JP2008526723A - Cdk、gsk及びオーロラキナーゼの活性を調節するピラゾール誘導体 - Google Patents

Cdk、gsk及びオーロラキナーゼの活性を調節するピラゾール誘導体 Download PDF

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JP2008526723A
JP2008526723A JP2007548900A JP2007548900A JP2008526723A JP 2008526723 A JP2008526723 A JP 2008526723A JP 2007548900 A JP2007548900 A JP 2007548900A JP 2007548900 A JP2007548900 A JP 2007548900A JP 2008526723 A JP2008526723 A JP 2008526723A
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JP2008526723A5 (https=
Inventor
バレリオ、ベルディーニ
マイケル、アリステア、オブライエン
マリア、グラツィア、カール
ニコラス、ガレス、モース、デビーズ
アドリアン、リアム、ギル
エバ、フィゲロア、ナバロ
スティーブン、ハワード
ゲリー、トレワーサ
アンドリュー、ジェームズ、ウッドヘッド
アリソン、ジョアン、ウルフォード
ポール、グラハム、ワイアット
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Astex Therapeutics Ltd
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    • C07DHETEROCYCLIC COMPOUNDS
    • C07D407/00Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/14Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07D231/10Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/14Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
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    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2007548900A 2004-12-30 2005-12-30 Cdk、gsk及びオーロラキナーゼの活性を調節するピラゾール誘導体 Withdrawn JP2008526723A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US64047404P 2004-12-30 2004-12-30
GB0428528A GB0428528D0 (en) 2004-12-30 2004-12-30 Pharmaceutical compounds
PCT/GB2005/005102 WO2006070198A1 (en) 2004-12-30 2005-12-30 Pyrazole derivatives as that modulate the activity of cdk, gsk and aurora kinases

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JP2008526723A true JP2008526723A (ja) 2008-07-24
JP2008526723A5 JP2008526723A5 (https=) 2009-02-19

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US (1) US20100160324A1 (https=)
EP (1) EP1836188A1 (https=)
JP (1) JP2008526723A (https=)
WO (1) WO2006070198A1 (https=)

Cited By (7)

* Cited by examiner, † Cited by third party
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JP2015535227A (ja) * 2012-10-26 2015-12-10 エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト Sykの3,4−二置換1h−ピラゾール及び4,5−二置換チアゾール阻害剤
JP2016535772A (ja) * 2013-11-08 2016-11-17 武田薬品工業株式会社 自己免疫疾患治療のためのピラゾール
JP2018513177A (ja) * 2015-04-22 2018-05-24 ライジェル ファーマシューティカルズ, インコーポレイテッド ピラゾール化合物ならびにこの化合物を作製および使用するための方法
JP2018516917A (ja) * 2015-06-04 2018-06-28 オーリジーン ディスカバリー テクノロジーズ リミテッドAurigene Discovery Technologies Limited Cdk阻害剤としての置換型ヘテロシクリル誘導体
JP2019537577A (ja) * 2016-10-26 2019-12-26 ライジェル ファーマシューティカルズ, インコーポレイテッド Irak阻害剤としての使用のためのオキサゾール誘導体およびその調製のための方法
JP2021529834A (ja) * 2018-07-03 2021-11-04 アイエフエム デュー インコーポレイテッド Sting活性に関連する状態を治療するための化合物および組成物
JP2022507697A (ja) * 2018-11-19 2022-01-18 アイエフエム デュー インコーポレイテッド Sting活性に関連する状態を治療するための化合物および組成物

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