CA2610767C - Tanaproget compositions containing ethinyl estradiol - Google Patents
Tanaproget compositions containing ethinyl estradiol Download PDFInfo
- Publication number
- CA2610767C CA2610767C CA2610767A CA2610767A CA2610767C CA 2610767 C CA2610767 C CA 2610767C CA 2610767 A CA2610767 A CA 2610767A CA 2610767 A CA2610767 A CA 2610767A CA 2610767 C CA2610767 C CA 2610767C
- Authority
- CA
- Canada
- Prior art keywords
- composition
- tanaproget
- product according
- ethinyl estradiol
- anhydrous lactose
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 188
- PYVFWTPEBMRKSR-UHFFFAOYSA-N tanaproget Chemical compound CN1C(C#N)=CC=C1C1=CC=C(NC(=S)OC2(C)C)C2=C1 PYVFWTPEBMRKSR-UHFFFAOYSA-N 0.000 title claims abstract description 118
- 229950001471 tanaproget Drugs 0.000 title claims abstract description 117
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 title claims abstract description 74
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 title claims abstract description 74
- 229960002568 ethinylestradiol Drugs 0.000 title claims abstract description 74
- 238000000034 method Methods 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 16
- 238000002657 hormone replacement therapy Methods 0.000 claims abstract description 9
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 70
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 64
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- 229960001375 lactose Drugs 0.000 claims description 7
- 239000008101 lactose Substances 0.000 claims description 7
- 230000000708 anti-progestin effect Effects 0.000 claims description 5
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- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 239000004322 Butylated hydroxytoluene Substances 0.000 description 2
- NLZUEZXRPGMBCV-UHFFFAOYSA-N Butylhydroxytoluene Chemical compound CC1=CC(C(C)(C)C)=C(O)C(C(C)(C)C)=C1 NLZUEZXRPGMBCV-UHFFFAOYSA-N 0.000 description 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- Reproductive Health (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68880605P | 2005-06-09 | 2005-06-09 | |
| US60/688,806 | 2005-06-09 | ||
| PCT/US2006/022150 WO2006135638A2 (en) | 2005-06-09 | 2006-06-07 | Tanaproget compositions containing ethinyl estradiol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2610767A1 CA2610767A1 (en) | 2006-12-21 |
| CA2610767C true CA2610767C (en) | 2014-09-23 |
Family
ID=37432377
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2610767A Expired - Fee Related CA2610767C (en) | 2005-06-09 | 2006-06-07 | Tanaproget compositions containing ethinyl estradiol |
Country Status (13)
| Country | Link |
|---|---|
| US (3) | US20060280800A1 (enExample) |
| EP (1) | EP1893217A2 (enExample) |
| JP (1) | JP5339903B2 (enExample) |
| CN (2) | CN103989687A (enExample) |
| AR (1) | AR057060A1 (enExample) |
| AU (1) | AU2006258048A1 (enExample) |
| BR (1) | BRPI0611250A2 (enExample) |
| CA (1) | CA2610767C (enExample) |
| HN (1) | HN2006020928A (enExample) |
| MX (1) | MX2007015571A (enExample) |
| PE (1) | PE20070001A1 (enExample) |
| TW (1) | TW200716137A (enExample) |
| WO (1) | WO2006135638A2 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP4958338B2 (ja) * | 1999-05-04 | 2012-06-20 | ワイス・エルエルシー | プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体 |
| JP5149160B2 (ja) * | 2005-04-28 | 2013-02-20 | ワイス・エルエルシー | ミクロ化タナプロゲットおよびこれを含む組成物 |
| ES2340610T3 (es) * | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| CN101166736B (zh) * | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| DK1874278T3 (da) | 2005-04-28 | 2009-09-28 | Wyeth Corp | Sammensætninger indeholdende mikroniseret tanaproget |
| CN103989687A (zh) | 2005-06-09 | 2014-08-20 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
| EA201070715A1 (ru) | 2007-12-20 | 2011-02-28 | Тева Вимен'С Хелс, Инк. | Режимы дозирования, фармацевтические композиции и упаковки для экстренной контрацепции |
| MX360191B (es) * | 2011-10-17 | 2018-10-24 | Lexicon Pharmaceuticals Inc | Formas de dosificacion solidas de 2-amino-3-(4-(2-amino-6-((r)-1-( 4-cloro-2-(3-metil-1h-pirazol-1-il)fenil)-2,2,2-trifluoroetoxi)pi rimidin-4-il)fenil) propanoato de (s)-etilo. |
| BR112014012444B1 (pt) | 2011-11-23 | 2021-12-14 | Therapeuticsmd, Inc | Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher |
| US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
| US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
| US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
| US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US20140006315A1 (en) * | 2012-07-02 | 2014-01-02 | Stèphane Etheve | Method of marketing oregano capsules containing thymoquinone |
| US9326997B2 (en) | 2012-09-24 | 2016-05-03 | Ahlam E. Elakkad | Composition and method for treation Oligoovulation, Oligomenorrhea and Amenorrhea |
| US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
| US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
| WO2014159377A1 (en) * | 2013-03-14 | 2014-10-02 | Teva Women's Health, Inc. | Compositions containing tanaproget and natural estrogens |
| RU2016143081A (ru) | 2014-05-22 | 2018-06-26 | Терапьютиксмд, Инк. | Натуральные комбинированные гормонозаместительные составы и терапии |
| US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
| KR20180126582A (ko) | 2016-04-01 | 2018-11-27 | 쎄러퓨틱스엠디, 인코퍼레이티드 | 스테로이드 호르몬 약제학적 조성물 |
| WO2017173044A1 (en) | 2016-04-01 | 2017-10-05 | Therapeuticsmd Inc. | Steroid hormone compositions in medium chain oils |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6423699B1 (en) * | 1999-05-04 | 2002-07-23 | American Home Products Corporation | Combination therapies using benzimidazolones |
| JP4958338B2 (ja) * | 1999-05-04 | 2012-06-20 | ワイス・エルエルシー | プロゲステロン受容体モジュレーターとしてのシクロチオカルバメート誘導体 |
| UA73119C2 (en) * | 2000-04-19 | 2005-06-15 | American Home Products Corpoir | Derivatives of cyclic thiocarbamates, pharmaceutical composition including noted derivatives of cyclic thiocarbamates and active ingredients of medicines as modulators of progesterone receptors |
| EP1515725A4 (en) * | 2002-06-25 | 2005-09-21 | Wyeth Corp | USE OF CYCLOTHIOCARBAMATE DERIVATIVES IN THE TREATMENT OF HORMONE-RELATED ILLNESSES |
| MXPA04012420A (es) * | 2002-06-25 | 2005-04-19 | Wyeth Corp | Derivados de ciclotiocabamativa como moduladores de rp y uso de los mismos para tratamiento de trastornos de la piel. |
| EP1773344A1 (en) * | 2004-07-07 | 2007-04-18 | Wyeth a Corporation of the State of Delaware | Cyclic progestin regimens and kits |
| DK1778710T3 (da) * | 2004-08-13 | 2012-04-16 | Wyeth Llc | Tanaprogetderivater, -metabolitter og anvendelser deraf |
| JP5149160B2 (ja) | 2005-04-28 | 2013-02-20 | ワイス・エルエルシー | ミクロ化タナプロゲットおよびこれを含む組成物 |
| DK1874278T3 (da) | 2005-04-28 | 2009-09-28 | Wyeth Corp | Sammensætninger indeholdende mikroniseret tanaproget |
| US7786297B2 (en) | 2005-04-28 | 2010-08-31 | Wyeth Llc | Purified form of tanaproget |
| CN101166736B (zh) | 2005-04-28 | 2013-02-06 | 惠氏公司 | 他那普戈特的多晶型ⅱ |
| ES2340610T3 (es) | 2005-04-28 | 2010-06-07 | Wyeth Llc | Composiciones de tanaproget micronizado y procedimientos de preparacion de las mismas. |
| CN103989687A (zh) | 2005-06-09 | 2014-08-20 | 惠氏公司 | 含有炔雌醇的tanaproget组合物 |
-
2006
- 2006-06-07 CN CN201410160290.6A patent/CN103989687A/zh active Pending
- 2006-06-07 JP JP2008515878A patent/JP5339903B2/ja not_active Expired - Fee Related
- 2006-06-07 AU AU2006258048A patent/AU2006258048A1/en not_active Abandoned
- 2006-06-07 HN HN2006020928A patent/HN2006020928A/es unknown
- 2006-06-07 EP EP06772444A patent/EP1893217A2/en not_active Ceased
- 2006-06-07 CA CA2610767A patent/CA2610767C/en not_active Expired - Fee Related
- 2006-06-07 BR BRPI0611250-1A patent/BRPI0611250A2/pt not_active IP Right Cessation
- 2006-06-07 TW TW095120116A patent/TW200716137A/zh unknown
- 2006-06-07 MX MX2007015571A patent/MX2007015571A/es unknown
- 2006-06-07 CN CNA200680020195XA patent/CN101193639A/zh active Pending
- 2006-06-07 PE PE2006000630A patent/PE20070001A1/es not_active Application Discontinuation
- 2006-06-07 US US11/448,965 patent/US20060280800A1/en not_active Abandoned
- 2006-06-07 WO PCT/US2006/022150 patent/WO2006135638A2/en not_active Ceased
- 2006-06-08 AR ARP060102394A patent/AR057060A1/es not_active Application Discontinuation
-
2011
- 2011-11-09 US US13/292,405 patent/US8664208B2/en not_active Expired - Fee Related
-
2014
- 2014-01-16 US US14/156,863 patent/US20140194398A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US8664208B2 (en) | 2014-03-04 |
| CN101193639A (zh) | 2008-06-04 |
| AU2006258048A1 (en) | 2006-12-21 |
| WO2006135638A3 (en) | 2007-03-15 |
| HN2006020928A (es) | 2011-02-16 |
| AR057060A1 (es) | 2007-11-14 |
| BRPI0611250A2 (pt) | 2011-02-15 |
| JP5339903B2 (ja) | 2013-11-13 |
| CN103989687A (zh) | 2014-08-20 |
| MX2007015571A (es) | 2008-03-06 |
| TW200716137A (en) | 2007-05-01 |
| PE20070001A1 (es) | 2007-01-29 |
| US20060280800A1 (en) | 2006-12-14 |
| WO2006135638A2 (en) | 2006-12-21 |
| JP2008543758A (ja) | 2008-12-04 |
| CA2610767A1 (en) | 2006-12-21 |
| US20140194398A1 (en) | 2014-07-10 |
| EP1893217A2 (en) | 2008-03-05 |
| US20120114748A1 (en) | 2012-05-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| EEER | Examination request | ||
| MKLA | Lapsed |
Effective date: 20160607 |