JP2004509845A5 - - Google Patents
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- Publication number
- JP2004509845A5 JP2004509845A5 JP2002500833A JP2002500833A JP2004509845A5 JP 2004509845 A5 JP2004509845 A5 JP 2004509845A5 JP 2002500833 A JP2002500833 A JP 2002500833A JP 2002500833 A JP2002500833 A JP 2002500833A JP 2004509845 A5 JP2004509845 A5 JP 2004509845A5
- Authority
- JP
- Japan
- Prior art keywords
- linker
- analogue
- spermine
- derivative according
- derivative
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PFNFFQXMRSDOHW-UHFFFAOYSA-N spermine Chemical compound NCCCNCCCCNCCCN PFNFFQXMRSDOHW-UHFFFAOYSA-N 0.000 claims 26
- 125000005647 linker group Chemical group 0.000 claims 15
- 229920000768 polyamine Polymers 0.000 claims 13
- 229940063675 spermine Drugs 0.000 claims 13
- UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 claims 11
- 230000015572 biosynthetic process Effects 0.000 claims 6
- 238000003786 synthesis reaction Methods 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- -1 t-butoxycarbonyl Chemical group 0.000 claims 5
- VLCYCQAOQCDTCN-UHFFFAOYSA-N eflornithine Chemical group NCCCC(N)(C(F)F)C(O)=O VLCYCQAOQCDTCN-UHFFFAOYSA-N 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 125000003118 aryl group Chemical group 0.000 claims 3
- 230000001413 cellular effect Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 3
- 230000035755 proliferation Effects 0.000 claims 3
- 125000002723 alicyclic group Chemical group 0.000 claims 2
- 125000003277 amino group Chemical group 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 2
- 229940124530 sulfonamide Drugs 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 230000001142 anti-diarrhea Effects 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000001624 naphthyl group Chemical group 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 125000006239 protecting group Chemical group 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US09/584,175 US6646149B1 (en) | 1997-07-15 | 2000-05-31 | Polyamine analogues as therapeutic and diagnostic agents |
| PCT/US2001/017795 WO2001092218A2 (en) | 2000-05-31 | 2001-05-31 | Polyamine analogues as therapeutic and diagnostic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2004509845A JP2004509845A (ja) | 2004-04-02 |
| JP2004509845A5 true JP2004509845A5 (https=) | 2005-04-21 |
Family
ID=24336202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002500833A Pending JP2004509845A (ja) | 2000-05-31 | 2001-05-31 | 治療剤及び診断剤としての新規ポリアミン類似体 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US6646149B1 (https=) |
| EP (1) | EP1317424A2 (https=) |
| JP (1) | JP2004509845A (https=) |
| KR (1) | KR100851452B1 (https=) |
| CN (1) | CN1512982A (https=) |
| AU (1) | AU2001268139A1 (https=) |
| CA (1) | CA2410935A1 (https=) |
| WO (1) | WO2001092218A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7312244B2 (en) * | 1999-04-30 | 2007-12-25 | Cellgate, Inc. | Polyamine analog-amino acid conjugates useful as anticancer agents |
| EP1088815A1 (en) * | 1999-09-28 | 2001-04-04 | Applied Research Systems ARS Holding N.V. | Pharmaceutically active sulfonyl amino acid derivatives |
| WO2002053519A2 (en) * | 2001-01-08 | 2002-07-11 | Mediquest Therapeutics, Inc. | Hydrophobic polyamine analogs and methods for their use |
| US7144920B2 (en) | 2002-09-23 | 2006-12-05 | Mediquest Therapeutics, Inc. | Polyamine analogs that activate antizyme frameshifting |
| US20070088081A1 (en) * | 2002-09-27 | 2007-04-19 | Research Foundation Of The University Of Central Florida Incorporated | Polyamine conjugates as selective NMDA inhibitors and anti-cancer drugs |
| GB0223563D0 (en) * | 2002-10-10 | 2002-11-20 | Secr Defence | Detection system |
| AU2005214149A1 (en) * | 2004-02-19 | 2005-09-01 | F2G Ltd | 2031 oxidoreductase |
| GB2414477A (en) * | 2004-05-25 | 2005-11-30 | Hunter Fleming Ltd | Novel polyamines and their therapeutic use |
| CN1980629B (zh) * | 2004-06-14 | 2010-06-16 | 荷兰联合利华有限公司 | 减少皮脂生成和缩小毛孔大小的方法 |
| US7199267B1 (en) * | 2005-10-21 | 2007-04-03 | Mediquest Therapeutics, Inc. | Recognition of oligiosaccaride molecular targets by polycationic small molecule inhibitors and treatment of immunological disorders and infectious diseases |
| US7411002B2 (en) * | 2006-06-07 | 2008-08-12 | The University Of Kansas | Polycationic sulfonamides and use thereof |
| EP2096106B1 (en) * | 2006-11-15 | 2014-06-18 | Nihon University | Novel polyamine derivatives |
| WO2008105441A1 (ja) * | 2007-02-27 | 2008-09-04 | Ajinomoto Co., Inc. | リン吸収抑制活性を有するポリアミノ酸化合物及びリン吸収抑制剤 |
| CN104892449B (zh) * | 2014-03-06 | 2017-06-13 | 天津红日药业股份有限公司 | 一种精胺类似物及其药用盐的制备方法和用途 |
| US20170273926A1 (en) * | 2016-03-24 | 2017-09-28 | Orbus Therapeutics, Inc. | Compositions and methods for use of eflornithine and derivatives and analogs thereof to treat cancers, including gliomas |
| HUE052620T2 (hu) | 2016-03-25 | 2021-05-28 | Aminex Therapeutics Inc | Biológiailag hozzáférhetõ poliaminok |
| IL314380A (en) | 2016-10-06 | 2024-09-01 | Orbus Therapeutics Inc | Preparations for administration of aflornithine |
| JP2023545674A (ja) | 2020-09-30 | 2023-10-31 | アミネックス セラピューティクス， インコーポレイテッド | ポリアミン輸送阻害剤およびｄｆｍｏの配合原薬 |
| US12605349B2 (en) | 2024-09-05 | 2026-04-21 | Orbus Therapeutics, Inc. | Methods of treating grade 3 astrocytoma |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4309442A (en) | 1977-07-11 | 1982-01-05 | Merrell Toraude Et Compagnie | Method for controlling fertility in mammals |
| US4590288A (en) * | 1983-06-29 | 1986-05-20 | Exxon Research And Engineering Co. | Bi- or polymetallic coordination complex |
| HU200093B (en) | 1983-12-20 | 1990-04-28 | Adam Kovacs | Process for production of medical compositions against tumour |
| ATE40572T1 (de) * | 1985-01-10 | 1989-02-15 | Molecular Diagnostics Inc | Photochemisches verfahren zum markieren von nucleinsaeuren zum nachweis in hybridisationsproben. |
| US4818770A (en) | 1986-10-22 | 1989-04-04 | Boyce Thompson Institute For Plant Research | Prevention of a plant disease by specific inhibition of fungal polyamine biosynthesis |
| US5342945A (en) | 1986-12-02 | 1994-08-30 | University Of Florida Research Foundation, Inc. | Anti-neoplastic, anti-viral or anti-retroviral spermine derivatives |
| US4774339A (en) | 1987-08-10 | 1988-09-27 | Molecular Probes, Inc. | Chemically reactive dipyrrometheneboron difluoride dyes |
| US5274113A (en) | 1991-11-01 | 1993-12-28 | Molecular Probes, Inc. | Long wavelength chemically reactive dipyrrometheneboron difluoride dyes and conjugates |
| US5433896A (en) | 1994-05-20 | 1995-07-18 | Molecular Probes, Inc. | Dibenzopyrrometheneboron difluoride dyes |
| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| US5248782A (en) | 1990-12-18 | 1993-09-28 | Molecular Probes, Inc. | Long wavelength heteroaryl-substituted dipyrrometheneboron difluoride dyes |
| US5312928A (en) | 1991-02-11 | 1994-05-17 | Cambridge Neuroscience | Calcium channel antagonists and methodology for their identification |
| US5187288A (en) | 1991-05-22 | 1993-02-16 | Molecular Probes, Inc. | Ethenyl-substituted dipyrrometheneboron difluoride dyes and their synthesis |
| DE69434889D1 (de) | 1994-02-08 | 2007-01-11 | Nps Pharma Inc | An einer neuen Stelle von Rezeptorabhängigen Kalziumkanälen wirkende Verbindungen zur Behandlung von neurologischen Erkrankungen |
| WO1996022962A1 (en) | 1995-01-23 | 1996-08-01 | The Trustees Of Columbia University In The City Of New York | Butyryl-tyrosinyl spermine, analogs thereof and methods of preparing and using same |
| US5583239A (en) | 1995-05-30 | 1996-12-10 | Lehigh University | Antimicrobial sterol conjugates |
| JP4044728B2 (ja) * | 1997-07-15 | 2008-02-06 | メディクエスト セラピューティックス インク | 治療および診断薬剤としての新規なポリアミンアナログ |
| AU7131698A (en) | 1998-04-21 | 1999-11-08 | Ilex Oncology, Inc. | Polyamine transport inhibitors |
| CA2318004A1 (en) * | 1999-09-15 | 2001-03-15 | Oridigm Corporation | Novel polyamine analogues as therapeutic and diagnostic agents |
-
2000
- 2000-05-31 US US09/584,175 patent/US6646149B1/en not_active Expired - Fee Related
-
2001
- 2001-05-31 AU AU2001268139A patent/AU2001268139A1/en not_active Abandoned
- 2001-05-31 EP EP01946044A patent/EP1317424A2/en not_active Withdrawn
- 2001-05-31 CN CNA018105106A patent/CN1512982A/zh active Pending
- 2001-05-31 KR KR1020027016255A patent/KR100851452B1/ko not_active Expired - Fee Related
- 2001-05-31 WO PCT/US2001/017795 patent/WO2001092218A2/en not_active Ceased
- 2001-05-31 JP JP2002500833A patent/JP2004509845A/ja active Pending
- 2001-05-31 CA CA002410935A patent/CA2410935A1/en not_active Abandoned
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