JP2009077712A - Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 - Google Patents

Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 Download PDF

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Publication number
JP2009077712A
JP2009077712A JP2008229396A JP2008229396A JP2009077712A JP 2009077712 A JP2009077712 A JP 2009077712A JP 2008229396 A JP2008229396 A JP 2008229396A JP 2008229396 A JP2008229396 A JP 2008229396A JP 2009077712 A JP2009077712 A JP 2009077712A
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seq
probe
braf
mutation
primer
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JP2009077712A5 (https=
Inventor
Rachel Langland
ラングランド レイチェル
Thad Sharp
シャープ サド
Stephen Will
ウィル スティーブン
Lin Wu
ウー リン
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F Hoffmann La Roche AG
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F Hoffmann La Roche AG
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Publication of JP2009077712A publication Critical patent/JP2009077712A/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2008229396A 2007-09-11 2008-09-08 Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 Pending JP2009077712A (ja)

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US99339107P 2007-09-11 2007-09-11

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JP2009077712A5 JP2009077712A5 (https=) 2011-10-13

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JP2015094227A Active JP6787651B2 (ja) 2007-09-11 2015-05-01 Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験

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EP (1) EP2036990B1 (https=)
JP (2) JP2009077712A (https=)
CN (1) CN101418340B (https=)
CA (1) CA2639416C (https=)
DK (1) DK2036990T3 (https=)
ES (1) ES2471097T3 (https=)
HR (1) HRP20140608T1 (https=)
PL (1) PL2036990T3 (https=)
PT (1) PT2036990E (https=)
SI (1) SI2036990T1 (https=)

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JP2013515736A (ja) * 2009-12-23 2013-05-09 プレキシコン インコーポレーテッド キナーゼ調節のための化合物及び方法ならびにそれらの適応症
JP2013543117A (ja) * 2010-09-30 2013-11-28 ドイチェス クレープスフォルシュングスツェントルム Ｂｒａｆｖ６００ｅに特異的に結合する抗体を使用する癌の診断のための手段及び方法
JP2013236625A (ja) * 2012-04-20 2013-11-28 Arkray Inc 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット
JP2015198659A (ja) * 2007-09-11 2015-11-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験

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WO2008063888A2 (en) 2006-11-22 2008-05-29 Plexxikon, Inc. Compounds modulating c-fms and/or c-kit activity and uses therefor
WO2011109440A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings Biomarkers for theranostics
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KR101739994B1 (ko) 2009-04-03 2017-05-25 에프. 호프만-라 로슈 아게 프로판-１-술폰산 ｛３-［５-（４-클로로-페닐）-１Ｈ-피롤로［２，３-ｂ］피리딘-３-카르보닐］-２，４-디플루오로-페닐｝-아미드 조성물 및 그의 용도
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US9150570B2 (en) 2012-05-31 2015-10-06 Plexxikon Inc. Synthesis of heterocyclic compounds
CN102816851A (zh) * 2012-08-29 2012-12-12 苏州旷远生物分子技术有限公司 用于检测braf基因v600e突变的引物、探针、试剂盒及方法
CN106148497A (zh) * 2015-04-09 2016-11-23 上海济远生物科技有限公司 Braf基因突变检测试剂盒及其应用
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AU2018269982B2 (en) * 2017-05-16 2024-06-13 Biomed Valley Discoveries, Inc. Compositions and methods for treating cancer with atypical BRAF mutations
US11529335B2 (en) * 2020-07-31 2022-12-20 University Of Iowa Research Foundation Compositions and methods for treating cancer
CN116144749B (zh) * 2022-09-23 2025-05-09 杭州佰辰医学检验所有限公司 一种检测人ApoE基因突变的引物探针组及试剂盒

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JPN6013027103; ＰＲＡＴＩＬＡＳ，　Ｃ．Ａ．　ｅｔ　ａｌ．: '"Ｔｈｅｒａｐｅｕｔｉｃ　ｓｔｒａｔｅｇｉｅｓ　ｆｏｒ　ｔａｒｇｅｔｉｎｇ　ＢＲＡＦ　ｉｎ　ｈｕｍａｎ　ｃａｎｃｅｒ．"' ＲＥＶＩＥＷＳ　ＯＮ　ＲＥＣＥＮＴ　ＣＬＩＮＩＣＡＬ　ＴＲＩＡＬＳ Ｖｏｌ．２，　Ｎｏ．２, 200705, Ｐ．１２１-１３４ *
JPN6013027105; ＳＨＩＮＯＺＡＫＩ，　Ｍ．　ｅｔ　ａｌ．: '"Ｕｔｉｌｉｔｙ　ｏｆ　ｃｉｒｃｕｌａｔｉｎｇ　Ｂ-ＲＡＦ　ＤＮＡ　ｍｕｔａｔｉｏｎ　ｉｎ　ｓｅｒｕｍ　ｆｏｒ　ｍｏｎｉｔｏｒｉｎｇ　ｍｅｌａｎｏｍａ　ｐａｔｉｅｎｔｓ　ｒｅｃｅｉｖｉｎｇ　ｂｉｏｃｈ' ＣＬＩＮＩＣＡＬ　ＣＡＮＣＥＲ　ＲＥＳＥＡＲＣＨ Ｖｏｌ．１３，　Ｎｏ．７, 20070401, Ｐ．２０６８-２０７４ *
JPN6013027107; ＳＡＬＶＡＴＯＲＥ，　Ｇ．　ｅｔ　ａｌ．: '"ＢＲＡＦ　ｉｓ　ａ　ｔｈｅｒａｐｅｕｔｉｃ　ｔａｒｇｅｔ　ｉｎ　ａｇｇｒｅｓｓｉｖｅ　ｔｈｙｒｏｉｄ　ｃａｒｃｉｎｏｍａ．"' ＣＬＩＮＩＣＡＬ　ＣＡＮＣＥＲ　ＲＥＳＥＡＲＣＨ Ｖｏｌ．１２，　Ｎｏ．５, 20060301, Ｐ．１６２３-１６２９ *
JPN6013062106; ＩＫＥＮＯＵＥ，　Ｔ．　ｅｔ　ａｌ．: '"Ｒａｐｉｄ　ｄｅｔｅｃｔｉｏｎ　ｏｆ　ｍｕｔａｔｉｏｎｓ　ｉｎ　ｔｈｅ　ＢＲＡＦ　ｇｅｎｅ　ｕｓｉｎｇ　ｒｅａｌ-ｔｉｍｅ　ｐｏｌｙｍｅｒａｓｅ　ｃｈａｉｎ　ｒｅａｃｔｉｏｎ　ａｎｄ　ｍｅｌｔｉｎｇ' ＣＡＮＣＥＲ　ＧＥＮＥＴＩＣＳ　ＡＮＤ　ＣＹＴＯＧＥＮＥＴＩＣＳ Ｖｏｌ．１４９，　Ｎｏ．１, 200402, Ｐ．６８-７１ *
JPN6013062107; ＪＡＲＲＹ，　Ａ．　ｅｔ　ａｌ．: '"Ｒｅａｌ-ｔｉｍｅ　ａｌｌｅｌｅ-ｓｐｅｃｉｆｉｃ　ａｍｐｌｉｆｉｃａｔｉｏｎ　ｆｏｒ　ｓｅｎｓｉｔｉｖｅ　ｄｅｔｅｃｔｉｏｎ　ｏｆ　ｔｈｅ　ＢＲＡＦ　ｍｕｔａｔｉｏｎ　Ｖ６００Ｅ．"' ＭＯＬＥＣＵＬＡＲ　ＡＮＤ　ＣＥＬＬＵＬＡＲ　ＰＲＯＢＥＳ Ｖｏｌ．１８，　Ｎｏ．５, 200410, Ｐ．３４９-３５２ *
JPN6013062109; ＴＨＯＭＡＳ，　Ｎ．Ｅ．　ｅｔ　ａｌ．: '"Ｔａｎｄｅｍ　ＢＲＡＦ　ｍｕｔａｔｉｏｎｓ　ｉｎ　ｐｒｉｍａｒｙ　ｉｎｖａｓｉｖｅ　ｍｅｌａｎｏｍａｓ．"' Ｊ．　ＩＮＶＥＳＴ．　ＤＥＲＭＡＴＯＬ． Ｖｏｌ．１２２，　Ｎｏ．５, 200405, Ｐ．１２４５-１２５０ *

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015198659A (ja) * 2007-09-11 2015-11-12 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験
JP2013515736A (ja) * 2009-12-23 2013-05-09 プレキシコン インコーポレーテッド キナーゼ調節のための化合物及び方法ならびにそれらの適応症
JP2013543117A (ja) * 2010-09-30 2013-11-28 ドイチェス クレープスフォルシュングスツェントルム Ｂｒａｆｖ６００ｅに特異的に結合する抗体を使用する癌の診断のための手段及び方法
US9297812B2 (en) 2010-09-30 2016-03-29 Deutsches Krebsforschungzentrum Means and methods for diagnosing cancer using an antibody which specifically binds to BRAF V600E
JP2013236625A (ja) * 2012-04-20 2013-11-28 Arkray Inc 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット
US9255298B2 (en) 2012-04-20 2016-02-09 Arkray, Inc. Probe, and polymorphism detection method using the same

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SI2036990T1 (sl) 2014-07-31
PT2036990E (pt) 2014-06-12
CA2639416A1 (en) 2009-03-11
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DK2036990T3 (da) 2014-06-30
PL2036990T3 (pl) 2014-09-30
JP2015198659A (ja) 2015-11-12
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