JP2009077712A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009077712A5 JP2009077712A5 JP2008229396A JP2008229396A JP2009077712A5 JP 2009077712 A5 JP2009077712 A5 JP 2009077712A5 JP 2008229396 A JP2008229396 A JP 2008229396A JP 2008229396 A JP2008229396 A JP 2008229396A JP 2009077712 A5 JP2009077712 A5 JP 2009077712A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- set forth
- sequence set
- nucleotide sequence
- kit
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002773 nucleotide Substances 0.000 claims 15
- 125000003729 nucleotide group Chemical group 0.000 claims 15
- 238000000034 method Methods 0.000 claims 7
- 239000000523 sample Substances 0.000 claims 7
- 230000035772 mutation Effects 0.000 claims 6
- 101000984753 Homo sapiens Serine/threonine-protein kinase B-raf Proteins 0.000 claims 5
- 102100027103 Serine/threonine-protein kinase B-raf Human genes 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 108091033319 polynucleotide Proteins 0.000 claims 3
- 102000040430 polynucleotide Human genes 0.000 claims 3
- 239000002157 polynucleotide Substances 0.000 claims 3
- KKVYYGGCHJGEFJ-UHFFFAOYSA-N 1-n-(4-chlorophenyl)-6-methyl-5-n-[3-(7h-purin-6-yl)pyridin-2-yl]isoquinoline-1,5-diamine Chemical compound N=1C=CC2=C(NC=3C(=CC=CN=3)C=3C=4N=CNC=4N=CN=3)C(C)=CC=C2C=1NC1=CC=C(Cl)C=C1 KKVYYGGCHJGEFJ-UHFFFAOYSA-N 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 101100381978 Mus musculus Braf gene Proteins 0.000 claims 2
- 230000003321 amplification Effects 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 238000003199 nucleic acid amplification method Methods 0.000 claims 2
- 230000035945 sensitivity Effects 0.000 claims 2
- 229940102297 B-raf kinase inhibitor Drugs 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 108020005187 Oligonucleotide Probes Proteins 0.000 claims 1
- 239000002774 b raf kinase inhibitor Substances 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 150000007523 nucleic acids Chemical class 0.000 claims 1
- 239000002751 oligonucleotide probe Substances 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99339107P | 2007-09-11 | 2007-09-11 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094227A Division JP6787651B2 (ja) | 2007-09-11 | 2015-05-01 | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009077712A JP2009077712A (ja) | 2009-04-16 |
| JP2009077712A5 true JP2009077712A5 (https=) | 2011-10-13 |
Family
ID=39942784
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008229396A Pending JP2009077712A (ja) | 2007-09-11 | 2008-09-08 | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
| JP2015094227A Active JP6787651B2 (ja) | 2007-09-11 | 2015-05-01 | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015094227A Active JP6787651B2 (ja) | 2007-09-11 | 2015-05-01 | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP2036990B1 (https=) |
| JP (2) | JP2009077712A (https=) |
| CN (1) | CN101418340B (https=) |
| CA (1) | CA2639416C (https=) |
| DK (1) | DK2036990T3 (https=) |
| ES (1) | ES2471097T3 (https=) |
| HR (1) | HRP20140608T1 (https=) |
| PL (1) | PL2036990T3 (https=) |
| PT (1) | PT2036990E (https=) |
| SI (1) | SI2036990T1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103424541B (zh) | 2006-05-18 | 2018-01-30 | 分子压型学会股份有限公司 | 确定针对病状的个性化医疗介入的系统和方法 |
| US8768629B2 (en) | 2009-02-11 | 2014-07-01 | Caris Mpi, Inc. | Molecular profiling of tumors |
| WO2008063888A2 (en) | 2006-11-22 | 2008-05-29 | Plexxikon, Inc. | Compounds modulating c-fms and/or c-kit activity and uses therefor |
| JP2009077712A (ja) * | 2007-09-11 | 2009-04-16 | F Hoffmann La Roche Ag | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
| WO2010056337A2 (en) | 2008-11-12 | 2010-05-20 | Caris Mpi, Inc. | Methods and systems of using exosomes for determining phenotypes |
| CN101487051B (zh) * | 2009-02-24 | 2011-07-20 | 广州益善生物技术有限公司 | Braf基因突变的检测探针、液相芯片及其检测方法 |
| MY172424A (en) | 2009-04-03 | 2019-11-25 | Hoffmann La Roche | Propane- i-sulfonic acid {3- (4-chloro-phenyl)-1h-pyrrolo [2, 3-b] pyridine-3-carconyl] -2, 4-difluoro-phenyl} -amide compositions and uses thereof |
| CN106220623A (zh) | 2009-11-06 | 2016-12-14 | 普莱希科公司 | 用于激酶调节的化合物和方法及其适应症 |
| WO2011060216A1 (en) | 2009-11-12 | 2011-05-19 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| US9238832B2 (en) * | 2009-12-11 | 2016-01-19 | Roche Molecular Systems, Inc. | Allele-specific amplification of nucleic acids |
| BR112012015745A2 (pt) * | 2009-12-23 | 2016-05-17 | Plexxikon Inc | compostos e métodos para a modulação de quinase, e indicações dos mesmos |
| CN102161990A (zh) * | 2010-02-24 | 2011-08-24 | 北京雅康博生物科技有限公司 | 用于定量检测braf突变的试剂盒 |
| EP2542696B1 (en) | 2010-03-01 | 2016-09-28 | Caris Life Sciences Switzerland Holdings GmbH | Biomarkers for theranostics |
| JP2013526852A (ja) | 2010-04-06 | 2013-06-27 | カリス ライフ サイエンシズ ルクセンブルク ホールディングス | 疾患に対する循環バイオマーカー |
| EP2616467A1 (en) | 2010-09-13 | 2013-07-24 | Concert Pharmaceuticals Inc. | Substituted azaindoles |
| DK2622348T3 (en) | 2010-09-30 | 2015-12-14 | Deutsches Krebsforsch | Means and methods for diagnosing cancer using an antibody which specifically binds to braf v600e |
| US9624213B2 (en) | 2011-02-07 | 2017-04-18 | Plexxikon Inc. | Compounds and methods for kinase modulation, and indications therefor |
| CA2828940C (en) | 2011-03-10 | 2024-04-16 | Provectus Pharmaceuticals, Inc. | Combination of local and systemic immunomodulative therapies for enhanced treatment of cancer |
| US8680066B2 (en) * | 2011-04-05 | 2014-03-25 | The United States of America as represented by the Development of Veterans Affairs | Methods for determining and inhibiting rheumatoid arthritis associated with the BRAF oncogene in a subject |
| JP6153758B2 (ja) * | 2012-04-20 | 2017-06-28 | アークレイ株式会社 | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット |
| US9150570B2 (en) | 2012-05-31 | 2015-10-06 | Plexxikon Inc. | Synthesis of heterocyclic compounds |
| CN102816851A (zh) * | 2012-08-29 | 2012-12-12 | 苏州旷远生物分子技术有限公司 | 用于检测braf基因v600e突变的引物、探针、试剂盒及方法 |
| CN106148497A (zh) * | 2015-04-09 | 2016-11-23 | 上海济远生物科技有限公司 | Braf基因突变检测试剂盒及其应用 |
| KR101775356B1 (ko) * | 2015-07-06 | 2017-09-06 | 재단법인 아산사회복지재단 | Parp 및 탄키라제 동시 저해제에 대한 감수성 결정 방법 |
| AU2016298175B2 (en) | 2015-07-28 | 2022-01-06 | University Of Iowa Research Foundation | Compositions and methods of treating cancer |
| ES2928773T3 (es) | 2017-01-17 | 2022-11-22 | Heparegenix Gmbh | Inhibidores de proteína cinasas para fomentar la regeneración hepática o reducir o prevenir la muerte de hepatocitos |
| EP3624896A4 (en) * | 2017-05-16 | 2021-03-31 | Biomed Valley Discoveries, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF CANCER WITH ATYPICAL BRAF MUTATIONS |
| US11529335B2 (en) * | 2020-07-31 | 2022-12-20 | University Of Iowa Research Foundation | Compositions and methods for treating cancer |
| CN116144749B (zh) * | 2022-09-23 | 2025-05-09 | 杭州佰辰医学检验所有限公司 | 一种检测人ApoE基因突变的引物探针组及试剂盒 |
Family Cites Families (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4458066A (en) | 1980-02-29 | 1984-07-03 | University Patents, Inc. | Process for preparing polynucleotides |
| US5604099A (en) | 1986-03-13 | 1997-02-18 | Hoffmann-La Roche Inc. | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US5310893A (en) | 1986-03-31 | 1994-05-10 | Hoffmann-La Roche Inc. | Method for HLA DP typing |
| CA1284931C (en) | 1986-03-13 | 1991-06-18 | Henry A. Erlich | Process for detecting specific nucleotide variations and genetic polymorphisms present in nucleic acids |
| US4851331A (en) | 1986-05-16 | 1989-07-25 | Allied Corporation | Method and kit for polynucleotide assay including primer-dependant DNA polymerase |
| US5310652A (en) | 1986-08-22 | 1994-05-10 | Hoffman-La Roche Inc. | Reverse transcription with thermostable DNA polymerase-high temperature reverse transcription |
| US5405774A (en) | 1986-08-22 | 1995-04-11 | Hoffmann-La Roche Inc. | DNA encoding a mutated thermostable nucleic acid polymerase enzyme from thermus species sps17 |
| US5079352A (en) | 1986-08-22 | 1992-01-07 | Cetus Corporation | Purified thermostable enzyme |
| US5795762A (en) | 1986-08-22 | 1998-08-18 | Roche Molecular Systems, Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5466591A (en) | 1986-08-22 | 1995-11-14 | Hoffmann-La Roche Inc. | 5' to 3' exonuclease mutations of thermostable DNA polymerases |
| US5618711A (en) | 1986-08-22 | 1997-04-08 | Hoffmann-La Roche Inc. | Recombinant expression vectors and purification methods for Thermus thermophilus DNA polymerase |
| US5693517A (en) | 1987-06-17 | 1997-12-02 | Roche Molecular Systems, Inc. | Reagents and methods for coupled high temperature reverse transcription and polymerase chain reactions |
| US5455170A (en) | 1986-08-22 | 1995-10-03 | Hoffmann-La Roche Inc. | Mutated thermostable nucleic acid polymerase enzyme from Thermus species Z05 |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US5561058A (en) | 1986-08-22 | 1996-10-01 | Hoffmann-La Roche Inc. | Methods for coupled high temperatures reverse transcription and polymerase chain reactions |
| US5352600A (en) | 1986-08-22 | 1994-10-04 | Hoffmann-La Roche Inc. | Purified thermostable enzyme |
| WO1989001050A1 (en) | 1987-07-31 | 1989-02-09 | The Board Of Trustees Of The Leland Stanford Junior University | Selective amplification of target polynucleotide sequences |
| CA1340807C (en) | 1988-02-24 | 1999-11-02 | Lawrence T. Malek | Nucleic acid amplification process |
| IE61148B1 (en) | 1988-03-10 | 1994-10-05 | Ici Plc | Method of detecting nucleotide sequences |
| US5639611A (en) | 1988-12-12 | 1997-06-17 | City Of Hope | Allele specific polymerase chain reaction |
| CA2020958C (en) | 1989-07-11 | 2005-01-11 | Daniel L. Kacian | Nucleic acid sequence amplification methods |
| US5137806A (en) | 1989-12-11 | 1992-08-11 | Board Of Regents, The University Of Texas System | Methods and compositions for the detection of sequences in selected DNA molecules |
| US5955589A (en) | 1991-12-24 | 1999-09-21 | Isis Pharmaceuticals Inc. | Gapped 2' modified oligonucleotides |
| US5210015A (en) | 1990-08-06 | 1993-05-11 | Hoffman-La Roche Inc. | Homogeneous assay system using the nuclease activity of a nucleic acid polymerase |
| JP2709311B2 (ja) | 1990-09-28 | 1998-02-04 | エフ．ホフマン−ラ ロシュ アクチェンゲゼルシャフト | 熱安定性ｄｎａポリメラーゼの５→３′のエキソヌクレアーゼ突然変異 |
| DE69128520T2 (de) | 1990-10-31 | 1998-07-09 | Tosoh Corp | Verfahren zum Nachweis oder Quantifizierung von Zielnukleinsäuren |
| IL100040A (en) | 1990-11-13 | 1995-12-31 | Siska Diagnostics Inc | Nucleic acid amplification by two enzyme self-sustained sequence replication |
| YU187991A (sh) | 1990-12-11 | 1994-09-09 | Hoechst Aktiengesellschaft | 3-(2)-amino-ali tiol-modifikovani, s fluorescentnom bojom vezani nukleozidi, nukleotidi i oligonukleotidi, postupak za njihovo dobijanje i njihova upotreba |
| US5455166A (en) | 1991-01-31 | 1995-10-03 | Becton, Dickinson And Company | Strand displacement amplification |
| US5994056A (en) | 1991-05-02 | 1999-11-30 | Roche Molecular Systems, Inc. | Homogeneous methods for nucleic acid amplification and detection |
| CA2081582A1 (en) | 1991-11-05 | 1993-05-06 | Teodorica Bugawan | Methods and reagents for hla class i dna typing |
| US5652099A (en) | 1992-02-12 | 1997-07-29 | Conrad; Michael J. | Probes comprising fluorescent nucleosides and uses thereof |
| ATE198358T1 (de) | 1992-04-27 | 2001-01-15 | Dartmouth College | Detektion von gensequenzen in biologischen flüssigkeiten |
| US5446137B1 (en) | 1993-12-09 | 1998-10-06 | Behringwerke Ag | Oligonucleotides containing 4'-substituted nucleotides |
| DE4415370A1 (de) | 1994-05-02 | 1995-11-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5491063A (en) | 1994-09-01 | 1996-02-13 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| DE4438918A1 (de) | 1994-11-04 | 1996-05-09 | Hoechst Ag | Modifizierte Oligonukleotide, deren Herstellung sowie deren Verwendung |
| US5571673A (en) | 1994-11-23 | 1996-11-05 | Hoffmann-La Roche Inc. | Methods for in-solution quenching of fluorescently labeled oligonucleotide probes |
| WO1997009451A1 (en) | 1995-09-08 | 1997-03-13 | Life Technologies, Inc. | Cloned dna polymerases from thermotoga and mutants thereof |
| EP0866071B1 (en) | 1997-03-20 | 2004-10-20 | F. Hoffmann-La Roche Ag | Modified primers |
| JP2001352989A (ja) * | 2000-06-14 | 2001-12-25 | Fujirebio Inc | Ｄｎａ、ｄｎａプローブ法用試薬及びｄｎａプローブ法 |
| US6852491B2 (en) * | 2001-09-04 | 2005-02-08 | Abbott Laboratories | Amplification and detection reagents for HIV-1 |
| JP2006500057A (ja) * | 2002-09-26 | 2006-01-05 | ノバルティス アクチエンゲゼルシャフト | Ｂ−ｒａｆ遺伝子における突然変異のｐｃｒに基づく診断的検出方法 |
| CA2518530A1 (en) * | 2003-03-11 | 2004-09-23 | Novartis Ag | Use of isoquinoline derivatives for treating cancer and map kinase related diseases |
| JP2005013221A (ja) * | 2003-06-03 | 2005-01-20 | Keio Gijuku | Ｂｒａｆ発現抑制を利用した癌の治療 |
| WO2005047542A1 (en) * | 2003-10-16 | 2005-05-26 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Treatments for inhibiting development and progression of nevi and melanoma having braf mutations |
| EP1541695A1 (en) * | 2003-12-09 | 2005-06-15 | Nanogen Recognomics GmbH | Use of a mutation in the BRAF gene for the determination of the malignancy of melanoma cells |
| DE102004005885A1 (de) * | 2004-02-05 | 2005-10-13 | Rheinische Friedrich-Wilhelms-Universität Bonn | Mutierte DNA-Polymerasen mit erhöhter Fehlpaarungs-Diskriminierung |
| US20070020657A1 (en) * | 2005-05-20 | 2007-01-25 | Grebe Stefan K | Methods for detecting circulating tumor cells |
| UA95244C2 (ru) | 2005-06-22 | 2011-07-25 | Плексикон, Инк. | Соединения и способ модулирования активности киназ, и показания для их применения |
| JP2009077712A (ja) * | 2007-09-11 | 2009-04-16 | F Hoffmann La Roche Ag | Ｂ−Ｒａｆキナーゼ阻害剤に対する感受性についての診断試験 |
-
2008
- 2008-09-08 JP JP2008229396A patent/JP2009077712A/ja active Pending
- 2008-09-08 CA CA2639416A patent/CA2639416C/en active Active
- 2008-09-10 CN CN200810173745.2A patent/CN101418340B/zh active Active
- 2008-09-11 SI SI200831226T patent/SI2036990T1/sl unknown
- 2008-09-11 DK DK08015997.3T patent/DK2036990T3/da active
- 2008-09-11 EP EP08015997.3A patent/EP2036990B1/en active Active
- 2008-09-11 PL PL08015997T patent/PL2036990T3/pl unknown
- 2008-09-11 PT PT80159973T patent/PT2036990E/pt unknown
- 2008-09-11 ES ES08015997.3T patent/ES2471097T3/es active Active
-
2014
- 2014-06-26 HR HRP20140608AT patent/HRP20140608T1/hr unknown
-
2015
- 2015-05-01 JP JP2015094227A patent/JP6787651B2/ja active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009077712A5 (https=) | ||
| JP6448534B2 (ja) | ヒトｂｒａｆのコドン６００における一塩基多型（ｓｎｐ）を検出する方法 | |
| JP2012526563A5 (https=) | ||
| JP2013501523A5 (https=) | ||
| WO2008106453A3 (en) | Utility of b-raf dna mutation in diagnosis and treatment of cancer | |
| HRP20140608T1 (hr) | Dijagnostiäśko ispitivanje podložnosti na inhibitore b-raf kinaze | |
| JP2008529532A5 (https=) | ||
| CN104350161A (zh) | 用于核酸分子中的敏感突变检测的组合物和方法 | |
| JP2016509833A5 (https=) | ||
| WO2018095401A1 (zh) | 一种改进的ARMS引物结构(Super-ARMS)及其使用方法 | |
| JP2012503985A5 (https=) | ||
| JP6531312B2 (ja) | Ｂｃｒ−ａｂｌ阻害剤耐性関連変異の検出方法及びこれを用いたｂｃｒ−ａｂｌ阻害剤耐性を予測するためのデータ取得方法 | |
| WO2008018305A1 (fr) | Procédé de détection d'une variation et kit à utiliser avec celui-ci | |
| JP2014501533A (ja) | 突然変異解析 | |
| CN111349692A (zh) | 进行聚合酶链式反应的方法及其相关应用 | |
| JP2020521440A5 (https=) | ||
| CN102985562A (zh) | 鉴别多态性乙肝病毒和kras致癌基因突变及其临床应用 | |
| JP2013081450A (ja) | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用試薬キット | |
| Pinzani et al. | BRAFV600E detection in melanoma is highly improved by COLD-PCR | |
| JP2013090622A (ja) | 多型検出用プローブ、多型検出方法、薬効判定方法及び多型検出用キット | |
| JP5917144B2 (ja) | 疾患関連遺伝子の多型検出用プローブおよびその用途 | |
| CN102959091A (zh) | 高灵敏度的突变基因检测方法 | |
| JP2018512121A5 (https=) | ||
| Kim et al. | Estimation of Wilson's disease incidence and carrier frequency in the Korean population by screening ATP7B major mutations in newborn filter papers using the SYBR green intercalator method based on the amplification refractory mutation system | |
| KR101819937B1 (ko) | ＰＮＡ 기반의 실시간 ＰＣＲ 클램핑을 이용한 Ｋ-ｒａｓ 돌연변이 검출 방법 및 키트 |