JP2008543758A5 - - Google Patents
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- Publication number
- JP2008543758A5 JP2008543758A5 JP2008515878A JP2008515878A JP2008543758A5 JP 2008543758 A5 JP2008543758 A5 JP 2008543758A5 JP 2008515878 A JP2008515878 A JP 2008515878A JP 2008515878 A JP2008515878 A JP 2008515878A JP 2008543758 A5 JP2008543758 A5 JP 2008543758A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- tanaproget
- ethinyl estradiol
- pharmaceutically acceptable
- daily dosage
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 claims 48
- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 claims 17
- 229950001471 tanaproget Drugs 0.000 claims 17
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 claims 14
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 claims 14
- 229960002568 ethinylestradiol Drugs 0.000 claims 14
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 14
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 9
- 229920002785 Croscarmellose sodium Polymers 0.000 claims 7
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 7
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 claims 7
- 229960004977 anhydrous lactose Drugs 0.000 claims 7
- 229960001681 croscarmellose sodium Drugs 0.000 claims 7
- 235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 claims 7
- 235000019359 magnesium stearate Nutrition 0.000 claims 7
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 7
- 239000008108 microcrystalline cellulose Substances 0.000 claims 7
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 150000003839 salts Chemical class 0.000 claims 7
- 238000000034 method Methods 0.000 claims 6
- 238000009472 formulation Methods 0.000 claims 3
- 238000002657 hormone replacement therapy Methods 0.000 claims 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 229960001375 lactose Drugs 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 229940057948 magnesium stearate Drugs 0.000 claims 2
- 230000000708 anti-progestin effect Effects 0.000 claims 1
- 239000003418 antiprogestin Substances 0.000 claims 1
- 239000003433 contraceptive agent Substances 0.000 claims 1
- 230000002254 contraceptive effect Effects 0.000 claims 1
- 238000007908 dry granulation Methods 0.000 claims 1
- 238000000227 grinding Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229940068196 placebo Drugs 0.000 claims 1
- 239000000902 placebo Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68880605P | 2005-06-09 | 2005-06-09 | |
| US60/688,806 | 2005-06-09 | ||
| PCT/US2006/022150 WO2006135638A2 (en) | 2005-06-09 | 2006-06-07 | Tanaproget compositions containing ethinyl estradiol |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008543758A JP2008543758A (ja) | 2008-12-04 |
| JP2008543758A5 true JP2008543758A5 (enExample) | 2009-07-23 |
| JP5339903B2 JP5339903B2 (ja) | 2013-11-13 |
Family
ID=37432377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515878A Expired - Fee Related JP5339903B2 (ja) | 2005-06-09 | 2006-06-07 | エチニルエストラジオールを含むタナプロゲット組成物 |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20060280800A1 (enExample) |
| EP (1) | EP1893217A2 (enExample) |
| JP (1) | JP5339903B2 (enExample) |
| CN (2) | CN101193639A (enExample) |
| AR (1) | AR057060A1 (enExample) |
| AU (1) | AU2006258048A1 (enExample) |
| BR (1) | BRPI0611250A2 (enExample) |
| CA (1) | CA2610767C (enExample) |
| HN (1) | HN2006020928A (enExample) |
| MX (1) | MX2007015571A (enExample) |
| PE (1) | PE20070001A1 (enExample) |
| TW (1) | TW200716137A (enExample) |
| WO (1) | WO2006135638A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CZ20013952A3 (cs) * | 1999-05-04 | 2002-05-15 | American Home Products Corporation | Deriváty cyklothiokarbamátu jako modulátory receptoru pro progesteron |
| ES2340610T3 (es) * | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| BRPI0610433A2 (pt) * | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| ES2340518T3 (es) * | 2005-04-28 | 2010-06-04 | Wyeth Llc | Tanaproget micronizado y composiciones que lo contienen. |
| WO2007030153A2 (en) | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| MX2007015571A (es) | 2005-06-09 | 2008-03-06 | Wyeth Corp | Composiciones de tanaproget que contienen etinilestradiol. |
| BRPI0819571A2 (pt) * | 2007-12-20 | 2019-09-24 | Teva Womenss Health Inc | "método para contracepção de emergência, pacote farmacêutico para contracepção de emergência e composição farmacêutica" |
| EP2753306B1 (en) * | 2011-10-17 | 2020-09-23 | Lexicon Pharmaceuticals, Inc. | Solid dosage forms of (s)-ethyl 2-amino-3-(4-(2-amino-6-((r)-1-(4-chloro-2-(3-methyl-1h-pyrazol-1-yl)phenyl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)phenyl)propanoate |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US20140006315A1 (en) * | 2012-07-02 | 2014-01-02 | Stèphane Etheve | Method of marketing oregano capsules containing thymoquinone |
| US9326997B2 (en) | 2012-09-24 | 2016-05-03 | Ahlam E. Elakkad | Composition and method for treation Oligoovulation, Oligomenorrhea and Amenorrhea |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| WO2014159377A1 (en) * | 2013-03-14 | 2014-10-02 | Teva Women's Health, Inc. | Compositions containing tanaproget and natural estrogens |
| CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
| WO2017173071A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical composition |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423699B1 (en) * | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
| CZ20013952A3 (cs) * | 1999-05-04 | 2002-05-15 | American Home Products Corporation | Deriváty cyklothiokarbamátu jako modulátory receptoru pro progesteron |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| TW200404548A (en) * | 2002-06-25 | 2004-04-01 | Wyeth Corp | Pharmaceutical composition containing cyclothiocarbamate derivatives in treatment of hormone-related conditions |
| AR040644A1 (es) | 2002-06-25 | 2005-04-13 | Wyeth Corp | Un moduladores del receptor de progesterona benzoxazina-2-tiona, una composicion farmaceutica, uso del compuesto para preparar un dedicamento para tratar una enfermedad neoplasica-hormona-dependiente y el uso de un compuesto benzoxazina-2-tiona, benzoxazina-2-ilideno cianamida o benzoxazina-2-iliden |
| MXPA06014579A (es) | 2004-07-07 | 2007-03-01 | Wyeth Corp | Regimenes de progestina ciclicos y equipos. |
| BRPI0514273A (pt) * | 2004-08-13 | 2008-06-10 | Wyeth Corp | composto, kit para monitorar terapia com tanaproget, método para detectar metabólitos de tanaproget, anticorpo, composição, kit para detectar metabólicos de tanaproget, e, uso de um derivado de glucuronìdeo de tanaproget ou um seu sal farmaceuticamente aceitável |
| ES2340518T3 (es) | 2005-04-28 | 2010-06-04 | Wyeth Llc | Tanaproget micronizado y composiciones que lo contienen. |
| WO2007030153A2 (en) | 2005-04-28 | 2007-03-15 | Wyeth | Compositions containing micronized tanaproget |
| ES2340610T3 (es) | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| CA2603786A1 (en) | 2005-04-28 | 2006-11-02 | Wyeth | Purified form of tanaproget |
| BRPI0610433A2 (pt) | 2005-04-28 | 2010-11-23 | Wyeth Corp | forma polimórfica ii de tanaproget, processos para preparar a mesma, e para preparar forma micronizada de um composto, composição farmacêutica, método de preparação de uma composição farmacêutica, e, uso da forma polimórfica ii de tanaproget ou da forma micronizada |
| MX2007015571A (es) | 2005-06-09 | 2008-03-06 | Wyeth Corp | Composiciones de tanaproget que contienen etinilestradiol. |
-
2006
- 2006-06-07 MX MX2007015571A patent/MX2007015571A/es unknown
- 2006-06-07 CA CA2610767A patent/CA2610767C/en not_active Expired - Fee Related
- 2006-06-07 EP EP06772444A patent/EP1893217A2/en not_active Ceased
- 2006-06-07 TW TW095120116A patent/TW200716137A/zh unknown
- 2006-06-07 BR BRPI0611250-1A patent/BRPI0611250A2/pt not_active IP Right Cessation
- 2006-06-07 PE PE2006000630A patent/PE20070001A1/es not_active Application Discontinuation
- 2006-06-07 US US11/448,965 patent/US20060280800A1/en not_active Abandoned
- 2006-06-07 JP JP2008515878A patent/JP5339903B2/ja not_active Expired - Fee Related
- 2006-06-07 CN CNA200680020195XA patent/CN101193639A/zh active Pending
- 2006-06-07 WO PCT/US2006/022150 patent/WO2006135638A2/en not_active Ceased
- 2006-06-07 CN CN201410160290.6A patent/CN103989687A/zh active Pending
- 2006-06-07 HN HN2006020928A patent/HN2006020928A/es unknown
- 2006-06-07 AU AU2006258048A patent/AU2006258048A1/en not_active Abandoned
- 2006-06-08 AR ARP060102394A patent/AR057060A1/es not_active Application Discontinuation
-
2011
- 2011-11-09 US US13/292,405 patent/US8664208B2/en not_active Expired - Fee Related
-
2014
- 2014-01-16 US US14/156,863 patent/US20140194398A1/en not_active Abandoned
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