JP2008530108A5 - - Google Patents
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- Publication number
- JP2008530108A5 JP2008530108A5 JP2007555228A JP2007555228A JP2008530108A5 JP 2008530108 A5 JP2008530108 A5 JP 2008530108A5 JP 2007555228 A JP2007555228 A JP 2007555228A JP 2007555228 A JP2007555228 A JP 2007555228A JP 2008530108 A5 JP2008530108 A5 JP 2008530108A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- medicament
- predisposed
- mammal
- manufacture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010028980 Neoplasm Diseases 0.000 claims 6
- 201000011510 cancer Diseases 0.000 claims 6
- 241000124008 Mammalia Species 0.000 claims 4
- 150000001875 compounds Chemical class 0.000 claims 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 241000725303 Human immunodeficiency virus Species 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 239000002246 antineoplastic agent Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 208000015181 infectious disease Diseases 0.000 claims 2
- 208000023275 Autoimmune disease Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 206010025323 Lymphomas Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 208000001132 Osteoporosis Diseases 0.000 claims 1
- 201000004681 Psoriasis Diseases 0.000 claims 1
- 206010052779 Transplant rejections Diseases 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 206010003246 arthritis Diseases 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 208000027866 inflammatory disease Diseases 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 210000004072 lung Anatomy 0.000 claims 1
- 201000000050 myeloid neoplasm Diseases 0.000 claims 1
- 201000008482 osteoarthritis Diseases 0.000 claims 1
- 210000001672 ovary Anatomy 0.000 claims 1
- 210000000496 pancreas Anatomy 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 230000017854 proteolysis Effects 0.000 claims 1
- 230000002797 proteolythic effect Effects 0.000 claims 1
- 238000001959 radiotherapy Methods 0.000 claims 1
- 208000037803 restenosis Diseases 0.000 claims 1
- 210000002460 smooth muscle Anatomy 0.000 claims 1
- 210000001519 tissue Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US65237005P | 2005-02-11 | 2005-02-11 | |
| US11/351,193 US7468383B2 (en) | 2005-02-11 | 2006-02-09 | Proteasome inhibitors and methods of using the same |
| PCT/US2006/004664 WO2006086600A1 (en) | 2005-02-11 | 2006-02-10 | Proteasome inhibitors and methods of using the same |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008530108A JP2008530108A (ja) | 2008-08-07 |
| JP2008530108A5 true JP2008530108A5 (enExample) | 2009-04-02 |
Family
ID=36579482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007555228A Pending JP2008530108A (ja) | 2005-02-11 | 2006-02-10 | プロテアソーム阻害剤及びそれらを使用する方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US7468383B2 (enExample) |
| EP (1) | EP1846424B1 (enExample) |
| JP (1) | JP2008530108A (enExample) |
| AT (1) | ATE456571T1 (enExample) |
| AU (1) | AU2006213814B2 (enExample) |
| CA (1) | CA2597273C (enExample) |
| CY (1) | CY1109985T1 (enExample) |
| DE (1) | DE602006012013D1 (enExample) |
| DK (1) | DK1846424T3 (enExample) |
| ES (1) | ES2339698T3 (enExample) |
| IL (1) | IL184678A (enExample) |
| MX (1) | MX2007009664A (enExample) |
| MY (1) | MY147921A (enExample) |
| NZ (1) | NZ560607A (enExample) |
| PL (1) | PL1846424T3 (enExample) |
| PT (1) | PT1846424E (enExample) |
| SI (1) | SI1846424T1 (enExample) |
| TW (1) | TWI367886B (enExample) |
| WO (1) | WO2006086600A1 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090286791A1 (en) * | 2001-11-27 | 2009-11-19 | Takeda Pharmaceutical Company Limited | Amide Compounds |
| WO2007011760A2 (en) * | 2005-07-15 | 2007-01-25 | Kalypsys, Inc. | Inhibitors of mitotic kinesin |
| KR101434522B1 (ko) | 2005-11-09 | 2014-08-26 | 오닉스 세라퓨틱스, 인크. | 효소 저해를 위한 화합물 |
| US7691852B2 (en) | 2006-06-19 | 2010-04-06 | Onyx Therapeutics, Inc. | Compounds for enzyme inhibition |
| CN105837608B (zh) * | 2007-08-06 | 2018-06-08 | 米伦纽姆医药公司 | 蛋白酶体抑制剂及其组合物和用途 |
| US20110118274A1 (en) * | 2007-08-23 | 2011-05-19 | Cornell Research Foundation, Inc. | Proteasome inhibitors and their use in treating pathogen infection and cancer |
| RS54847B2 (sr) | 2007-10-04 | 2019-09-30 | Onyx Therapeutics Inc | Inhibitori kristalne peptid epoksi keton proteaze i sinteza aminokiselinskih keto-epoksida |
| WO2009051581A1 (en) * | 2007-10-16 | 2009-04-23 | Millennium Pharmaceuticals, Inc. | Proteasome inhibitors |
| EP2088205A1 (en) | 2008-02-11 | 2009-08-12 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | PSMB10: A diagnosis marker and therapeutic target of chronic rejection. |
| EP2730580A1 (en) | 2008-06-17 | 2014-05-14 | Millennium Pharmaceuticals, Inc. | Boronate ester compounds and pharmaceutical compositions thereof |
| BRPI0916576A2 (pt) * | 2008-08-04 | 2017-06-27 | Chdi Inc | pelo menos uma entidade química, composição farmacêutica, e, método para tratar uma condição ou distúrbio. |
| AR075090A1 (es) | 2008-09-29 | 2011-03-09 | Millennium Pharm Inc | Derivados de acido 1-amino-2-ciclobutiletilboronico inhibidores de proteosoma,utiles como agentes anticancerigenos, y composiciones farmaceuticas que los comprenden. |
| JP5675629B2 (ja) | 2008-10-21 | 2015-02-25 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | ペプチドエポキシケトンを用いた併用療法 |
| AR075899A1 (es) | 2009-03-20 | 2011-05-04 | Onyx Therapeutics Inc | Tripeptidos epoxicetonas cristalinos inhibidores de proteasa |
| EP2238973A1 (en) | 2009-04-07 | 2010-10-13 | Cephalon France | Lyophilized preparations of proteasome inhibitors |
| JP5919196B2 (ja) | 2009-11-13 | 2016-05-18 | オニキス セラピューティクス, インク.Onyx Therapeutics, Inc. | 転移抑制のためのペプチドエポキシケトンの使用 |
| WO2011087822A1 (en) | 2009-12-22 | 2011-07-21 | Cephalon, Inc. | Proteasome inhibitors and processes for their preparation, purification and use |
| PH12012501480A1 (en) | 2010-01-25 | 2012-10-22 | Chdi Foundation Inc | Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| MA34133B1 (fr) * | 2010-03-01 | 2013-04-03 | Onyx Therapeutics Inc | Composes pour inhibiteurs de l'immunoproteasome |
| US9126997B1 (en) | 2010-09-07 | 2015-09-08 | Northwestern University | Synergistic effect of glucocorticoid receptor agonists in combination with proteosome inhibitors for treating leukemia and myeloma |
| US8884009B2 (en) | 2010-10-14 | 2014-11-11 | Synthon Bv | Process for making bortezomib and intermediates for the process |
| EP3243515B1 (en) | 2011-08-30 | 2019-10-16 | CHDI Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| AU2012300246A1 (en) | 2011-08-30 | 2014-03-06 | Chdi Foundation, Inc. | Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof |
| US20140105921A1 (en) | 2012-07-09 | 2014-04-17 | Onyx Therapeutics, Inc. | Prodrugs of Peptide Epoxy Ketone Protease Inhibitors |
| WO2014072985A1 (en) * | 2012-11-06 | 2014-05-15 | Natco Pharma Limited | Novel boronic acid derivatives as anti cancer agents |
| US9493439B1 (en) | 2014-04-07 | 2016-11-15 | University Of Kentucky Research Foundation | Proteasome inhibitors |
| PT3129016T (pt) | 2014-04-08 | 2018-10-01 | Neurovive Pharmaceutical Ab | Compostos novos |
| KR102509950B1 (ko) | 2014-05-20 | 2023-03-14 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 일차 암 치료법 후 사용하기 위한 붕소-함유 프로테아좀 저해제 |
| AP2017009724A0 (en) | 2014-07-17 | 2017-01-31 | Chdi Foundation Inc | Methods and compositions for treating hiv-related disorders |
| SG11201907945YA (en) | 2017-02-28 | 2019-09-27 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Azetidine derivative |
| GB201808149D0 (en) | 2018-05-18 | 2018-07-11 | Univ Court Univ Of Glasgow | Protected amino acids |
| MX2021001089A (es) * | 2018-08-02 | 2021-05-12 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Borato de derivado de azetidina. |
Family Cites Families (59)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3301354A1 (de) | 1983-01-18 | 1984-07-19 | Matth. Hohner Ag, 7218 Trossingen | Elektronisches musikinstrument |
| US4499082A (en) * | 1983-12-05 | 1985-02-12 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid peptides |
| US4537773A (en) * | 1983-12-05 | 1985-08-27 | E. I. Du Pont De Nemours And Company | α-Aminoboronic acid derivatives |
| US5242904A (en) * | 1987-06-05 | 1993-09-07 | The Dupont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| US5250720A (en) * | 1987-06-05 | 1993-10-05 | The Dupont Merck Pharmaceutical Company | Intermediates for preparing peptide boronic acid inhibitors of trypsin-like proteases |
| US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
| EP0315574A3 (de) * | 1987-11-05 | 1990-08-22 | Hoechst Aktiengesellschaft | Renin-Inhibitoren |
| WO1989009225A1 (en) | 1988-03-28 | 1989-10-05 | The Regents Of The University Of California | Nerve growth factor peptides |
| US5023236A (en) * | 1988-04-07 | 1991-06-11 | Corvas, Inc. | Factor VII/VIIA active site inhibitors |
| US5106948A (en) * | 1988-05-27 | 1992-04-21 | Mao Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| US4963655A (en) * | 1988-05-27 | 1990-10-16 | Mayo Foundation For Medical Education And Research | Boron analogs of amino acid/peptide protease inhibitors |
| US5159060A (en) * | 1988-05-27 | 1992-10-27 | Mayo Foundation For Medical Education And Research | Cytotoxic boronic acid peptide analogs |
| DE3827340A1 (de) | 1988-08-12 | 1990-02-15 | Hoechst Ag | Verwendung von (alpha)-aminoboronsaeure-derivaten zur prophylaxe und behandlung von viruserkrankungen |
| HUT62312A (en) | 1990-03-05 | 1993-04-28 | Cephalon Inc | Process for producing chymotrypsin-like proteases and their inhibitors |
| DE69217935T2 (de) * | 1992-08-14 | 1997-10-09 | Procter & Gamble | Alpha-aminoborsäurehaltige flüssige Waschmittel |
| JPH08507754A (ja) | 1993-02-10 | 1996-08-20 | ザ・プレジデント・アンド・フェローズ・オブ・ハーバード・カレッジ | Mhc−1拘束性抗原提示におけるatp−ユビキチン依存蛋白分解の役割およびそのインヒビター |
| IL109319A0 (en) | 1993-04-27 | 1994-07-31 | Du Pont Merck Pharma | Amidino and guanidino substituted boronic acid compounds |
| US5658885A (en) | 1993-04-27 | 1997-08-19 | The Dupont Merck Pharmaceutical Company | Amidino and guanidino substituted boronic acid inhibitors of trypsin-like enzymes |
| DE69431718T2 (de) | 1993-04-30 | 2003-07-10 | Merck & Co., Inc. | Thrombin-inhibitoren |
| US5672582A (en) | 1993-04-30 | 1997-09-30 | Merck & Co., Inc. | Thrombin inhibitors |
| FR2707085B1 (fr) * | 1993-06-30 | 1995-08-18 | Adir | Nouveaux dérivés d'alpha amino acides, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent. |
| ATE211129T1 (de) | 1993-10-01 | 2002-01-15 | Merrell Pharma Inc | Inhibitoren von beta-amyloid-protein-herstellung |
| IL111175A0 (en) | 1993-10-07 | 1994-12-29 | Du Pont Merck Pharma | Electrophilic peptide analogs as inhibitors of trypsin-like serine proteases and pharmaceutical compositions containing them |
| GB9401483D0 (en) | 1994-01-26 | 1994-03-23 | Sandoz Ltd | Organic compounds |
| US5693617A (en) * | 1994-03-15 | 1997-12-02 | Proscript, Inc. | Inhibitors of the 26s proteolytic complex and the 20s proteasome contained therein |
| US6660268B1 (en) | 1994-03-18 | 2003-12-09 | The President And Fellows Of Harvard College | Proteasome regulation of NF-KB activity |
| US6083903A (en) * | 1994-10-28 | 2000-07-04 | Leukosite, Inc. | Boronic ester and acid compounds, synthesis and uses |
| US5550262A (en) * | 1994-11-14 | 1996-08-27 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| US5614649A (en) * | 1994-11-14 | 1997-03-25 | Cephalon, Inc. | Multicatalytic protease inhibitors |
| US5834487A (en) * | 1996-09-24 | 1998-11-10 | Cv Therapeutics | Inhibition of 26S and 20S proteasome by indanones |
| HU227742B1 (en) | 1996-10-18 | 2012-02-28 | Vertex Pharma | Inhibitors of serine proteases, particularly hepatitis c virus ns3 protease |
| GB9623908D0 (en) | 1996-11-18 | 1997-01-08 | Hoffmann La Roche | Amino acid derivatives |
| US6096778A (en) * | 1997-10-07 | 2000-08-01 | Cephalon, Inc. | α-ketoamide multicatalytic protease inhibitors |
| CA2314259A1 (en) | 1997-12-16 | 1999-06-24 | Robert Siman | Multicatalytic protease inhibitors for use as anti-tumor agents |
| US6075150A (en) * | 1998-01-26 | 2000-06-13 | Cv Therapeutics, Inc. | α-ketoamide inhibitors of 20S proteasome |
| GB9806815D0 (en) | 1998-03-30 | 1998-05-27 | Hoffmann La Roche | Amino acid derivatives |
| US6462019B1 (en) | 1998-07-10 | 2002-10-08 | Osteoscreen, Inc. | Inhibitors of proteasomal activity and production for stimulating bone growth |
| EP0995757A3 (en) | 1998-08-26 | 2002-05-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Bivalent inhibitors of the proteasome |
| KR20010080267A (ko) | 1998-10-20 | 2001-08-22 | 밀레니엄 파머슈티컬스 인코퍼레이티드 | 프로테아솜 억제제 약물 작용을 모니터링하는 방법 |
| EP1053750A1 (en) | 1999-04-22 | 2000-11-22 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Use of proteasome-inhibitor for the induction of programmed cell death (apoptosis) |
| ATE270268T1 (de) | 1999-04-27 | 2004-07-15 | Novartis Pharma Gmbh | 2,4-diamino-3-hydroxycarboxylsäurederivate als proteasome inhibitoren |
| SE9901573D0 (sv) | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
| AU5788800A (en) | 1999-07-07 | 2001-01-22 | Du Pont Pharmaceuticals Company | Peptide boronic acid inhibitors of hepatitis c virus protease |
| US7122627B2 (en) | 1999-07-26 | 2006-10-17 | Bristol-Myers Squibb Company | Lactam inhibitors of Hepatitis C virus NS3 protease |
| WO2001020995A1 (en) | 1999-09-23 | 2001-03-29 | Washington University | Compounds directed against pilus biogenesis and activity in pathogenic bacteria; methods and compositions for synthesis thereof |
| CA2385958A1 (en) | 1999-10-20 | 2001-04-26 | Osteoscreen, Inc. | Inhibitors of proteasomal activity for stimulating bone and hair growth |
| NZ523781A (en) | 2000-07-21 | 2004-10-29 | Corvas Int Inc | Novel peptides as NS3-serine protease inhibitors of hepatitis C virus |
| EP2305291A1 (de) | 2000-10-12 | 2011-04-06 | ViroLogik GmbH | Verwendung von Proteasome Hemmern zur Behandlung von HIV Infektionen |
| US6699835B2 (en) * | 2001-01-25 | 2004-03-02 | The United States Of America As Represented By The Department Of Health And Human Services | Formulation of boronic acid compounds |
| BR0208786A (pt) | 2001-04-09 | 2004-03-09 | Allan Christian Shaw | Métodod para identificação de proteìnas de bactérias intracelulares |
| US7214769B2 (en) | 2001-05-23 | 2007-05-08 | The Curators Of The University Of Missouri | Method for inverse solid phase synthesis of peptides |
| ATE317850T1 (de) | 2001-05-30 | 2006-03-15 | Novartis Pharma Gmbh | 2-((n-(2-amino-3-(heteroaryl- oder - aryl)propionyl)aminoacyl)amino)- alkylboronsäurederivate |
| KR100399359B1 (ko) * | 2001-07-07 | 2003-09-26 | 삼성전자주식회사 | 전하 펌프 회로 |
| WO2003015706A2 (en) | 2001-08-16 | 2003-02-27 | Washington State University Research Foundation | Borinic acid protease inhibitors |
| JPWO2003033507A1 (ja) | 2001-10-12 | 2005-02-03 | 杏林製薬株式会社 | ベンジルマロン酸誘導体およびそれを含有するプロテアソーム阻害薬 |
| JP4412586B2 (ja) * | 2002-01-08 | 2010-02-10 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | エポネマイシンおよびエポキソマイシン類似物およびそれらの用途 |
| US20060237868A1 (en) | 2003-08-13 | 2006-10-26 | Seiko Precision Inc. | Method and device for manufacturing card |
| US7576206B2 (en) * | 2003-08-14 | 2009-08-18 | Cephalon, Inc. | Proteasome inhibitors and methods of using the same |
| CN101772507B (zh) | 2007-08-06 | 2012-12-12 | 米伦纽姆医药公司 | 蛋白酶体抑制剂 |
-
2006
- 2006-02-09 US US11/351,193 patent/US7468383B2/en not_active Expired - Fee Related
- 2006-02-10 JP JP2007555228A patent/JP2008530108A/ja active Pending
- 2006-02-10 PL PL06734698T patent/PL1846424T3/pl unknown
- 2006-02-10 AU AU2006213814A patent/AU2006213814B2/en not_active Ceased
- 2006-02-10 AT AT06734698T patent/ATE456571T1/de active
- 2006-02-10 EP EP06734698A patent/EP1846424B1/en not_active Not-in-force
- 2006-02-10 MY MYPI20060567A patent/MY147921A/en unknown
- 2006-02-10 WO PCT/US2006/004664 patent/WO2006086600A1/en not_active Ceased
- 2006-02-10 NZ NZ560607A patent/NZ560607A/en not_active IP Right Cessation
- 2006-02-10 CA CA2597273A patent/CA2597273C/en not_active Expired - Fee Related
- 2006-02-10 PT PT06734698T patent/PT1846424E/pt unknown
- 2006-02-10 DK DK06734698.1T patent/DK1846424T3/da active
- 2006-02-10 ES ES06734698T patent/ES2339698T3/es active Active
- 2006-02-10 SI SI200630615T patent/SI1846424T1/sl unknown
- 2006-02-10 TW TW095104473A patent/TWI367886B/zh not_active IP Right Cessation
- 2006-02-10 DE DE602006012013T patent/DE602006012013D1/de active Active
- 2006-02-10 MX MX2007009664A patent/MX2007009664A/es active IP Right Grant
-
2007
- 2007-07-17 IL IL184678A patent/IL184678A/en not_active IP Right Cessation
-
2008
- 2008-11-06 US US12/265,998 patent/US8283367B2/en not_active Expired - Fee Related
-
2010
- 2010-04-27 CY CY20101100375T patent/CY1109985T1/el unknown
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