JP2008542403A - 歯の石灰化 - Google Patents
歯の石灰化 Download PDFInfo
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- JP2008542403A JP2008542403A JP2008515000A JP2008515000A JP2008542403A JP 2008542403 A JP2008542403 A JP 2008542403A JP 2008515000 A JP2008515000 A JP 2008515000A JP 2008515000 A JP2008515000 A JP 2008515000A JP 2008542403 A JP2008542403 A JP 2008542403A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/24—Phosphorous; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/42—Phosphorus; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/66—Enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/70—Biological properties of the composition as a whole
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Chemical & Material Sciences (AREA)
- Inorganic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Oral & Maxillofacial Surgery (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Dental Preparations (AREA)
Abstract
Description
低石灰化病変の通常の原因は、カリエス及びフッ素沈着である。
一態様において、本発明は、歯表面にタンパク質破壊剤を接触させる、及び歯表面に安定化アモルファスリン酸カルシウム(ACP)及び安定化アモルファスフッ化リン酸カルシウム(ACFP)を接触させることを含めた、歯表面または表面下を石灰化する方法を提供する。歯表面というのは、好ましくは歯エナメル質のことである。一実施形態において、歯表面は、カリエス、歯浸食またはフッ素沈着により生じる病変のようなエナメル質における病変である。
好適なタンパク質破壊剤は何れも、本発明の方法で使用可能である。この阻害剤は、歯の上のペリクルのような処理する表面にわたって形成されたタンパク質バリアを減縮することが求められる。好適な阻害剤の例には、漂白剤、界面活性剤、カオトロピック剤(例えば、尿素)、リン酸塩高濃縮物、プロテアーゼカクテル(例えば、エンドペプチダーゼ、プロテイナーゼ及びエキソペプチダーゼ)、並びにその他何れかのタンパク質可溶化剤、阻害剤または加水分解剤が含まれる。
Glu及びAspの2−アミノアジピン酸(Aad);
Glu及びAspの2−アミノピメリン酸(Apm);
Met、Leu及びその他の脂肪族アミノ酸の2−アミノ酪酸(Abu);
Met、Leu及びその他の脂肪族アミノ酸の2−アミノヘプタン酸(Ahe);
Glyの2−アミノイソ酪酸(Aib);
Val、Leu及びIleのシクロヘキシルアラニン(Cha);
Arg及びLysのホモアルギニン(Har);
Lys、Arg及びHisの2,3−ジアミノプロピオン酸(Dpr);
Gly、Pro及びAlaのN−エチルグリシン(EtGly);
Asn及びGlnのN−エチルアスパラギン酸(EtAsn);
Lysのヒドロキシルリシン(Hyl);
Lysのアロヒドロキシルリシン(AHyl);
Pro、Ser及びThrの3−(及び4−)ヒドロキシプロリン(3Hyp、4Hyp);
Ile、Leu及びValのアロイソロイシン(AIle);
Alaのp−アミジノフェニルアラニン;
Gly、Pro、AlaのN−メチルグリシン(MeGly、サルコシン);
IleのN−メチルイソロイシン(MeIle);
Met及びその他の脂肪族アミノ酸のノルバリン(Nva);
Met及びその他の脂肪族アミノ酸のノルロイシン(Nle);
Lys、Arg及びHisのオルニチン(Orn);
Thr、Asn及びGlnのシトルリン(Cit)及びメチオニンスルホキシド(MSO);
PheのN−メチルフェニルアラニン(MePhe)、トリメチルフェニルアラニン、ハロ(F、Cl、Br及びI)フェニルアラニン、トリフルオリルフェニルアラニン。
グリセリン
CPP−ACP
D−ソルビトール
二酸化ケイ素
カルボキシメチルセルロースナトリウム(CMC−Na)
プロピレングリコール
二酸化チタン
キシリトール
リン酸
グアーガム
酸化亜鉛
サッカリンナトリウム
エチルp−ヒドロキシベンゾエート
酸化マグネシウム
ブチルp−ヒドロキシベンゾエート
プロピルp−ヒドロキシベンゾエート
このような組成物は、Tooth MousseTMの商品名でGC Corporationから販売されている。これは、タンパク質破壊剤の後に使用に好適であり、好適な時間に歯の上に保持されることを容易にするためにペースト状またはクリーム状である。或いは、この石灰化組成物は、次亜塩素酸ナトリウムのようなタンパク質破壊剤を含む場合がある。
Claims (15)
- 歯表面または表面下を石灰化する方法であって、該歯表面または表面下と、タンパク質破壊剤及び安定化アモルファスリン酸カルシウム(ACP)または安定化アモルファスフッ化リン酸カルシウム(ACFP)とを接触させることを含む、方法。
- 該歯表面が歯エナメル質である、請求項1に記載の方法。
- 該歯表面が歯エナメル質における病変である、請求項1に記載の方法。
- 該病変が虫歯、歯の浸食またはフッ素沈着により生じる、請求項3に記載の方法。
- 該ACP及び/またはACFPが、ホスホペプチドで安定化されている、請求項1に記載の方法。
- 該ホスホペプチドがカゼインホスホペプチドである、請求項5に記載の方法。
- 該ACPまたはACFPが塩基相にある、請求項1に記載の方法。
- 該タンパク質破壊剤が、漂白剤、界面活性剤、カオトロピック剤、プロテアーゼ、及びプロテアーゼの混合物からなる群の1つ以上から選択される、請求項1に記載の方法。
- 該漂白剤が次亜塩素酸ナトリウムまたは過酸化カルバミド漂白剤である、請求項8に記載の方法。
- 歯エナメル質における病変を再石灰化する方法であって、該病変と、タンパク質破壊剤及び安定化ACP及び/またはACFPとを接触させることを含む、方法。
- フッ素沈着を処置する方法であって、歯エナメル質におけるフッ素沈着病変と、タンパク質破壊剤及び安定化ACP及び/またはACFPとを接触させることを含む、方法。
- 虫歯を処置する方法であって、歯エナメル質におけるカリエス病変と、タンパク質破壊剤及び安定化ACP及び/またはACFPとを接触させることを含む、方法。
- 歯の浸食を処置する方法であって、浸食により生じた歯エナメル質における病変と、タンパク質破壊剤及び安定化ACP及び/またはACFPとを接触させることを含む、方法。
- 歯エナメル質上の白斑病変を低減させる方法であって、白斑病変と、タンパク質破壊剤及び安定化ACP及び/またはACFPとを接触させることを含む、方法。
- 虫歯、フッ素沈着及び歯の浸食の1つ以上を処置または予防するためのキットであって、薬学的に許容される担体中に(a)タンパク質破壊剤及び(b)CPP−ACPまたはCPP−ACFP複合体を含む、キット。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AU2005902961 | 2005-06-07 | ||
AU2005902961A AU2005902961A0 (en) | 2005-06-07 | Dental mineralisation | |
PCT/AU2006/000785 WO2006130913A1 (en) | 2005-06-07 | 2006-06-07 | Dental mineralization |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2008542403A true JP2008542403A (ja) | 2008-11-27 |
JP2008542403A5 JP2008542403A5 (ja) | 2009-07-23 |
JP5539648B2 JP5539648B2 (ja) | 2014-07-02 |
Family
ID=37498029
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2008515000A Active JP5539648B2 (ja) | 2005-06-07 | 2006-06-07 | 歯の石灰化 |
Country Status (15)
Country | Link |
---|---|
US (2) | US8673363B2 (ja) |
EP (1) | EP1888014B1 (ja) |
JP (1) | JP5539648B2 (ja) |
CN (2) | CN104013963A (ja) |
AR (1) | AR057353A1 (ja) |
AU (1) | AU2006255486B2 (ja) |
BR (1) | BRPI0610885B1 (ja) |
CA (1) | CA2611077C (ja) |
DK (1) | DK1888014T3 (ja) |
ES (1) | ES2399345T3 (ja) |
MX (1) | MX2007015496A (ja) |
NZ (1) | NZ563944A (ja) |
PT (1) | PT1888014E (ja) |
RU (1) | RU2413498C2 (ja) |
WO (1) | WO2006130913A1 (ja) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2011518215A (ja) * | 2008-04-21 | 2011-06-23 | ザ ユニバーシティ オブ ダンディー | 石灰化組織の再石灰化 |
JP2011178725A (ja) * | 2010-03-02 | 2011-09-15 | Showa Univ | エナメル質石灰化促進材セット |
JP2011200256A (ja) * | 2006-04-05 | 2011-10-13 | Cadbury Adams Usa Llc | チューインガム組成物及びキット |
KR20160040229A (ko) * | 2013-07-23 | 2016-04-12 | 더 유니버시티 오브 멜버른 | 치아 광화를 위한 조성물 및 방법 |
WO2022113931A1 (ja) * | 2020-11-24 | 2022-06-02 | 株式会社西尾 | 歯質強化方法及び歯のホワイトニング方法 |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
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US8609071B2 (en) | 2004-11-25 | 2013-12-17 | The University Of Melbourne | Stabilized calcium phosphate complexes |
AR057353A1 (es) | 2005-06-07 | 2007-11-28 | Univ Melbourne | Mineralizacion dental |
BRPI0611976B1 (pt) | 2005-06-24 | 2018-07-10 | The University Of Melbourne | Complexos iônicos |
CN101378720B (zh) * | 2006-02-09 | 2012-04-25 | 墨尔本大学 | 氟化物组合物及用于牙齿矿化的方法 |
EA012038B1 (ru) * | 2007-05-11 | 2009-06-30 | Людмила Николаевна Дедова | Способ минерализации тканей корня зуба |
CA2735171C (en) * | 2008-08-29 | 2023-10-03 | Oral Health Australia Pty Ltd | Prevention, treatment and diagnosis of p.gingivalis infection |
IT1392394B1 (it) * | 2008-12-22 | 2012-03-02 | Vittoria | Materiale composito dotato di proprietà di autoriparazione e di rilascio di principi attivi, per applicazioni biomediche |
US8741268B2 (en) * | 2009-09-10 | 2014-06-03 | Preventive Technologies, Inc. | Dental prophylactic paste |
US8715625B1 (en) | 2010-05-10 | 2014-05-06 | The Clorox Company | Natural oral care compositions |
RU2541054C1 (ru) * | 2013-09-03 | 2015-02-10 | Евгений Андреевич Лавренюк | Способ лечения эрозии зубов |
RU2716134C2 (ru) | 2013-12-24 | 2020-03-06 | Де Юниверсити Оф Мельбурн | Стабилизированные композиции на основе олова (II) |
JP2016102069A (ja) * | 2014-11-27 | 2016-06-02 | 株式会社ジーシー | 歯面清掃方法、歯面清掃用組成物、及びその使用方法 |
GB2535989A (en) * | 2015-02-26 | 2016-09-07 | Dr Heff's Products Ltd | Dental product, use of a dental product and methods of use of a dental product |
KR20180069058A (ko) | 2015-10-26 | 2018-06-22 | 바스프 에스이 | 부동 단백질을 포함하는 구강 케어 제품 및 방법 |
KR20240055159A (ko) | 2017-03-14 | 2024-04-26 | 더 유니버시티 오브 멜버른 | 치은염을 위한 치료 |
BR112021011819A2 (pt) * | 2018-12-18 | 2021-08-31 | International Flavors & Fragrances Inc. | Composição de microcápsula, processo para preparar uma composição de microcápsula, e, produto de consumo |
CN113766904A (zh) * | 2019-03-13 | 2021-12-07 | 墨尔本大学 | 促进矿化的组合物和方法 |
AU2020234723A1 (en) * | 2019-03-13 | 2021-10-07 | The University Of Melbourne | Concealment of hypomineralised lesions |
CN111249178A (zh) * | 2020-03-20 | 2020-06-09 | 成都爱睿康乐医疗器械有限公司 | 一种儿童防龋牙膏 |
WO2024042191A1 (en) | 2022-08-26 | 2024-02-29 | Blissandmore Gmbh | Oral care compositions |
WO2024089262A1 (en) | 2022-10-28 | 2024-05-02 | Queen Mary University Of London | Toothpaste composition |
Citations (2)
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JPH08143436A (ja) * | 1994-11-21 | 1996-06-04 | Kazue Yamagishi | 歯の漂白剤及びこの漂白剤を用いた歯の漂白方法 |
JP2002500626A (ja) * | 1997-03-13 | 2002-01-08 | ザ ユニヴァーシティ オブ メルボルン | カルシウムホスホペプチド複合体 |
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US4522805A (en) | 1983-06-08 | 1985-06-11 | Norman Gordon | Tooth and gum dentifrice |
CA1315480C (en) | 1986-06-12 | 1993-03-30 | Eric Charles Reynolds | Phosphopeptides |
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US5227154A (en) | 1991-08-22 | 1993-07-13 | The University Of Melbourne | Phosphopeptides for the treatment of dental calculus |
EP0651652B1 (en) | 1992-06-29 | 2000-02-09 | The University Of Melbourne | Treatment for sensitive teeth |
JP4040705B2 (ja) | 1996-01-24 | 2008-01-30 | 株式会社サンギ | 口腔組成物 |
JP2975337B2 (ja) | 1997-02-20 | 1999-11-10 | 雪印乳業株式会社 | カルシウム複合体 |
FR2791573B1 (fr) | 1999-03-30 | 2003-04-11 | Pf Medicament | Utilisation d'un extrait de serenoa repens pour la fabrication d'un medicament destine au traitement du cancer de la prostate |
US6521215B2 (en) * | 1999-05-28 | 2003-02-18 | Devin Okay | Compositions and methods for tooth treatment |
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GB9929919D0 (en) | 1999-12-17 | 2000-02-09 | Hannah Research Inst The | Calcium phosphate nanoclusters and their applications |
JP2002338447A (ja) * | 2001-05-15 | 2002-11-27 | Kuraray Co Ltd | 歯科用組成物 |
AUPR517701A0 (en) | 2001-05-21 | 2001-06-14 | University Of Melbourne, The | Dental restorative materials |
EP1461005A2 (en) | 2002-01-03 | 2004-09-29 | The Procter & Gamble Company | Stable oral compositions comprising casein phosphopeptide complexes and fluoride |
AU2002351356A1 (en) | 2002-01-03 | 2003-07-30 | The Procter And Gamble Company | Stable oral compositions comprising casein phosphopeptide complexes and flouride |
NZ522071A (en) | 2002-10-18 | 2005-07-29 | Patrick Joseph Silcock | Hydrolysed casein phosphoprotein preparations for bioactive metal ion delivery and teeth remineralisation |
JP4340069B2 (ja) | 2003-01-10 | 2009-10-07 | 雪印乳業株式会社 | カルシウム複合体の製造法 |
US20050089481A1 (en) | 2003-10-23 | 2005-04-28 | Gc Corporation | Composition for caries prevention |
US20060183081A1 (en) * | 2004-09-27 | 2006-08-17 | Al Bevilacqua | Tooth bleaching system and method |
AR057353A1 (es) | 2005-06-07 | 2007-11-28 | Univ Melbourne | Mineralizacion dental |
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2006
- 2006-06-07 AR ARP060102378A patent/AR057353A1/es unknown
- 2006-06-07 ES ES06741201T patent/ES2399345T3/es active Active
- 2006-06-07 RU RU2007149555/15A patent/RU2413498C2/ru active
- 2006-06-07 NZ NZ563944A patent/NZ563944A/en unknown
- 2006-06-07 JP JP2008515000A patent/JP5539648B2/ja active Active
- 2006-06-07 PT PT67412015T patent/PT1888014E/pt unknown
- 2006-06-07 CA CA2611077A patent/CA2611077C/en active Active
- 2006-06-07 DK DK06741201.5T patent/DK1888014T3/da active
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Cited By (8)
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JP2011200256A (ja) * | 2006-04-05 | 2011-10-13 | Cadbury Adams Usa Llc | チューインガム組成物及びキット |
JP2011518215A (ja) * | 2008-04-21 | 2011-06-23 | ザ ユニバーシティ オブ ダンディー | 石灰化組織の再石灰化 |
JP2011178725A (ja) * | 2010-03-02 | 2011-09-15 | Showa Univ | エナメル質石灰化促進材セット |
KR20160040229A (ko) * | 2013-07-23 | 2016-04-12 | 더 유니버시티 오브 멜버른 | 치아 광화를 위한 조성물 및 방법 |
JP2016527236A (ja) * | 2013-07-23 | 2016-09-08 | ザ ユニバーシティー オブ メルボルンThe University of Melbourne | 歯の石灰化のための組成物および方法 |
JP2019218365A (ja) * | 2013-07-23 | 2019-12-26 | ザ ユニバーシティー オブ メルボルンThe University of Melbourne | 歯の石灰化のための組成物および方法 |
KR102221531B1 (ko) * | 2013-07-23 | 2021-03-02 | 더 유니버시티 오브 멜버른 | 치아 광화를 위한 조성물 및 방법 |
WO2022113931A1 (ja) * | 2020-11-24 | 2022-06-02 | 株式会社西尾 | 歯質強化方法及び歯のホワイトニング方法 |
Also Published As
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CA2611077C (en) | 2014-07-15 |
EP1888014B1 (en) | 2012-11-14 |
CN101217932A (zh) | 2008-07-09 |
EP1888014A1 (en) | 2008-02-20 |
AU2006255486B2 (en) | 2011-06-02 |
JP5539648B2 (ja) | 2014-07-02 |
BRPI0610885A2 (pt) | 2010-08-03 |
WO2006130913A1 (en) | 2006-12-14 |
AR057353A1 (es) | 2007-11-28 |
US20080193557A1 (en) | 2008-08-14 |
DK1888014T3 (da) | 2013-02-18 |
MX2007015496A (es) | 2008-03-04 |
CA2611077A1 (en) | 2006-12-14 |
AU2006255486A1 (en) | 2006-12-14 |
US20140147512A1 (en) | 2014-05-29 |
CN104013963A (zh) | 2014-09-03 |
ES2399345T3 (es) | 2013-03-27 |
US8673363B2 (en) | 2014-03-18 |
EP1888014A4 (en) | 2009-09-02 |
BRPI0610885B1 (pt) | 2018-07-10 |
PT1888014E (pt) | 2013-02-15 |
RU2413498C2 (ru) | 2011-03-10 |
RU2007149555A (ru) | 2009-07-10 |
NZ563944A (en) | 2010-03-26 |
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