ツバキ油、トウモロコシ油、ナタネ油、綿実油、パラフィン、ヒマシ油、プラスチベース、ラッカセイ油、ラノリン、ワセリン、プロピレングリコール等。
上記医薬組成物では、(a)成分の光不安定化が改善されており、光曝露による変色が抑制されているので、該医薬組成物は、光の透過性が高く内部を視認可能な透明部分を有する包装体に収容されて提供することできる。即ち、本発明は、更に、透明部分を有する包装体に上記医薬組成物が収容されてなる医薬製品を提供する。
前述するように、(a)成分を含む医薬組成物に(b)成分を配合することによって、該医薬組成物の光曝露による変色(着色)を抑制することができる。従って、本発明は、(a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種を含む医薬組成物に、(b)ビタミンB6類を配合することを特徴とする、該医薬組成物の光曝露時の着色抑制方法を提供する。
表1に記載の処方に従い、各水性医薬組成物を調製した(実施例1及び比較例1−3)。調製後、すぐに各水性医薬組成物の波長405nmでの吸光度(A405)を測定した。更に以下の試験を行い、その光に対する安定性について評価した。
表2に記載の処方に従い、各水性医薬組成物を調製した(実施例2及び比較例4)。これらの水性医薬組成物を用いて、以下の試験を行い、その光に対する安定性について評価した。
表3及び4に記載の処方で、点眼剤(実施例3−17)が調製される。
Claims (6)
- (a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種と、(b)ビタミンB6類とを含有することを特徴とする、医薬組成物。
- 前記(a)成分が、ロメフロキサシン及びその薬理学的に許容される塩よりなる群から選択される少なくとも1種である、請求項1に記載の医薬組成物。
- 水性組成物である、請求項1又は2に記載の医薬組成物。
- 点眼剤である、請求項1乃至3のいずれかに記載の医薬組成物。
- 透明部分を有する包装体に、請求項1乃至4のいずれかに記載の医薬組成物が収容されてなることを特徴とする、医薬製品。
- (a)ロメフロキサシン、オフロキサシン、レボフロキサシン、ガチフロキサシン、トスフロキサシン、モキシフロキサシン、及びそれらの薬理学的に許容される塩よりなる群から選択される少なくとも1種を含む医薬組成物に、(b)ビタミンB6類を配合することを特徴とする、該医薬組成物の光曝露時の着色抑制方法。
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102342910A (zh) * | 2011-10-03 | 2012-02-08 | 白求恩医科大学制药厂 | 一种盐酸左氧氟沙星注射液药物组合物及制备方法 |
JP2013129618A (ja) * | 2011-12-21 | 2013-07-04 | Nippon Tenganyaku Kenkyusho:Kk | 防腐効力および物性を向上させたレボフロキサシン含有水性液剤 |
JP2014024794A (ja) * | 2012-07-27 | 2014-02-06 | Nippon Tenganyaku Kenkyusho:Kk | チモロールまたはその薬学的に許容される塩を含有する水性組成物およびその光安定化方法 |
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Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10279481A (ja) * | 1997-02-04 | 1998-10-20 | Senju Pharmaceut Co Ltd | ピリドンカルボン酸の可溶化方法、その可溶化剤および可溶化されたピリドンカルボン酸からなる水性液剤 |
WO2000010570A1 (fr) * | 1998-08-21 | 2000-03-02 | Senju Pharmaceutical Co., Ltd. | Preparations liquides aqueuses |
JP2001158739A (ja) * | 1999-09-21 | 2001-06-12 | Kyowa Hakko Kogyo Co Ltd | プロアントシアニジンとビタミンb6誘導体またはその塩とを含有する組成物 |
WO2001080858A1 (fr) * | 2000-04-24 | 2001-11-01 | Daiichi Pharmaceutical Co., Ltd. | Preparation liquide stable |
JP2002002825A (ja) * | 2000-06-19 | 2002-01-09 | Taisho Pharm Ind Ltd | キノロン系抗菌薬液体製剤及びその包装体 |
RU2247560C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Комбинированный состав с противотуберкулёзным действием |
RU2247559C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Противотуберкулёзное средство |
JP2005336153A (ja) * | 2004-04-28 | 2005-12-08 | Rohto Pharmaceut Co Ltd | プラノプロフェン含有組成物 |
-
2008
- 2008-03-03 JP JP2008052660A patent/JP5258331B2/ja not_active Expired - Fee Related
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPH10279481A (ja) * | 1997-02-04 | 1998-10-20 | Senju Pharmaceut Co Ltd | ピリドンカルボン酸の可溶化方法、その可溶化剤および可溶化されたピリドンカルボン酸からなる水性液剤 |
WO2000010570A1 (fr) * | 1998-08-21 | 2000-03-02 | Senju Pharmaceutical Co., Ltd. | Preparations liquides aqueuses |
JP2001158739A (ja) * | 1999-09-21 | 2001-06-12 | Kyowa Hakko Kogyo Co Ltd | プロアントシアニジンとビタミンb6誘導体またはその塩とを含有する組成物 |
WO2001080858A1 (fr) * | 2000-04-24 | 2001-11-01 | Daiichi Pharmaceutical Co., Ltd. | Preparation liquide stable |
JP2002002825A (ja) * | 2000-06-19 | 2002-01-09 | Taisho Pharm Ind Ltd | キノロン系抗菌薬液体製剤及びその包装体 |
RU2247560C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Комбинированный состав с противотуберкулёзным действием |
RU2247559C1 (ru) * | 2003-12-29 | 2005-03-10 | Открытое акционерное общество "Химико-фармацевтический комбинат "АКРИХИН" (ОАО "АКРИХИН") | Противотуберкулёзное средство |
JP2005336153A (ja) * | 2004-04-28 | 2005-12-08 | Rohto Pharmaceut Co Ltd | プラノプロフェン含有組成物 |
Cited By (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2563985C2 (ru) * | 2011-03-23 | 2015-09-27 | Тояма Кемикал Ко., Лтд. | Фармацевтическая композиция, содержащая тосуфлоксацин или его соль |
CN102342910A (zh) * | 2011-10-03 | 2012-02-08 | 白求恩医科大学制药厂 | 一种盐酸左氧氟沙星注射液药物组合物及制备方法 |
JP2013129618A (ja) * | 2011-12-21 | 2013-07-04 | Nippon Tenganyaku Kenkyusho:Kk | 防腐効力および物性を向上させたレボフロキサシン含有水性液剤 |
JP2014024794A (ja) * | 2012-07-27 | 2014-02-06 | Nippon Tenganyaku Kenkyusho:Kk | チモロールまたはその薬学的に許容される塩を含有する水性組成物およびその光安定化方法 |
JP5686454B1 (ja) * | 2013-12-12 | 2015-03-18 | 株式会社メニコン | コンタクトレンズ装着用液剤およびそれを用いたコンタクトレンズの屈折率向上方法 |
JP2015132804A (ja) * | 2013-12-12 | 2015-07-23 | 株式会社メニコン | コンタクトレンズ装着用液剤およびそれを用いたコンタクトレンズの屈折率向上方法 |
JP2017503842A (ja) * | 2014-01-24 | 2017-02-02 | ラム・セラピューティクス,インコーポレーテッド | 癌治療のためのアピリモド(apilimod)組成物 |
US11266654B2 (en) | 2014-01-24 | 2022-03-08 | AI Therapeutics, Inc. | Apilimod compositions and methods for using same |
US11166944B2 (en) | 2014-11-07 | 2021-11-09 | AI Therapeutics, Inc. | Apilimod compositions and methods for using same in the treatment of renal cancer |
CN114129590A (zh) * | 2021-12-07 | 2022-03-04 | 湖北远大天天明制药有限公司 | 一种眼用组合物及其制备方法与应用 |
CN114129590B (zh) * | 2021-12-07 | 2023-09-29 | 湖北远大天天明制药有限公司 | 一种眼用组合物及其制备方法与应用 |
CN115337263A (zh) * | 2022-08-09 | 2022-11-15 | 江苏汉晨药业有限公司 | 一种盐酸洛美沙星滴眼液 |
CN115337263B (zh) * | 2022-08-09 | 2023-10-03 | 江苏汉晨药业有限公司 | 一种盐酸洛美沙星滴眼液 |
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