JP2009148257A5 - - Google Patents
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- JP2009148257A5 JP2009148257A5 JP2008317743A JP2008317743A JP2009148257A5 JP 2009148257 A5 JP2009148257 A5 JP 2009148257A5 JP 2008317743 A JP2008317743 A JP 2008317743A JP 2008317743 A JP2008317743 A JP 2008317743A JP 2009148257 A5 JP2009148257 A5 JP 2009148257A5
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- Prior art keywords
- polypeptide
- nucleotide sequence
- fgf
- nucleic acid
- acid molecule
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 229920001184 polypeptide Polymers 0.000 claims 22
- 229920001850 Nucleic acid sequence Polymers 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 8
- 238000000034 method Methods 0.000 claims 7
- 210000004027 cells Anatomy 0.000 claims 6
- 150000001875 compounds Chemical class 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 229920003013 deoxyribonucleic acid Polymers 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 230000000295 complement Effects 0.000 claims 2
- 239000002773 nucleotide Substances 0.000 claims 2
- 125000003729 nucleotide group Chemical group 0.000 claims 2
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 230000037396 body weight Effects 0.000 claims 1
- 210000003527 eukaryotic cell Anatomy 0.000 claims 1
- 210000001236 prokaryotic cell Anatomy 0.000 claims 1
Claims (13)
- 単離された核酸分子であって、以下：
（ａ）配列番号１のヌクレオチド１４２〜ヌクレオチド６８８に示すヌクレオチド配列；
（ｂ）配列番号５に示すポリペプチドをコードするヌクレオチド配列；
（ｃ）配列番号１のヌクレオチド１４２〜ヌクレオチド６８８に示すヌクレオチド配列に少なくとも９５パーセント同一であるヌクレオチド配列であって、コードされるポリペプチドが、動物の体重を減少させる、前記ヌクレオチド配列；および
（ｄ）（ａ）〜（ｃ）のいずれかに相補的なヌクレオチド配列、
からなる群より選択されるヌクレオチド配列を含む、単離された核酸分子。 - 単離された核酸分子であって、以下：
（ａ）カルボキシル末端短縮化および／またはアミノ末端短縮化を有する配列番号５に示すポリペプチドをコードするヌクレオチド配列であって、短縮化ポリペプチドが、少なくとも１５０個のアミノ酸残基を含み、コードされるポリペプチドが、動物の体重を減少させる、ヌクレオチド配列；
（ｂ）配列番号５に示すポリペプチドに少なくとも９５パーセント同一であって、動物の体重を減少させるポリペプチドをコードするヌクレオチド配列；および
（ｃ）（ａ）〜（ｂ）のいずれかに相補的なヌクレオチド配列、
からなる群より選択されるヌクレオチド配列を含む、単離された核酸分子。 - 請求項１または２に記載の核酸分子を含む、ベクター。
- 請求項３に記載のベクターを含む、宿主細胞。
- 真核生物細胞である、請求項４に記載の宿主細胞。
- 原核生物細胞である、請求項４に記載の宿主細胞。
- ＦＧＦ様ポリペプチドを産生するプロセスであって、請求項４に記載の宿主細胞を、該ポリペプチドを発現するために適切な条件下で培養する工程、および必要に応じて、該ポリペプチドを該培養物から単離する工程を包含する、プロセス。
- 請求項７に記載のプロセスによって産生される、ポリペプチド。
- 前記核酸分子が、ネイティブなＦＧＦ様ポリペプチドをコードするＤＮＡに作動可能に連結された、ネイティブなＦＧＦ様ポリペプチドについてのプロモーターＤＮＡ以外のプロモーターＤＮＡを含む、請求項７に記載のプロセス。
- 化合物が、ＦＧＦ様ポリペプチド活性またはＦＧＦ様ポリペプチド産生を阻害するか否かを決定するためのプロセスであって、請求項４、５または６に記載の細胞を、該化合物に曝露する工程、および該細胞中でのＦＧＦ様ポリペプチド活性またはＦＧＦ様ポリペプチド産生を測定する工程を包含する、プロセス。
- 請求項１または２のいずれかに記載の核酸分子によってコードされる、単離されたポリペプチド。
- 請求項１から３のいずれか１項に記載の核酸分子を含む、トランスジェニック非ヒト哺乳動物。
- 化合物が、ＦＧＦ様ポリペプチド活性またはＦＧＦ様ポリペプチド産生を阻害するか否かを決定するためのプロセスであって、請求項１２に記載のトランスジェニック哺乳動物を該化合物に曝露する工程、および該哺乳動物中でのＦＧＦ様ポリペプチド活性またはＦＧＦ様ポリペプチド産生を測定する工程を包含する、プロセス。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/391,861 | 1999-09-07 | ||
| US09/391,861 US7408047B1 (en) | 1999-09-07 | 1999-09-07 | Fibroblast growth factor-like polypeptides |
| US09/644,052 | 2000-08-23 | ||
| US09/644,052 US7459540B1 (en) | 1999-09-07 | 2000-08-23 | Fibroblast growth factor-like polypeptides |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006220748A Division JP2007044044A (ja) | 1999-09-07 | 2006-08-11 | 線維芽細胞増殖因子様ポリペプチド |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010084503A Division JP2010213705A (ja) | 1999-09-07 | 2010-03-31 | 線維芽細胞増殖因子様ポリペプチド |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009148257A JP2009148257A (ja) | 2009-07-09 |
| JP2009148257A5 true JP2009148257A5 (ja) | 2011-05-12 |
| JP4943410B2 JP4943410B2 (ja) | 2012-05-30 |
Family
ID=27013655
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522384A Expired - Fee Related JP4793836B2 (ja) | 1999-09-07 | 2000-09-05 | 線維芽細胞増殖因子様ポリペプチド |
| JP2006220748A Withdrawn JP2007044044A (ja) | 1999-09-07 | 2006-08-11 | 線維芽細胞増殖因子様ポリペプチド |
| JP2008317743A Expired - Fee Related JP4943410B2 (ja) | 1999-09-07 | 2008-12-12 | 線維芽細胞増殖因子様ポリペプチド |
| JP2010084503A Pending JP2010213705A (ja) | 1999-09-07 | 2010-03-31 | 線維芽細胞増殖因子様ポリペプチド |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001522384A Expired - Fee Related JP4793836B2 (ja) | 1999-09-07 | 2000-09-05 | 線維芽細胞増殖因子様ポリペプチド |
| JP2006220748A Withdrawn JP2007044044A (ja) | 1999-09-07 | 2006-08-11 | 線維芽細胞増殖因子様ポリペプチド |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010084503A Pending JP2010213705A (ja) | 1999-09-07 | 2010-03-31 | 線維芽細胞増殖因子様ポリペプチド |
Country Status (13)
| Country | Link |
|---|---|
| US (10) | US7459540B1 (ja) |
| EP (4) | EP1218509B9 (ja) |
| JP (4) | JP4793836B2 (ja) |
| AT (1) | ATE430197T1 (ja) |
| AU (1) | AU7350000A (ja) |
| CA (1) | CA2383774C (ja) |
| CY (1) | CY1109166T1 (ja) |
| DE (1) | DE60042122D1 (ja) |
| DK (1) | DK1218509T3 (ja) |
| ES (1) | ES2326407T3 (ja) |
| MX (1) | MXPA02002384A (ja) |
| PT (1) | PT1218509E (ja) |
| WO (1) | WO2001018172A2 (ja) |
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- 2000-09-05 WO PCT/US2000/024373 patent/WO2001018172A2/en active Application Filing
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- 2000-09-05 EP EP10010387A patent/EP2284189A3/en not_active Withdrawn
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