JP2009512624A5 - - Google Patents
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- Publication number
- JP2009512624A5 JP2009512624A5 JP2008515804A JP2008515804A JP2009512624A5 JP 2009512624 A5 JP2009512624 A5 JP 2009512624A5 JP 2008515804 A JP2008515804 A JP 2008515804A JP 2008515804 A JP2008515804 A JP 2008515804A JP 2009512624 A5 JP2009512624 A5 JP 2009512624A5
- Authority
- JP
- Japan
- Prior art keywords
- isopropyl
- oxo
- oct
- amide
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 21
- -1 1-methylimidazole-4-yl Chemical group 0.000 claims 16
- BUKWSRWWSFMAKN-UHFFFAOYSA-N 2-oxo-3-propan-2-ylbenzimidazole-1-carboxylic acid Chemical compound C1=CC=C2N(C(O)=O)C(=O)N(C(C)C)C2=C1 BUKWSRWWSFMAKN-UHFFFAOYSA-N 0.000 claims 16
- 125000000217 alkyl group Chemical group 0.000 claims 15
- 239000001257 hydrogen Substances 0.000 claims 10
- 229910052739 hydrogen Inorganic materials 0.000 claims 10
- 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 8
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 6
- 150000001408 amides Chemical class 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 5
- 150000002431 hydrogen Chemical class 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 239000003937 drug carrier Substances 0.000 claims 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 2
- 125000002883 imidazolyl group Chemical group 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 2
- 125000004194 piperazin-1-yl group Chemical group [H]N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 125000006239 protecting group Chemical group 0.000 claims 2
- 206010010774 Constipation Diseases 0.000 claims 1
- 206010052105 Gastrointestinal hypomotility Diseases 0.000 claims 1
- 206010021518 Impaired gastric emptying Diseases 0.000 claims 1
- 201000005081 Intestinal Pseudo-Obstruction Diseases 0.000 claims 1
- 206010033799 Paralysis Diseases 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000003111 delayed effect Effects 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 201000006549 dyspepsia Diseases 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000002496 gastric effect Effects 0.000 claims 1
- 208000021302 gastroesophageal reflux disease Diseases 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 208000003243 intestinal obstruction Diseases 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000002980 postoperative effect Effects 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims 1
- 0 C*(C)(*)C(CC1)CCS1(=O)=O Chemical compound C*(C)(*)C(CC1)CCS1(=O)=O 0.000 description 1
- CMJLMPKFQPJDKP-UHFFFAOYSA-N CC(CC1)CS1(=O)=O Chemical compound CC(CC1)CS1(=O)=O CMJLMPKFQPJDKP-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68804805P | 2005-06-07 | 2005-06-07 | |
| US60/688,048 | 2005-06-07 | ||
| PCT/US2006/021765 WO2006133104A2 (en) | 2005-06-07 | 2006-06-06 | Benzoimidazolone-carboxamide compounds as 5-ht4 receptor agonists |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009512624A JP2009512624A (ja) | 2009-03-26 |
| JP2009512624A5 true JP2009512624A5 (https=) | 2009-07-02 |
| JP5086248B2 JP5086248B2 (ja) | 2012-11-28 |
Family
ID=37499008
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008515804A Expired - Fee Related JP5086248B2 (ja) | 2005-06-07 | 2006-06-06 | ５−ｈｔ４受容体アゴニストとしてのベンゾイミダゾロン−カルボキサミド化合物 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US7317022B2 (https=) |
| EP (1) | EP1902053B1 (https=) |
| JP (1) | JP5086248B2 (https=) |
| AT (1) | ATE495171T1 (https=) |
| DE (1) | DE602006019595D1 (https=) |
| ES (1) | ES2359673T3 (https=) |
| WO (1) | WO2006133104A2 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| US7399862B2 (en) * | 2004-11-05 | 2008-07-15 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
| WO2006052889A2 (en) * | 2004-11-05 | 2006-05-18 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| CA2588037A1 (en) * | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
| CN101163701A (zh) * | 2005-03-02 | 2008-04-16 | 施万制药 | 作为5-ht4受体激动剂的喹啉酮化合物 |
| MY143574A (en) | 2005-11-22 | 2011-05-31 | Theravance Inc | Carbamate compounds as 5-ht4 receptor agonists |
| EP2241567A4 (en) * | 2008-02-13 | 2011-11-09 | Eisai R&D Man Co Ltd | Bicycloamine DERIVATIVE |
| US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
| AR080056A1 (es) | 2010-02-01 | 2012-03-07 | Novartis Ag | Derivados de ciclohexil-amida como antagonistas de los receptores de crf |
| WO2011092290A1 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Pyrazolo[5,1b]oxazole derivatives as crf-1 receptor antagonists |
| EP2531490B1 (en) | 2010-02-02 | 2014-10-15 | Novartis AG | Cyclohexyl amide derivatives as crf receptor antagonists |
| MX2020003242A (es) | 2017-09-22 | 2020-09-18 | Jubilant Epipad LLC | Compuestos heterociclicos como inhibidores de pad. |
| AU2018352142B2 (en) | 2017-10-18 | 2022-08-25 | Jubilant Epipad LLC | Imidazo-pyridine compounds as PAD inhibitors |
| KR20200085836A (ko) | 2017-11-06 | 2020-07-15 | 주빌런트 프로델 엘엘씨 | Pd1/pd-l1 활성화 억제제로서의 피리미딘 유도체 |
| BR112020010322A2 (pt) | 2017-11-24 | 2020-11-17 | Jubilant Episcribe Llc | composto da fórmula i; composto da fórmula ia; composto da fórmula ib; processo de preparação de compostos da fórmula i; composição farmacêutica; método para o tratamento e/ou prevenção de várias doenças; uso dos compostos; método para o tratamento de câncer; e método para o tratamento e/ou prevenção de uma afecção mediada por prmt5 ou um distúrbio proliferativo ou câncer |
| SG11202008950PA (en) | 2018-03-13 | 2020-10-29 | Jubilant Prodel LLC | Bicyclic compounds as inhibitors of pd1/pd-l1 interaction/activation |
| CN115073311B (zh) * | 2022-03-23 | 2023-05-23 | 河南大学 | 一种高效制备n,n′-二（2羟乙基）苯胺的合成方法 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5223511A (en) | 1987-09-23 | 1993-06-29 | Boehringer Ingelheim Italia S.P.A. | Benzimidazoline-2-oxo-1-carboxylic acid compounds useful as 5-HT receptor antagonists |
| IT1231413B (it) | 1987-09-23 | 1991-12-04 | Angeli Inst Spa | Derivati dell'acido benzimidazolin-2-osso-1-carbossilico utili come antagonisti dei recettori 5-ht |
| JP3829879B2 (ja) | 1994-05-18 | 2006-10-04 | 大正製薬株式会社 | キノリンカルボン酸誘導体 |
| IT1275903B1 (it) | 1995-03-14 | 1997-10-24 | Boehringer Ingelheim Italia | Esteri e ammidi della 1,4-piperidina disostituita |
| US6069152A (en) * | 1997-10-07 | 2000-05-30 | Eli Lilly And Company | 5-HT4 agonists and antagonists |
| GB9721139D0 (en) * | 1997-10-07 | 1997-12-03 | Glaxo Group Ltd | Medicaments |
| IT1298271B1 (it) | 1998-02-18 | 1999-12-20 | Boehringer Ingelheim Italia | Esteri ed ammidi dell'acido 2-oxo-2,3-diidro-benzimidazol-1- carbossilico |
| EP1173168A2 (en) | 1999-04-28 | 2002-01-23 | Respiratorius AB | Compound for use as a medicament for treatment of disorders involving bronchocontraction |
| CN1355698A (zh) * | 1999-06-15 | 2002-06-26 | 呼吸器有限公司 | 可用作治疗有关支气管收缩的机能障碍的药物的化合物 |
| IT1313625B1 (it) | 1999-09-22 | 2002-09-09 | Boehringer Ingelheim Italia | Derivati benzimidazolonici aventi affinita' mista per i recettori diserotonina e dopamina. |
| KR100738784B1 (ko) | 2003-09-03 | 2007-07-12 | 화이자 인코포레이티드 | 5-ｈｔ4 수용체 효능 활성을 갖는 벤즈이미다졸론 |
| TW200533348A (en) | 2004-02-18 | 2005-10-16 | Theravance Inc | Indazole-carboxamide compounds as 5-ht4 receptor agonists |
| TWI351282B (en) | 2004-04-07 | 2011-11-01 | Theravance Inc | Quinolinone-carboxamide compounds as 5-ht4 recepto |
| WO2006052889A2 (en) | 2004-11-05 | 2006-05-18 | Theravance, Inc. | Quinolinone-carboxamide compounds |
| US7399862B2 (en) | 2004-11-05 | 2008-07-15 | Theravance, Inc. | 5-HT4 receptor agonist compounds |
| CA2588037A1 (en) | 2004-12-22 | 2006-06-29 | Theravance, Inc. | Indazole-carboxamide compounds |
-
2006
- 2006-06-06 EP EP06772173A patent/EP1902053B1/en active Active
- 2006-06-06 AT AT06772173T patent/ATE495171T1/de not_active IP Right Cessation
- 2006-06-06 DE DE602006019595T patent/DE602006019595D1/de active Active
- 2006-06-06 WO PCT/US2006/021765 patent/WO2006133104A2/en not_active Ceased
- 2006-06-06 US US11/447,459 patent/US7317022B2/en active Active
- 2006-06-06 ES ES06772173T patent/ES2359673T3/es active Active
- 2006-06-06 JP JP2008515804A patent/JP5086248B2/ja not_active Expired - Fee Related
-
2007
- 2007-11-20 US US11/986,212 patent/US7772239B2/en not_active Expired - Fee Related
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