JP2008538586A - 酸化ストレスに関連する疾患および病気の処置のためのｎ−アセチルシステインアミド（ｎａｃアミド） - Google Patents

酸化ストレスに関連する疾患および病気の処置のためのｎ−アセチルシステインアミド（ｎａｃアミド） Download PDF

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JP2008538586A
JP2008538586A JP2008507992A JP2008507992A JP2008538586A JP 2008538586 A JP2008538586 A JP 2008538586A JP 2008507992 A JP2008507992 A JP 2008507992A JP 2008507992 A JP2008507992 A JP 2008507992A JP 2008538586 A JP2008538586 A JP 2008538586A
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nac amide
mixture
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nac
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グレン エー． ゴールドスタイン，
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JP2008507992A 2005-04-21 2006-04-21 酸化ストレスに関連する疾患および病気の処置のためのｎ−アセチルシステインアミド（ｎａｃアミド） Pending JP2008538586A (ja)

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Application Number Priority Date Filing Date Title
US67356105P 2005-04-21 2005-04-21
US70596705P 2005-08-05 2005-08-05
PCT/US2006/015548 WO2006116353A2 (en) 2005-04-21 2006-04-21 N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress

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JP2008538586A true JP2008538586A (ja) 2008-10-30
JP2008538586A5 JP2008538586A5 (https=) 2009-07-09

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US (3) US20090234011A1 (https=)
EP (1) EP1877044A4 (https=)
JP (1) JP2008538586A (https=)
KR (1) KR20080028357A (https=)
AU (1) AU2006238888A1 (https=)
CA (1) CA2606053A1 (https=)
IL (1) IL186684A0 (https=)
RU (1) RU2007143040A (https=)
WO (1) WO2006116353A2 (https=)

Cited By (12)

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JP2011088829A (ja) * 2009-10-20 2011-05-06 Chube Univ 発癌毒性の評価方法及び発癌予防・治療剤
JP2012102041A (ja) * 2010-11-09 2012-05-31 Maruzen Pharmaceut Co Ltd 抗酸化剤及び抗炎症剤
JP2015527999A (ja) * 2012-07-10 2015-09-24 エックスピーディ・ホールディングス・リミテッド・ライアビリティ・カンパニーＸＰＤ Ｈｏｌｄｉｎｇｓ ＬＬＣ 安定化された多機能酸化防止化合物およびその使用方法
JP2016523975A (ja) * 2013-07-10 2016-08-12 グレン・エー・ゴールドスタイン 穿通性頭部外傷の処置におけるｎ−アセチルシステインアミドの使用
JP2017534673A (ja) * 2014-09-15 2017-11-24 サウンド・ファーマシューティカルズ・インコーポレイテッド 精神病性障害を治療するための方法および組成物
JP2018503689A (ja) * 2015-01-27 2018-02-08 フローレンゲイル・エル・エル・シー 治癒性局所用組成物
JP2019501226A (ja) * 2016-01-11 2019-01-17 プレッドファルマ・アーベー 急性肝不全及び他の肝毒性状態を治療及び／又はこれらから保護するための方法及び製剤
JP2021502323A (ja) * 2017-11-09 2021-01-28 ナキュイティ ファーマシューティカルズ， インク．Ｎａｃｕｉｔｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 重水素濃縮ｎ−アセチルシステインアミド（ｄ−ｎａｃａ，ｄｅｕｔｅｒｉｕｍ−ｅｎｒｉｃｈｅｄ ｎ−ａｃｅｔｙｌｃｙｓｔｅｉｎｅ ａｍｉｄｅ）及び（２ｒ，２ｒ’）−３，３’−ジスルファンジイルビス（２−アセトアミドプロパンアミド）（ｄｉｎａｃａ）を作製する、並びに酸化ストレスが関与する疾患を治療するためにｄ−ｎａｃａ及びｄｉｎａｃａを使用する方法
JP2021193119A (ja) * 2014-11-07 2021-12-23 ザ・ジョンズ・ホプキンス・ユニバーシティー Ｎ−アセチルシステインアミドによる網膜色素変性症の治療
JP2022518174A (ja) * 2019-01-11 2022-03-14 ナキュイティ ファーマシューティカルズ， インク． 放射線皮膚炎の予防及び治療、並びに皮膚ライトニング、皮膚ホワイトニング、並びに皮膚改善のためのｎ－アセチルシステインアミド（ｎａｃａ）及び（２ｒ，２ｒ’）－３，３’－ジスルファンジイルビス（２－アセトアミドプロパンアミド）（ｄｉｎａｃａ）
JP2023511369A (ja) * 2020-01-24 2023-03-17 ナキュイティ ファーマシューティカルズ， インク． 酸化ストレスの疾患及び傷害の治療のためのプロドラッグ
US12245998B2 (en) 2019-01-11 2025-03-11 Nacuity Pharmaceuticals, Inc. N-acetylcysteine amide (NACA) and (2R,2R′)-3,3′ disulfanediyl bis(2-acetamidopropanamide) (diNACA) for the prevention and treatment of radiation pneumonitis and treatment of pulmonary function in Cystic Fibrosis

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DK1616869T3 (da) 1999-01-25 2012-05-07 Nat Jewish Health Substituerede porphyriner og deres terapeutiske anvendelse
US8993627B2 (en) 2005-04-21 2015-03-31 Sentient Lifesciences, Inc. N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress
US20090234011A1 (en) 2005-04-21 2009-09-17 Goldstein Glenn A N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress
EP1968609A4 (en) * 2005-12-20 2010-06-09 Silamed Inc PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS
ZA200902203B (en) * 2006-10-23 2010-08-25 Mental Health Res Inst Of Vict Combination therapy
US20080146579A1 (en) * 2006-12-15 2008-06-19 N.V. Nutricia Treatment of patients with chronic pulmonary diseases and nutritional compositions therefore
WO2008121171A1 (en) * 2007-01-12 2008-10-09 Cornell Research Foundation, Inc. Adenylyl cyclases as novel targets for antibacterial interventions
US9095578B2 (en) * 2007-01-12 2015-08-04 Cornell Research Foundation, Inc. Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens
IL188681A0 (en) * 2008-01-09 2008-12-29 Amino Acid Solutions Inc Pharmaceutical compositions and methods utilizing a d-amino acid
EP2291182A1 (en) * 2008-05-13 2011-03-09 Genmedica Therapeutics SL Salicylate conjugates useful for treating metabolic disorders
US11382895B2 (en) 2008-05-23 2022-07-12 National Jewish Health Methods for treating injury associated with exposure to an alkylating species
CN102421424A (zh) * 2009-03-16 2012-04-18 根梅迪卡治疗公司 用于治疗代谢性疾病的组合疗法
CA2755069A1 (en) * 2009-03-16 2010-09-23 Genmedica Therapeutics Sl Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
TWI535440B (zh) 2009-10-26 2016-06-01 Ｌｇ生命科學有限公司 包括吲哚化合物之醫藥組成物
WO2012033235A1 (ko) * 2010-09-06 2012-03-15 서울대학교 산학협력단 Ｎ-아세틸-ｌ-시스테인 또는 이의 유도체를 포함하는 불안 장애 치료용 약학 조성물
FR2964967A1 (fr) * 2010-09-17 2012-03-23 Exsymol Sa Peptidomimetiques derives de la methionine et leur utilisation dans la protection des mitochondries des cellules cutanees
US8466197B2 (en) 2010-12-14 2013-06-18 Genmedica Therapeutics Sl Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders
ES2893825T3 (es) 2011-02-04 2022-02-10 Hough Ear Inst Métodos de tratamiento de lesiones cerebrales
WO2013138744A1 (en) * 2012-03-16 2013-09-19 M. Alphabet 1, Llc Compositions for the treatment of skin disorders
WO2013152076A1 (en) * 2012-04-04 2013-10-10 The Brigham And Women's Hospital, Inc. Compositions and methods for treating hypertension
CA2871774C (en) * 2012-04-26 2021-05-18 Sentient Lifesciences, Inc. Use of n-acetylcysteine amide in the treatment of disease and injury
US20130296430A1 (en) * 2012-05-03 2013-11-07 Antonio Hardan Compositions and methods for treating autism and autism spectrum disorder
EP3674297A1 (en) 2013-11-08 2020-07-01 Promentis Pharmaceuticals, Inc. Substituted n-acetyl-l-cysteine derivatives and related compounds
US20150209309A1 (en) * 2014-01-24 2015-07-30 Brighton Biotech, Inc Naca for the treatment of chronic or acute cognitive dysfunction
US20150209310A1 (en) * 2014-01-24 2015-07-30 Brighton Biotech, Inc. Naca for the treatment of chronic or low impact brain trauma
US20170049727A1 (en) * 2014-02-12 2017-02-23 Glenn A. Goldstein Use of N-Acetylcysteine Amide in the Treatment of Acquired Immune Deficiency Syndrome and HIV Infection
WO2016077467A1 (en) 2014-11-11 2016-05-19 The Johns Hopkins University Biomarkers useful in the treatment of subjects having diseases of the eye
WO2016197089A1 (en) * 2015-06-05 2016-12-08 Goldstein Glenn A Use of n-acetylcysteine amide in the treatment of acetaminophen overdose
CA3022013C (en) 2016-04-29 2025-08-12 Ophirex, Inc. Secreted pla2 inhibitors for immediate treatment of hymenoptera envenomation
US20240342118A1 (en) * 2017-09-20 2024-10-17 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives
EP3684756A4 (en) 2017-09-20 2020-10-28 NaCuity Pharmaceuticals, Inc. SYNTHESIS OF N-ACETYLCYSTEIN AMIDE AND ITS DERIVATIVES
US11548851B2 (en) 2017-09-20 2023-01-10 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide and derivatives thereof
US11091433B2 (en) 2017-09-20 2021-08-17 Nacuity Pharmaceutials, Inc. Method for preparation of N-acetyl cysteine amide and derivatives thereof
US20240368072A1 (en) * 2017-09-20 2024-11-07 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives
US20240217927A1 (en) * 2017-11-09 2024-07-04 Nacuity Pharmaceuticals, Inc. Methods of Making Deuterium-Enriched N-Acetylcysteine Amide (D-NACA) and (2R,2R)-3,3-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress
US20190151271A1 (en) * 2017-11-21 2019-05-23 The Johns Hopkins University Compositions and methods for treatment of eye diseases
JP7336143B2 (ja) * 2017-11-28 2023-08-31 セルツーイン、 インコーポレイテッド リアルタイムなグルタチオンの測定による治療用細胞の品質向上方法
CU20200106A7 (es) 2018-06-20 2021-08-06 Axcella Health Inc Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias
US11497758B2 (en) 2018-11-15 2022-11-15 Samuel L. Shepherd Method of treating oxidative stress due to radiation exposure
EP3908341A4 (en) 2019-01-11 2022-03-02 NaCuity Pharmaceuticals, Inc. TREATMENT OF AGE-RELATED MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY WITH N-ACETYLCYSTEINE AMIDE (NACA) OR (2R,2R')-3,3'-BIS(2-ACETAMIDOPROPANAMIDE) DISULFANEDIYL (DINACA)
CN109758581A (zh) * 2019-02-14 2019-05-17 上海市东方医院（同济大学附属东方医院） 一种抗氧化磁性氧化铁纳米颗粒及其制备方法
JP7498504B2 (ja) * 2019-06-13 2024-06-12 シャンハイ ケチョウ ファーマ，インコーポレイテッド 脳神経または心臓保護剤としてのアミノチオール系化合物の使用
US12090130B2 (en) 2019-12-18 2024-09-17 Neuronasal, Inc. Methods of treating brain disorders
WO2021252378A1 (en) * 2020-06-08 2021-12-16 Nacuity Pharmaceuticals, Inc. Prevention or treatment of covid-19
US20230263725A1 (en) * 2020-07-09 2023-08-24 Beyond Barriers Therapeutics, Inc. Intranasal administration of an antioxidant compound for treating coronavirus infection
IL300416A (en) * 2020-08-06 2023-04-01 Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd Oleylcysteine amide or its derivatives and their uses
EP3960168A1 (en) * 2020-08-28 2022-03-02 Université de Genève Compositions and methods comprising d-cysteine or a derivative thereof
CN112602724B (zh) * 2020-12-21 2021-09-24 上海汉今医疗科技有限公司 一种感染性医疗废物消毒液及其制备方法
AU2022204064A1 (en) 2021-07-16 2023-02-02 Samuel L. Shepherd Method of treating oxidative stress due to radiation exposure
CN115449065B (zh) * 2022-09-21 2023-09-22 中南大学湘雅医院 一种nac改性血液净化膜及其制备方法
WO2026015776A1 (en) * 2024-07-12 2026-01-15 Nacuity Pharmaceuticals, Inc. Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369106B1 (en) * 1996-12-26 2002-04-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
US6420429B1 (en) * 1997-12-23 2002-07-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Brain targeted low molecular weight hydrophobic antioxidant compounds

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5696109A (en) * 1992-12-07 1997-12-09 Eukarion, Inc. Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease
US5691380A (en) 1995-06-29 1997-11-25 The Procter & Gamble Company Stable n-acetylcysteine compositions and methods for treating human skin therewith
US5733535A (en) * 1995-10-25 1998-03-31 The Procter & Gamble Co. Topical compositions containing N-acetylcysteine and odor masking materials
US5962421A (en) * 1996-05-16 1999-10-05 Zambon, S.A. Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases
US5874468A (en) 1996-12-26 1999-02-23 Yissum Brain targeted low molecular weight hydrophobic antioxidant compounds
US6719969B1 (en) 1999-08-09 2004-04-13 The Regents Of The University Of Michigan Treatment of liver disease and injury with CXC chemokines
JP2002226457A (ja) * 2001-02-02 2002-08-14 Ajinomoto Co Inc 新規シスチン誘導体及び炎症因子活性化抑制剤
US6623754B2 (en) * 2001-05-21 2003-09-23 Noveon Ip Holdings Corp. Dosage form of N-acetyl cysteine
WO2003016551A2 (en) * 2001-08-16 2003-02-27 Boyce Thompson Institute For Plant Research, Inc. Novel salicylic acid-binding protein encoding nucleic acid, sabp2, and methods of use thereof
US20060211628A1 (en) * 2002-08-02 2006-09-21 Daphne Atlas Treatment of multiple sclerosis with brain targeted anti oxidant compounds
WO2004095926A2 (en) * 2003-04-28 2004-11-11 Monsanto Technology, Llc Treatment of plants and plant propagation materials with an antioxidant to improve plant health and/or yield
US20090234011A1 (en) 2005-04-21 2009-09-17 Goldstein Glenn A N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress
WO2006132712A2 (en) 2005-04-21 2006-12-14 Goldstein Glenn A N-acetylcysteine amide (nac amide) for enhancing plant resistance and tolerance to environmental stress
US20080200548A1 (en) * 2005-04-21 2008-08-21 Goldstein Glenn A N-Acetylcysteine Amide (Nac Amide) for Treatment of Oxidative Stress Associated with Infertility

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6369106B1 (en) * 1996-12-26 2002-04-09 Yissum Research Development Company Of The Hebrew University Of Jerusalem Treatment of ischemic brain injuries with brain targeted anti oxidant compounds
US6420429B1 (en) * 1997-12-23 2002-07-16 Yissum Research Development Company Of The Hebrew University Of Jerusalem Brain targeted low molecular weight hydrophobic antioxidant compounds

Cited By (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2011088829A (ja) * 2009-10-20 2011-05-06 Chube Univ 発癌毒性の評価方法及び発癌予防・治療剤
JP2012102041A (ja) * 2010-11-09 2012-05-31 Maruzen Pharmaceut Co Ltd 抗酸化剤及び抗炎症剤
JP2015527999A (ja) * 2012-07-10 2015-09-24 エックスピーディ・ホールディングス・リミテッド・ライアビリティ・カンパニーＸＰＤ Ｈｏｌｄｉｎｇｓ ＬＬＣ 安定化された多機能酸化防止化合物およびその使用方法
JP2016523975A (ja) * 2013-07-10 2016-08-12 グレン・エー・ゴールドスタイン 穿通性頭部外傷の処置におけるｎ−アセチルシステインアミドの使用
JP2017534673A (ja) * 2014-09-15 2017-11-24 サウンド・ファーマシューティカルズ・インコーポレイテッド 精神病性障害を治療するための方法および組成物
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US12472157B2 (en) 2014-11-07 2025-11-18 Nacuity Pharmaceuticals, Inc. Treatment of retinitis pigmentosa with n-acetylcysteine amide
JP2018503689A (ja) * 2015-01-27 2018-02-08 フローレンゲイル・エル・エル・シー 治癒性局所用組成物
US11260060B2 (en) 2016-01-11 2022-03-01 Egetis Therapeutics Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
US12303516B2 (en) 2016-01-11 2025-05-20 Egetis Therapeutics Ab Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions
JP2022019973A (ja) * 2016-01-11 2022-01-27 エゲティス・セラピューティクス・アーベー 急性肝不全及び他の肝毒性状態を治療及び／又はこれらから保護するための方法及び製剤
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JP2021502323A (ja) * 2017-11-09 2021-01-28 ナキュイティ ファーマシューティカルズ， インク．Ｎａｃｕｉｔｙ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． 重水素濃縮ｎ−アセチルシステインアミド（ｄ−ｎａｃａ，ｄｅｕｔｅｒｉｕｍ−ｅｎｒｉｃｈｅｄ ｎ−ａｃｅｔｙｌｃｙｓｔｅｉｎｅ ａｍｉｄｅ）及び（２ｒ，２ｒ’）−３，３’−ジスルファンジイルビス（２−アセトアミドプロパンアミド）（ｄｉｎａｃａ）を作製する、並びに酸化ストレスが関与する疾患を治療するためにｄ−ｎａｃａ及びｄｉｎａｃａを使用する方法
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