RU2007143040A - Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом - Google Patents
Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом Download PDFInfo
- Publication number
- RU2007143040A RU2007143040A RU2007143040/15A RU2007143040A RU2007143040A RU 2007143040 A RU2007143040 A RU 2007143040A RU 2007143040/15 A RU2007143040/15 A RU 2007143040/15A RU 2007143040 A RU2007143040 A RU 2007143040A RU 2007143040 A RU2007143040 A RU 2007143040A
- Authority
- RU
- Russia
- Prior art keywords
- mixture
- isomer
- item
- compound
- disease
- Prior art date
Links
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title claims abstract 21
- 201000010099 disease Diseases 0.000 title claims abstract 13
- 230000036542 oxidative stress Effects 0.000 title claims abstract 3
- YVDBIXASASLJPM-BYPYZUCNSA-N (2r)-n-acetyl-2-amino-3-sulfanylpropanamide Chemical compound CC(=O)NC(=O)[C@@H](N)CS YVDBIXASASLJPM-BYPYZUCNSA-N 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 62
- UJCHIZDEQZMODR-BYPYZUCNSA-N (2r)-2-acetamido-3-sulfanylpropanamide Chemical compound CC(=O)N[C@@H](CS)C(N)=O UJCHIZDEQZMODR-BYPYZUCNSA-N 0.000 claims abstract 35
- 210000004027 cell Anatomy 0.000 claims abstract 13
- 210000001519 tissue Anatomy 0.000 claims abstract 11
- 239000003963 antioxidant agent Substances 0.000 claims abstract 8
- 208000035475 disorder Diseases 0.000 claims abstract 8
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 claims abstract 8
- 230000007170 pathology Effects 0.000 claims abstract 8
- 230000003078 antioxidant effect Effects 0.000 claims abstract 7
- 108010024636 Glutathione Proteins 0.000 claims abstract 4
- 208000036142 Viral infection Diseases 0.000 claims abstract 4
- 230000006378 damage Effects 0.000 claims abstract 4
- 229960003180 glutathione Drugs 0.000 claims abstract 4
- 238000012261 overproduction Methods 0.000 claims abstract 4
- 239000007800 oxidant agent Substances 0.000 claims abstract 4
- 230000009385 viral infection Effects 0.000 claims abstract 4
- 244000005700 microbiome Species 0.000 claims abstract 3
- 208000030507 AIDS Diseases 0.000 claims abstract 2
- 200000000007 Arterial disease Diseases 0.000 claims abstract 2
- 208000019838 Blood disease Diseases 0.000 claims abstract 2
- 208000020084 Bone disease Diseases 0.000 claims abstract 2
- 206010007559 Cardiac failure congestive Diseases 0.000 claims abstract 2
- 208000024172 Cardiovascular disease Diseases 0.000 claims abstract 2
- 206010019280 Heart failures Diseases 0.000 claims abstract 2
- 208000019693 Lung disease Diseases 0.000 claims abstract 2
- 208000029578 Muscle disease Diseases 0.000 claims abstract 2
- 208000012902 Nervous system disease Diseases 0.000 claims abstract 2
- 208000025966 Neurological disease Diseases 0.000 claims abstract 2
- 208000001132 Osteoporosis Diseases 0.000 claims abstract 2
- 208000024777 Prion disease Diseases 0.000 claims abstract 2
- 206010040047 Sepsis Diseases 0.000 claims abstract 2
- 208000027418 Wounds and injury Diseases 0.000 claims abstract 2
- 208000006673 asthma Diseases 0.000 claims abstract 2
- 210000000601 blood cell Anatomy 0.000 claims abstract 2
- 210000004351 coronary vessel Anatomy 0.000 claims abstract 2
- 206010012601 diabetes mellitus Diseases 0.000 claims abstract 2
- 150000002148 esters Chemical class 0.000 claims abstract 2
- 231100000573 exposure to toxins Toxicity 0.000 claims abstract 2
- 208000014951 hematologic disease Diseases 0.000 claims abstract 2
- 208000018706 hematopoietic system disease Diseases 0.000 claims abstract 2
- 208000015181 infectious disease Diseases 0.000 claims abstract 2
- 208000027866 inflammatory disease Diseases 0.000 claims abstract 2
- 208000014674 injury Diseases 0.000 claims abstract 2
- 208000002780 macular degeneration Diseases 0.000 claims abstract 2
- 201000004792 malaria Diseases 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 2
- 230000005855 radiation Effects 0.000 claims abstract 2
- 208000037803 restenosis Diseases 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 208000007056 sickle cell anemia Diseases 0.000 claims abstract 2
- 201000008827 tuberculosis Diseases 0.000 claims abstract 2
- 239000000203 mixture Substances 0.000 claims 53
- 150000001875 compounds Chemical class 0.000 claims 41
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims 18
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 18
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 16
- 238000001914 filtration Methods 0.000 claims 16
- WFDIJRYMOXRFFG-UHFFFAOYSA-N Acetic anhydride Chemical compound CC(=O)OC(C)=O WFDIJRYMOXRFFG-UHFFFAOYSA-N 0.000 claims 15
- 238000001035 drying Methods 0.000 claims 14
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 claims 12
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 claims 12
- NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 claims 10
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims 10
- 238000002156 mixing Methods 0.000 claims 10
- 239000003446 ligand Substances 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 9
- BAVYZALUXZFZLV-UHFFFAOYSA-N Methylamine Chemical compound NC BAVYZALUXZFZLV-UHFFFAOYSA-N 0.000 claims 8
- 159000000021 acetate salts Chemical class 0.000 claims 8
- 150000008064 anhydrides Chemical class 0.000 claims 8
- QAEDZJGFFMLHHQ-UHFFFAOYSA-N trifluoroacetic anhydride Chemical compound FC(F)(F)C(=O)OC(=O)C(F)(F)F QAEDZJGFFMLHHQ-UHFFFAOYSA-N 0.000 claims 8
- 239000007788 liquid Substances 0.000 claims 7
- 238000004519 manufacturing process Methods 0.000 claims 7
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 claims 6
- 239000002105 nanoparticle Substances 0.000 claims 6
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 5
- 235000019270 ammonium chloride Nutrition 0.000 claims 5
- 235000017281 sodium acetate Nutrition 0.000 claims 5
- 239000001632 sodium acetate Substances 0.000 claims 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 4
- 239000004202 carbamide Substances 0.000 claims 4
- 230000000694 effects Effects 0.000 claims 4
- 230000014509 gene expression Effects 0.000 claims 4
- 239000012280 lithium aluminium hydride Substances 0.000 claims 4
- -1 lithium aluminum hydride Chemical compound 0.000 claims 4
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 4
- UYCAUPASBSROMS-AWQJXPNKSA-M sodium;2,2,2-trifluoroacetate Chemical compound [Na+].[O-][13C](=O)[13C](F)(F)F UYCAUPASBSROMS-AWQJXPNKSA-M 0.000 claims 4
- 150000003573 thiols Chemical class 0.000 claims 4
- 150000001408 amides Chemical class 0.000 claims 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 230000001476 alcoholic effect Effects 0.000 claims 2
- 229910021529 ammonia Inorganic materials 0.000 claims 2
- 238000004458 analytical method Methods 0.000 claims 2
- 230000000903 blocking effect Effects 0.000 claims 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims 2
- 238000010438 heat treatment Methods 0.000 claims 2
- IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 claims 2
- 229910000041 hydrogen chloride Inorganic materials 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 230000001590 oxidative effect Effects 0.000 claims 2
- 230000001376 precipitating effect Effects 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 230000000451 tissue damage Effects 0.000 claims 2
- 231100000827 tissue damage Toxicity 0.000 claims 2
- 238000005406 washing Methods 0.000 claims 2
- OYPOYMPGFACTLO-RGVONZFCSA-N (2r)-2-amino-3-[[(2r)-2,3-diamino-3-oxopropyl]disulfanyl]propanamide;dihydrochloride Chemical compound Cl.Cl.NC(=O)[C@@H](N)CSSC[C@H](N)C(N)=O OYPOYMPGFACTLO-RGVONZFCSA-N 0.000 claims 1
- PFRXZICTHLYYGK-UHFFFAOYSA-N 2,5,7-trimethoxynaphthalene-1,4-dione Chemical compound C1=C(OC)C=C2C(=O)C(OC)=CC(=O)C2=C1OC PFRXZICTHLYYGK-UHFFFAOYSA-N 0.000 claims 1
- VKUYLANQOAKALN-UHFFFAOYSA-N 2-[benzyl-(4-methoxyphenyl)sulfonylamino]-n-hydroxy-4-methylpentanamide Chemical compound C1=CC(OC)=CC=C1S(=O)(=O)N(C(CC(C)C)C(=O)NO)CC1=CC=CC=C1 VKUYLANQOAKALN-UHFFFAOYSA-N 0.000 claims 1
- 241000894006 Bacteria Species 0.000 claims 1
- OYPOYMPGFACTLO-XWJKVJTJSA-N Cl.Cl.NC(=O)[C@H](N)CSSC[C@@H](N)C(N)=O Chemical compound Cl.Cl.NC(=O)[C@H](N)CSSC[C@@H](N)C(N)=O OYPOYMPGFACTLO-XWJKVJTJSA-N 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 238000000018 DNA microarray Methods 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102100032742 Histone-lysine N-methyltransferase SETD2 Human genes 0.000 claims 1
- 101000654725 Homo sapiens Histone-lysine N-methyltransferase SETD2 Proteins 0.000 claims 1
- 101001046870 Homo sapiens Hypoxia-inducible factor 1-alpha Proteins 0.000 claims 1
- 102100022875 Hypoxia-inducible factor 1-alpha Human genes 0.000 claims 1
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 1
- 102000000422 Matrix Metalloproteinase 3 Human genes 0.000 claims 1
- 108010016160 Matrix Metalloproteinase 3 Proteins 0.000 claims 1
- 102000005741 Metalloproteases Human genes 0.000 claims 1
- 108010006035 Metalloproteases Proteins 0.000 claims 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims 1
- 238000000636 Northern blotting Methods 0.000 claims 1
- 102100030416 Stromelysin-1 Human genes 0.000 claims 1
- 101710108790 Stromelysin-1 Proteins 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- 239000000412 dendrimer Substances 0.000 claims 1
- 229920000736 dendritic polymer Polymers 0.000 claims 1
- 235000015872 dietary supplement Nutrition 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 229960000304 folic acid Drugs 0.000 claims 1
- 235000019152 folic acid Nutrition 0.000 claims 1
- 239000011724 folic acid Substances 0.000 claims 1
- 230000003394 haemopoietic effect Effects 0.000 claims 1
- 238000003119 immunoblot Methods 0.000 claims 1
- 238000010166 immunofluorescence Methods 0.000 claims 1
- 239000003547 immunosorbent Substances 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 230000037353 metabolic pathway Effects 0.000 claims 1
- UDHSAWHYRXHQJP-HNCPQSOCSA-N methyl (2R)-2-amino-3-phenylmethoxypropanoate hydrochloride Chemical compound Cl.COC(=O)[C@H](N)COCC1=CC=CC=C1 UDHSAWHYRXHQJP-HNCPQSOCSA-N 0.000 claims 1
- QVJDVOZRQMIIHP-PPHPATTJSA-N methyl (2r)-2-amino-3-benzylsulfanylpropanoate;hydrochloride Chemical compound Cl.COC(=O)[C@@H](N)CSCC1=CC=CC=C1 QVJDVOZRQMIIHP-PPHPATTJSA-N 0.000 claims 1
- QVJDVOZRQMIIHP-HNCPQSOCSA-N methyl (2s)-2-amino-3-benzylsulfanylpropanoate;hydrochloride Chemical compound Cl.COC(=O)[C@H](N)CSCC1=CC=CC=C1 QVJDVOZRQMIIHP-HNCPQSOCSA-N 0.000 claims 1
- 229920000962 poly(amidoamine) Polymers 0.000 claims 1
- 238000001556 precipitation Methods 0.000 claims 1
- 230000004223 radioprotective effect Effects 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- NGDIAZZSCVVCEW-UHFFFAOYSA-M sodium;butyl sulfate Chemical compound [Na+].CCCCOS([O-])(=O)=O NGDIAZZSCVVCEW-UHFFFAOYSA-M 0.000 claims 1
- 238000001179 sorption measurement Methods 0.000 claims 1
- 230000004936 stimulating effect Effects 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 230000002792 vascular Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82B—NANOSTRUCTURES FORMED BY MANIPULATION OF INDIVIDUAL ATOMS, MOLECULES, OR LIMITED COLLECTIONS OF ATOMS OR MOLECULES AS DISCRETE UNITS; MANUFACTURE OR TREATMENT THEREOF
- B82B3/00—Manufacture or treatment of nanostructures by manipulation of individual atoms or molecules, or limited collections of atoms or molecules as discrete units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/06—Free radical scavengers or antioxidants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/06—Antianaemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/18—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/34—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups
- C07C233/35—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/36—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by amino groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to a hydrogen atom or to a carbon atom of an acyclic saturated carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
- C07C323/40—Y being a hydrogen or a carbon atom
- C07C323/41—Y being a hydrogen or an acyclic carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- D—TEXTILES; PAPER
- D01—NATURAL OR MAN-MADE THREADS OR FIBRES; SPINNING
- D01D—MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES OR RIBBONS
- D01D5/00—Formation of filaments, threads, or the like
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Molecular Biology (AREA)
- Cardiology (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Neurology (AREA)
- Heart & Thoracic Surgery (AREA)
- Biochemistry (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- AIDS & HIV (AREA)
- Dermatology (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US67356105P | 2005-04-21 | 2005-04-21 | |
| US60/673,561 | 2005-04-21 | ||
| US70596705P | 2005-08-05 | 2005-08-05 | |
| US60/705,967 | 2005-08-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2007143040A true RU2007143040A (ru) | 2009-05-27 |
Family
ID=37215387
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007143040/15A RU2007143040A (ru) | 2005-04-21 | 2006-04-21 | Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20090234011A1 (https=) |
| EP (1) | EP1877044A4 (https=) |
| JP (1) | JP2008538586A (https=) |
| KR (1) | KR20080028357A (https=) |
| AU (1) | AU2006238888A1 (https=) |
| CA (1) | CA2606053A1 (https=) |
| IL (1) | IL186684A0 (https=) |
| RU (1) | RU2007143040A (https=) |
| WO (1) | WO2006116353A2 (https=) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1616869T3 (da) | 1999-01-25 | 2012-05-07 | Nat Jewish Health | Substituerede porphyriner og deres terapeutiske anvendelse |
| US8993627B2 (en) | 2005-04-21 | 2015-03-31 | Sentient Lifesciences, Inc. | N-acetylcysteine amide (NAC amide) for the treatment of diseases and conditions associated with oxidative stress |
| US20090234011A1 (en) | 2005-04-21 | 2009-09-17 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress |
| EP1968609A4 (en) * | 2005-12-20 | 2010-06-09 | Silamed Inc | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR THE USE OF HIGHLY LIPOPHILIC SULFHYDRYL COMPOUNDS |
| ZA200902203B (en) * | 2006-10-23 | 2010-08-25 | Mental Health Res Inst Of Vict | Combination therapy |
| US20080146579A1 (en) * | 2006-12-15 | 2008-06-19 | N.V. Nutricia | Treatment of patients with chronic pulmonary diseases and nutritional compositions therefore |
| WO2008121171A1 (en) * | 2007-01-12 | 2008-10-09 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for antibacterial interventions |
| US9095578B2 (en) * | 2007-01-12 | 2015-08-04 | Cornell Research Foundation, Inc. | Adenylyl cyclases as novel targets for the treatment of infection by eukaryotic pathogens |
| IL188681A0 (en) * | 2008-01-09 | 2008-12-29 | Amino Acid Solutions Inc | Pharmaceutical compositions and methods utilizing a d-amino acid |
| EP2291182A1 (en) * | 2008-05-13 | 2011-03-09 | Genmedica Therapeutics SL | Salicylate conjugates useful for treating metabolic disorders |
| US11382895B2 (en) | 2008-05-23 | 2022-07-12 | National Jewish Health | Methods for treating injury associated with exposure to an alkylating species |
| CN102421424A (zh) * | 2009-03-16 | 2012-04-18 | 根梅迪卡治疗公司 | 用于治疗代谢性疾病的组合疗法 |
| CA2755069A1 (en) * | 2009-03-16 | 2010-09-23 | Genmedica Therapeutics Sl | Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders |
| JP2011088829A (ja) * | 2009-10-20 | 2011-05-06 | Chube Univ | 発癌毒性の評価方法及び発癌予防・治療剤 |
| TWI535440B (zh) | 2009-10-26 | 2016-06-01 | Ｌｇ生命科學有限公司 | 包括吲哚化合物之醫藥組成物 |
| WO2012033235A1 (ko) * | 2010-09-06 | 2012-03-15 | 서울대학교 산학협력단 | Ｎ-아세틸-ｌ-시스테인 또는 이의 유도체를 포함하는 불안 장애 치료용 약학 조성물 |
| FR2964967A1 (fr) * | 2010-09-17 | 2012-03-23 | Exsymol Sa | Peptidomimetiques derives de la methionine et leur utilisation dans la protection des mitochondries des cellules cutanees |
| JP5854592B2 (ja) * | 2010-11-09 | 2016-02-09 | 丸善製薬株式会社 | 抗酸化剤及び抗炎症剤 |
| US8466197B2 (en) | 2010-12-14 | 2013-06-18 | Genmedica Therapeutics Sl | Thiocarbonates as anti-inflammatory and antioxidant compounds useful for treating metabolic disorders |
| ES2893825T3 (es) | 2011-02-04 | 2022-02-10 | Hough Ear Inst | Métodos de tratamiento de lesiones cerebrales |
| WO2013138744A1 (en) * | 2012-03-16 | 2013-09-19 | M. Alphabet 1, Llc | Compositions for the treatment of skin disorders |
| WO2013152076A1 (en) * | 2012-04-04 | 2013-10-10 | The Brigham And Women's Hospital, Inc. | Compositions and methods for treating hypertension |
| CA2871774C (en) * | 2012-04-26 | 2021-05-18 | Sentient Lifesciences, Inc. | Use of n-acetylcysteine amide in the treatment of disease and injury |
| US20130296430A1 (en) * | 2012-05-03 | 2013-11-07 | Antonio Hardan | Compositions and methods for treating autism and autism spectrum disorder |
| CA3078006C (en) | 2012-07-10 | 2022-04-26 | Xpd Holdings, Llc | Stabilized multi-functional antioxidant compounds and methods of use |
| WO2015006569A2 (en) * | 2013-07-10 | 2015-01-15 | Sentient Lifesciences, Inc. | Use of n-acetylcysteine amide in the treatment of penetrating head injury |
| EP3674297A1 (en) | 2013-11-08 | 2020-07-01 | Promentis Pharmaceuticals, Inc. | Substituted n-acetyl-l-cysteine derivatives and related compounds |
| US20150209309A1 (en) * | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc | Naca for the treatment of chronic or acute cognitive dysfunction |
| US20150209310A1 (en) * | 2014-01-24 | 2015-07-30 | Brighton Biotech, Inc. | Naca for the treatment of chronic or low impact brain trauma |
| US20170049727A1 (en) * | 2014-02-12 | 2017-02-23 | Glenn A. Goldstein | Use of N-Acetylcysteine Amide in the Treatment of Acquired Immune Deficiency Syndrome and HIV Infection |
| KR20230107890A (ko) * | 2014-09-15 | 2023-07-18 | 사운드 파마슈티칼스 인코퍼레이티드 | 정신병적 장애를 치료하기 위한 방법 및 조성물 |
| US12472157B2 (en) * | 2014-11-07 | 2025-11-18 | Nacuity Pharmaceuticals, Inc. | Treatment of retinitis pigmentosa with n-acetylcysteine amide |
| WO2016077467A1 (en) | 2014-11-11 | 2016-05-19 | The Johns Hopkins University | Biomarkers useful in the treatment of subjects having diseases of the eye |
| WO2016123223A1 (en) * | 2015-01-27 | 2016-08-04 | Florengale, Llc | Healing topical composition |
| WO2016197089A1 (en) * | 2015-06-05 | 2016-12-08 | Goldstein Glenn A | Use of n-acetylcysteine amide in the treatment of acetaminophen overdose |
| EP3402475B1 (en) * | 2016-01-11 | 2021-10-20 | Egetis Therapeutics AB | Methods and formulations for treatment of and/or protection against acute liver failure and other hepatotoxic conditions |
| CA3022013C (en) | 2016-04-29 | 2025-08-12 | Ophirex, Inc. | Secreted pla2 inhibitors for immediate treatment of hymenoptera envenomation |
| US20240342118A1 (en) * | 2017-09-20 | 2024-10-17 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives |
| EP3684756A4 (en) | 2017-09-20 | 2020-10-28 | NaCuity Pharmaceuticals, Inc. | SYNTHESIS OF N-ACETYLCYSTEIN AMIDE AND ITS DERIVATIVES |
| US11548851B2 (en) | 2017-09-20 | 2023-01-10 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide and derivatives thereof |
| US11091433B2 (en) | 2017-09-20 | 2021-08-17 | Nacuity Pharmaceutials, Inc. | Method for preparation of N-acetyl cysteine amide and derivatives thereof |
| US20240368072A1 (en) * | 2017-09-20 | 2024-11-07 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives |
| US20240217927A1 (en) * | 2017-11-09 | 2024-07-04 | Nacuity Pharmaceuticals, Inc. | Methods of Making Deuterium-Enriched N-Acetylcysteine Amide (D-NACA) and (2R,2R)-3,3-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress |
| US20190135741A1 (en) | 2017-11-09 | 2019-05-09 | Nacuity Pharmaceuticals, Inc. | Methods of Making Deuterium-Enriched N-acetylcysteine Amide (D-NACA) and (2R, 2R')-3,3'-Disulfanediyl BIS(2-Acetamidopropanamide) (DINACA) and Using D-NACA and DINACA to Treat Diseases Involving Oxidative Stress |
| US20190151271A1 (en) * | 2017-11-21 | 2019-05-23 | The Johns Hopkins University | Compositions and methods for treatment of eye diseases |
| JP7336143B2 (ja) * | 2017-11-28 | 2023-08-31 | セルツーイン、 インコーポレイテッド | リアルタイムなグルタチオンの測定による治療用細胞の品質向上方法 |
| CU20200106A7 (es) | 2018-06-20 | 2021-08-06 | Axcella Health Inc | Composiciones y métodos para el tratamiento de hemoglobinopatías y talasemias |
| US11497758B2 (en) | 2018-11-15 | 2022-11-15 | Samuel L. Shepherd | Method of treating oxidative stress due to radiation exposure |
| EP3908271A4 (en) | 2019-01-11 | 2022-10-26 | NaCuity Pharmaceuticals, Inc. | N-ACETYLCYSTEINE AMIDE (NACA) AND (2R,2R')-3,3'-DISULFANDIYL BIS-(2-ACETAMIDOPROPANAMIDE) (DINACA) FOR THE PREVENTION AND TREATMENT OF RADIATION DERMATITIS AND SKIN LIGHTENING AND IMPROVEMENT |
| EP3908341A4 (en) | 2019-01-11 | 2022-03-02 | NaCuity Pharmaceuticals, Inc. | TREATMENT OF AGE-RELATED MACULAR DEGENERATION, GLAUCOMA AND DIABETIC RETINOPATHY WITH N-ACETYLCYSTEINE AMIDE (NACA) OR (2R,2R')-3,3'-BIS(2-ACETAMIDOPROPANAMIDE) DISULFANEDIYL (DINACA) |
| WO2020146660A1 (en) * | 2019-01-11 | 2020-07-16 | Nacuity Pharmaceuticals, Inc. | N-acetylcysteine amide (naca) and (2r,2r')-3-3'-disulfanediyl bis (2-acetamidopropanamide) (dinaca) for prevention and treatment of radiation pneumonitis and treatment of pulmonary function in cystic fibrosis |
| CN109758581A (zh) * | 2019-02-14 | 2019-05-17 | 上海市东方医院（同济大学附属东方医院） | 一种抗氧化磁性氧化铁纳米颗粒及其制备方法 |
| JP7498504B2 (ja) * | 2019-06-13 | 2024-06-12 | シャンハイ ケチョウ ファーマ，インコーポレイテッド | 脳神経または心臓保護剤としてのアミノチオール系化合物の使用 |
| US12090130B2 (en) | 2019-12-18 | 2024-09-17 | Neuronasal, Inc. | Methods of treating brain disorders |
| AU2021209953B2 (en) * | 2020-01-24 | 2024-08-22 | Nacuity Pharmaceuticals, Inc. | Prodrug for the treatment of disease and injury of oxidative stress |
| WO2021252378A1 (en) * | 2020-06-08 | 2021-12-16 | Nacuity Pharmaceuticals, Inc. | Prevention or treatment of covid-19 |
| US20230263725A1 (en) * | 2020-07-09 | 2023-08-24 | Beyond Barriers Therapeutics, Inc. | Intranasal administration of an antioxidant compound for treating coronavirus infection |
| IL300416A (en) * | 2020-08-06 | 2023-04-01 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Oleylcysteine amide or its derivatives and their uses |
| EP3960168A1 (en) * | 2020-08-28 | 2022-03-02 | Université de Genève | Compositions and methods comprising d-cysteine or a derivative thereof |
| CN112602724B (zh) * | 2020-12-21 | 2021-09-24 | 上海汉今医疗科技有限公司 | 一种感染性医疗废物消毒液及其制备方法 |
| AU2022204064A1 (en) | 2021-07-16 | 2023-02-02 | Samuel L. Shepherd | Method of treating oxidative stress due to radiation exposure |
| CN115449065B (zh) * | 2022-09-21 | 2023-09-22 | 中南大学湘雅医院 | 一种nac改性血液净化膜及其制备方法 |
| WO2026015776A1 (en) * | 2024-07-12 | 2026-01-15 | Nacuity Pharmaceuticals, Inc. | Method for preparation of n-acetyl cysteine amide or di- n-acetyl cysteine amide and derivatives |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5696109A (en) * | 1992-12-07 | 1997-12-09 | Eukarion, Inc. | Synthetic catalytic free radical scavengers useful as antioxidants for prevention and therapy of disease |
| US5691380A (en) | 1995-06-29 | 1997-11-25 | The Procter & Gamble Company | Stable n-acetylcysteine compositions and methods for treating human skin therewith |
| US5733535A (en) * | 1995-10-25 | 1998-03-31 | The Procter & Gamble Co. | Topical compositions containing N-acetylcysteine and odor masking materials |
| US5962421A (en) * | 1996-05-16 | 1999-10-05 | Zambon, S.A. | Pharmacological association between N-acetylcysteine and levulose for preventing cellular death and related diseases |
| US6369106B1 (en) * | 1996-12-26 | 2002-04-09 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Treatment of ischemic brain injuries with brain targeted anti oxidant compounds |
| US5874468A (en) | 1996-12-26 | 1999-02-23 | Yissum | Brain targeted low molecular weight hydrophobic antioxidant compounds |
| US6420429B1 (en) * | 1997-12-23 | 2002-07-16 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Brain targeted low molecular weight hydrophobic antioxidant compounds |
| US6719969B1 (en) | 1999-08-09 | 2004-04-13 | The Regents Of The University Of Michigan | Treatment of liver disease and injury with CXC chemokines |
| JP2002226457A (ja) * | 2001-02-02 | 2002-08-14 | Ajinomoto Co Inc | 新規シスチン誘導体及び炎症因子活性化抑制剤 |
| US6623754B2 (en) * | 2001-05-21 | 2003-09-23 | Noveon Ip Holdings Corp. | Dosage form of N-acetyl cysteine |
| WO2003016551A2 (en) * | 2001-08-16 | 2003-02-27 | Boyce Thompson Institute For Plant Research, Inc. | Novel salicylic acid-binding protein encoding nucleic acid, sabp2, and methods of use thereof |
| US20060211628A1 (en) * | 2002-08-02 | 2006-09-21 | Daphne Atlas | Treatment of multiple sclerosis with brain targeted anti oxidant compounds |
| WO2004095926A2 (en) * | 2003-04-28 | 2004-11-11 | Monsanto Technology, Llc | Treatment of plants and plant propagation materials with an antioxidant to improve plant health and/or yield |
| US20090234011A1 (en) | 2005-04-21 | 2009-09-17 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for the treatment of diseases and conditions associated with oxidative stress |
| WO2006132712A2 (en) | 2005-04-21 | 2006-12-14 | Goldstein Glenn A | N-acetylcysteine amide (nac amide) for enhancing plant resistance and tolerance to environmental stress |
| US20080200548A1 (en) * | 2005-04-21 | 2008-08-21 | Goldstein Glenn A | N-Acetylcysteine Amide (Nac Amide) for Treatment of Oxidative Stress Associated with Infertility |
-
2006
- 2006-04-21 US US11/912,293 patent/US20090234011A1/en not_active Abandoned
- 2006-04-21 CA CA002606053A patent/CA2606053A1/en not_active Abandoned
- 2006-04-21 KR KR1020077027031A patent/KR20080028357A/ko not_active Withdrawn
- 2006-04-21 WO PCT/US2006/015548 patent/WO2006116353A2/en not_active Ceased
- 2006-04-21 AU AU2006238888A patent/AU2006238888A1/en not_active Abandoned
- 2006-04-21 RU RU2007143040/15A patent/RU2007143040A/ru unknown
- 2006-04-21 JP JP2008507992A patent/JP2008538586A/ja active Pending
- 2006-04-21 EP EP06751310A patent/EP1877044A4/en not_active Withdrawn
-
2007
- 2007-10-16 IL IL186684A patent/IL186684A0/en unknown
-
2010
- 2010-01-12 US US12/686,106 patent/US8354449B2/en not_active Expired - Fee Related
- 2010-02-17 US US12/707,092 patent/US8937099B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| WO2006116353A2 (en) | 2006-11-02 |
| WO2006116353A3 (en) | 2007-06-28 |
| JP2008538586A (ja) | 2008-10-30 |
| WO2006116353A8 (en) | 2008-03-13 |
| US20100137441A1 (en) | 2010-06-03 |
| KR20080028357A (ko) | 2008-03-31 |
| US8937099B2 (en) | 2015-01-20 |
| CA2606053A1 (en) | 2006-11-02 |
| US20100120920A1 (en) | 2010-05-13 |
| AU2006238888A1 (en) | 2006-11-02 |
| US8354449B2 (en) | 2013-01-15 |
| EP1877044A4 (en) | 2009-09-02 |
| EP1877044A2 (en) | 2008-01-16 |
| US20090234011A1 (en) | 2009-09-17 |
| IL186684A0 (en) | 2008-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2007143040A (ru) | Амид n-ацетилцистеина (амид nac) в лечении заболеваний и состояний, связанных с окислительным стрессом | |
| JP2008538586A5 (https=) | ||
| US20250115546A1 (en) | Linkers for antibody drug conjugates | |
| EP2061749B1 (en) | Positively charged water-soluble prodrugs of acetaminophen and related compounds with very fast skin penetration rate | |
| CA2205555C (en) | Use of nitric oxide-releasing agents for reducing metastasis risk | |
| JP2010539245A (ja) | 薬物担体 | |
| US20260070948A1 (en) | Cyclic cell-penetrating peptides with cargo | |
| CA2371625A1 (en) | Polyamines and their use in therapy | |
| CZ330896A3 (cs) | Použití látky, která brání nebo minimalizuje oxidaci polynenasycené mastné kyseliny a způsoby s tímto použitím spojené | |
| WO2008000070B1 (en) | Glycyrrhetinic acid derivatives | |
| JP2004501189A5 (https=) | ||
| EP2623495B1 (en) | Positively charged water-soluble prodrugs of n-arylanthranilic acids with very fast skin penetration rate | |
| CA2816997A1 (en) | Novel polymer derivative of cytidine metabolic antagonist | |
| US20210024485A1 (en) | Compound for the prophylaxis or treatment of organ damage | |
| AU2012328343B2 (en) | Compounds for the treatment of influenza | |
| KR20140097108A (ko) | 전구약물로서의 펜타미딘 아미독심 산 에스테르류 및 이의 약물로서의 용도 | |
| CN102149702A (zh) | 新型亚甲二氧基酚化合物和其治疗疾病的用途 | |
| US20070048252A1 (en) | Conjugates of the hydrophilic polymer and the molecules from boxwood extraction, and pharmaceutical compositions of the conjugates | |
| US11524078B2 (en) | Water-soluble macromolecular derivative of Venetoclax | |
| CN116041361A (zh) | 一种小白菊内酯的氨基酸衍生物及其制备方法和用途 | |
| CN116496288A (zh) | 一种小白菊内酯Boc保护的胺类衍生物及其制备方法和用途 | |
| CN101367775B (zh) | 一种绕丹宁衍生物、其制备方法及其应用 | |
| US8299091B2 (en) | Aminoisoquinoline thrombin inhibitor with improved bioavailability | |
| JP6612004B1 (ja) | グルコース消費促進剤および解糖系促進剤 | |
| JP2011190257A (ja) | 組織線維化疾患の予防または治療剤 |