JP2008531711A5 - - Google Patents
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- Publication number
- JP2008531711A5 JP2008531711A5 JP2007558181A JP2007558181A JP2008531711A5 JP 2008531711 A5 JP2008531711 A5 JP 2008531711A5 JP 2007558181 A JP2007558181 A JP 2007558181A JP 2007558181 A JP2007558181 A JP 2007558181A JP 2008531711 A5 JP2008531711 A5 JP 2008531711A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- oxo
- oct
- isopropyl
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000000217 alkyl group Chemical group 0.000 claims 35
- -1 2-oxoimidazolidine-1 -Yl Chemical class 0.000 claims 26
- 150000001875 compounds Chemical class 0.000 claims 20
- UUCJNYSXZJNSLE-UHFFFAOYSA-N 2-oxo-1-propan-2-ylquinoline-3-carboxylic acid Chemical compound C1=CC=C2C=C(C(O)=O)C(=O)N(C(C)C)C2=C1 UUCJNYSXZJNSLE-UHFFFAOYSA-N 0.000 claims 18
- 229910052739 hydrogen Inorganic materials 0.000 claims 18
- 239000001257 hydrogen Substances 0.000 claims 18
- 229910052799 carbon Inorganic materials 0.000 claims 13
- 150000001408 amides Chemical class 0.000 claims 12
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 11
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 10
- 150000002431 hydrogen Chemical class 0.000 claims 10
- 150000003839 salts Chemical class 0.000 claims 10
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 9
- 239000012453 solvate Substances 0.000 claims 9
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 8
- 125000003545 alkoxy group Chemical group 0.000 claims 8
- 229910052757 nitrogen Inorganic materials 0.000 claims 8
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 8
- 239000000203 mixture Substances 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 6
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims 5
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 5
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 206010010774 Constipation Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 229910052736 halogen Inorganic materials 0.000 claims 3
- 150000002367 halogens Chemical class 0.000 claims 3
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 3
- 230000004899 motility Effects 0.000 claims 3
- 125000004076 pyridyl group Chemical group 0.000 claims 3
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 3
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
- 241000124008 Mammalia Species 0.000 claims 2
- 150000001721 carbon Chemical group 0.000 claims 2
- 230000001684 chronic effect Effects 0.000 claims 2
- 206010012601 diabetes mellitus Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 2
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 1
- 125000006704 (C5-C6) cycloalkyl group Chemical group 0.000 claims 1
- 125000001731 2-cyanoethyl group Chemical group [H]C([H])(*)C([H])([H])C#N 0.000 claims 1
- SYPWCPLBAKQKML-UHFFFAOYSA-N 4-(oxolane-2-carbonyl)piperazine-1-carboxylic acid Chemical compound C1CN(C(=O)O)CCN1C(=O)C1OCCC1 SYPWCPLBAKQKML-UHFFFAOYSA-N 0.000 claims 1
- DDOWCQQXWQWZQD-UHFFFAOYSA-N 4-acetylpiperazine-1-carboxylic acid Chemical compound CC(=O)N1CCN(C(O)=O)CC1 DDOWCQQXWQWZQD-UHFFFAOYSA-N 0.000 claims 1
- OHZUEFKOZYWUFF-UHFFFAOYSA-N 4-hydroxypiperidine-1-carboxylic acid Chemical compound OC1CCN(C(O)=O)CC1 OHZUEFKOZYWUFF-UHFFFAOYSA-N 0.000 claims 1
- VETXQJLDLLEFBI-UHFFFAOYSA-N 4-methylsulfonylpiperazine-1-carboxylic acid Chemical compound CS(=O)(=O)N1CCN(C(O)=O)CC1 VETXQJLDLLEFBI-UHFFFAOYSA-N 0.000 claims 1
- 208000012895 Gastric disease Diseases 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 208000007542 Paresis Diseases 0.000 claims 1
- 206010054048 Postoperative ileus Diseases 0.000 claims 1
- 239000011203 carbon fibre reinforced carbon Substances 0.000 claims 1
- 125000000753 cycloalkyl group Chemical group 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 210000000936 intestine Anatomy 0.000 claims 1
- 239000012948 isocyanate Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- JZMJDSHXVKJFKW-UHFFFAOYSA-N methyl sulfate Chemical compound COS(O)(=O)=O JZMJDSHXVKJFKW-UHFFFAOYSA-N 0.000 claims 1
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 1
- 208000000689 peptic esophagitis Diseases 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 1
- 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
- 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims 1
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims 1
- 125000000168 pyrrolyl group Chemical group 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 125000000547 substituted alkyl group Chemical group 0.000 claims 1
- 0 CC(C*(C)CN(C(CC1)C2)C1CC2NC(C1=Cc2ccccc2N(*)C1=O)=O)CN(*)* Chemical compound CC(C*(C)CN(C(CC1)C2)C1CC2NC(C1=Cc2ccccc2N(*)C1=O)=O)CN(*)* 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65800705P | 2005-03-02 | 2005-03-02 | |
| US60/658,007 | 2005-03-02 | ||
| PCT/US2006/007284 WO2006094063A1 (en) | 2005-03-02 | 2006-03-01 | Quinolinone compounds as 5-ht4 receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008531711A JP2008531711A (ja) | 2008-08-14 |
| JP2008531711A5 true JP2008531711A5 (https=) | 2009-03-26 |
| JP5042043B2 JP5042043B2 (ja) | 2012-10-03 |
Family
ID=36588769
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007558181A Expired - Fee Related JP5042043B2 (ja) | 2005-03-02 | 2006-03-01 | ５−ｈｔ４レセプターアゴニストであるキノリン化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US7446114B2 (https=) |
| EP (1) | EP1871772B1 (https=) |
| JP (1) | JP5042043B2 (https=) |
| KR (1) | KR20070107807A (https=) |
| CN (1) | CN101163701A (https=) |
| AU (1) | AU2006218603A1 (https=) |
| BR (1) | BRPI0608392A2 (https=) |
| CA (1) | CA2599404A1 (https=) |
| EA (1) | EA013567B1 (https=) |
| ES (1) | ES2523851T3 (https=) |
| IL (1) | IL185407A0 (https=) |
| MX (1) | MX2007010769A (https=) |
| NO (1) | NO20074884L (https=) |
| NZ (1) | NZ560828A (https=) |
| WO (1) | WO2006094063A1 (https=) |
| ZA (1) | ZA200707142B (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| TWI377206B (en) | 2005-04-06 | 2012-11-21 | Theravance Inc | Crystalline form of a quinolinone-carboxamide compound |
| MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
| GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
| EP2123769B1 (en) * | 2007-02-19 | 2016-05-18 | Kaneka Corporation | Method for producing optically active 3-aminopiperidine or salt thereof |
| JP5540099B2 (ja) * | 2009-09-14 | 2014-07-02 | スベン ライフ サイエンシズ リミティド | ５−ｈｔ４受容体リガンドとしての１，２−ジヒドロ−２−オキソキノリン化合物 |
| HK1247105A1 (zh) | 2015-04-02 | 2018-09-21 | Theravance Biopharma R&D Ip, Llc | Mu类鸦片受体拮抗剂与类鸦片药剂的组合剂型 |
| US12275746B2 (en) | 2022-01-11 | 2025-04-15 | Suven Life Sciences Limited | Pyrrolo[1,2-b]-2-pyridazinone compounds as 5-HT4 receptor agonists |
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| GB8527052D0 (en) * | 1985-11-02 | 1985-12-04 | Beecham Group Plc | Compounds |
| HU895334D0 (en) * | 1986-07-30 | 1990-01-28 | Sandoz Ag | Process for the preparation of nasal pharmaceutical compositions |
| US4948803A (en) * | 1986-11-21 | 1990-08-14 | Glaxo Group Limited | Medicaments for treatment on prevention of withdrawal syndrome |
| GB8701022D0 (en) * | 1987-01-19 | 1987-02-18 | Beecham Group Plc | Treatment |
| IT1231413B (it) | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| US5223511A (en) * | 1987-09-23 | 1993-06-29 | Boehringer Ingelheim Italia S.P.A. | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists |
| IT1226389B (it) * | 1988-07-12 | 1991-01-15 | Angeli Inst Spa | Nuovi derivati ammidinici e guanidinici |
| US5017573A (en) * | 1988-07-29 | 1991-05-21 | Dainippon Pharmaceutical Co., Ltd. | Indazole-3-carboxylic acid derivatives |
| EP0410509A1 (en) * | 1989-07-25 | 1991-01-30 | Duphar International Research B.V | New substituted 1H-indazole-3-carboxamides |
| JPH045289A (ja) | 1990-04-24 | 1992-01-09 | Hokuriku Seiyaku Co Ltd | アミド化合物 |
| JP3122671B2 (ja) * | 1990-05-23 | 2001-01-09 | 協和醗酵工業株式会社 | 複素環式化合物 |
| HU211081B (en) * | 1990-12-18 | 1995-10-30 | Sandoz Ag | Process for producing indole derivatives as serotonin antagonists and pharmaceutical compositions containing the same |
| DE69113284T2 (de) * | 1990-12-28 | 1996-02-22 | Kyowa Hakko Kogyo Co., Ltd., Tokio/Tokyo | Chinolinderivat. |
| WO1993003725A1 (en) | 1991-08-20 | 1993-03-04 | Smithkline Beecham Plc | 5-ht4 receptor antagonists |
| EP0603220A1 (en) * | 1991-09-12 | 1994-06-29 | Smithkline Beecham Plc | Azabicyclic compounds as 5-ht 4? receptor antagonists |
| MX9305947A (es) * | 1992-09-29 | 1994-06-30 | Smithkline Beecham Plc | Compuestos antagonistas del receptor 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que las contienen. |
| EP0670319A4 (en) * | 1992-11-20 | 1996-01-17 | Thaisho Pharmaceutical Co Ltd | HETEROCYCLIC COMPOUNDS. |
| TW251287B (https=) | 1993-04-30 | 1995-07-11 | Nissei Co Ltd | |
| GB9310582D0 (en) * | 1993-05-22 | 1993-07-07 | Smithkline Beecham Plc | Pharmaceuticals |
| AU679336B2 (en) * | 1994-02-28 | 1997-06-26 | Taisho Pharmaceutical Co., Ltd. | Heterocyclic compound |
| US5864039A (en) * | 1994-03-30 | 1999-01-26 | Yoshitomi Pharmaceutical Industries, Ltd. | Benzoic acid compounds and use thereof as medicaments |
| GB9406857D0 (en) * | 1994-04-07 | 1994-06-01 | Sandoz Ltd | Improvements in or relating to organic compounds |
| JP3829879B2 (ja) * | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
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| JP3829880B2 (ja) | 1994-12-27 | 2006-10-04 | 大正製薬株式会社 | 化学中間体 |
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| BRPI0409592A (pt) * | 2003-04-21 | 2006-05-02 | Pfizer | compostos imidazopiridina tendo atividade agonìstica do receptor 5-ht4 e atividade antagonìstica do receptor 5-ht3 |
| WO2005000837A1 (en) | 2003-06-19 | 2005-01-06 | Janssen Pharmaceutica N.V. | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5ht4-antagonists |
| JO2478B1 (en) | 2003-06-19 | 2009-01-20 | جانسين فارماسوتيكا ان. في. | (Aminomethyl) -biperidine benzamides as 5 HT4 antagonists |
| UA86204C2 (uk) | 2003-09-03 | 2009-04-10 | Пфайзер Инк. | Сполуки бензімідазолону, які мають 5-нт4 рецепторну агоністичну активність |
| US7346224B2 (en) * | 2003-11-07 | 2008-03-18 | Mitsubishi Electric Research Laboratories, Inc. | System and method for classifying pixels in images |
| DE602004026095D1 (de) | 2003-11-24 | 2010-04-29 | Pfizer | Chinoloncarbonsäureverbindungen mit 5-ht4-rezeptoragonistischer wirkung |
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| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| CA2569654C (en) * | 2004-06-15 | 2010-12-21 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| US7737163B2 (en) * | 2004-06-15 | 2010-06-15 | Pfizer Inc. | Benzimidazolone carboxylic acid derivatives |
| EP1807423B1 (en) | 2004-11-05 | 2009-05-20 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| ATE441646T1 (de) | 2004-11-05 | 2009-09-15 | Theravance Inc | 5-ht4-rezeptoragonistenverbindungen |
| ATE469897T1 (de) * | 2004-12-22 | 2010-06-15 | Theravance Inc | Indazolcarbonsäureamidverbindungen |
| US7317022B2 (en) | 2005-06-07 | 2008-01-08 | Theravance, Inc. | Benzoimidazolone-carboxamide compounds as 5-HT4 receptors agonists |
| MY143574A (en) * | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
-
2006
- 2006-03-01 NZ NZ560828A patent/NZ560828A/en not_active IP Right Cessation
- 2006-03-01 WO PCT/US2006/007284 patent/WO2006094063A1/en not_active Ceased
- 2006-03-01 JP JP2007558181A patent/JP5042043B2/ja not_active Expired - Fee Related
- 2006-03-01 KR KR1020077022429A patent/KR20070107807A/ko not_active Ceased
- 2006-03-01 CN CNA2006800131887A patent/CN101163701A/zh active Pending
- 2006-03-01 AU AU2006218603A patent/AU2006218603A1/en not_active Abandoned
- 2006-03-01 CA CA002599404A patent/CA2599404A1/en not_active Abandoned
- 2006-03-01 EA EA200701867A patent/EA013567B1/ru not_active IP Right Cessation
- 2006-03-01 ES ES06736578.3T patent/ES2523851T3/es not_active Expired - Lifetime
- 2006-03-01 BR BRPI0608392-7A patent/BRPI0608392A2/pt not_active IP Right Cessation
- 2006-03-01 US US11/365,320 patent/US7446114B2/en active Active
- 2006-03-01 MX MX2007010769A patent/MX2007010769A/es active IP Right Grant
- 2006-03-01 EP EP06736578.3A patent/EP1871772B1/en not_active Expired - Lifetime
-
2007
- 2007-08-21 IL IL185407A patent/IL185407A0/en unknown
- 2007-08-23 ZA ZA200707142A patent/ZA200707142B/xx unknown
- 2007-09-25 NO NO20074884A patent/NO20074884L/no not_active Application Discontinuation
-
2008
- 2008-09-22 US US12/234,906 patent/US7875629B2/en not_active Expired - Fee Related
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