JP2008543780A5 - - Google Patents

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Publication number

JP2008543780A5

JP2008543780A5 JP2008515997A JP2008515997A JP2008543780A5 JP 2008543780 A5 JP2008543780 A5 JP 2008543780A5 JP 2008515997 A JP2008515997 A JP 2008515997A JP 2008515997 A JP2008515997 A JP 2008515997A JP 2008543780 A5 JP2008543780 A5 JP 2008543780A5

Authority

JP

Japan

Prior art keywords

trifluoro

indazol

fluorophenyl

propan

phenyl

Prior art date

2006-06-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

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• -1 methoxy, amino Chemical group 0.000 claims 45
• 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 38
• 125000001424 substituent group Chemical group 0.000 claims 26
• 239000005973 Carvone Substances 0.000 claims 17
• 229910052736 halogen Inorganic materials 0.000 claims 17
• 150000002367 halogens Chemical class 0.000 claims 17
• 239000002253 acid Substances 0.000 claims 16
• 229910052757 nitrogen Inorganic materials 0.000 claims 16
• 125000001072 heteroaryl group Chemical group 0.000 claims 15
• 150000003457 sulfones Chemical class 0.000 claims 15
• 150000003462 sulfoxides Chemical class 0.000 claims 15
• 229910052717 sulfur Inorganic materials 0.000 claims 15
• 125000004434 sulfur atom Chemical group 0.000 claims 15
• 125000000623 heterocyclic group Chemical group 0.000 claims 14
• 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 14
• 125000004433 nitrogen atom Chemical group N* 0.000 claims 14
• 125000004043 oxo group Chemical group O=* 0.000 claims 14
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 14
• 125000004093 cyano group Chemical group *C#N 0.000 claims 13
• 125000003118 aryl group Chemical group 0.000 claims 12
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 12
• 125000002252 acyl group Chemical group 0.000 claims 10
• 125000000753 cycloalkyl group Chemical group 0.000 claims 10
• 239000000651 prodrug Substances 0.000 claims 9
• 229940002612 prodrug Drugs 0.000 claims 9
• 150000003839 salts Chemical class 0.000 claims 9
• 239000012453 solvate Substances 0.000 claims 9
• 125000004457 alkyl amino carbonyl group Chemical group 0.000 claims 8
• 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 8
• 125000004104 aryloxy group Chemical group 0.000 claims 8
• 150000001875 compounds Chemical class 0.000 claims 8
• 125000000392 cycloalkenyl group Chemical group 0.000 claims 8
• 125000004473 dialkylaminocarbonyl group Chemical group 0.000 claims 8
• 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims 7
• 125000006726 (C1-C5) alkenyl group Chemical group 0.000 claims 6
• 150000004702 methyl esters Chemical class 0.000 claims 6
• 125000000217 alkyl group Chemical group 0.000 claims 5
• UWYZHKAOTLEWKK-UHFFFAOYSA-N 1,2,3,4-tetrahydroisoquinoline Chemical compound C1=CC=C2CNCCC2=C1 UWYZHKAOTLEWKK-UHFFFAOYSA-N 0.000 claims 4
• LBUJPTNKIBCYBY-UHFFFAOYSA-N 1,2,3,4-tetrahydroquinoline Chemical compound C1=CC=C2CCCNC2=C1 LBUJPTNKIBCYBY-UHFFFAOYSA-N 0.000 claims 4
• FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 claims 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 4
• SIKJAQJRHWYJAI-UHFFFAOYSA-N Indole Chemical compound C1=CC=C2NC=CC2=C1 SIKJAQJRHWYJAI-UHFFFAOYSA-N 0.000 claims 4
• SMWDFEZZVXVKRB-UHFFFAOYSA-N Quinoline Chemical compound N1=CC=CC2=CC=CC=C21 SMWDFEZZVXVKRB-UHFFFAOYSA-N 0.000 claims 4
• 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 4
• 125000003435 aroyl group Chemical group 0.000 claims 4
• 229910052739 hydrogen Inorganic materials 0.000 claims 4
• 239000001257 hydrogen Substances 0.000 claims 4
• AWJUIBRHMBBTKR-UHFFFAOYSA-N isoquinoline Chemical compound C1=NC=CC2=CC=CC=C21 AWJUIBRHMBBTKR-UHFFFAOYSA-N 0.000 claims 4
• 239000008194 pharmaceutical composition Substances 0.000 claims 4
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 3
• 125000004494 ethyl ester group Chemical group 0.000 claims 3
• DLFVBJFMPXGRIB-UHFFFAOYSA-N thioacetamide Natural products CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 3
• KHODLLKHOGMTPD-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-(2,3,6-trifluorophenoxy)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=C(F)C=CC(F)=C1F KHODLLKHOGMTPD-UHFFFAOYSA-N 0.000 claims 2
• DKVCFMNGGAGTMS-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-(2,4,6-trichlorophenoxy)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=C(Cl)C=C(Cl)C=C1Cl DKVCFMNGGAGTMS-UHFFFAOYSA-N 0.000 claims 2
• HQIRVEZFZJAXIH-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-(2,4,6-trimethylphenoxy)propan-2-ol Chemical compound CC1=CC(C)=CC(C)=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 HQIRVEZFZJAXIH-UHFFFAOYSA-N 0.000 claims 2
• YXHFTMOFRWQUSB-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-[2-(trifluoromethyl)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC=C1C(F)(F)F YXHFTMOFRWQUSB-UHFFFAOYSA-N 0.000 claims 2
• YNZUOKZWFXXVOD-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-[3-(trifluoromethyl)phenyl]sulfanylpropan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=CC(C(F)(F)F)=C1 YNZUOKZWFXXVOD-UHFFFAOYSA-N 0.000 claims 2
• FQLNAHBZANJHMK-UHFFFAOYSA-N 1,1,1-trifluoro-2-(1-phenylindazol-5-yl)-3-pyridin-2-ylsulfanylpropan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=CC=N1 FQLNAHBZANJHMK-UHFFFAOYSA-N 0.000 claims 2
• XZNHEXNAEKYPDZ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(2,4,6-trimethylanilino)propan-2-ol Chemical compound CC1=CC(C)=CC(C)=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 XZNHEXNAEKYPDZ-UHFFFAOYSA-N 0.000 claims 2
• ABOIXWKMTCPJAL-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(2-methylanilino)propan-2-ol Chemical compound CC1=CC=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 ABOIXWKMTCPJAL-UHFFFAOYSA-N 0.000 claims 2
• OMHCGUBOJFKWLY-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(3-methylanilino)propan-2-ol Chemical compound CC1=CC=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 OMHCGUBOJFKWLY-UHFFFAOYSA-N 0.000 claims 2
• LBJRIPBEOJCKPM-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-methylsulfanylanilino)propan-2-ol Chemical compound C1=CC(SC)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 LBJRIPBEOJCKPM-UHFFFAOYSA-N 0.000 claims 2
• BFOULVJPUNHLFN-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5-nitroindol-1-yl)propan-2-ol Chemical compound C1=CC2=CC([N+]([O-])=O)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BFOULVJPUNHLFN-UHFFFAOYSA-N 0.000 claims 2
• YAIBHJIMNDKMEN-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(6-methoxyindol-1-yl)propan-2-ol Chemical compound C12=CC(OC)=CC=C2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YAIBHJIMNDKMEN-UHFFFAOYSA-N 0.000 claims 2
• IBERHYAYFNVFMN-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(7-nitroindol-1-yl)propan-2-ol Chemical compound C1=CC2=CC=CC([N+]([O-])=O)=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IBERHYAYFNVFMN-UHFFFAOYSA-N 0.000 claims 2
• HWCNTNKBNJUYSL-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[(2-methylquinolin-8-yl)amino]propan-2-ol Chemical compound C12=NC(C)=CC=C2C=CC=C1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HWCNTNKBNJUYSL-UHFFFAOYSA-N 0.000 claims 2
• IQEAXBDMAFGEEO-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[6-(trifluoromethyl)indol-1-yl]propan-2-ol Chemical compound C1=CC2=CC=C(C(F)(F)F)C=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IQEAXBDMAFGEEO-UHFFFAOYSA-N 0.000 claims 2
• HAAGSHGNYBAKSW-UHFFFAOYSA-N 1,1,1-trifluoro-3-(4-fluoroindol-1-yl)-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=C(F)C=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HAAGSHGNYBAKSW-UHFFFAOYSA-N 0.000 claims 2
• GKYPCDNFOIMHSA-UHFFFAOYSA-N 1,1,1-trifluoro-3-(5-fluoroindol-1-yl)-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC(F)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 GKYPCDNFOIMHSA-UHFFFAOYSA-N 0.000 claims 2
• YMCMJGZBRWJYRY-UHFFFAOYSA-N 1,1,1-trifluoro-3-(7-fluoroindol-1-yl)-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC=CC(F)=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YMCMJGZBRWJYRY-UHFFFAOYSA-N 0.000 claims 2
• FTNJQNQLEGKTGD-UHFFFAOYSA-N 1,3-benzodioxole Chemical compound C1=CC=C2OCOC2=C1 FTNJQNQLEGKTGD-UHFFFAOYSA-N 0.000 claims 2
• ZZHGHWKXQKMSRJ-UHFFFAOYSA-N 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-6-carbonitrile Chemical compound C1=CC2=CC=C(C#N)C=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZZHGHWKXQKMSRJ-UHFFFAOYSA-N 0.000 claims 2
• BAXOFTOLAUCFNW-UHFFFAOYSA-N 1H-indazole Chemical compound C1=CC=C2C=NNC2=C1 BAXOFTOLAUCFNW-UHFFFAOYSA-N 0.000 claims 2
• MYGAUECXBHJHHA-UHFFFAOYSA-N 2,2,2-trifluoro-1-(3-fluoro-4-methylphenyl)-1-(1-phenylindazol-5-yl)ethanol Chemical compound C1=C(F)C(C)=CC=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 MYGAUECXBHJHHA-UHFFFAOYSA-N 0.000 claims 2
• WBSHYGBWZGYONQ-UHFFFAOYSA-N 2-[5-methoxy-1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indol-3-yl]acetonitrile Chemical compound C1=C(CC#N)C2=CC(OC)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WBSHYGBWZGYONQ-UHFFFAOYSA-N 0.000 claims 2
• 125000004200 2-methoxyethyl group Chemical group [H]C([H])([H])OC([H])([H])C([H])([H])* 0.000 claims 2
• CQXXTVYPCUTNRE-UHFFFAOYSA-N 2-n-ethyl-1-n-methylbenzene-1,2-diamine Chemical compound CCNC1=CC=CC=C1NC CQXXTVYPCUTNRE-UHFFFAOYSA-N 0.000 claims 2
• YRLORWPBJZEGBX-UHFFFAOYSA-N 3,4-dihydro-2h-1,4-benzoxazine Chemical compound C1=CC=C2NCCOC2=C1 YRLORWPBJZEGBX-UHFFFAOYSA-N 0.000 claims 2
• AGNAWHARCORCTN-UHFFFAOYSA-N 3-(2,5-dimethylindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC2=CC(C)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AGNAWHARCORCTN-UHFFFAOYSA-N 0.000 claims 2
• AIYLAKIFIBCKCH-UHFFFAOYSA-N 3-(2,6-dichlorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=C(Cl)C=CC=C1Cl AIYLAKIFIBCKCH-UHFFFAOYSA-N 0.000 claims 2
• UAQFKAJQXLVJTD-UHFFFAOYSA-N 3-(2,6-dimethylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC=CC(C)=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UAQFKAJQXLVJTD-UHFFFAOYSA-N 0.000 claims 2
• HRHWAQZUQXDLKQ-UHFFFAOYSA-N 3-(2-chloro-3,5-difluorophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC(F)=CC(F)=C1Cl HRHWAQZUQXDLKQ-UHFFFAOYSA-N 0.000 claims 2
• PQFCZPZBPWRJOE-UHFFFAOYSA-N 3-(3-bromoanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=CC(Br)=C1 PQFCZPZBPWRJOE-UHFFFAOYSA-N 0.000 claims 2
• LYUKSXXZNUACKY-UHFFFAOYSA-N 3-(3-chloroanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=CC(Cl)=C1 LYUKSXXZNUACKY-UHFFFAOYSA-N 0.000 claims 2
• CQMXTEPEXKTHKS-UHFFFAOYSA-N 3-(4-bromoindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=C(Br)C=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 CQMXTEPEXKTHKS-UHFFFAOYSA-N 0.000 claims 2
• ABAQIVQTPSJFPJ-UHFFFAOYSA-N 3-(4-bromophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Br)C=C1 ABAQIVQTPSJFPJ-UHFFFAOYSA-N 0.000 claims 2
• DJHBRNZUUSSZAD-UHFFFAOYSA-N 3-(4-chloroanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=C(Cl)C=C1 DJHBRNZUUSSZAD-UHFFFAOYSA-N 0.000 claims 2
• RMTJIDDNAKVALU-UHFFFAOYSA-N 3-(4-chloroindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=C(Cl)C=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RMTJIDDNAKVALU-UHFFFAOYSA-N 0.000 claims 2
• RSAKTFHJGXRWRU-UHFFFAOYSA-N 3-(5-chloro-2-methylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC=C(Cl)C=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 RSAKTFHJGXRWRU-UHFFFAOYSA-N 0.000 claims 2
• CVLMYXVNXXSSFC-UHFFFAOYSA-N 3-(6-bromoindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC=C(Br)C=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 CVLMYXVNXXSSFC-UHFFFAOYSA-N 0.000 claims 2
• KROICDVPYQJXJU-UHFFFAOYSA-N 3-(6-chloroindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC=C(Cl)C=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KROICDVPYQJXJU-UHFFFAOYSA-N 0.000 claims 2
• GVBRYFXGUUUMQJ-UHFFFAOYSA-N 3-(7-bromoindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC=CC(Br)=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 GVBRYFXGUUUMQJ-UHFFFAOYSA-N 0.000 claims 2
• PMTGJEGONAEXRK-UHFFFAOYSA-N 3-(7-chloroindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC=CC(Cl)=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PMTGJEGONAEXRK-UHFFFAOYSA-N 0.000 claims 2
• URFFXVSAOWPILN-UHFFFAOYSA-N 3-(7-ethylindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=2C(CC)=CC=CC=2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 URFFXVSAOWPILN-UHFFFAOYSA-N 0.000 claims 2
• WLWIIKIEYRTFQR-UHFFFAOYSA-N 3-[(4-chloronaphthalen-1-yl)amino]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C(Cl)C2=CC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WLWIIKIEYRTFQR-UHFFFAOYSA-N 0.000 claims 2
• XBBXVUDOTQXPJU-UHFFFAOYSA-N 3-[3-[(dimethylamino)methyl]-5-methoxyindol-1-yl]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=C(CN(C)C)C2=CC(OC)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 XBBXVUDOTQXPJU-UHFFFAOYSA-N 0.000 claims 2
• VGCNKQRIISGXHN-UHFFFAOYSA-N 3-[3-[(dimethylamino)methyl]-6-methoxyindol-1-yl]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C12=CC(OC)=CC=C2C(CN(C)C)=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VGCNKQRIISGXHN-UHFFFAOYSA-N 0.000 claims 2
• JFFXFALPAKDYDG-UHFFFAOYSA-N 3-[3-[2,2,2-trifluoro-1-hydroxy-1-[1-(4-methylphenyl)indazol-5-yl]ethyl]indol-1-yl]propane-1,2-diol Chemical compound C1=CC(C)=CC=C1N1C2=CC=C(C(O)(C=3C4=CC=CC=C4N(CC(O)CO)C=3)C(F)(F)F)C=C2C=N1 JFFXFALPAKDYDG-UHFFFAOYSA-N 0.000 claims 2
• PCQJSOPOXGKIAV-UHFFFAOYSA-N 4-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(C#N)C=C1 PCQJSOPOXGKIAV-UHFFFAOYSA-N 0.000 claims 2
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Natural products CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 2
• 102000003676 Glucocorticoid Receptors Human genes 0.000 claims 2
• 108090000079 Glucocorticoid Receptors Proteins 0.000 claims 2
• 125000000066 S-methyl group Chemical group [H]C([H])([H])S* 0.000 claims 2
• RFRXIWQYSOIBDI-UHFFFAOYSA-N benzarone Chemical compound CCC=1OC2=CC=CC=C2C=1C(=O)C1=CC=C(O)C=C1 RFRXIWQYSOIBDI-UHFFFAOYSA-N 0.000 claims 2
• JFDZBHWFFUWGJE-UHFFFAOYSA-N benzenecarbonitrile Natural products N#CC1=CC=CC=C1 JFDZBHWFFUWGJE-UHFFFAOYSA-N 0.000 claims 2
• BNBQRQQYDMDJAH-UHFFFAOYSA-N benzodioxan Chemical compound C1=CC=C2OCCOC2=C1 BNBQRQQYDMDJAH-UHFFFAOYSA-N 0.000 claims 2
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
• 239000003937 drug carrier Substances 0.000 claims 2
• 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 claims 2
• PZOUSPYUWWUPPK-UHFFFAOYSA-N indole Natural products CC1=CC=CC2=C1C=CN2 PZOUSPYUWWUPPK-UHFFFAOYSA-N 0.000 claims 2
• RKJUIXBNRJVNHR-UHFFFAOYSA-N indolenine Natural products C1=CC=C2CC=NC2=C1 RKJUIXBNRJVNHR-UHFFFAOYSA-N 0.000 claims 2
• OMRAHPYTEIIFMH-UHFFFAOYSA-N methyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-3-carboxylate Chemical compound C12=CC=CC=C2C(C(=O)OC)=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OMRAHPYTEIIFMH-UHFFFAOYSA-N 0.000 claims 2
• FFWWFYMSSUQXKC-UHFFFAOYSA-N methyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-4-carboxylate Chemical compound C1=CC=2C(C(=O)OC)=CC=CC=2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FFWWFYMSSUQXKC-UHFFFAOYSA-N 0.000 claims 2
• UBNVYHUBUSBCAB-UHFFFAOYSA-N methyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-5-carboxylate Chemical compound C1=CC2=CC(C(=O)OC)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UBNVYHUBUSBCAB-UHFFFAOYSA-N 0.000 claims 2
• QXGKOLLGBSZAHA-UHFFFAOYSA-N methyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-6-carboxylate Chemical compound C12=CC(C(=O)OC)=CC=C2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 QXGKOLLGBSZAHA-UHFFFAOYSA-N 0.000 claims 2
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
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• 125000001624 naphthyl group Chemical group 0.000 claims 2
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• 239000000546 pharmaceutical excipient Substances 0.000 claims 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
• 125000004455 (C1-C3) alkylthio group Chemical group 0.000 claims 1
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• YNBFFVFYFIVIRS-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(2-phenylanilino)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=CC=C1C1=CC=CC=C1 YNBFFVFYFIVIRS-UHFFFAOYSA-N 0.000 claims 1
• HJDNPYQIBKMRIF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(2-phenylindol-1-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CN(C1=CC=CC=C1C=1)C=1C1=CC=CC=C1 HJDNPYQIBKMRIF-UHFFFAOYSA-N 0.000 claims 1
• WNKOVVVCSDJIDE-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(3-methoxyanilino)propan-2-ol Chemical compound COC1=CC=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 WNKOVVVCSDJIDE-UHFFFAOYSA-N 0.000 claims 1
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• KBKVQQIHNVSMOF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-methoxyanilino)propan-2-ol Chemical compound C1=CC(OC)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 KBKVQQIHNVSMOF-UHFFFAOYSA-N 0.000 claims 1
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• QYEUHQSNIDUPKV-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-methylanilino)propan-2-ol Chemical compound C1=CC(C)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 QYEUHQSNIDUPKV-UHFFFAOYSA-N 0.000 claims 1
• OCCVNRBROFYMLF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-methylindol-1-yl)propan-2-ol Chemical compound C1=CC=2C(C)=CC=CC=2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OCCVNRBROFYMLF-UHFFFAOYSA-N 0.000 claims 1
• BEROEOGKHAWPLD-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-methylphenoxy)propan-2-ol Chemical compound C1=CC(C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 BEROEOGKHAWPLD-UHFFFAOYSA-N 0.000 claims 1
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• IOFOBIFZGNCDDF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-nitroindol-1-yl)propan-2-ol Chemical compound C1=CC2=C([N+]([O-])=O)C=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IOFOBIFZGNCDDF-UHFFFAOYSA-N 0.000 claims 1
• HZBRXNBKDBCRKY-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-phenoxyanilino)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC(C=C1)=CC=C1OC1=CC=CC=C1 HZBRXNBKDBCRKY-UHFFFAOYSA-N 0.000 claims 1
• DHGPXGSHJTUMID-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-phenylanilino)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC(C=C1)=CC=C1C1=CC=CC=C1 DHGPXGSHJTUMID-UHFFFAOYSA-N 0.000 claims 1
• LOKYFZFSZRJCPE-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-phenylmethoxyindol-1-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CN(C1=CC=C2)C=CC1=C2OCC1=CC=CC=C1 LOKYFZFSZRJCPE-UHFFFAOYSA-N 0.000 claims 1
• ZOPGWKLNBKQOOZ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(4-propan-2-ylanilino)propan-2-ol Chemical compound C1=CC(C(C)C)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 ZOPGWKLNBKQOOZ-UHFFFAOYSA-N 0.000 claims 1
• ZIHIAOUXDCMKAQ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5,6,7,8-tetrahydronaphthalen-1-ylamino)propan-2-ol Chemical compound C=1C=CC=2CCCCC=2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZIHIAOUXDCMKAQ-UHFFFAOYSA-N 0.000 claims 1
• BIHSNSMJQAFRTE-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5,6,7,8-tetrahydronaphthalen-1-yloxy)propan-2-ol Chemical compound C=1C=CC=2CCCCC=2C=1OCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BIHSNSMJQAFRTE-UHFFFAOYSA-N 0.000 claims 1
• VEXVWGGVSNVHFY-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5,6,7,8-tetrahydronaphthalen-2-yloxy)propan-2-ol Chemical compound C=1C=C2CCCCC2=CC=1OCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VEXVWGGVSNVHFY-UHFFFAOYSA-N 0.000 claims 1
• JZGZOYDRHAYQHQ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5-methoxyindol-1-yl)propan-2-ol Chemical compound C1=CC2=CC(OC)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 JZGZOYDRHAYQHQ-UHFFFAOYSA-N 0.000 claims 1
• PVNLOCSHSJWTMN-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(5-methylindol-1-yl)propan-2-ol Chemical compound C1=CC2=CC(C)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PVNLOCSHSJWTMN-UHFFFAOYSA-N 0.000 claims 1
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• NIHFWQJSLBEZEE-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(6-methoxynaphthalen-2-yl)oxypropan-2-ol Chemical compound C1=CC2=CC(OC)=CC=C2C=C1OCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NIHFWQJSLBEZEE-UHFFFAOYSA-N 0.000 claims 1
• AVJUAXAFRMTMSK-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(6-methylindol-1-yl)propan-2-ol Chemical compound C12=CC(C)=CC=C2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AVJUAXAFRMTMSK-UHFFFAOYSA-N 0.000 claims 1
• VPDHOFWSEXDPMO-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(6-phenylmethoxyindol-1-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CN(C1=C2)C=CC1=CC=C2OCC1=CC=CC=C1 VPDHOFWSEXDPMO-UHFFFAOYSA-N 0.000 claims 1
• MYVIAADZVCGUEF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(7-methylindol-1-yl)propan-2-ol Chemical compound C1=2C(C)=CC=CC=2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MYVIAADZVCGUEF-UHFFFAOYSA-N 0.000 claims 1
• ZPNSAIYQYLOEBV-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(isoquinolin-5-ylamino)propan-2-ol Chemical compound C=1C=CC2=CN=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZPNSAIYQYLOEBV-UHFFFAOYSA-N 0.000 claims 1
• LHNUVDFRLORRKP-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(n-methylanilino)propan-2-ol Chemical compound C=1C=CC=CC=1N(C)CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LHNUVDFRLORRKP-UHFFFAOYSA-N 0.000 claims 1
• MMAAKRFAHFQACC-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(naphthalen-1-ylamino)propan-2-ol Chemical compound C=1C=CC2=CC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MMAAKRFAHFQACC-UHFFFAOYSA-N 0.000 claims 1
• UKQPSSVVGWZRKX-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(naphthalen-2-ylamino)propan-2-ol Chemical compound C=1C=C2C=CC=CC2=CC=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UKQPSSVVGWZRKX-UHFFFAOYSA-N 0.000 claims 1
• LZZYMDMNNQRRNE-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(quinolin-5-ylamino)propan-2-ol Chemical compound C=1C=CC2=NC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LZZYMDMNNQRRNE-UHFFFAOYSA-N 0.000 claims 1
• WUQILSKWBLAAHF-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-(quinolin-6-ylamino)propan-2-ol Chemical compound C=1C=C2N=CC=CC2=CC=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WUQILSKWBLAAHF-UHFFFAOYSA-N 0.000 claims 1
• MYYKIWBXWIWCSA-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[(2-methylnaphthalen-1-yl)amino]propan-2-ol Chemical compound CC1=CC=C2C=CC=CC2=C1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MYYKIWBXWIWCSA-UHFFFAOYSA-N 0.000 claims 1
• ZUAXTGKVTKILAA-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[(4-methoxyphenyl)methylamino]propan-2-ol Chemical compound C1=CC(OC)=CC=C1CNCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 ZUAXTGKVTKILAA-UHFFFAOYSA-N 0.000 claims 1
• XRQTUSLCEUUQEP-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[(6-methoxypyridin-3-yl)amino]propan-2-ol Chemical compound C1=NC(OC)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 XRQTUSLCEUUQEP-UHFFFAOYSA-N 0.000 claims 1
• RNGWDCVVDAKQPB-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[2-(trifluoromethoxy)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC=C1OC(F)(F)F RNGWDCVVDAKQPB-UHFFFAOYSA-N 0.000 claims 1
• VNVALFRMEUVLQG-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[2-(trifluoromethyl)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC=C1C(F)(F)F VNVALFRMEUVLQG-UHFFFAOYSA-N 0.000 claims 1
• XKBORQQHPWXQLL-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[2-fluoro-5-(trifluoromethyl)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC(C(F)(F)F)=CC=C1F XKBORQQHPWXQLL-UHFFFAOYSA-N 0.000 claims 1
• FSUBSGYXWRAJLI-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[2-fluoro-5-(trifluoromethyl)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC(C(F)(F)F)=CC=C1F FSUBSGYXWRAJLI-UHFFFAOYSA-N 0.000 claims 1
• XCBLDAHZMAEQOJ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[2-methoxy-5-(trifluoromethyl)anilino]propan-2-ol Chemical compound COC1=CC=C(C(F)(F)F)C=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 XCBLDAHZMAEQOJ-UHFFFAOYSA-N 0.000 claims 1
• IEJJOPPIEOMHIV-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-(1,3-oxazol-5-yl)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC(C=1)=CC=CC=1C1=CN=CO1 IEJJOPPIEOMHIV-UHFFFAOYSA-N 0.000 claims 1
• IDLIDANKIRPSSI-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-(methoxymethyl)indol-1-yl]propan-2-ol Chemical compound C12=CC=CC=C2C(COC)=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IDLIDANKIRPSSI-UHFFFAOYSA-N 0.000 claims 1
• RXVCQDVOOZKSCV-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-(trifluoromethoxy)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=CC(OC(F)(F)F)=C1 RXVCQDVOOZKSCV-UHFFFAOYSA-N 0.000 claims 1
• CCKHFMQQGZZHMO-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-(trifluoromethoxy)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(OC(F)(F)F)=C1 CCKHFMQQGZZHMO-UHFFFAOYSA-N 0.000 claims 1
• DUQZZAXYMVALEB-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-(trifluoromethyl)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=CC(C(F)(F)F)=C1 DUQZZAXYMVALEB-UHFFFAOYSA-N 0.000 claims 1
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• GWKTUBGTXAVVQO-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[3-methoxy-5-(trifluoromethyl)anilino]propan-2-ol Chemical compound FC(F)(F)C1=CC(OC)=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 GWKTUBGTXAVVQO-UHFFFAOYSA-N 0.000 claims 1
• QGXPFYZOYLYTGL-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[4-(pyridin-4-ylmethyl)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC(C=C1)=CC=C1CC1=CC=NC=C1 QGXPFYZOYLYTGL-UHFFFAOYSA-N 0.000 claims 1
• ORINIDZRNQGQOU-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[4-(trifluoromethoxy)anilino]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=C(OC(F)(F)F)C=C1 ORINIDZRNQGQOU-UHFFFAOYSA-N 0.000 claims 1
• DGYJMSXEZUHSJS-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[4-(trifluoromethyl)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(C(F)(F)F)C=C1 DGYJMSXEZUHSJS-UHFFFAOYSA-N 0.000 claims 1
• KTEUZLFHTJGOST-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[4-(trifluoromethylsulfanyl)phenoxy]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(SC(F)(F)F)C=C1 KTEUZLFHTJGOST-UHFFFAOYSA-N 0.000 claims 1
• LZZNVWDXLIBVBZ-UHFFFAOYSA-N 1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-3-[4-methoxy-3-(trifluoromethyl)anilino]propan-2-ol Chemical compound C1=C(C(F)(F)F)C(OC)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 LZZNVWDXLIBVBZ-UHFFFAOYSA-N 0.000 claims 1
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• FUZYWODFPUVQHT-UHFFFAOYSA-N 1-(3-chloro-5-fluorophenyl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC(F)=CC(Cl)=C1 FUZYWODFPUVQHT-UHFFFAOYSA-N 0.000 claims 1
• LLQWBBPKCZRSSD-UHFFFAOYSA-N 1-(3-chlorophenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=CC(Cl)=C1 LLQWBBPKCZRSSD-UHFFFAOYSA-N 0.000 claims 1
• FGPYROZMJZTLST-UHFFFAOYSA-N 1-(3-chlorophenyl)-2,2,2-trifluoro-1-(1-pyridin-2-ylindazol-5-yl)ethanol Chemical compound C=1C=C2N(C=3N=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=CC(Cl)=C1 FGPYROZMJZTLST-UHFFFAOYSA-N 0.000 claims 1
• WZPSKTKKWMYXCL-UHFFFAOYSA-N 1-(3-chlorophenyl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=CC(Cl)=C1 WZPSKTKKWMYXCL-UHFFFAOYSA-N 0.000 claims 1
• IMUWSWXJCJGKAF-UHFFFAOYSA-N 1-(4-aminonaphthalen-1-yl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C12=CC=CC=C2C(N)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 IMUWSWXJCJGKAF-UHFFFAOYSA-N 0.000 claims 1
• FXLPALMEDPXDFZ-UHFFFAOYSA-N 1-(4-aminonaphthalen-1-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC=CC=C2C(N)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FXLPALMEDPXDFZ-UHFFFAOYSA-N 0.000 claims 1
• RKLCYCHQJRVKOD-UHFFFAOYSA-N 1-(4-bromo-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC=CC(Br)=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RKLCYCHQJRVKOD-UHFFFAOYSA-N 0.000 claims 1
• VLAOEXUUNVQLBD-UHFFFAOYSA-N 1-(4-chloro-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC=CC(Cl)=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VLAOEXUUNVQLBD-UHFFFAOYSA-N 0.000 claims 1
• PEADOHNTUHFVEG-UHFFFAOYSA-N 1-(4-chloro-2-methylphenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound CC1=CC(Cl)=CC=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 PEADOHNTUHFVEG-UHFFFAOYSA-N 0.000 claims 1
• RTUATXDDKDQRHR-UHFFFAOYSA-N 1-(4-chloro-3-fluorophenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=C(Cl)C(F)=C1 RTUATXDDKDQRHR-UHFFFAOYSA-N 0.000 claims 1
• GXRQXZWQGXPQQH-UHFFFAOYSA-N 1-(4-chloro-3-fluorophenyl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=C(Cl)C(F)=C1 GXRQXZWQGXPQQH-UHFFFAOYSA-N 0.000 claims 1
• GCIXXRURGHWXCI-UHFFFAOYSA-N 1-(4-chloro-3-methylphenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C1=C(Cl)C(C)=CC(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 GCIXXRURGHWXCI-UHFFFAOYSA-N 0.000 claims 1
• XWLWLJMJFFMSQP-UHFFFAOYSA-N 1-(4-chloro-3-methylphenyl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C1=C(Cl)C(C)=CC(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 XWLWLJMJFFMSQP-UHFFFAOYSA-N 0.000 claims 1
• HUEXGVFGCBAFQS-UHFFFAOYSA-N 1-(4-chlorophenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=C(Cl)C=C1 HUEXGVFGCBAFQS-UHFFFAOYSA-N 0.000 claims 1
• VERCLWGPPJONGY-UHFFFAOYSA-N 1-(4-chlorophenyl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=C(Cl)C=C1 VERCLWGPPJONGY-UHFFFAOYSA-N 0.000 claims 1
• QXZPMLMTDWEHKX-UHFFFAOYSA-N 1-(4-ethylphenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C1=CC(CC)=CC=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 QXZPMLMTDWEHKX-UHFFFAOYSA-N 0.000 claims 1
• JGCSUSWWXBAVBP-UHFFFAOYSA-N 1-(4-tert-butyl-2,6-dimethylphenyl)-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound CC1=CC(C(C)(C)C)=CC(C)=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 JGCSUSWWXBAVBP-UHFFFAOYSA-N 0.000 claims 1
• IBKGTLXPQXFZSS-UHFFFAOYSA-N 1-(5-bromo-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC=C(Br)C=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IBKGTLXPQXFZSS-UHFFFAOYSA-N 0.000 claims 1
• LAIUTIAEYQIOAY-UHFFFAOYSA-N 1-(5-chloro-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC=C(Cl)C=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LAIUTIAEYQIOAY-UHFFFAOYSA-N 0.000 claims 1
• KQRRLIOQYKTKTC-UHFFFAOYSA-N 1-(6-bromo-1-methylindol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC=C(Br)C=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KQRRLIOQYKTKTC-UHFFFAOYSA-N 0.000 claims 1
• VSFRMNXFAPQKOL-UHFFFAOYSA-N 1-(6-bromo-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC(Br)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VSFRMNXFAPQKOL-UHFFFAOYSA-N 0.000 claims 1
• NBMKCTCZRYWUHL-UHFFFAOYSA-N 1-(6-chloro-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=CC(Cl)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 NBMKCTCZRYWUHL-UHFFFAOYSA-N 0.000 claims 1
• BGEOKDQCCSTZIS-UHFFFAOYSA-N 1-(7-amino-1-methylindol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC=CC(N)=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BGEOKDQCCSTZIS-UHFFFAOYSA-N 0.000 claims 1
• GXTRQWDLFRAVML-UHFFFAOYSA-N 1-(7-bromo-1-methylindol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC=CC(Br)=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 GXTRQWDLFRAVML-UHFFFAOYSA-N 0.000 claims 1
• AAMNIDJGPKCFCM-UHFFFAOYSA-N 1-(7-bromo-1h-indol-3-yl)-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1NC2=C(Br)C=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AAMNIDJGPKCFCM-UHFFFAOYSA-N 0.000 claims 1
• RQCGVXKUCOURNR-UHFFFAOYSA-N 1-[1-(2-cyclopropyl-2-hydroxyethyl)indol-4-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C1CC1C(O)CN(C1=CC=C2)C=CC1=C2C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RQCGVXKUCOURNR-UHFFFAOYSA-N 0.000 claims 1
• QXHAUKHKVNYZFC-UHFFFAOYSA-N 1-[1-(4-chlorophenyl)indazol-5-yl]-2,2,2-trifluoro-1-(4-fluoronaphthalen-1-yl)ethanol Chemical compound C=1C=C(F)C2=CC=CC=C2C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=C(Cl)C=C1 QXHAUKHKVNYZFC-UHFFFAOYSA-N 0.000 claims 1
• VSZQWBGNQJYTJB-UHFFFAOYSA-N 1-[1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indol-3-yl]ethanone Chemical compound C12=CC=CC=C2C(C(=O)C)=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VSZQWBGNQJYTJB-UHFFFAOYSA-N 0.000 claims 1
• KAVPSOBRYSBMRQ-UHFFFAOYSA-N 1-[1-[4-(dimethylamino)phenyl]indazol-5-yl]-2,2,2-trifluoro-1-(4-fluoronaphthalen-1-yl)ethanol Chemical compound C1=CC(N(C)C)=CC=C1N1C2=CC=C(C(O)(C=3C4=CC=CC=C4C(F)=CC=3)C(F)(F)F)C=C2C=N1 KAVPSOBRYSBMRQ-UHFFFAOYSA-N 0.000 claims 1
• OJZNATFIJYHPDP-UHFFFAOYSA-N 1-[1-[4-(dimethylamino)phenyl]indazol-5-yl]-2,2,2-trifluoro-1-naphthalen-1-ylethanol Chemical compound C1=CC(N(C)C)=CC=C1N1C2=CC=C(C(O)(C=3C4=CC=CC=C4C=CC=3)C(F)(F)F)C=C2C=N1 OJZNATFIJYHPDP-UHFFFAOYSA-N 0.000 claims 1
• MLESWIGTHQZKTQ-UHFFFAOYSA-N 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-3-carbonitrile Chemical compound C1=C(C#N)C2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MLESWIGTHQZKTQ-UHFFFAOYSA-N 0.000 claims 1
• WDMAYVSASYYWGE-UHFFFAOYSA-N 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-5-carbonitrile Chemical compound C1=CC2=CC(C#N)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WDMAYVSASYYWGE-UHFFFAOYSA-N 0.000 claims 1
• OFSNRBMYRFEHKU-UHFFFAOYSA-N 1-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]indole-3-carbonitrile Chemical compound C1=C(C#N)C2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 OFSNRBMYRFEHKU-UHFFFAOYSA-N 0.000 claims 1
• IDCMSDTXQOVIEC-UHFFFAOYSA-N 1-[3,5-difluoro-4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]phenyl]ethanone Chemical compound FC1=CC(C(=O)C)=CC(F)=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 IDCMSDTXQOVIEC-UHFFFAOYSA-N 0.000 claims 1
• WSNSIHBWAZVTGJ-UHFFFAOYSA-N 1-[4-(dimethylamino)naphthalen-1-yl]-2,2,2-trifluoro-1-(1-phenylindazol-5-yl)ethanol Chemical compound C12=CC=CC=C2C(N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 WSNSIHBWAZVTGJ-UHFFFAOYSA-N 0.000 claims 1
• OQXMJSMAGHPWBN-UHFFFAOYSA-N 1-[4-(dimethylamino)naphthalen-1-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC=CC=C2C(N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 OQXMJSMAGHPWBN-UHFFFAOYSA-N 0.000 claims 1
• YZAKRICSMFNERI-UHFFFAOYSA-N 1-[4-[4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]phenyl]piperazin-1-yl]ethanone Chemical compound C1CN(C(=O)C)CCN1C(C=C1)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 YZAKRICSMFNERI-UHFFFAOYSA-N 0.000 claims 1
• KEQDGZLHLHNFRX-UHFFFAOYSA-N 1-[5-[2-(dimethylamino)ethylamino]-1-methylindol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C12=CC(NCCN(C)C)=CC=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KEQDGZLHLHNFRX-UHFFFAOYSA-N 0.000 claims 1
• YMMAXFFPTSMQMH-UHFFFAOYSA-N 1-[6-[2-(dimethylamino)ethyl-methylamino]-1-methylindol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1N(C)C2=CC(N(C)CCN(C)C)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YMMAXFFPTSMQMH-UHFFFAOYSA-N 0.000 claims 1
• ZRXAJYSANJOMRN-UHFFFAOYSA-N 1-[6-[2-(dimethylamino)ethylamino]-1-methylindol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C=1N(C)C2=CC(NCCN(C)C)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZRXAJYSANJOMRN-UHFFFAOYSA-N 0.000 claims 1
• GNCOBMYJYWXWJC-UHFFFAOYSA-N 1-[6-bromo-1-[(4-methoxyphenyl)methyl]indol-3-yl]-2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]ethanol Chemical compound C1=CC(OC)=CC=C1CN1C2=CC(Br)=CC=C2C(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 GNCOBMYJYWXWJC-UHFFFAOYSA-N 0.000 claims 1
• YMUVSDXOSOSOOS-UHFFFAOYSA-N 1-methyl-3-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indole-6-carbonitrile Chemical compound C12=CC=C(C#N)C=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YMUVSDXOSOSOOS-UHFFFAOYSA-N 0.000 claims 1
• JOIVJYCZDNAVOH-UHFFFAOYSA-N 1-methyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]quinolin-2-one Chemical compound C=1C(=O)N(C)C2=CC=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 JOIVJYCZDNAVOH-UHFFFAOYSA-N 0.000 claims 1
• DELANSVSHXAJKI-UHFFFAOYSA-N 1-morpholin-4-yl-2-[3-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indol-1-yl]ethanone Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C(C1=CC=CC=C11)=CN1CC(=O)N1CCOCC1 DELANSVSHXAJKI-UHFFFAOYSA-N 0.000 claims 1
• OCCLWZLZCCRABT-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(2,4,5-trimethylphenyl)ethanol Chemical compound C1=C(C)C(C)=CC(C)=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 OCCLWZLZCCRABT-UHFFFAOYSA-N 0.000 claims 1
• KXCHBQKGPQHDHA-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(2,4,6-trimethylphenyl)ethanol Chemical compound CC1=CC(C)=CC(C)=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 KXCHBQKGPQHDHA-UHFFFAOYSA-N 0.000 claims 1
• WCTRKWVVNBLWQD-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(2-phenylphenyl)ethanol Chemical compound C=1C=CC=C(C=2C=CC=CC=2)C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 WCTRKWVVNBLWQD-UHFFFAOYSA-N 0.000 claims 1
• WDIYHIYLIMXTPJ-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(3-phenylphenyl)ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C(C=1)=CC=CC=1C1=CC=CC=C1 WDIYHIYLIMXTPJ-UHFFFAOYSA-N 0.000 claims 1
• JZLVJMDYIOSEFX-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(4-phenylphenyl)ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C(C=C1)=CC=C1C1=CC=CC=C1 JZLVJMDYIOSEFX-UHFFFAOYSA-N 0.000 claims 1
• SGBHXGFBUFAPKN-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-(4-propan-2-ylphenyl)ethanol Chemical compound C1=CC(C(C)C)=CC=C1C(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 SGBHXGFBUFAPKN-UHFFFAOYSA-N 0.000 claims 1
• IAMPQEQXTDIDKK-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-[2-(piperidin-1-ylmethyl)phenyl]ethanol Chemical compound C=1C=CC=C(CN2CCCCC2)C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 IAMPQEQXTDIDKK-UHFFFAOYSA-N 0.000 claims 1
• XURBVEFOJGIAIS-UHFFFAOYSA-N 2,2,2-trifluoro-1-(1-phenylindazol-5-yl)-1-[3-(piperidin-1-ylmethyl)phenyl]ethanol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C(C=1)=CC=CC=1CN1CCCCC1 XURBVEFOJGIAIS-UHFFFAOYSA-N 0.000 claims 1
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• HVHCCOUGOMRWMN-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(1-methyl-6-pyridin-3-ylindol-3-yl)ethanol Chemical compound C1=C2N(C)C=C(C(O)(C=3C=C4C=NN(C4=CC=3)C=3C=CC(F)=CC=3)C(F)(F)F)C2=CC=C1C1=CC=CN=C1 HVHCCOUGOMRWMN-UHFFFAOYSA-N 0.000 claims 1
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• WGNBTOXMBDDZJQ-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(5-methoxy-4-methyl-1h-indol-3-yl)ethanol Chemical compound C12=C(C)C(OC)=CC=C2NC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WGNBTOXMBDDZJQ-UHFFFAOYSA-N 0.000 claims 1
• HPMHYUPTZVHMHH-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(5-methyl-1h-indol-3-yl)ethanol Chemical compound C12=CC(C)=CC=C2NC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HPMHYUPTZVHMHH-UHFFFAOYSA-N 0.000 claims 1
• KBNGMAITOJWXBS-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(6-methoxy-1h-indol-3-yl)ethanol Chemical compound C=1NC2=CC(OC)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 KBNGMAITOJWXBS-UHFFFAOYSA-N 0.000 claims 1
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• WGBOIXKSSNHRSC-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(6-methyl-1h-indol-3-yl)ethanol Chemical compound C=1NC2=CC(C)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 WGBOIXKSSNHRSC-UHFFFAOYSA-N 0.000 claims 1
• UFWQSJDXKOEYEL-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(7-methoxy-1h-indol-3-yl)ethanol Chemical compound C=1NC=2C(OC)=CC=CC=2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UFWQSJDXKOEYEL-UHFFFAOYSA-N 0.000 claims 1
• ZNHGNRICCNXHST-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-(7-methyl-1h-indol-3-yl)ethanol Chemical compound C=1NC=2C(C)=CC=CC=2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 ZNHGNRICCNXHST-UHFFFAOYSA-N 0.000 claims 1
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• VZLXQGFSDKQTKT-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-[4-(methylamino)naphthalen-1-yl]ethanol Chemical compound C12=CC=CC=C2C(NC)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VZLXQGFSDKQTKT-UHFFFAOYSA-N 0.000 claims 1
• VWKMJVJWCBLLSZ-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-[6-(2-methoxyethylamino)-1-methylindol-3-yl]ethanol Chemical compound C=1N(C)C2=CC(NCCOC)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VWKMJVJWCBLLSZ-UHFFFAOYSA-N 0.000 claims 1
• NJEMVYLMXIKBHM-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-[6-(furan-2-yl)-1-methylindol-3-yl]ethanol Chemical compound C1=C2N(C)C=C(C(O)(C=3C=C4C=NN(C4=CC=3)C=3C=CC(F)=CC=3)C(F)(F)F)C2=CC=C1C1=CC=CO1 NJEMVYLMXIKBHM-UHFFFAOYSA-N 0.000 claims 1
• LSNKKWDYVRZHDG-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-[6-[2-methoxyethyl(methyl)amino]-1-methylindol-3-yl]ethanol Chemical compound C=1N(C)C2=CC(N(C)CCOC)=CC=C2C=1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LSNKKWDYVRZHDG-UHFFFAOYSA-N 0.000 claims 1
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• QSWLILRZTSSXJR-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-naphthalen-1-ylethanol Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 QSWLILRZTSSXJR-UHFFFAOYSA-N 0.000 claims 1
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• UXSDJPCJZINOAE-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-quinolin-4-ylethanol Chemical compound C=1C=NC2=CC=CC=C2C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 UXSDJPCJZINOAE-UHFFFAOYSA-N 0.000 claims 1
• QPKCFAAZMUVLLR-UHFFFAOYSA-N 2,2,2-trifluoro-1-[1-(4-fluorophenyl)indol-5-yl]-1-naphthalen-1-ylethanol Chemical compound C=1C=CC2=CC=CC=C2C=1C(C(F)(F)F)(O)C(C=C1C=C2)=CC=C1N2C1=CC=C(F)C=C1 QPKCFAAZMUVLLR-UHFFFAOYSA-N 0.000 claims 1
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• QOWFYDABVPQKIM-UHFFFAOYSA-N 3-(2,4-dimethylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC(C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 QOWFYDABVPQKIM-UHFFFAOYSA-N 0.000 claims 1
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• QWVHNTFZRQTSBY-UHFFFAOYSA-N 3-(2,5-dimethylphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC=C(C)C(SCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 QWVHNTFZRQTSBY-UHFFFAOYSA-N 0.000 claims 1
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• OYYTZMVARBFXIZ-UHFFFAOYSA-N 3-(2,6-dimethylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC=CC(C)=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 OYYTZMVARBFXIZ-UHFFFAOYSA-N 0.000 claims 1
• XNMKZKHYWYQRCN-UHFFFAOYSA-N 3-(2,6-dimethylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC=CC(C)=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 XNMKZKHYWYQRCN-UHFFFAOYSA-N 0.000 claims 1
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• JPDWHXYZAOWYRM-UHFFFAOYSA-N 3-(3,4-dichlorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(Cl)C(Cl)=C1 JPDWHXYZAOWYRM-UHFFFAOYSA-N 0.000 claims 1
• WBMQDGGPFSXYAM-UHFFFAOYSA-N 3-(3,4-difluorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(F)C(F)=C1 WBMQDGGPFSXYAM-UHFFFAOYSA-N 0.000 claims 1
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• PDEJRWRQOJVVOS-UHFFFAOYSA-N 3-(3,4-dihydro-2h-quinolin-1-yl)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1CCC2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 PDEJRWRQOJVVOS-UHFFFAOYSA-N 0.000 claims 1
• SSAJCDQDMNLEES-UHFFFAOYSA-N 3-(3,4-dihydro-2h-quinoxalin-1-yl)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1CNC2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 SSAJCDQDMNLEES-UHFFFAOYSA-N 0.000 claims 1
• IISVQECHPVQXQA-UHFFFAOYSA-N 3-(3,4-dimethoxyphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=C(OC)C(OC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 IISVQECHPVQXQA-UHFFFAOYSA-N 0.000 claims 1
• YECMPNZPQZMVJQ-UHFFFAOYSA-N 3-(3,4-dimethoxyphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=C(OC)C(OC)=CC=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 YECMPNZPQZMVJQ-UHFFFAOYSA-N 0.000 claims 1
• MFHHXPJAJWNSIE-UHFFFAOYSA-N 3-(3,4-dimethylphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=C(C)C(C)=CC=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 MFHHXPJAJWNSIE-UHFFFAOYSA-N 0.000 claims 1
• GNRLDOCXUZMLRC-UHFFFAOYSA-N 3-(3,5-dichlorophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC(Cl)=CC(Cl)=C1 GNRLDOCXUZMLRC-UHFFFAOYSA-N 0.000 claims 1
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• BINOLXXWPNDJNL-UHFFFAOYSA-N 3-(3,5-dichlorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC(Cl)=CC(Cl)=C1 BINOLXXWPNDJNL-UHFFFAOYSA-N 0.000 claims 1
• KEVIPXLRINWXAP-UHFFFAOYSA-N 3-(3,5-difluorophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC(F)=CC(F)=C1 KEVIPXLRINWXAP-UHFFFAOYSA-N 0.000 claims 1
• YZJTVNXSSICGFR-UHFFFAOYSA-N 3-(3,5-difluorophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC(F)=CC(F)=C1 YZJTVNXSSICGFR-UHFFFAOYSA-N 0.000 claims 1
• RDEDKOJKHWAFAR-UHFFFAOYSA-N 3-(3,5-dimethoxyanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound COC1=CC(OC)=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 RDEDKOJKHWAFAR-UHFFFAOYSA-N 0.000 claims 1
• FJVORDUEPDGGIQ-UHFFFAOYSA-N 3-(3,5-dimethylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC(C)=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 FJVORDUEPDGGIQ-UHFFFAOYSA-N 0.000 claims 1
• SDRNUWZLMLPPDC-UHFFFAOYSA-N 3-(3,5-dimethylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC(C)=CC(OCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 SDRNUWZLMLPPDC-UHFFFAOYSA-N 0.000 claims 1
• BXOGPWULZPTNHP-UHFFFAOYSA-N 3-(3,5-dimethylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC(C)=CC(OCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 BXOGPWULZPTNHP-UHFFFAOYSA-N 0.000 claims 1
• LWKIOMOSGZLFPD-UHFFFAOYSA-N 3-(3,5-dimethylphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC(C)=CC(SCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 LWKIOMOSGZLFPD-UHFFFAOYSA-N 0.000 claims 1
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• RWNSTSDIIUVGGI-UHFFFAOYSA-N 3-(3-bromophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(Br)=C1 RWNSTSDIIUVGGI-UHFFFAOYSA-N 0.000 claims 1
• GSPSLJROMKQARP-UHFFFAOYSA-N 3-(3-bromophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=CC(Br)=C1 GSPSLJROMKQARP-UHFFFAOYSA-N 0.000 claims 1
• CVIUVBOUCBHKQC-UHFFFAOYSA-N 3-(3-chloro-2-fluorophenyl)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CC1=CC=CC(Cl)=C1F CVIUVBOUCBHKQC-UHFFFAOYSA-N 0.000 claims 1
• YUMLZVDLHAIDEU-UHFFFAOYSA-N 3-(3-chloro-2-methylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=C(Cl)C=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 YUMLZVDLHAIDEU-UHFFFAOYSA-N 0.000 claims 1
• VMUOFARSIOKTHQ-UHFFFAOYSA-N 3-(3-chloro-4-fluorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(F)C(Cl)=C1 VMUOFARSIOKTHQ-UHFFFAOYSA-N 0.000 claims 1
• IZPOJXXTQVCNGH-UHFFFAOYSA-N 3-(3-chloro-4-methylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=C(Cl)C(C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 IZPOJXXTQVCNGH-UHFFFAOYSA-N 0.000 claims 1
• VAEGSHOPPGETBL-UHFFFAOYSA-N 3-(3-chloro-4-methylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=C(Cl)C(C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 VAEGSHOPPGETBL-UHFFFAOYSA-N 0.000 claims 1
• KKXAPXRCBIOLQL-UHFFFAOYSA-N 3-(3-chlorophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(Cl)=C1 KKXAPXRCBIOLQL-UHFFFAOYSA-N 0.000 claims 1
• DUSCCSBRKMUYOZ-UHFFFAOYSA-N 3-(3-chlorophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(Cl)=C1 DUSCCSBRKMUYOZ-UHFFFAOYSA-N 0.000 claims 1
• RJDQEVMJTOJCNX-UHFFFAOYSA-N 3-(3-chlorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=CC(Cl)=C1 RJDQEVMJTOJCNX-UHFFFAOYSA-N 0.000 claims 1
• YAAPQBHRUVXXMT-UHFFFAOYSA-N 3-(3-ethoxyphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CCOC1=CC=CC(SCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 YAAPQBHRUVXXMT-UHFFFAOYSA-N 0.000 claims 1
• MTFPEQFCTUWSEE-UHFFFAOYSA-N 3-(4,5-dimethoxy-2-methylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=C(OC)C(OC)=CC(C)=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 MTFPEQFCTUWSEE-UHFFFAOYSA-N 0.000 claims 1
• KEOJUYHDQZQSMM-UHFFFAOYSA-N 3-(4,6-dimethylpyrimidin-2-yl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC(C)=NC(SCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=N1 KEOJUYHDQZQSMM-UHFFFAOYSA-N 0.000 claims 1
• LWZMWSVGFKILQZ-UHFFFAOYSA-N 3-(4-anilinophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC(C=C1)=CC=C1NC1=CC=CC=C1 LWZMWSVGFKILQZ-UHFFFAOYSA-N 0.000 claims 1
• LOSJSPWXHORNJU-UHFFFAOYSA-N 3-(4-bromo-2-methylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC(Br)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 LOSJSPWXHORNJU-UHFFFAOYSA-N 0.000 claims 1
• NVCSGDYPOCLCDP-UHFFFAOYSA-N 3-(4-bromo-3-methylphenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=C(Br)C(C)=CC(OCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 NVCSGDYPOCLCDP-UHFFFAOYSA-N 0.000 claims 1
• ZYQUKGNESVDXHH-UHFFFAOYSA-N 3-(4-bromo-3-methylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=C(Br)C(C)=CC(OCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 ZYQUKGNESVDXHH-UHFFFAOYSA-N 0.000 claims 1
• XNLLFXMNHIGFJR-UHFFFAOYSA-N 3-(4-bromophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Br)C=C1 XNLLFXMNHIGFJR-UHFFFAOYSA-N 0.000 claims 1
• PLUUOPCIQDSLHW-UHFFFAOYSA-N 3-(4-bromophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(Br)C=C1 PLUUOPCIQDSLHW-UHFFFAOYSA-N 0.000 claims 1
• GCJVPYFQFZHKRR-UHFFFAOYSA-N 3-(4-chloro-2,6-dimethylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC(Cl)=CC(C)=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 GCJVPYFQFZHKRR-UHFFFAOYSA-N 0.000 claims 1
• GOMOKZYHXILZDE-UHFFFAOYSA-N 3-(4-chloro-2-fluorophenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C=C1F GOMOKZYHXILZDE-UHFFFAOYSA-N 0.000 claims 1
• IDDUWXUSBVINAR-UHFFFAOYSA-N 3-(4-chloro-2-fluorophenyl)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CC1=CC=C(Cl)C=C1F IDDUWXUSBVINAR-UHFFFAOYSA-N 0.000 claims 1
• YXBRHWCQUGUHMD-UHFFFAOYSA-N 3-(4-chloro-3-fluorophenyl)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CC1=CC=C(Cl)C(F)=C1 YXBRHWCQUGUHMD-UHFFFAOYSA-N 0.000 claims 1
• AXASLHIFEVRFOE-UHFFFAOYSA-N 3-(4-chlorophenoxy)-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C=C1 AXASLHIFEVRFOE-UHFFFAOYSA-N 0.000 claims 1
• RAXRFAVGURTFHN-UHFFFAOYSA-N 3-(4-chlorophenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(Cl)C=C1 RAXRFAVGURTFHN-UHFFFAOYSA-N 0.000 claims 1
• CCRXIUSMHZMMJQ-UHFFFAOYSA-N 3-(4-tert-butylphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=CC(C(C)(C)C)=CC=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 CCRXIUSMHZMMJQ-UHFFFAOYSA-N 0.000 claims 1
• SAIBECSVSQCJBB-UHFFFAOYSA-N 3-(5,6-dimethoxyindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=2C=C(OC)C(OC)=CC=2C=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SAIBECSVSQCJBB-UHFFFAOYSA-N 0.000 claims 1
• AQJCDHUNEQYMMD-UHFFFAOYSA-N 3-(5-bromoindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC(Br)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AQJCDHUNEQYMMD-UHFFFAOYSA-N 0.000 claims 1
• CNLDFMQWVXITEN-UHFFFAOYSA-N 3-(5-chloro-2-methylanilino)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC=C(Cl)C=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 CNLDFMQWVXITEN-UHFFFAOYSA-N 0.000 claims 1
• JOUCAKXXUKFJJJ-UHFFFAOYSA-N 3-(5-chloro-2-methylphenoxy)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound CC1=CC=C(Cl)C=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 JOUCAKXXUKFJJJ-UHFFFAOYSA-N 0.000 claims 1
• VJKBFWUHHPIVMT-UHFFFAOYSA-N 3-(5-chloroindol-1-yl)-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC2=CC(Cl)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 VJKBFWUHHPIVMT-UHFFFAOYSA-N 0.000 claims 1
• AANLMFZXOUDEED-UHFFFAOYSA-N 3-(5-tert-butyl-2-methylphenyl)sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CC1=CC=C(C(C)(C)C)C=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 AANLMFZXOUDEED-UHFFFAOYSA-N 0.000 claims 1
• YXDGAFVLRPYKQV-UHFFFAOYSA-N 3-[(4-chloronaphthalen-1-yl)amino]-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C(Cl)C2=CC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 YXDGAFVLRPYKQV-UHFFFAOYSA-N 0.000 claims 1
• YNAXWQMYZZMLFH-UHFFFAOYSA-N 3-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]phenol Chemical compound OC1=CC=CC(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 YNAXWQMYZZMLFH-UHFFFAOYSA-N 0.000 claims 1
• UQKYIOAQVZVKBR-UHFFFAOYSA-N 3-[2-[(dimethylamino)methyl]phenoxy]-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CN(C)CC1=CC=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 UQKYIOAQVZVKBR-UHFFFAOYSA-N 0.000 claims 1
• SAXFULDGWORUBX-UHFFFAOYSA-N 3-[2-chloro-5-(trifluoromethyl)anilino]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC(C(F)(F)F)=CC=C1Cl SAXFULDGWORUBX-UHFFFAOYSA-N 0.000 claims 1
• OBAWKRZIMADWOA-UHFFFAOYSA-N 3-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(C#N)=C1 OBAWKRZIMADWOA-UHFFFAOYSA-N 0.000 claims 1
• SNQSJDINBLKXPH-UHFFFAOYSA-N 3-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=CC(C#N)=C1 SNQSJDINBLKXPH-UHFFFAOYSA-N 0.000 claims 1
• VKQJXOARSUQGSS-UHFFFAOYSA-N 3-[3,5-bis(trifluoromethyl)phenyl]sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC(C(F)(F)F)=CC(C(F)(F)F)=C1 VKQJXOARSUQGSS-UHFFFAOYSA-N 0.000 claims 1
• ABYPWMRJESSMQY-UHFFFAOYSA-N 3-[3-(dimethylamino)phenoxy]-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound CN(C)C1=CC=CC(OCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 ABYPWMRJESSMQY-UHFFFAOYSA-N 0.000 claims 1
• TUHZZQFQUXSHDF-UHFFFAOYSA-N 3-[3-[(dimethylamino)methyl]indol-1-yl]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C12=CC=CC=C2C(CN(C)C)=CN1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 TUHZZQFQUXSHDF-UHFFFAOYSA-N 0.000 claims 1
• FXPZNYANNNBKHA-UHFFFAOYSA-N 3-[3-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indol-1-yl]propane-1,2-diol Chemical compound C12=CC=CC=C2N(CC(O)CO)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FXPZNYANNNBKHA-UHFFFAOYSA-N 0.000 claims 1
• JKSZMXDFPVECLA-UHFFFAOYSA-N 3-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=NC=C(C(F)(F)F)C=C1Cl JKSZMXDFPVECLA-UHFFFAOYSA-N 0.000 claims 1
• SZOZYNLEXTUQAA-UHFFFAOYSA-N 3-[4-(4-chlorophenyl)pyrimidin-2-yl]sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC(N=1)=NC=CC=1C1=CC=C(Cl)C=C1 SZOZYNLEXTUQAA-UHFFFAOYSA-N 0.000 claims 1
• LEIJZVODFRWACO-UHFFFAOYSA-N 3-[4-(dimethylamino)anilino]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C1=CC(N(C)C)=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 LEIJZVODFRWACO-UHFFFAOYSA-N 0.000 claims 1
• VZZRPNQABNQPMC-UHFFFAOYSA-N 3-[4-[(dimethylamino)methyl]phenoxy]-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C1=CC(CN(C)C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 VZZRPNQABNQPMC-UHFFFAOYSA-N 0.000 claims 1
• GTRPGCBJOPNPLK-UHFFFAOYSA-N 3-[4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]imidazol-1-yl]propane-1,2-diol Chemical compound OCC(O)CN1C=NC(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 GTRPGCBJOPNPLK-UHFFFAOYSA-N 0.000 claims 1
• YUFINADXMWHTLS-UHFFFAOYSA-N 3-[4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indol-1-yl]propane-1,2-diol Chemical compound C1=CC=C2N(CC(O)CO)C=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YUFINADXMWHTLS-UHFFFAOYSA-N 0.000 claims 1
• KWPMSCIEVPDEBX-UHFFFAOYSA-N 3-[4-bromo-2-(trifluoromethoxy)phenyl]sulfanyl-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CSC1=CC=C(Br)C=C1OC(F)(F)F KWPMSCIEVPDEBX-UHFFFAOYSA-N 0.000 claims 1
• ZZWIUMCFSHNCBM-UHFFFAOYSA-N 3-[4-chloro-3-(trifluoromethyl)phenoxy]-1,1,1-trifluoro-2-(1-phenylindazol-5-yl)propan-2-ol Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C(C(F)(F)F)=C1 ZZWIUMCFSHNCBM-UHFFFAOYSA-N 0.000 claims 1
• KXHPWBMHEJQLEE-UHFFFAOYSA-N 3-[4-chloro-3-(trifluoromethyl)phenoxy]-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C(C(F)(F)F)=C1 KXHPWBMHEJQLEE-UHFFFAOYSA-N 0.000 claims 1
• QZSYWEFEISMGNW-UHFFFAOYSA-N 3-acridin-4-yloxy-1,1,1-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]propan-2-ol Chemical compound C=1C=CC2=CC3=CC=CC=C3N=C2C=1OCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 QZSYWEFEISMGNW-UHFFFAOYSA-N 0.000 claims 1
• BJZBPFQDVNWQGC-UHFFFAOYSA-N 3-chloro-4-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=C(C#N)C=C1Cl BJZBPFQDVNWQGC-UHFFFAOYSA-N 0.000 claims 1
• VSXMSYVKRKWKDG-UHFFFAOYSA-N 3-ethyl-1,2-oxazol-5-amine Chemical compound CCC=1C=C(N)ON=1 VSXMSYVKRKWKDG-UHFFFAOYSA-N 0.000 claims 1
• JUWWLOCCJYGKQS-UHFFFAOYSA-N 3-hydroxy-4-[4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indol-1-yl]butanenitrile Chemical compound C1=CC=C2N(CC(CC#N)O)C=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 JUWWLOCCJYGKQS-UHFFFAOYSA-N 0.000 claims 1
• FHCNASLQXTWOOQ-UHFFFAOYSA-N 4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)C1=CC=C(C#N)C=C1 FHCNASLQXTWOOQ-UHFFFAOYSA-N 0.000 claims 1
• PEAXMWUSAZDTEZ-UHFFFAOYSA-N 4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]naphthalene-1-carbonitrile Chemical compound C=1C=C(C#N)C2=CC=CC=C2C=1C(C(F)(F)F)(O)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PEAXMWUSAZDTEZ-UHFFFAOYSA-N 0.000 claims 1
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• BFIITWVUMZWYII-UHFFFAOYSA-N 4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)N)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 BFIITWVUMZWYII-UHFFFAOYSA-N 0.000 claims 1
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• VRTQHVSHSPYIAG-UHFFFAOYSA-N 4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(C#N)C=C1 VRTQHVSHSPYIAG-UHFFFAOYSA-N 0.000 claims 1
• MQIZLXCYCAFLEE-UHFFFAOYSA-N 4-[5-(2,2,2-trifluoro-1-hydroxy-1-naphthalen-1-ylethyl)indazol-1-yl]phenol Chemical compound C1=CC(O)=CC=C1N1C2=CC=C(C(O)(C=3C4=CC=CC=C4C=CC=3)C(F)(F)F)C=C2C=N1 MQIZLXCYCAFLEE-UHFFFAOYSA-N 0.000 claims 1
• SWOZCISMIZAKTO-UHFFFAOYSA-N 4-[5-[1-(3-chloro-4-fluorophenyl)-2,2,2-trifluoro-1-hydroxyethyl]indazol-1-yl]phenol Chemical compound C1=CC(O)=CC=C1N1C2=CC=C(C(O)(C=3C=C(Cl)C(F)=CC=3)C(F)(F)F)C=C2C=N1 SWOZCISMIZAKTO-UHFFFAOYSA-N 0.000 claims 1
• XRURXISTABIKDF-UHFFFAOYSA-N 4-[5-[2,2,2-trifluoro-1-(4-fluoronaphthalen-1-yl)-1-hydroxyethyl]indazol-1-yl]phenol Chemical compound C1=CC(O)=CC=C1N1C2=CC=C(C(O)(C=3C4=CC=CC=C4C(F)=CC=3)C(F)(F)F)C=C2C=N1 XRURXISTABIKDF-UHFFFAOYSA-N 0.000 claims 1
• IFYSEBKWTWWJFH-UHFFFAOYSA-N 4-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=C(C#N)C=C1 IFYSEBKWTWWJFH-UHFFFAOYSA-N 0.000 claims 1
• FHLQXUMYRQYNLY-UHFFFAOYSA-N 4-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]naphthalene-1-carbonitrile Chemical compound C=1C=C(C#N)C2=CC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FHLQXUMYRQYNLY-UHFFFAOYSA-N 0.000 claims 1
• LNJAVPNSODXHKP-UHFFFAOYSA-N 4-[[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]amino]naphthalene-1-carbonitrile Chemical compound C=1C=C(C#N)C2=CC=CC=C2C=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 LNJAVPNSODXHKP-UHFFFAOYSA-N 0.000 claims 1
• PPTACCQEFVVDIL-UHFFFAOYSA-N 4-chloro-2-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC(Cl)=CC=C1C#N PPTACCQEFVVDIL-UHFFFAOYSA-N 0.000 claims 1
• PBQMVLNBKCOLQX-UHFFFAOYSA-N 4-methyl-7-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]sulfanylchromen-2-one Chemical compound C1=CC=2C(C)=CC(=O)OC=2C=C1SCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 PBQMVLNBKCOLQX-UHFFFAOYSA-N 0.000 claims 1
• FPWUFNFAVGIWTD-UHFFFAOYSA-N 5-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]-1,3-dihydrobenzimidazol-2-one Chemical compound C=1C=C2NC(=O)NC2=CC=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 FPWUFNFAVGIWTD-UHFFFAOYSA-N 0.000 claims 1
• ZYRITYXOQZWKAQ-UHFFFAOYSA-N 5-bromo-2-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Br)C=C1C#N ZYRITYXOQZWKAQ-UHFFFAOYSA-N 0.000 claims 1
• GGZZGDWIISDUDE-UHFFFAOYSA-N 5-bromo-2-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Br)C=C1C#N GGZZGDWIISDUDE-UHFFFAOYSA-N 0.000 claims 1
• ZCNJUWJURHYPBN-UHFFFAOYSA-N 5-chloro-2-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C=C1C#N ZCNJUWJURHYPBN-UHFFFAOYSA-N 0.000 claims 1
• UKVSKILXUNVGOB-UHFFFAOYSA-N 5-chloro-2-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzonitrile Chemical compound C=1C=C2N(C=3C=CC=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)COC1=CC=C(Cl)C=C1C#N UKVSKILXUNVGOB-UHFFFAOYSA-N 0.000 claims 1
• QLCWDAZLWINTPI-UHFFFAOYSA-N 5-chloro-2-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzonitrile Chemical compound C=1C=C2N(C=3C=CC(F)=CC=3)N=CC2=CC=1C(C(F)(F)F)(O)CNC1=CC=C(Cl)C=C1C#N QLCWDAZLWINTPI-UHFFFAOYSA-N 0.000 claims 1
• CTSHFTSOFBCFSZ-UHFFFAOYSA-N 6-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]-3h-2-benzofuran-1-one Chemical compound C=1C=C2COC(=O)C2=CC=1NCC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 CTSHFTSOFBCFSZ-UHFFFAOYSA-N 0.000 claims 1
• ZJYLHIFGUXGWQK-UHFFFAOYSA-N 6-methyl-2-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]sulfanyl-4-(trifluoromethyl)pyridine-3-carbonitrile Chemical compound CC1=CC(C(F)(F)F)=C(C#N)C(SCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=N1 ZJYLHIFGUXGWQK-UHFFFAOYSA-N 0.000 claims 1
• 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims 1
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
• HMOHBBHQVAPSKN-UHFFFAOYSA-N CC(COC(C=C1)=CC=C1NC1=CC=CC=C1)(C1=CC=C2N(C3=CC=CC=C3)N=CC2=C1)O Chemical compound CC(COC(C=C1)=CC=C1NC1=CC=CC=C1)(C1=CC=C2N(C3=CC=CC=C3)N=CC2=C1)O HMOHBBHQVAPSKN-UHFFFAOYSA-N 0.000 claims 1
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 claims 1
• DFNYGALUNNFWKJ-UHFFFAOYSA-N aminoacetonitrile Chemical compound NCC#N DFNYGALUNNFWKJ-UHFFFAOYSA-N 0.000 claims 1
• AGSPXMVUFBBBMO-UHFFFAOYSA-N beta-aminopropionitrile Chemical compound NCCC#N AGSPXMVUFBBBMO-UHFFFAOYSA-N 0.000 claims 1
• 229910052799 carbon Inorganic materials 0.000 claims 1
• 150000002148 esters Chemical class 0.000 claims 1
• AORMLIQSCJWBJO-UHFFFAOYSA-N ethyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-2-carboxylate Chemical compound CCOC(=O)C1=CC2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 AORMLIQSCJWBJO-UHFFFAOYSA-N 0.000 claims 1
• HNZAPAOWRQNSDA-UHFFFAOYSA-N ethyl 2-[2-methyl-1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indol-3-yl]acetate Chemical compound C12=CC=CC=C2C(CC(=O)OCC)=C(C)N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 HNZAPAOWRQNSDA-UHFFFAOYSA-N 0.000 claims 1
• UENAGQKTLVEHLY-UHFFFAOYSA-N ethyl 3-methoxy-4-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzoate Chemical compound COC1=CC(C(=O)OCC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 UENAGQKTLVEHLY-UHFFFAOYSA-N 0.000 claims 1
• PZMZHMNSDLISDR-UHFFFAOYSA-N ethyl 3-methoxy-4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzoate Chemical compound COC1=CC(C(=O)OCC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 PZMZHMNSDLISDR-UHFFFAOYSA-N 0.000 claims 1
• RFZOUPMDDUAVAC-UHFFFAOYSA-N ethyl 4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]quinoline-3-carboxylate Chemical compound CCOC(=O)C1=CN=C2C=CC=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 RFZOUPMDDUAVAC-UHFFFAOYSA-N 0.000 claims 1
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
• BEBCJVAWIBVWNZ-UHFFFAOYSA-N glycinamide Chemical compound NCC(N)=O BEBCJVAWIBVWNZ-UHFFFAOYSA-N 0.000 claims 1
• 125000001188 haloalkyl group Chemical group 0.000 claims 1
• SUSJWUQBAWBXEK-UHFFFAOYSA-N methyl 1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indole-2-carboxylate Chemical compound COC(=O)C1=CC2=CC=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SUSJWUQBAWBXEK-UHFFFAOYSA-N 0.000 claims 1
• YWMMCNPDIKTZQF-UHFFFAOYSA-N methyl 2-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]sulfanylbenzoate Chemical compound COC(=O)C1=CC=CC=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 YWMMCNPDIKTZQF-UHFFFAOYSA-N 0.000 claims 1
• IBDZRZORIXPKDG-UHFFFAOYSA-N methyl 2-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC=C1NCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 IBDZRZORIXPKDG-UHFFFAOYSA-N 0.000 claims 1
• JHBUWRRJVNDNJO-UHFFFAOYSA-N methyl 3-[[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]amino]benzoate Chemical compound COC(=O)C1=CC=CC(NCC(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC(F)=CC=2)C(F)(F)F)=C1 JHBUWRRJVNDNJO-UHFFFAOYSA-N 0.000 claims 1
• SRAVATYLXGUPHD-UHFFFAOYSA-N methyl 4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzoate Chemical compound C1=CC(C(=O)OC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 SRAVATYLXGUPHD-UHFFFAOYSA-N 0.000 claims 1
• IOFWRLZVAFBUHX-UHFFFAOYSA-N methyl 5-acetyl-2-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]benzoate Chemical compound COC(=O)C1=CC(C(C)=O)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 IOFWRLZVAFBUHX-UHFFFAOYSA-N 0.000 claims 1
• XHYBOFKOFLRMPT-UHFFFAOYSA-N methyl 5-acetyl-2-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]benzoate Chemical compound COC(=O)C1=CC(C(C)=O)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 XHYBOFKOFLRMPT-UHFFFAOYSA-N 0.000 claims 1
• MGJXBDMLVWIYOQ-UHFFFAOYSA-N methylazanide Chemical compound [NH-]C MGJXBDMLVWIYOQ-UHFFFAOYSA-N 0.000 claims 1
• PHCRDLIWXVYBSR-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 PHCRDLIWXVYBSR-UHFFFAOYSA-N 0.000 claims 1
• LPLYALJVSXPYGJ-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]naphthalene-1-sulfonamide Chemical compound C12=CC=CC=C2C(S(=O)(=O)N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LPLYALJVSXPYGJ-UHFFFAOYSA-N 0.000 claims 1
• QYFFXUYECQVZKR-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]quinoline-3-carboxamide Chemical compound CN(C)C(=O)C1=CN=C2C=CC=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 QYFFXUYECQVZKR-UHFFFAOYSA-N 0.000 claims 1
• VSBFVSIWIVXWGI-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 VSBFVSIWIVXWGI-UHFFFAOYSA-N 0.000 claims 1
• MUTREBKHINDDRN-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]naphthalene-1-sulfonamide Chemical compound C12=CC=CC=C2C(S(=O)(=O)N(C)C)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 MUTREBKHINDDRN-UHFFFAOYSA-N 0.000 claims 1
• LGAKBGBICVUNRX-UHFFFAOYSA-N n,n-dimethyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]quinoline-3-carboxamide Chemical compound CN(C)C(=O)C1=CN=C2C=CC=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 LGAKBGBICVUNRX-UHFFFAOYSA-N 0.000 claims 1
• YWRRSYLPWYZTHV-UHFFFAOYSA-N n-[1-methyl-3-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indol-7-yl]methanesulfonamide Chemical compound C12=CC=CC(NS(C)(=O)=O)=C2N(C)C=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 YWRRSYLPWYZTHV-UHFFFAOYSA-N 0.000 claims 1
• BBJZYWHSYXGWGM-UHFFFAOYSA-N n-[2-[5-methoxy-1-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropyl]indol-3-yl]ethyl]acetamide Chemical compound C1=C(CCNC(C)=O)C2=CC(OC)=CC=C2N1CC(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 BBJZYWHSYXGWGM-UHFFFAOYSA-N 0.000 claims 1
• QAEHWKLFMSAAHZ-UHFFFAOYSA-N n-[3-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]phenyl]acetamide Chemical compound CC(=O)NC1=CC=CC(C(O)(C=2C=C3C=NN(C3=CC=2)C=2C=CC=CC=2)C(F)(F)F)=C1 QAEHWKLFMSAAHZ-UHFFFAOYSA-N 0.000 claims 1
• ULQKXYRVNIPBEI-UHFFFAOYSA-N n-[4-[3,3,3-trifluoro-2-[1-(4-fluorophenyl)indazol-5-yl]-2-hydroxypropoxy]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC(F)=CC=3)C2=C1 ULQKXYRVNIPBEI-UHFFFAOYSA-N 0.000 claims 1
• UYWWVSTWQUNMFU-UHFFFAOYSA-N n-[4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]phenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 UYWWVSTWQUNMFU-UHFFFAOYSA-N 0.000 claims 1
• SSNYMZVYEGCYDX-UHFFFAOYSA-N n-[4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propoxy]phenyl]butanamide Chemical compound C1=CC(NC(=O)CCC)=CC=C1OCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 SSNYMZVYEGCYDX-UHFFFAOYSA-N 0.000 claims 1
• CYRTXHPLSBSAHC-UHFFFAOYSA-N n-[4-[3,3,3-trifluoro-2-hydroxy-2-(1-phenylindazol-5-yl)propyl]sulfanylphenyl]acetamide Chemical compound C1=CC(NC(=O)C)=CC=C1SCC(O)(C(F)(F)F)C1=CC=C(N(N=C2)C=3C=CC=CC=3)C2=C1 CYRTXHPLSBSAHC-UHFFFAOYSA-N 0.000 claims 1
• MZXUYTKLAUUPIS-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)NC)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 MZXUYTKLAUUPIS-UHFFFAOYSA-N 0.000 claims 1
• IYMNPSZPORLHIK-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]naphthalene-1-sulfonamide Chemical compound C12=CC=CC=C2C(S(=O)(=O)NC)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 IYMNPSZPORLHIK-UHFFFAOYSA-N 0.000 claims 1
• LAPLJIMUMMJYOE-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]quinoline-3-carboxamide Chemical compound CNC(=O)C1=CN=C2C=CC=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 LAPLJIMUMMJYOE-UHFFFAOYSA-N 0.000 claims 1
• ZZUVNVJQMSZIHX-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]naphthalene-1-carboxamide Chemical compound C12=CC=CC=C2C(C(=O)NC)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 ZZUVNVJQMSZIHX-UHFFFAOYSA-N 0.000 claims 1
• IZYTWISJLIGSDF-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]naphthalene-1-sulfonamide Chemical compound C12=CC=CC=C2C(S(=O)(=O)NC)=CC=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 IZYTWISJLIGSDF-UHFFFAOYSA-N 0.000 claims 1
• KWTGVQWHJYBMJS-UHFFFAOYSA-N n-methyl-4-[2,2,2-trifluoro-1-hydroxy-1-(1-phenylindazol-5-yl)ethyl]quinoline-3-carboxamide Chemical compound CNC(=O)C1=CN=C2C=CC=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=CC=C1 KWTGVQWHJYBMJS-UHFFFAOYSA-N 0.000 claims 1
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
• SMQASOLEVYFYIX-UHFFFAOYSA-N tert-butyl 4-[2,2,2-trifluoro-1-[1-(4-fluorophenyl)indazol-5-yl]-1-hydroxyethyl]indole-1-carboxylate Chemical compound C1=CC=C2N(C(=O)OC(C)(C)C)C=CC2=C1C(O)(C(F)(F)F)C(C=C1C=N2)=CC=C1N2C1=CC=C(F)C=C1 SMQASOLEVYFYIX-UHFFFAOYSA-N 0.000 claims 1