JP2008524410A - 耐感染性ポリウレタンフォーム、その製造方法および殺菌性創傷被覆におけるその使用 - Google Patents
耐感染性ポリウレタンフォーム、その製造方法および殺菌性創傷被覆におけるその使用 Download PDFInfo
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Abstract
Description
a)2〜6個の水酸基、20〜112の水酸基価および10重量%以上のエチレンオキシド(EO)含量のポリエーテルポリオール、
b)酸化防止剤、
c)触媒、
d)ヘキサメチレンジイソシアネートまたは変性ヘキサメチレンジイソシアネート、
e)抗菌活性剤、
f)高吸収剤、
g)発泡剤
から特に構成された1種の親水性ポリウレタンフォームゲルを含み、ここで、ポリウレタンの形成成分a)およびd)の官能基の積は少なくとも5.2であり、触媒量c)は、ポリオールa)を基準として0.005重量%〜0.5重量%であり、酸化防止剤b)の量は、ポリオールa)を基準として少なくとも0.1重量%であり、成分d)中の遊離のNCO基の、成分a)中の遊離のOH基に対する比(イソシアネートインデックス/100)は、0.30〜0.70の範囲で選択され、活性剤e)の量は、ポリオールa)を基準として0.0001重量%〜25重量%、好ましくは0.001重量%〜5重量%、およびさらに好ましくは0.01重量%〜1重量%である。本発明のポリウレタンゲル材料のイソシアネートインデックス(K,反応に使用される遊離のNCO基の、遊離のOH基に対する比X100)は、使用されるイソシアネート成分(FI)およびポリオール成分(FP)の官能性に従って30〜70の範囲、好ましくは45〜60の範囲で変化する。ゲル形成に必要なイソシアネートインデックスは次式
(A) (A)および(B)の合計を基準として、25〜62重量%もしくは他に15〜62重量%、好ましくは30〜60重量%もしくは他に20〜57重量%、さらに好ましくは40〜57重量%もしくは他に25〜47重量%の、高分子量マトリックスとしての共有結合的に架橋したポリウレタン、および
(B) (A)および(B)の合計を基準として、75〜38重量%もしくは他に85〜38重量%、好ましくは70〜40重量%もしくは他に80〜43重量%、さらに好ましくは60〜43重量%もしくは他に75〜53重量%の1種以上のポリヒドロキシ化合物であって、800、好ましくは1000、さらに好ましくは1500より小さい分子量を有するヒドロキシ化合物を実質的に含まない液体分散剤として、二次原子価力によってマトリックス中に強固に保持され、1000〜12000、好ましくは1500〜8000、さらに好ましくは2000〜6000の平均分子量、および20〜112、好ましくは25〜84、さらに好ましくは28〜56の平均OH価を有するポリヒドロキシ化合物、およびまた
(C) (A)および(B)の合計を基準として、0.00001〜25重量%、好ましくは0.001〜5重量%、さらに好ましくは0.001〜2.5重量%の活性剤、好ましくはポリヘキサメチレンビグアニド、より好ましくはその塩酸塩、および適切な場合には、1種以上のさらなる活性剤、およびまた
(D) (A)および(B)の合計を基準として、0.1〜50重量%、好ましくは2〜30重量%、さらに好ましくは25〜29重量%の、高吸収剤、
(E) (A)および(B)の合計を基準として、0.01〜10重量%の発泡剤、およびまたもし適切な場合には、
(F) (A)および(B)の合計を基準として、0〜100重量%の充填剤および/または添加物質を含み、
I) 1種以上のポリイソシアネート、
II) 平均分子量1000〜12000および平均OH価20から112を有する1種以上のポリヒドロキシ化合物、
III)1種以上の抗菌活性剤、
IV) 1種以上の水吸収性材料、
V) 室温で液体または気体である発泡剤、およびまた適切な場合は、
VI) イソシアネート基とヒドロキシル基との反応の触媒および促進剤、およびまた適切な場合には、
VII)ポリウレタン化学からそれ自体知られた充填剤および添加物質、
からなる混合物の反応によって得られるポリウレタンゲルからなる親水性ポリウレタンゲルフォームを好ましくは使用することもさらに可能であり、ここで、該混合物は、分子量800未満を有するヒドロキシ化合物が実質的に存在せず、ポリイソシアネートの平均官能基数(FI)が好ましくは2〜4であり、ポリヒドロキシ化合物の平均官能基数(FP)が3〜6であり、イソシアネートインデックス(K)が式
− 創傷の微生物感染の抑制および再感染の防止
− 創傷滲出物の吸収および不可逆的保持、およびそれによる治癒過程のサポート
− 創傷滲出物とともにフォームに吸収された細菌の殺傷
− ポリウレタン材料の皮膚相容性
− 創傷接触材料の頻繁な交換(現在一日当たり数回)が不要になり、少なくとも3日から5日まで創傷上に該接触材料をとどめておくことが可能となり、そのため新しい皮膚組織が破壊されることなく良好に形成することができる。
− 創傷の断熱
− 細菌の抑制を支援する抗生物質または痛み緩和用の局所麻酔薬などのさらなる活性剤をポリマー中に取り込ませ、それから継続的に再びゆっくり放出させることができる。
− 適切な場合に、酵素、成長因子および細胞移植(例えば幹細胞)を介して創傷治癒の促進。
(実施例)
Claims (7)
- 殺菌剤としてPHMBおよび/またはその塩酸塩を含む発泡親水性ポリウレタンゲルであり、高吸収剤とともに、前記殺菌剤が、微粒子分散液および/または均質溶液としてポリウレタンゲル中に存在することを特徴とする発泡親水性ポリウレタンゲル。
- 広域スペクトル抗生物質、抗菌活性剤、抗真菌活性剤、抗病原性ペプチド、局所麻酔薬、殺菌効果、止血効果、創傷治癒効果、免疫調節効果もしくは肉芽形成促進効果、または中枢神経系への効果を有する活性剤の群から選択される少なくとも1種のさらなる治療剤を単独または組み合わせて追加的に使用できることを特徴とする、請求項1に記載の発泡親水性ポリウレタン。
- 所望の活性剤の存在下でモノマーと発泡剤とを反応させることによる、請求項1または2に記載の発泡親水性ポリウレタンを製造するための方法であり、重合前に少なくとも1種の活性剤をモノマーの混合物中へ混合することを特徴とする方法。
- 医療機器を製造するための、請求項1または2に記載の発泡親水性ポリウレタンの使用。
- 少なくとも1層の創傷接触材料を製造するための、請求項1または2に記載の発泡親水性ポリウレタンの使用。
- 大きな創傷または慢性の創傷用の創傷接触材料を製造するための、請求項1または2に記載の発泡親水性ポリウレタンの使用。
- 請求項1または2に記載の少なくとも1種の発泡親水性ポリウレタンを含む創傷接触材料。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
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DE102004061406.7 | 2004-12-21 | ||
DE102004061406A DE102004061406A1 (de) | 2004-12-21 | 2004-12-21 | Infektionsresistente Polyurethanschäume, Verfahren zu ihrer Herstellung und Verwendung in antiseptisch ausgestatteten Wundauflagen |
PCT/EP2005/013340 WO2006066752A1 (de) | 2004-12-21 | 2005-12-13 | Infektionsresistente polyurethanschäume, verfahren zu ihrer herstellung und verwendung in antiseptisch ausgestatteten wundauflagen |
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JP2008524410A true JP2008524410A (ja) | 2008-07-10 |
JP2008524410A5 JP2008524410A5 (ja) | 2009-02-12 |
JP5201993B2 JP5201993B2 (ja) | 2013-06-05 |
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JP2007547262A Expired - Fee Related JP5201993B2 (ja) | 2004-12-21 | 2005-12-13 | 耐感染性ポリウレタンフォーム、その製造方法および殺菌性創傷被覆におけるその使用 |
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US (2) | US8147857B2 (ja) |
EP (1) | EP1830896B1 (ja) |
JP (1) | JP5201993B2 (ja) |
KR (1) | KR20080004449A (ja) |
CN (1) | CN101124001A (ja) |
AT (1) | ATE410194T1 (ja) |
AU (1) | AU2005318512B2 (ja) |
BR (1) | BRPI0519194A2 (ja) |
CA (1) | CA2591072C (ja) |
DE (2) | DE102004061406A1 (ja) |
DK (1) | DK1830896T3 (ja) |
EA (1) | EA016503B1 (ja) |
ES (1) | ES2314746T3 (ja) |
IL (1) | IL184007A (ja) |
MX (1) | MX2007007431A (ja) |
NO (1) | NO20073149L (ja) |
NZ (1) | NZ555943A (ja) |
PL (1) | PL1830896T3 (ja) |
PT (1) | PT1830896E (ja) |
WO (1) | WO2006066752A1 (ja) |
ZA (1) | ZA200704656B (ja) |
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Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2013505310A (ja) * | 2009-09-18 | 2013-02-14 | ビーエーエスエフ ソシエタス・ヨーロピア | 超吸収体を備えた連続気泡フォーム |
US11407851B2 (en) | 2016-12-02 | 2022-08-09 | The Texas A&M University System | Chemically modified shape memory polymer embolic foams with increased X-ray visualization |
JP2020506249A (ja) * | 2016-12-06 | 2020-02-27 | ザ テキサス エーアンドエム ユニバーシティ システムThe Texas A&M University System | 抗菌形状記憶ポリマー |
US20190322795A1 (en) * | 2016-12-29 | 2019-10-24 | Alcare Co., Ltd. | Foam and composition for foam |
US11952455B2 (en) * | 2016-12-29 | 2024-04-09 | Alcare Co., Ltd. | Foam and composition for foam |
US11597792B2 (en) | 2017-10-30 | 2023-03-07 | The Texas A&M University System | Radiopaque thermoplastic polymer |
Also Published As
Publication number | Publication date |
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DK1830896T3 (da) | 2009-02-09 |
NO20073149L (no) | 2007-07-02 |
PL1830896T3 (pl) | 2009-04-30 |
US20100021514A1 (en) | 2010-01-28 |
BRPI0519194A2 (pt) | 2008-12-30 |
EP1830896A1 (de) | 2007-09-12 |
ES2314746T3 (es) | 2009-03-16 |
IL184007A0 (en) | 2007-10-31 |
EP1830896B1 (de) | 2008-10-08 |
AU2005318512A1 (en) | 2006-06-29 |
ZA200704656B (en) | 2009-01-28 |
KR20080004449A (ko) | 2008-01-09 |
WO2006066752A1 (de) | 2006-06-29 |
CA2591072A1 (en) | 2006-06-29 |
PT1830896E (pt) | 2008-12-22 |
JP5201993B2 (ja) | 2013-06-05 |
ATE410194T1 (de) | 2008-10-15 |
AU2005318512B2 (en) | 2009-09-24 |
DE502005005656D1 (de) | 2008-11-20 |
CA2591072C (en) | 2013-04-09 |
EA016503B1 (ru) | 2012-05-30 |
DE102004061406A1 (de) | 2006-07-06 |
NZ555943A (en) | 2009-12-24 |
US20120156274A1 (en) | 2012-06-21 |
EA200701183A1 (ru) | 2008-04-28 |
MX2007007431A (es) | 2007-10-04 |
US8147857B2 (en) | 2012-04-03 |
IL184007A (en) | 2011-06-30 |
CN101124001A (zh) | 2008-02-13 |
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