JP2007538084A5 - - Google Patents
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- Publication number
- JP2007538084A5 JP2007538084A5 JP2007527345A JP2007527345A JP2007538084A5 JP 2007538084 A5 JP2007538084 A5 JP 2007538084A5 JP 2007527345 A JP2007527345 A JP 2007527345A JP 2007527345 A JP2007527345 A JP 2007527345A JP 2007538084 A5 JP2007538084 A5 JP 2007538084A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- compound according
- unsubstituted
- ring
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 44
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 9
- 208000035475 disorder Diseases 0.000 claims 9
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- 125000003386 piperidinyl group Chemical group 0.000 claims 7
- 208000024827 Alzheimer disease Diseases 0.000 claims 5
- RWRDLPDLKQPQOW-UHFFFAOYSA-N Pyrrolidine Chemical group C1CCNC1 RWRDLPDLKQPQOW-UHFFFAOYSA-N 0.000 claims 5
- 125000000217 alkyl group Chemical group 0.000 claims 5
- 210000003169 central nervous system Anatomy 0.000 claims 5
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- 210000001428 peripheral nervous system Anatomy 0.000 claims 5
- 206010047700 Vomiting Diseases 0.000 claims 4
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 4
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 4
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims 3
- 108091005482 5-HT4 receptors Proteins 0.000 claims 3
- -1 N (C1-C8) carbocycle Chemical group 0.000 claims 3
- 125000003342 alkenyl group Chemical group 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000003725 azepanyl group Chemical group 0.000 claims 3
- 239000004031 partial agonist Substances 0.000 claims 3
- 239000000018 receptor agonist Substances 0.000 claims 3
- 229940044601 receptor agonist Drugs 0.000 claims 3
- 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 claims 2
- 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 2
- 208000019901 Anxiety disease Diseases 0.000 claims 2
- 206010003658 Atrial Fibrillation Diseases 0.000 claims 2
- 208000028698 Cognitive impairment Diseases 0.000 claims 2
- 206010010774 Constipation Diseases 0.000 claims 2
- 208000010228 Erectile Dysfunction Diseases 0.000 claims 2
- 208000019454 Feeding and Eating disease Diseases 0.000 claims 2
- 208000012895 Gastric disease Diseases 0.000 claims 2
- 208000007882 Gastritis Diseases 0.000 claims 2
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 208000032382 Ischaemic stroke Diseases 0.000 claims 2
- 208000019695 Migraine disease Diseases 0.000 claims 2
- 206010028813 Nausea Diseases 0.000 claims 2
- 208000004756 Respiratory Insufficiency Diseases 0.000 claims 2
- 206010038678 Respiratory depression Diseases 0.000 claims 2
- 206010046543 Urinary incontinence Diseases 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 206010003119 arrhythmia Diseases 0.000 claims 2
- 230000006793 arrhythmia Effects 0.000 claims 2
- 125000002393 azetidinyl group Chemical group 0.000 claims 2
- 125000004069 aziridinyl group Chemical group 0.000 claims 2
- 229910052794 bromium Inorganic materials 0.000 claims 2
- 229910052801 chlorine Inorganic materials 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 201000006549 dyspepsia Diseases 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 230000030136 gastric emptying Effects 0.000 claims 2
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 201000001881 impotence Diseases 0.000 claims 2
- 229910052740 iodine Inorganic materials 0.000 claims 2
- 206010027599 migraine Diseases 0.000 claims 2
- 230000008693 nausea Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 2
- 230000008673 vomiting Effects 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
- 206010012289 Dementia Diseases 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims 1
- 125000005055 alkyl alkoxy group Chemical group 0.000 claims 1
- 159000000007 calcium salts Chemical class 0.000 claims 1
- 229910052799 carbon Inorganic materials 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000001072 heteroaryl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000011777 magnesium Substances 0.000 claims 1
- 229910052749 magnesium Inorganic materials 0.000 claims 1
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 239000011591 potassium Substances 0.000 claims 1
- 229910052700 potassium Inorganic materials 0.000 claims 1
- 239000002469 receptor inverse agonist Substances 0.000 claims 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 239000003523 serotonin 4 antagonist Substances 0.000 claims 1
- 239000011734 sodium Substances 0.000 claims 1
- 229910052708 sodium Inorganic materials 0.000 claims 1
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 0 CCCCC(C)(CCC)CC(C(*=*)N1*)C(*)=C(C(*N*(*)*)=O)C1=O Chemical compound CCCCC(C)(CCC)CC(C(*=*)N1*)C(*)=C(C(*N*(*)*)=O)C1=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US57185204P | 2004-05-17 | 2004-05-17 | |
| US60/571,852 | 2004-05-17 | ||
| US10/955,434 | 2004-09-30 | ||
| US10/955,434 US7488736B2 (en) | 2004-05-17 | 2004-09-30 | Thienopyridinone compounds and methods of treatment |
| PCT/US2005/017121 WO2005121151A2 (en) | 2004-05-17 | 2005-05-16 | Thienopyridinone compounds and methods of treatment |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007538084A JP2007538084A (ja) | 2007-12-27 |
| JP2007538084A5 true JP2007538084A5 (https=) | 2008-07-03 |
| JP4897683B2 JP4897683B2 (ja) | 2012-03-14 |
Family
ID=35310219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007527345A Expired - Fee Related JP4897683B2 (ja) | 2004-05-17 | 2005-05-16 | チエノピリジノン化合物及び治療方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US7488736B2 (https=) |
| EP (1) | EP1746994A4 (https=) |
| JP (1) | JP4897683B2 (https=) |
| KR (1) | KR101216296B1 (https=) |
| AU (1) | AU2005252632B2 (https=) |
| BR (1) | BRPI0510022A (https=) |
| CA (1) | CA2567268C (https=) |
| IL (1) | IL178996A0 (https=) |
| MA (1) | MA28582B1 (https=) |
| NO (1) | NO20065814L (https=) |
| RU (1) | RU2006144867A (https=) |
| WO (1) | WO2005121151A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7488736B2 (en) | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7598265B2 (en) * | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| WO2006081332A1 (en) * | 2005-01-25 | 2006-08-03 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| CN101384367B (zh) * | 2006-02-14 | 2012-05-30 | 埃克森美孚化学专利公司 | 一种制造mcm-22族分子筛的方法 |
| US8114894B2 (en) * | 2008-12-03 | 2012-02-14 | Nanotherapeutics, Inc. | Bicyclic compounds and methods of making and using same |
| US8557994B2 (en) * | 2009-07-27 | 2013-10-15 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
| US9453027B2 (en) | 2009-07-27 | 2016-09-27 | Daljit Singh Dhanoa | Deuterium-enriched pyridinonecarboxamides and derivatives |
| CA2813711A1 (en) | 2010-10-14 | 2012-04-19 | Immunahr Ab | 1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxanilides as ahr activators. |
| WO2013009830A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| WO2013009812A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc | Methods of treatment |
| WO2013009810A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| WO2013009827A1 (en) * | 2011-07-13 | 2013-01-17 | Tempero Pharmaceuticals, Inc. | Methods of treatment |
| LT4004002T (lt) | 2019-07-22 | 2024-10-25 | Lupin Limited | Makrocikliniai junginiai kaip sting agonistai ir jų naudojimo būdai bei metodai |
| CN114569566A (zh) * | 2020-12-02 | 2022-06-03 | 四川科瑞德制药股份有限公司 | 一种盐酸米那普仑制剂的制备方法 |
| IL314038A (en) | 2022-01-11 | 2024-09-01 | Suven Life Sciences Ltd | Pyrrolo[1,2-b]-2-pyridazinone compounds as 5-HT4 receptor agonists |
| US11725016B1 (en) * | 2022-06-02 | 2023-08-15 | Nanopharmaceutics, Inc | Compositions and methods for oral delivery of crystalline PRX-3140 potassium salt |
| EP4719356A1 (en) * | 2023-06-05 | 2026-04-08 | Nanopharmaceutics, Inc. | Compositions and methods for oral delivery of sustained release crystalline prx-3140 |
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| GB1570494A (en) * | 1975-11-28 | 1980-07-02 | Ici Ltd | Thienopyrimidine derivatives and their use as pesticides |
| DE2925175A1 (de) * | 1979-06-22 | 1981-01-08 | Basf Ag | Verfahren zur herstellung von isatosaeureanhydriden |
| IT1203323B (it) * | 1987-02-02 | 1989-02-15 | Hoechst Italia Spa | Additivo fotoattivatore per composizioni polimeriche costituito dal sale metallico di una cera ossidata |
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| DE19724980A1 (de) * | 1997-06-13 | 1998-12-17 | Basf Ag | 3-Substituierte 3,4-Dihydro-thieno[2,3-d]pyrimidin-Derivate, ihre Herstellung und Verwendung |
| JPH11130777A (ja) | 1997-08-13 | 1999-05-18 | Takeda Chem Ind Ltd | チエノピリジン誘導体、その中間体およびそれらの製造法 |
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| WO1999043681A1 (en) * | 1998-02-26 | 1999-09-02 | Neurogen Corporation | 4-(4-piperidylmethylamino) substituted heteroaryl fused pyridines: gaba brain receptor ligands |
| DE19815026A1 (de) * | 1998-04-03 | 1999-10-07 | Hoechst Schering Agrevo Gmbh | Substituierte Piperidine, Verfahren zu ihrer Herstellung und ihre Verwendung als Schädlingsbekämpfungsmittel und Fungizide |
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| SE9902987D0 (sv) | 1999-08-24 | 1999-08-24 | Astra Pharma Prod | Novel compounds |
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| EP1270568A1 (en) | 2001-06-19 | 2003-01-02 | Biofrontera Pharmaceuticals AG | 1-methyl-4-(3-ethoxy-9h-thioxanthene-ylidene)-piperidine and its use as 5-HT2B and/or H1 antagonist |
| WO2003020728A1 (en) * | 2001-08-30 | 2003-03-13 | Pharmacia & Upjohn Company | 4-THIOXO-4,7-DIHYDRO-THIENO[2,3-b]PYRIDINE-5-CARBOTHIOAMIDES AS ANTIVIRAL AGENTS |
| MXPA03000145A (es) * | 2002-01-07 | 2003-07-15 | Pfizer | Compuestos de oxo u oxi-piridina como moduladores de receptores 5-ht4. |
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| US20040138238A1 (en) * | 2002-08-08 | 2004-07-15 | Dhanoa Dale S. | Substituted aminopyrimidine compounds as neurokinin antagonists |
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| US20040097492A1 (en) * | 2002-11-01 | 2004-05-20 | Pratt John K | Anti-infective agents |
| US7153858B2 (en) * | 2003-01-31 | 2006-12-26 | Epix Delaware, Inc. | Arylpiperazinyl compounds |
| US20050222175A1 (en) * | 2004-03-31 | 2005-10-06 | Dhanoa Dale S | New piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| US7612078B2 (en) * | 2003-03-31 | 2009-11-03 | Epix Delaware, Inc. | Piperidinylamino-thieno[2,3-D] pyrimidine compounds |
| JP4677518B2 (ja) * | 2003-03-31 | 2011-04-27 | エピックス デラウェア， インコーポレイテッド | 新規ピペリジニルアミノ−チエノ［２，３−ｄ］ピリミジン化合物 |
| US7119205B2 (en) * | 2003-05-16 | 2006-10-10 | Abbott Laboratories | Thienopyridones as AMPK activators for the treatment of diabetes and obesity |
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| US7488736B2 (en) | 2004-05-17 | 2009-02-10 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US20060084806A1 (en) * | 2004-07-21 | 2006-04-20 | Ramasubramanian Sridharan | Processes for the preparation of imidazo[1,2-a] pyridine derivatives |
| US7576211B2 (en) * | 2004-09-30 | 2009-08-18 | Epix Delaware, Inc. | Synthesis of thienopyridinone compounds and related intermediates |
| US7407966B2 (en) * | 2004-10-07 | 2008-08-05 | Epix Delaware, Inc. | Thienopyridinone compounds and methods of treatment |
| US7598265B2 (en) | 2004-09-30 | 2009-10-06 | Epix Delaware, Inc. | Compositions and methods for treating CNS disorders |
| WO2006081332A1 (en) * | 2005-01-25 | 2006-08-03 | Epix Delaware, Inc. | Substituted arylamine compounds and their use as 5-ht6 modulators |
| EP1965807A4 (en) * | 2005-11-23 | 2010-10-27 | Epix Delaware Inc | S1P RECEPTOR MODULATING COMPOUNDS AND THEIR USE |
| AR061637A1 (es) | 2006-06-26 | 2008-09-10 | Epix Delaware Inc | Composiciones y metodos de tratamiento de trastornos del snc |
| US20100184749A1 (en) | 2006-10-12 | 2010-07-22 | EPIX Delaware ,Inc. | Benzothiadiazine compounds and their use |
| AR064245A1 (es) | 2006-11-17 | 2009-03-25 | Epix Delaware Inc | Analogos de adenosina y su uso |
-
2004
- 2004-09-30 US US10/955,434 patent/US7488736B2/en not_active Expired - Lifetime
-
2005
- 2005-05-16 WO PCT/US2005/017121 patent/WO2005121151A2/en not_active Ceased
- 2005-05-16 CA CA2567268A patent/CA2567268C/en not_active Expired - Lifetime
- 2005-05-16 BR BRPI0510022-4A patent/BRPI0510022A/pt not_active Application Discontinuation
- 2005-05-16 RU RU2006144867/04A patent/RU2006144867A/ru not_active Application Discontinuation
- 2005-05-16 JP JP2007527345A patent/JP4897683B2/ja not_active Expired - Fee Related
- 2005-05-16 AU AU2005252632A patent/AU2005252632B2/en not_active Ceased
- 2005-05-16 EP EP05779361A patent/EP1746994A4/en not_active Withdrawn
-
2006
- 2006-11-01 IL IL178996A patent/IL178996A0/en unknown
- 2006-11-13 MA MA29451A patent/MA28582B1/fr unknown
- 2006-11-15 KR KR1020067023904A patent/KR101216296B1/ko not_active Expired - Fee Related
- 2006-12-15 NO NO20065814A patent/NO20065814L/no not_active Application Discontinuation
-
2008
- 2008-12-24 US US12/343,818 patent/US7982040B2/en not_active Expired - Lifetime
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