JP2008531675A5 - - Google Patents

Info

Publication number

JP2008531675A5

JP2008531675A5 JP2007557595A JP2007557595A JP2008531675A5 JP 2008531675 A5 JP2008531675 A5 JP 2008531675A5 JP 2007557595 A JP2007557595 A JP 2007557595A JP 2007557595 A JP2007557595 A JP 2007557595A JP 2008531675 A5 JP2008531675 A5 JP 2008531675A5

Authority

JP

Japan

Prior art keywords

pharmaceutical composition

composition according

group

disease

compound

Prior art date

2006-03-02

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Pending

Links

• Espacenet
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• 239000008194 pharmaceutical composition Substances 0.000 claims 24
• 150000001875 compounds Chemical class 0.000 claims 10
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 125000001882 gamma-linolenoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims 4
• 230000004770 neurodegeneration Effects 0.000 claims 4
• 208000016192 Demyelinating disease Diseases 0.000 claims 3
• 206010012305 Demyelination Diseases 0.000 claims 3
• 208000015122 neurodegenerative disease Diseases 0.000 claims 3
• 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 3
• GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims 2
• 208000024827 Alzheimer disease Diseases 0.000 claims 2
• 102000004127 Cytokines Human genes 0.000 claims 2
• 108090000695 Cytokines Proteins 0.000 claims 2
• 206010019196 Head injury Diseases 0.000 claims 2
• 208000018737 Parkinson disease Diseases 0.000 claims 2
• 208000006011 Stroke Diseases 0.000 claims 2
• 102000046299 Transforming Growth Factor beta1 Human genes 0.000 claims 2
• 101800002279 Transforming growth factor beta-1 Proteins 0.000 claims 2
• 102100040247 Tumor necrosis factor Human genes 0.000 claims 2
• 230000005856 abnormality Effects 0.000 claims 2
• 125000002252 acyl group Chemical group 0.000 claims 2
• 125000001931 aliphatic group Chemical group 0.000 claims 2
• 125000003342 alkenyl group Chemical group 0.000 claims 2
• 125000003545 alkoxy group Chemical group 0.000 claims 2
• YZXBAPSDXZZRGB-DOFZRALJSA-N arachidonic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(O)=O YZXBAPSDXZZRGB-DOFZRALJSA-N 0.000 claims 2
• 125000003710 aryl alkyl group Chemical group 0.000 claims 2
• 210000004369 blood Anatomy 0.000 claims 2
• 239000008280 blood Substances 0.000 claims 2
• 208000007118 chronic progressive multiple sclerosis Diseases 0.000 claims 2
• 201000010099 disease Diseases 0.000 claims 2
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
• 125000002768 hydroxyalkyl group Chemical group 0.000 claims 2
• 238000000034 method Methods 0.000 claims 2
• 210000005036 nerve Anatomy 0.000 claims 2
• 235000020777 polyunsaturated fatty acids Nutrition 0.000 claims 2
• 239000003755 preservative agent Substances 0.000 claims 2
• 230000002335 preservative effect Effects 0.000 claims 2
• 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
• MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
• HOBAELRKJCKHQD-UHFFFAOYSA-N (8Z,11Z,14Z)-8,11,14-eicosatrienoic acid Natural products CCCCCC=CCC=CCC=CCCCCCCC(O)=O HOBAELRKJCKHQD-UHFFFAOYSA-N 0.000 claims 1
• VCKSNYNNVSOWEE-UHFFFAOYSA-N 1,3-dioxan-5-ol Chemical compound OC1COCOC1 VCKSNYNNVSOWEE-UHFFFAOYSA-N 0.000 claims 1
• CDMIHGQHXYTDIH-QNEBEIHSSA-N 1,3-dioxan-5-yl (6z,9z,12z)-octadeca-6,9,12-trienoate Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(=O)OC1COCOC1 CDMIHGQHXYTDIH-QNEBEIHSSA-N 0.000 claims 1
• UGYGOFHDQPGZET-QNEBEIHSSA-N 5-[(6z,9z,12z)-octadeca-6,9,12-trienoxy]-1,3-dioxane Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCOC1COCOC1 UGYGOFHDQPGZET-QNEBEIHSSA-N 0.000 claims 1
• 208000016026 Abnormality of the immune system Diseases 0.000 claims 1
• 208000011231 Crohn disease Diseases 0.000 claims 1
• 235000021298 Dihomo-γ-linolenic acid Nutrition 0.000 claims 1
• 206010018985 Haemorrhage intracranial Diseases 0.000 claims 1
• 208000032843 Hemorrhage Diseases 0.000 claims 1
• 206010020751 Hypersensitivity Diseases 0.000 claims 1
• -1 IL-1β Proteins 0.000 claims 1
• 102000003814 Interleukin-10 Human genes 0.000 claims 1
• 108090000174 Interleukin-10 Proteins 0.000 claims 1
• 102000003816 Interleukin-13 Human genes 0.000 claims 1
• 108090000176 Interleukin-13 Proteins 0.000 claims 1
• 208000008574 Intracranial Hemorrhages Diseases 0.000 claims 1
• 208000028389 Nerve injury Diseases 0.000 claims 1
• 208000012902 Nervous system disease Diseases 0.000 claims 1
• 208000007400 Relapsing-Remitting Multiple Sclerosis Diseases 0.000 claims 1
• 206010040047 Sepsis Diseases 0.000 claims 1
• 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
• 229930003427 Vitamin E Natural products 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 208000026935 allergic disease Diseases 0.000 claims 1
• 230000007815 allergy Effects 0.000 claims 1
• 239000003963 antioxidant agent Substances 0.000 claims 1
• 230000003078 antioxidant effect Effects 0.000 claims 1
• 235000006708 antioxidants Nutrition 0.000 claims 1
• 235000021342 arachidonic acid Nutrition 0.000 claims 1
• 229940114079 arachidonic acid Drugs 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 208000006673 asthma Diseases 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 208000034158 bleeding Diseases 0.000 claims 1
• 230000000740 bleeding effect Effects 0.000 claims 1
• 239000002775 capsule Substances 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 239000011248 coating agent Substances 0.000 claims 1
• 238000000576 coating method Methods 0.000 claims 1
• 230000001276 controlling effect Effects 0.000 claims 1
• 235000005911 diet Nutrition 0.000 claims 1
• 230000000378 dietary effect Effects 0.000 claims 1
• HOBAELRKJCKHQD-QNEBEIHSSA-N dihomo-γ-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCCCC(O)=O HOBAELRKJCKHQD-QNEBEIHSSA-N 0.000 claims 1
• 239000003085 diluting agent Substances 0.000 claims 1
• 230000008482 dysregulation Effects 0.000 claims 1
• VZCCETWTMQHEPK-UHFFFAOYSA-N gamma-Linolensaeure Natural products CCCCCC=CCC=CCC=CCCCCC(O)=O VZCCETWTMQHEPK-UHFFFAOYSA-N 0.000 claims 1
• VZCCETWTMQHEPK-QNEBEIHSSA-N gamma-linolenic acid Chemical compound CCCCC\C=C/C\C=C/C\C=C/CCCCC(O)=O VZCCETWTMQHEPK-QNEBEIHSSA-N 0.000 claims 1
• 235000020664 gamma-linolenic acid Nutrition 0.000 claims 1
• WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims 1
• 229960002733 gamolenic acid Drugs 0.000 claims 1
• 150000004820 halides Chemical class 0.000 claims 1
• 210000000987 immune system Anatomy 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 150000002632 lipids Chemical class 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 201000006417 multiple sclerosis Diseases 0.000 claims 1
• 230000008764 nerve damage Effects 0.000 claims 1
• 230000002028 premature Effects 0.000 claims 1
• 206010063401 primary progressive multiple sclerosis Diseases 0.000 claims 1
• 230000001105 regulatory effect Effects 0.000 claims 1
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
• 230000002269 spontaneous effect Effects 0.000 claims 1
• 208000024891 symptom Diseases 0.000 claims 1
• 238000003786 synthesis reaction Methods 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• 238000002560 therapeutic procedure Methods 0.000 claims 1
• 238000005809 transesterification reaction Methods 0.000 claims 1
• 235000019165 vitamin E Nutrition 0.000 claims 1
• 229940046009 vitamin E Drugs 0.000 claims 1
• 239000011709 vitamin E Substances 0.000 claims 1