JP2008528468A5 - - Google Patents
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- JP2008528468A5 JP2008528468A5 JP2007551743A JP2007551743A JP2008528468A5 JP 2008528468 A5 JP2008528468 A5 JP 2008528468A5 JP 2007551743 A JP2007551743 A JP 2007551743A JP 2007551743 A JP2007551743 A JP 2007551743A JP 2008528468 A5 JP2008528468 A5 JP 2008528468A5
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- Japan
- Prior art keywords
- compound
- formula
- optionally
- hydrogen
- alkoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 21
- 239000003112 inhibitor Substances 0.000 claims 16
- 230000002401 inhibitory effect Effects 0.000 claims 16
- 125000003545 alkoxy group Chemical group 0.000 claims 14
- 229910052739 hydrogen Inorganic materials 0.000 claims 14
- 239000001257 hydrogen Substances 0.000 claims 14
- 230000001472 cytotoxic Effects 0.000 claims 11
- 231100000433 cytotoxic Toxicity 0.000 claims 11
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 10
- UFHFLCQGNIYNRP-UHFFFAOYSA-N hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 10
- 229910052731 fluorine Inorganic materials 0.000 claims 9
- 239000011737 fluorine Substances 0.000 claims 9
- YCKRFDGAMUMZLT-UHFFFAOYSA-N fluorine atom Chemical compound [F] YCKRFDGAMUMZLT-UHFFFAOYSA-N 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 229910052736 halogen Inorganic materials 0.000 claims 8
- 150000002367 halogens Chemical class 0.000 claims 8
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 125000000217 alkyl group Chemical group 0.000 claims 7
- 229910052801 chlorine Inorganic materials 0.000 claims 7
- 239000000460 chlorine Substances 0.000 claims 7
- 150000001204 N-oxides Chemical class 0.000 claims 6
- ZAMOUSCENKQFHK-UHFFFAOYSA-N chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims 6
- 239000003814 drug Substances 0.000 claims 6
- -1 fluorine) Chemical class 0.000 claims 6
- 229910052760 oxygen Inorganic materials 0.000 claims 6
- 150000003839 salts Chemical class 0.000 claims 6
- 239000011780 sodium chloride Substances 0.000 claims 6
- 239000012453 solvate Substances 0.000 claims 6
- 125000002837 carbocyclic group Chemical group 0.000 claims 5
- 125000001153 fluoro group Chemical group F* 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 5
- 229910052717 sulfur Inorganic materials 0.000 claims 5
- 201000011510 cancer Diseases 0.000 claims 4
- 125000004432 carbon atoms Chemical group C* 0.000 claims 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 4
- 125000001424 substituent group Chemical group 0.000 claims 4
- OVPNQJVDAFNBDN-UHFFFAOYSA-N 4-{[(2,6-dichlorophenyl)carbonyl]amino}-N-piperidin-4-yl-1H-pyrazole-3-carboxamide Chemical compound ClC1=CC=CC(Cl)=C1C(=O)NC1=CNN=C1C(=O)NC1CCNCC1 OVPNQJVDAFNBDN-UHFFFAOYSA-N 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 150000002431 hydrogen Chemical class 0.000 claims 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004008 6 membered carbocyclic group Chemical group 0.000 claims 2
- 230000002159 abnormal effect Effects 0.000 claims 2
- 125000004453 alkoxycarbonyl group Chemical group 0.000 claims 2
- 230000000340 anti-metabolite Effects 0.000 claims 2
- 108090001123 antibodies Proteins 0.000 claims 2
- 102000004965 antibodies Human genes 0.000 claims 2
- 239000002256 antimetabolite Substances 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 125000004435 hydrogen atoms Chemical group [H]* 0.000 claims 2
- UWANMJIXIZUGCE-UHFFFAOYSA-N 4-[(2,6-difluorobenzoyl)amino]-N-(1-methylpiperidin-4-yl)-1H-pyrazole-5-carboxamide Chemical compound C1CN(C)CCC1NC(=O)C1=NNC=C1NC(=O)C1=C(F)C=CC=C1F UWANMJIXIZUGCE-UHFFFAOYSA-N 0.000 claims 1
- CXBHMSHVCKEEGW-UHFFFAOYSA-N 4-[(2,6-difluorobenzoyl)amino]-N-piperidin-4-yl-1H-pyrazole-5-carboxamide Chemical compound FC1=CC=CC(F)=C1C(=O)NC1=CNN=C1C(=O)NC1CCNCC1 CXBHMSHVCKEEGW-UHFFFAOYSA-N 0.000 claims 1
- GEJVJGWDUTWXOU-UHFFFAOYSA-N 4-[(2-fluoro-6-methoxybenzoyl)amino]-1H-pyrazole-5-carboxylic acid Chemical compound COC1=CC=CC(F)=C1C(=O)NC1=C(C(O)=O)NN=C1 GEJVJGWDUTWXOU-UHFFFAOYSA-N 0.000 claims 1
- 108091007476 CDKs Proteins 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N Camptothecin Natural products C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- GAGWJHPBXLXJQN-UORFTKCHSA-N Capecitabine Chemical compound C1=C(F)C(NC(=O)OCCCCC)=NC(=O)N1[C@H]1[C@H](O)[C@H](O)[C@@H](C)O1 GAGWJHPBXLXJQN-UORFTKCHSA-N 0.000 claims 1
- 229960004117 Capecitabine Drugs 0.000 claims 1
- 108010022830 Cetuximab Proteins 0.000 claims 1
- 102000003903 Cyclin-Dependent Kinases Human genes 0.000 claims 1
- 108090000266 Cyclin-Dependent Kinases Proteins 0.000 claims 1
- 229960000684 Cytarabine Drugs 0.000 claims 1
- UHDGCWIWMRVCDJ-CCXZUQQUSA-N Cytosar Chemical compound O=C1N=C(N)C=CN1[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O1 UHDGCWIWMRVCDJ-CCXZUQQUSA-N 0.000 claims 1
- STQGQHZAVUOBTE-VGBVRHCVSA-N DAUNOMYCIN Chemical class O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(C)=O)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 STQGQHZAVUOBTE-VGBVRHCVSA-N 0.000 claims 1
- 230000004568 DNA-binding Effects 0.000 claims 1
- ZDZOTLJHXYCWBA-VCVYQWHSSA-N Docetaxel Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
- 229940121643 EGFR tyrosine kinase inhibitors Drugs 0.000 claims 1
- 229960001433 Erlotinib Drugs 0.000 claims 1
- AAKJLRGGTJKAMG-UHFFFAOYSA-N Erlotinib Chemical compound C=12C=C(OCCOC)C(OCCOC)=CC2=NC=NC=1NC1=CC=CC(C#C)=C1 AAKJLRGGTJKAMG-UHFFFAOYSA-N 0.000 claims 1
- XGALLCVXEZPNRQ-UHFFFAOYSA-N Gefitinib Chemical compound C=12C=C(OCCCN3CCOCC3)C(OC)=CC2=NC=NC=1NC1=CC=C(F)C(Cl)=C1 XGALLCVXEZPNRQ-UHFFFAOYSA-N 0.000 claims 1
- SDUQYLNIPVEERB-QPPQHZFASA-N Gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 claims 1
- RCINICONZNJXQF-MZXODVADSA-N Intaxel Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 claims 1
- 239000005411 L01XE02 - Gefitinib Substances 0.000 claims 1
- 239000005551 L01XE03 - Erlotinib Substances 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 101710018346 PDGFRB Proteins 0.000 claims 1
- 102100004939 PDGFRB Human genes 0.000 claims 1
- 229960001592 Paclitaxel Drugs 0.000 claims 1
- IVTVGDXNLFLDRM-HNNXBMFYSA-N Tomudex Chemical compound C=1C=C2NC(C)=NC(=O)C2=CC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)S1 IVTVGDXNLFLDRM-HNNXBMFYSA-N 0.000 claims 1
- 108010010691 Trastuzumab Proteins 0.000 claims 1
- 108010073929 Vascular Endothelial Growth Factor A Proteins 0.000 claims 1
- 102000009524 Vascular Endothelial Growth Factor A Human genes 0.000 claims 1
- 241000863480 Vinca Species 0.000 claims 1
- MDYDKUVTFIXODZ-UHFFFAOYSA-N [NH-]C1CCNCC1 Chemical compound [NH-]C1CCNCC1 MDYDKUVTFIXODZ-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000003797 alkaloid derivatives Chemical class 0.000 claims 1
- 229930013930 alkaloids Natural products 0.000 claims 1
- 125000004390 alkyl sulfonyl group Chemical group 0.000 claims 1
- 125000002947 alkylene group Chemical group 0.000 claims 1
- 125000004429 atoms Chemical group 0.000 claims 1
- 125000000051 benzyloxy group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])O* 0.000 claims 1
- 239000011230 binding agent Substances 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 229960005395 cetuximab Drugs 0.000 claims 1
- 125000001309 chloro group Chemical group Cl* 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 125000004093 cyano group Chemical group *C#N 0.000 claims 1
- 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims 1
- 229960003668 docetaxel Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002708 enhancing Effects 0.000 claims 1
- 102000017256 epidermal growth factor-activated receptor activity proteins Human genes 0.000 claims 1
- 108040009258 epidermal growth factor-activated receptor activity proteins Proteins 0.000 claims 1
- 229960002584 gefitinib Drugs 0.000 claims 1
- 229960005277 gemcitabine Drugs 0.000 claims 1
- 238000005984 hydrogenation reaction Methods 0.000 claims 1
- 210000004962 mammalian cells Anatomy 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-M methanesulfonate Chemical class CS([O-])(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-M 0.000 claims 1
- 229960000485 methotrexate Drugs 0.000 claims 1
- 230000011987 methylation Effects 0.000 claims 1
- 238000007069 methylation reaction Methods 0.000 claims 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 1
- 125000004043 oxo group Chemical group O=* 0.000 claims 1
- 230000037361 pathway Effects 0.000 claims 1
- WBXPDJSOTKVWSJ-ZDUSSCGKSA-N pemetrexed Chemical compound C=1NC=2NC(N)=NC(=O)C=2C=1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 WBXPDJSOTKVWSJ-ZDUSSCGKSA-N 0.000 claims 1
- 229960005079 pemetrexed Drugs 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 150000003058 platinum compounds Chemical class 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 229960004432 raltitrexed Drugs 0.000 claims 1
- 229930003347 taxol Natural products 0.000 claims 1
- 229960000575 trastuzumab Drugs 0.000 claims 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 claims 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US64597605P | 2005-01-21 | 2005-01-21 | |
| US64598705P | 2005-01-21 | 2005-01-21 | |
| US64611305P | 2005-01-21 | 2005-01-21 | |
| US64598605P | 2005-01-21 | 2005-01-21 | |
| US64597505P | 2005-01-21 | 2005-01-21 | |
| US60/645,976 | 2005-01-21 | ||
| US60/645,975 | 2005-01-21 | ||
| US60/646,113 | 2005-01-21 | ||
| US60/645,986 | 2005-01-21 | ||
| US60/645,987 | 2005-01-21 | ||
| PCT/GB2006/000204 WO2006077424A1 (en) | 2005-01-21 | 2006-01-20 | Pharmaceutical compounds |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008528468A JP2008528468A (ja) | 2008-07-31 |
| JP2008528468A5 true JP2008528468A5 (US20040106767A1-20040603-C00005.png) | 2009-03-19 |
| JP5475234B2 JP5475234B2 (ja) | 2014-04-16 |
Family
ID=35911102
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007551743A Expired - Fee Related JP5475234B2 (ja) | 2005-01-21 | 2006-01-20 | 医薬化合物 |
Country Status (10)
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005012256A1 (en) * | 2003-07-22 | 2005-02-10 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
| AR052559A1 (es) * | 2005-01-21 | 2007-03-21 | Astex Therapeutics Ltd | Derivados de pirazol para inhibir cdk's y gsk's |
| AR054425A1 (es) * | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
| BRPI0606319A2 (pt) * | 2005-01-21 | 2009-06-16 | Astex Therapeutics Ltd | compostos farmacêuticos |
| US20080139620A1 (en) * | 2005-01-21 | 2008-06-12 | Astex Therapeutics Limited | Pyrazole Derivatives For The Inhibition Of Cdk's And Gsk's |
| WO2008007113A2 (en) * | 2006-07-14 | 2008-01-17 | Astex Therapeutics Limited | Pharmaceutical combinations |
| US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
| MX2007008781A (es) * | 2005-01-21 | 2007-09-11 | Astex Therapeutics Ltd | Compuestos farmaceuticos. |
| CN101133088B (zh) * | 2005-03-03 | 2011-04-13 | 三菱丽阳株式会社 | 聚合物粒子、含有它的树脂组合物、成型体 |
| US8354501B2 (en) * | 2005-08-02 | 2013-01-15 | Trustees Of Tufts College | Methods for stepwise deposition of silk fibroin coatings |
| CA2651152A1 (en) * | 2006-05-05 | 2007-11-15 | Astex Therapeutics Limited | 4- (2,6-dichloro-benzoylamino) -1h-pyrazole-3-carboxylic acid (1-methanesulphonyl-piperidin-4-yl) -amide for the treatment of cancer |
| WO2007129062A1 (en) * | 2006-05-08 | 2007-11-15 | Astex Therapeutics Limited | Pharmaceutical combinations of diazole derivatives for cancer treatment |
| JP2009543771A (ja) * | 2006-07-14 | 2009-12-10 | アステックス・セラピューティクス・リミテッド | 医薬化合物 |
| EP2070916A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | 2-Aryl-thiazol-4-carbonsäureamid-Derivate, deren Herstellung und Verwendung als Arzneimittel |
| EP2070924A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-Hetarylthiazol-4-carbonsäureamid-Derivative, deren Herstellung und Verwendung als Arzneimittel |
| EP2070925A1 (de) | 2007-12-10 | 2009-06-17 | Bayer Schering Pharma Aktiengesellschaft | Neue 2-substituierte Tiazol-4-carbonsäureamid-Derivative deren Herstellung und Verwendung als Arzneimittel |
| EP2324358A1 (en) * | 2008-07-23 | 2011-05-25 | F. Hoffmann-La Roche AG | Monitoring anti-angiogenesis therapy |
| WO2010068925A1 (en) * | 2008-12-11 | 2010-06-17 | Abraxis Bioscience, Llc | Combinations and modes of administration of therapeutic agents and combination therapy |
| KR20100101054A (ko) * | 2009-03-07 | 2010-09-16 | 주식회사 메디젠텍 | 세포핵에서 세포질로의 ｇｓｋ３의 이동을 억제하는 화합물을 함유하는 세포핵에서 세포질로의 ｇｓｋ３ 이동에 의해 발생되는 질환의 치료 또는 예방용 약학적 조성물 |
| CN105189493B (zh) | 2013-02-27 | 2017-04-12 | 持田制药株式会社 | 新型吡唑衍生物 |
| BR112017024727A2 (pt) | 2015-05-18 | 2018-07-31 | Syn Nat Products Entpr Llc | cocristal, composição farmacêutica, método de tratamento de uma doença em um indivíduo e processo de produção de um cocristal |
| CA2988992A1 (en) * | 2015-06-19 | 2016-12-22 | Syn-Nat Products Enterprise LLC | Pharmaceutical composition of carboplatin based co-crystals and use thereof |
| CN108697093A (zh) | 2015-06-19 | 2018-10-23 | 新纳特产品公司 | 含卡铂的组合物及其用途 |
| CN116854745A (zh) | 2015-06-25 | 2023-10-10 | 新纳特产品公司 | 药物共晶组合物及其用途 |
| AU2017234042B2 (en) | 2016-03-17 | 2020-11-19 | F. Hoffmann-La Roche Ag | 5-ethyl-4-methyl-pyrazole-3-carboxamide derivative having activity as agonist of TAAR |
| EP3503923B1 (en) | 2016-08-23 | 2023-10-04 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of hepatocellular carcinoma |
| WO2018130443A1 (de) | 2017-01-10 | 2018-07-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
| AU2018207776B2 (en) | 2017-01-10 | 2021-06-17 | Bayer Aktiengesellschaft | Heterocyclene derivatives as pest control agents |
| AU2018234903B2 (en) | 2017-03-16 | 2024-02-08 | Eisai R&D Management Co., Ltd. | Combination therapies for the treatment of breast cancer |
| CN107235906B (zh) * | 2017-06-28 | 2020-05-01 | 郑州大学第一附属医院 | 一组吡唑酰胺类衍生物及其应用 |
| CN107686477B (zh) * | 2017-09-30 | 2020-01-31 | 武汉九州钰民医药科技有限公司 | 作为cdk4/6抑制剂的新型化合物及其应用 |
| CN110776501B (zh) * | 2019-08-22 | 2021-04-02 | 联宁（苏州）生物制药有限公司 | 一种用于抗体药物偶联物的药物毒素pnu-159682的制备方法及其中间体 |
| TWI759829B (zh) * | 2019-08-23 | 2022-04-01 | 財團法人生物技術開發中心 | 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物 |
| IL272145A (en) * | 2020-01-20 | 2021-07-29 | Stem Cell Medicine Ltd | Cosmetic preparations with protein concentrate from a conditioned growth medium of stem cells from adipose tissue |
| KR102549327B1 (ko) * | 2021-01-20 | 2023-06-29 | 연세대학교 산학협력단 | 저분화 화합물의 조합을 유효성분으로 포함하는 뇌종양의 예방 또는 치료용 조성물 |
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-
2006
- 2006-01-20 AU AU2006207321A patent/AU2006207321B2/en not_active Ceased
- 2006-01-20 WO PCT/GB2006/000204 patent/WO2006077424A1/en active Application Filing
- 2006-01-20 BR BRPI0606480-9A patent/BRPI0606480A/pt not_active IP Right Cessation
- 2006-01-20 MX MX2007008810A patent/MX2007008810A/es active IP Right Grant
- 2006-01-20 CA CA2594474A patent/CA2594474C/en not_active Expired - Fee Related
- 2006-01-20 CN CN2006800091803A patent/CN101146532B/zh not_active Expired - Fee Related
- 2006-01-20 EP EP06700912A patent/EP1845974A1/en not_active Withdrawn
- 2006-01-20 KR KR1020077018889A patent/KR101345002B1/ko not_active IP Right Cessation
- 2006-01-20 US US11/814,456 patent/US20080161251A1/en not_active Abandoned
- 2006-01-20 JP JP2007551743A patent/JP5475234B2/ja not_active Expired - Fee Related
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