JP2009055921A5 - - Google Patents
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- Publication number
- JP2009055921A5 JP2009055921A5 JP2008282154A JP2008282154A JP2009055921A5 JP 2009055921 A5 JP2009055921 A5 JP 2009055921A5 JP 2008282154 A JP2008282154 A JP 2008282154A JP 2008282154 A JP2008282154 A JP 2008282154A JP 2009055921 A5 JP2009055921 A5 JP 2009055921A5
- Authority
- JP
- Japan
- Prior art keywords
- pns scp
- seq
- cell
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 230000000694 effects Effects 0.000 claims 5
- 210000003527 eukaryotic cell Anatomy 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 3
- 210000004978 chinese hamster ovary cell Anatomy 0.000 claims 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims 1
- 101710172814 Sodium channel protein Proteins 0.000 claims 1
- 241000269370 Xenopus <genus> Species 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
- ZRALSGWEFCBTJO-UHFFFAOYSA-O guanidinium Chemical compound NC(N)=[NH2+] ZRALSGWEFCBTJO-UHFFFAOYSA-O 0.000 claims 1
- 150000002500 ions Chemical class 0.000 claims 1
- 210000004498 neuroglial cell Anatomy 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 210000000287 oocyte Anatomy 0.000 claims 1
- 210000001428 peripheral nervous system Anatomy 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33402994A | 1994-11-02 | 1994-11-02 | |
| US48240195A | 1995-06-07 | 1995-06-07 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006356815A Division JP2007169286A (ja) | 1994-11-02 | 2006-12-29 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2009055921A JP2009055921A (ja) | 2009-03-19 |
| JP2009055921A5 true JP2009055921A5 (enExample) | 2010-03-25 |
Family
ID=26989015
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8515424A Withdrawn JP2000503521A (ja) | 1994-11-02 | 1995-11-02 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2002143880A Pending JP2003047484A (ja) | 1994-11-02 | 2002-05-17 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2006356815A Pending JP2007169286A (ja) | 1994-11-02 | 2006-12-29 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2008282154A Pending JP2009055921A (ja) | 1994-11-02 | 2008-10-31 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2008282171A Pending JP2009118844A (ja) | 1994-11-02 | 2008-10-31 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP8515424A Withdrawn JP2000503521A (ja) | 1994-11-02 | 1995-11-02 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2002143880A Pending JP2003047484A (ja) | 1994-11-02 | 2002-05-17 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
| JP2006356815A Pending JP2007169286A (ja) | 1994-11-02 | 2006-12-29 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008282171A Pending JP2009118844A (ja) | 1994-11-02 | 2008-10-31 | 末梢神経系特異的ナトリウムチャンネル、それをコードするｄｎａ、結晶化、ｘ線回折、コンピューター分子モデリング、合理的薬物設計、薬物スクリーニング、ならびにその製造法および使用法 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US6110672A (enExample) |
| EP (2) | EP0789575B8 (enExample) |
| JP (5) | JP2000503521A (enExample) |
| AT (1) | ATE407207T1 (enExample) |
| AU (1) | AU697465B2 (enExample) |
| CA (1) | CA2204355C (enExample) |
| DE (1) | DE69535830D1 (enExample) |
| DK (1) | DK0789575T3 (enExample) |
| ES (1) | ES2314978T3 (enExample) |
| MX (1) | MX9703187A (enExample) |
| NZ (1) | NZ296748A (enExample) |
| PT (1) | PT789575E (enExample) |
| WO (1) | WO1996014077A1 (enExample) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK0789575T3 (da) | 1994-11-02 | 2009-01-12 | Nps Pharma Inc | Perifer-nerve-system-specifikke natriumkanaler, DNA kodende derfor, screening af lægemidler og fremgangsmåder til fremstilling og anvendelse deraf |
| US6184349B1 (en) | 1995-10-11 | 2001-02-06 | Syntex (Usa) Inc. | Cloned peripheral nerve, tetrodotoxin-resistant sodium channel α-subunit |
| US6030810A (en) | 1997-02-26 | 2000-02-29 | Delgado; Stephen Gregory | Cloned tetrodotoxin-sensitive sodium channel α-subunit and a splice variant thereof |
| EP0875570A3 (en) * | 1997-05-01 | 1999-12-22 | Smithkline Beecham Plc | Neurodegenerative polypeptides HHPDZ65 |
| CH693031A5 (de) * | 1997-11-20 | 2003-01-31 | Hoffmann La Roche | Nucleinsäure, die einen Nervengewebe-Natriumkanal kodiert. |
| AU3908700A (en) * | 1999-03-26 | 2000-10-16 | Human Genome Sciences, Inc. | 48 human secreted proteins |
| US7083777B1 (en) * | 1999-04-02 | 2006-08-01 | The Brigham And Women's Hospital, Inc. | Immunomodulating polymers |
| EP2112234A3 (en) | 1999-11-26 | 2010-06-16 | McGill University | Loci for idiopathic generalized epilepsy, mutations thereof and method using same to assess, diagnose, prognose or treat epilepsy |
| AU2001273888A1 (en) * | 2000-07-05 | 2002-01-14 | Neurosearch A/S | New sodium channel (rnav1.5a) and use thereof |
| GB0021617D0 (en) * | 2000-09-02 | 2000-10-18 | Imp College Innovations Ltd | Diagnosis and treatment of cancer |
| WO2002024722A2 (en) * | 2000-09-19 | 2002-03-28 | Prochon Biotech Ltd. | Crystalline fgf9 dimer and methods of use |
| DE10054878A1 (de) * | 2000-11-06 | 2002-05-08 | Boehringer Ingelheim Int | Natriumkanäle vom Typus der peripheren Nerven |
| SV2003000753A (es) | 2000-12-05 | 2003-06-16 | Brigham & Womens Hospital | Uso de polisacaridos zwitterionicos para la especifica modulacion del progreso inmunologico |
| WO2003060525A1 (en) * | 2002-01-17 | 2003-07-24 | Evotec Neurosciences Gmbh | Diagnostic and therapeutic use of the voltage-gated ion channel scn2a for neurodegenerative diseases |
| US7659082B2 (en) * | 2002-02-19 | 2010-02-09 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
| US9278088B2 (en) | 2002-02-19 | 2016-03-08 | Xenon Pharmaceuticals Inc. | Methods for identifying analgesic agents |
| AU2003219933A1 (en) | 2002-02-25 | 2003-09-09 | Vanderbilt University | Expression system for human brain-specific voltage-gated sodium channel, type 1 |
| AU2003297693A1 (en) * | 2002-12-04 | 2004-06-23 | Euro-Celtique S.A. | Splice variant of human sodium iii channel (hnaiii18) |
| EP1638581A2 (en) * | 2003-03-31 | 2006-03-29 | The Brigham And Women's Hospital, Inc. | Zwitterionic immunomodulators for the treatment of asthma and allergy |
| AU2005207002B2 (en) * | 2004-01-21 | 2011-03-17 | University Of Utah Research Foundation | Mutant sodium channel Nav1.7 and methods related thereto |
| WO2005076981A2 (en) * | 2004-02-05 | 2005-08-25 | Board Of Regents, The University Of Texas System | Methods and compositions related to neuronal differentiation |
| US7485468B2 (en) | 2004-10-15 | 2009-02-03 | Galapagos Bv | Molecular targets and compounds, and methods to identify the same, useful in the treatment of joint degenerative and inflammatory diseases |
| WO2007092451A2 (en) | 2006-02-06 | 2007-08-16 | The Brigham And Women's Hospital, Inc. | Zwitterionic polysaccharides for promotion of immune system maturation and health |
| JP2010529173A (ja) * | 2007-06-14 | 2010-08-26 | ハマースミス・イメイネット・リミテッド | 神経活性の測定 |
| US20120283116A1 (en) | 2009-09-11 | 2012-11-08 | Leppert Mark F | Mutant Sodium Channel Nav1.7 and Methods Related Thereto |
| US9539281B2 (en) | 2011-07-12 | 2017-01-10 | The Brigham And Women's Hospital, Inc. | Lipid-containing PSA compositions, methods of isolation and methods of use thereof |
| CN113637040A (zh) | 2015-08-19 | 2021-11-12 | 哈佛学院院长及董事 | 脂化psa组合物和方法 |
| CA3030974A1 (en) | 2016-07-15 | 2018-01-18 | President And Fellows Of Harvard College | Glycolipid compositions and methods of use |
| WO2024216284A2 (en) * | 2023-04-13 | 2024-10-17 | The Medical College Of Wisconsin, Inc. | Voltage gated sodium channel-specific peptide aptamers and uses thereof |
Family Cites Families (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL137318C (enExample) | 1964-06-09 | |||
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| US4500530A (en) * | 1980-11-26 | 1985-02-19 | Boucher John H | Method of treating horses to inhibit or reduce increases in crenated red blood cells during exercise |
| US4405712A (en) | 1981-07-01 | 1983-09-20 | The United States Of America As Represented By The Department Of Health And Human Services | LTR-Vectors |
| NZ201918A (en) | 1981-09-18 | 1987-04-30 | Genentech Inc | N-terminal methionyl analogues of bovine growth hormone |
| US4656134A (en) | 1982-01-11 | 1987-04-07 | Board Of Trustees Of Leland Stanford Jr. University | Gene amplification in eukaryotic cells |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| US4699880A (en) | 1984-09-25 | 1987-10-13 | Immunomedics, Inc. | Method of producing monoclonal anti-idiotype antibody |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US4965188A (en) | 1986-08-22 | 1990-10-23 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme |
| US4766067A (en) | 1985-05-31 | 1988-08-23 | President And Fellows Of Harvard College | Gene amplification |
| AU606320B2 (en) | 1985-11-01 | 1991-02-07 | International Genetic Engineering, Inc. | Modular assembly of antibody genes, antibodies prepared thereby and use |
| GB8601597D0 (en) | 1986-01-23 | 1986-02-26 | Wilson R H | Nucleotide sequences |
| US4800159A (en) | 1986-02-07 | 1989-01-24 | Cetus Corporation | Process for amplifying, detecting, and/or cloning nucleic acid sequences |
| US5322770A (en) | 1989-12-22 | 1994-06-21 | Hoffman-Laroche Inc. | Reverse transcription with thermostable DNA polymerases - high temperature reverse transcription |
| US4889818A (en) | 1986-08-22 | 1989-12-26 | Cetus Corporation | Purified thermostable enzyme |
| US4921794A (en) | 1987-01-14 | 1990-05-01 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US4795699A (en) | 1987-01-14 | 1989-01-03 | President And Fellows Of Harvard College | T7 DNA polymerase |
| US5130238A (en) | 1988-06-24 | 1992-07-14 | Cangene Corporation | Enhanced nucleic acid amplification process |
| US5091310A (en) | 1988-09-23 | 1992-02-25 | Cetus Corporation | Structure-independent dna amplification by the polymerase chain reaction |
| US5066584A (en) | 1988-09-23 | 1991-11-19 | Cetus Corporation | Methods for generating single stranded dna by the polymerase chain reaction |
| US5142033A (en) | 1988-09-23 | 1992-08-25 | Hoffmann-La Roche Inc. | Structure-independent DNA amplification by the polymerase chain reaction |
| US5082670A (en) | 1988-12-15 | 1992-01-21 | The Regents Of The University Of California | Method of grafting genetically modified cells to treat defects, disease or damage or the central nervous system |
| US4994370A (en) | 1989-01-03 | 1991-02-19 | The United States Of America As Represented By The Department Of Health And Human Services | DNA amplification technique |
| WO1990009441A1 (en) | 1989-02-01 | 1990-08-23 | The General Hospital Corporation | Herpes simplex virus type i expression vector |
| WO1990009391A1 (en) * | 1989-02-13 | 1990-08-23 | Arch Development Corporation | Nucleic acid encoding sodium channel protein |
| US5380836A (en) * | 1989-02-13 | 1995-01-10 | Arch Development Corporation | Nucleic acid encoding sodium channel protein |
| EP0445749B1 (en) * | 1990-03-08 | 1996-07-10 | Fujisawa Pharmaceutical Co., Ltd. | N-Monosubstituted cyclopentenylamines, a process for their preparation and their use as medicaments |
| IE911869A1 (en) | 1990-06-01 | 1991-12-04 | Regeneron Pharma | A family of map2 protein kinases |
| DK0550687T3 (da) | 1990-09-28 | 1999-12-13 | Hoffmann La Roche | 5' til 3'-exonukleasemutationer af termostabile DNA-polymeraser |
| WO1992006693A1 (en) | 1990-10-22 | 1992-04-30 | Fox Chase Cancer Center | Dna construct for providing rna therapy |
| WO1993003743A1 (en) | 1991-08-16 | 1993-03-04 | The General Hospital Corporation | Method of gene delivery to post-mitotic cells |
| US5356777A (en) * | 1992-10-01 | 1994-10-18 | University Of Pittsburgh | Methods of detecting periodic paralysis in horses |
| US5338671A (en) | 1992-10-07 | 1994-08-16 | Eastman Kodak Company | DNA amplification with thermostable DNA polymerase and polymerase inhibiting antibody |
| US5340728A (en) | 1992-12-09 | 1994-08-23 | E. I. Du Pont De Nemours And Company | Method for amplification of targeted segments of nucleic acid using nested polymerase chain reaction |
| WO1994014978A1 (de) | 1992-12-18 | 1994-07-07 | Strack Hans B | Verbesserte ausbeuten von pcr-produkten in gegenwart von dna-einzelstrang bindendem protein und dessen präparation aus thermus flavus |
| DK0789575T3 (da) | 1994-11-02 | 2009-01-12 | Nps Pharma Inc | Perifer-nerve-system-specifikke natriumkanaler, DNA kodende derfor, screening af lægemidler og fremgangsmåder til fremstilling og anvendelse deraf |
-
1995
- 1995-11-02 DK DK95939723T patent/DK0789575T3/da active
- 1995-11-02 WO PCT/US1995/014251 patent/WO1996014077A1/en not_active Ceased
- 1995-11-02 EP EP95939723A patent/EP0789575B8/en not_active Revoked
- 1995-11-02 DE DE69535830T patent/DE69535830D1/de not_active Expired - Lifetime
- 1995-11-02 NZ NZ296748A patent/NZ296748A/xx not_active IP Right Cessation
- 1995-11-02 MX MX9703187A patent/MX9703187A/es unknown
- 1995-11-02 EP EP08102871A patent/EP1985703A3/en not_active Withdrawn
- 1995-11-02 AT AT95939723T patent/ATE407207T1/de active
- 1995-11-02 PT PT95939723T patent/PT789575E/pt unknown
- 1995-11-02 JP JP8515424A patent/JP2000503521A/ja not_active Withdrawn
- 1995-11-02 US US08/836,325 patent/US6110672A/en not_active Expired - Lifetime
- 1995-11-02 ES ES95939723T patent/ES2314978T3/es not_active Expired - Lifetime
- 1995-11-02 AU AU41434/96A patent/AU697465B2/en not_active Ceased
- 1995-11-02 CA CA002204355A patent/CA2204355C/en not_active Expired - Fee Related
-
1999
- 1999-12-09 US US09/457,571 patent/US6703486B2/en not_active Expired - Fee Related
-
2002
- 2002-05-17 JP JP2002143880A patent/JP2003047484A/ja active Pending
-
2004
- 2004-01-29 US US10/768,798 patent/US20040229792A1/en not_active Abandoned
-
2006
- 2006-12-29 JP JP2006356815A patent/JP2007169286A/ja active Pending
-
2007
- 2007-06-06 US US11/810,919 patent/US8012748B2/en not_active Expired - Fee Related
- 2007-06-06 US US11/810,882 patent/US20090029415A1/en not_active Abandoned
-
2008
- 2008-10-31 JP JP2008282154A patent/JP2009055921A/ja active Pending
- 2008-10-31 JP JP2008282171A patent/JP2009118844A/ja active Pending
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