JP2008531585A5 - - Google Patents
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- Publication number
- JP2008531585A5 JP2008531585A5 JP2007557169A JP2007557169A JP2008531585A5 JP 2008531585 A5 JP2008531585 A5 JP 2008531585A5 JP 2007557169 A JP2007557169 A JP 2007557169A JP 2007557169 A JP2007557169 A JP 2007557169A JP 2008531585 A5 JP2008531585 A5 JP 2008531585A5
- Authority
- JP
- Japan
- Prior art keywords
- groups
- polar
- group
- npl
- nonpolar
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- -1 hydroxy ethoxymethyl Chemical group 0.000 claims 67
- 229910052739 hydrogen Inorganic materials 0.000 claims 52
- 239000001257 hydrogen Substances 0.000 claims 52
- 229910052717 sulfur Inorganic materials 0.000 claims 44
- 150000002431 hydrogen Chemical class 0.000 claims 43
- 229910052760 oxygen Inorganic materials 0.000 claims 40
- 125000000217 alkyl group Chemical group 0.000 claims 39
- 238000000034 method Methods 0.000 claims 38
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 29
- IAYJZWFYUSNIPN-UHFFFAOYSA-N 2-[4,5-dihydroxy-2-(hydroxymethyl)-6-(4-nitrophenoxy)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound OC1C(O)C(O)C(CO)OC1OC1C(CO)OC(OC=2C=CC(=CC=2)[N+]([O-])=O)C(O)C1O IAYJZWFYUSNIPN-UHFFFAOYSA-N 0.000 claims 27
- 125000003118 aryl group Chemical group 0.000 claims 27
- 125000001072 heteroaryl group Chemical group 0.000 claims 27
- 125000005843 halogen group Chemical group 0.000 claims 26
- 125000003545 alkoxy group Chemical group 0.000 claims 25
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 19
- 206010028980 Neoplasm Diseases 0.000 claims 17
- 201000011510 cancer Diseases 0.000 claims 15
- 125000005549 heteroarylene group Chemical group 0.000 claims 11
- 125000000732 arylene group Chemical group 0.000 claims 10
- 125000000753 cycloalkyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 9
- 125000002431 aminoalkoxy group Chemical group 0.000 claims 9
- 150000003839 salts Chemical class 0.000 claims 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 8
- 125000004442 acylamino group Chemical group 0.000 claims 8
- 125000003342 alkenyl group Chemical group 0.000 claims 8
- 125000003282 alkyl amino group Chemical group 0.000 claims 8
- 125000004414 alkyl thio group Chemical group 0.000 claims 8
- 125000002947 alkylene group Chemical group 0.000 claims 8
- 125000000304 alkynyl group Chemical group 0.000 claims 8
- 125000004397 aminosulfonyl group Chemical group NS(=O)(=O)* 0.000 claims 8
- 125000001584 benzyloxycarbonyl group Chemical group C(=O)(OCC1=CC=CC=C1)* 0.000 claims 8
- 125000004093 cyano group Chemical group *C#N 0.000 claims 8
- 125000004663 dialkyl amino group Chemical group 0.000 claims 8
- 125000000623 heterocyclic group Chemical group 0.000 claims 8
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 claims 8
- 150000007659 semicarbazones Chemical class 0.000 claims 8
- 239000012453 solvate Substances 0.000 claims 8
- 239000003085 diluting agent Substances 0.000 claims 7
- 239000003937 drug carrier Substances 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 7
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 6
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 230000005907 cancer growth Effects 0.000 claims 3
- 125000003739 carbamimidoyl group Chemical group C(N)(=N)* 0.000 claims 3
- 235000019260 propionic acid Nutrition 0.000 claims 3
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 claims 3
- 229930192474 thiophene Natural products 0.000 claims 3
- ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims 2
- UUEVFMOUBSLVJW-UHFFFAOYSA-N oxo-[[1-[2-[2-[2-[4-(oxoazaniumylmethylidene)pyridin-1-yl]ethoxy]ethoxy]ethyl]pyridin-4-ylidene]methyl]azanium;dibromide Chemical compound [Br-].[Br-].C1=CC(=C[NH+]=O)C=CN1CCOCCOCCN1C=CC(=C[NH+]=O)C=C1 UUEVFMOUBSLVJW-UHFFFAOYSA-N 0.000 claims 2
- 125000004890 (C1-C6) alkylamino group Chemical group 0.000 claims 1
- 125000006619 (C1-C6) dialkylamino group Chemical group 0.000 claims 1
- 125000002030 1,2-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([*:2])C([H])=C1[H] 0.000 claims 1
- 125000001989 1,3-phenylene group Chemical group [H]C1=C([H])C([*:1])=C([H])C([*:2])=C1[H] 0.000 claims 1
- 125000001140 1,4-phenylene group Chemical group [H]C1=C([H])C([*:2])=C([H])C([H])=C1[*:1] 0.000 claims 1
- 125000000022 2-aminoethyl group Chemical group [H]C([*])([H])C([H])([H])N([H])[H] 0.000 claims 1
- 206010027476 Metastases Diseases 0.000 claims 1
- CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims 1
- 125000004202 aminomethyl group Chemical group [H]N([H])C([H])([H])* 0.000 claims 1
- SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 230000012010 growth Effects 0.000 claims 1
- 230000009401 metastasis Effects 0.000 claims 1
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 1
- UGQZLDXDWSPAOM-UHFFFAOYSA-N pyrrolo[3,4-f]isoindole-1,3,5,7-tetrone Chemical group C1=C2C(=O)NC(=O)C2=CC2=C1C(=O)NC2=O UGQZLDXDWSPAOM-UHFFFAOYSA-N 0.000 claims 1
- 230000004614 tumor growth Effects 0.000 claims 1
- 0 CCCC=C(N)NCc1cc(C)c(*)c(C#Cc2cccc(C#Cc3c(*)c(I=C)cc(CNC(N)=N)c3)c2)c1 Chemical compound CCCC=C(N)NCc1cc(C)c(*)c(C#Cc2cccc(C#Cc3c(*)c(I=C)cc(CNC(N)=N)c3)c2)c1 0.000 description 1
- JHPFXVWWEKHLNZ-UHFFFAOYSA-N CNC(NCCc1cc(C#Cc2cc(C#Cc3cc(Br)cc(CCNC(N)=N)c3)ccc2)cc(Br)c1)=N Chemical compound CNC(NCCc1cc(C#Cc2cc(C#Cc3cc(Br)cc(CCNC(N)=N)c3)ccc2)cc(Br)c1)=N JHPFXVWWEKHLNZ-UHFFFAOYSA-N 0.000 description 1
- HMXJHVZFZQKEQK-UHFFFAOYSA-N NCCNC(c1cc(Br)cc(C#Cc2cccc(C#Cc3cc(Br)cc(C(NCCN)=O)c3)c2)c1)O Chemical compound NCCNC(c1cc(Br)cc(C#Cc2cccc(C#Cc3cc(Br)cc(C(NCCN)=O)c3)c2)c1)O HMXJHVZFZQKEQK-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65609205P | 2005-02-25 | 2005-02-25 | |
| PCT/US2006/006487 WO2006093813A2 (en) | 2005-02-25 | 2006-02-24 | Facially amphiphilic polymers and oligomers, compositions thereof, and use thereof in methods of treating cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008531585A JP2008531585A (ja) | 2008-08-14 |
| JP2008531585A5 true JP2008531585A5 (https=) | 2009-04-09 |
Family
ID=36941658
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007557169A Pending JP2008531585A (ja) | 2005-02-25 | 2006-02-24 | 表面が両親媒性のポリマーおよびオリゴマー、それらの組成物そして癌治療方法におけるそれらの使用 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20060241052A1 (https=) |
| EP (5) | EP2433628A1 (https=) |
| JP (1) | JP2008531585A (https=) |
| KR (1) | KR20080004475A (https=) |
| AU (1) | AU2006218805A1 (https=) |
| CA (1) | CA2599205A1 (https=) |
| TW (2) | TW200722098A (https=) |
| WO (1) | WO2006093813A2 (https=) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2314087T3 (es) * | 2001-03-08 | 2009-03-16 | The Trustees Of The University Of Pennsylvania | Polimeros facialmente anfifilicos como agentes antiinfecciosos. |
| WO2004082634A2 (en) | 2003-03-17 | 2004-09-30 | The Trustees Of The University Of Pennsylvania | Facially amphiphilic polymers and oligomers and uses thereof |
| JP5260877B2 (ja) | 2004-01-23 | 2013-08-14 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 面に対して両親媒性のポリアリール及びポリアリールアルキニルのポリマー及びオリゴマー並びにそれらの使用 |
| KR101172722B1 (ko) | 2004-06-15 | 2012-08-16 | 폴리메딕스, 인코포레이티드 | 다가양이온성 화합물 및 이의 용도 |
| US20090092574A1 (en) * | 2006-12-29 | 2009-04-09 | Scott Richard W | Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof |
| KR100842351B1 (ko) * | 2007-01-04 | 2008-06-30 | 한국생명공학연구원 | 인돌 유도체를 유효성분으로 함유하는 암 예방 및 치료용약학적 조성물 |
| RU2530899C2 (ru) | 2008-07-28 | 2014-10-20 | Селлсьютикс Корпорейшн | Противомалярийные соединения |
| TWI478915B (zh) | 2008-10-27 | 2015-04-01 | Cellceutix Corp | 宿主防禦之合成模擬物及其用途 |
| EP2389067A4 (en) * | 2008-12-10 | 2012-06-13 | Polymedix Inc | ANTIMICROBIAL MOLECULES FOR THE TREATMENT OF MYCOBACTERIUM STRAINS WITH MULTIDRUG RESISTANCE AND LARGE RESISTANCE TO DRUGS |
| KR101094299B1 (ko) | 2009-12-17 | 2011-12-19 | 삼성모바일디스플레이주식회사 | 선형 증발원 및 이를 포함하는 증착 장치 |
| DK2709619T3 (en) | 2011-05-16 | 2018-01-15 | Cellceutix Corp | RELATIONSHIPS FOR USING THE TREATMENT OF MUCOSITIS |
| WO2013090185A1 (en) | 2011-12-13 | 2013-06-20 | Polymedix, Inc. | Cyclic compounds and methods of making and using the same |
| KR20140129030A (ko) * | 2012-01-18 | 2014-11-06 | 셀슈틱스 코포레이션 | 캔디다증 및 아스퍼질러스 감염을 치료하기 위한 화합물 및 방법 |
| CN109305926B (zh) * | 2018-10-18 | 2021-06-25 | 吉林大学 | 一种可形成分子内氢键的芳酰胺类金属配体及其制备方法与应用 |
| WO2021248008A1 (en) | 2020-06-05 | 2021-12-09 | Innovation Pharmaceuticals Inc. | Arylamide compounds for treatment and prevention of viral infections |
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| JP5260877B2 (ja) * | 2004-01-23 | 2013-08-14 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 面に対して両親媒性のポリアリール及びポリアリールアルキニルのポリマー及びオリゴマー並びにそれらの使用 |
| KR101172722B1 (ko) * | 2004-06-15 | 2012-08-16 | 폴리메딕스, 인코포레이티드 | 다가양이온성 화합물 및 이의 용도 |
| AU2005332637B2 (en) * | 2004-07-23 | 2011-04-07 | The Trustees Of The University Of Pennsylvania | Antimicrobial copolymers and uses thereof |
-
2006
- 2006-02-24 CA CA002599205A patent/CA2599205A1/en not_active Abandoned
- 2006-02-24 EP EP11010096A patent/EP2433628A1/en not_active Withdrawn
- 2006-02-24 EP EP10015189A patent/EP2301349A2/en not_active Withdrawn
- 2006-02-24 EP EP06735949A patent/EP1855704A4/en not_active Withdrawn
- 2006-02-24 US US11/361,050 patent/US20060241052A1/en not_active Abandoned
- 2006-02-24 AU AU2006218805A patent/AU2006218805A1/en not_active Abandoned
- 2006-02-24 EP EP11010095A patent/EP2433627A1/en not_active Withdrawn
- 2006-02-24 KR KR1020077022131A patent/KR20080004475A/ko not_active Ceased
- 2006-02-24 EP EP10015892A patent/EP2298074A3/en not_active Withdrawn
- 2006-02-24 JP JP2007557169A patent/JP2008531585A/ja active Pending
- 2006-02-24 WO PCT/US2006/006487 patent/WO2006093813A2/en not_active Ceased
- 2006-02-27 TW TW095106642A patent/TW200722098A/zh unknown
- 2006-02-27 TW TW101108505A patent/TW201231063A/zh unknown
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