JP2008520741A - 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール - Google Patents

翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール Download PDF

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JP2008520741A
JP2008520741A JP2007543449A JP2007543449A JP2008520741A JP 2008520741 A JP2008520741 A JP 2008520741A JP 2007543449 A JP2007543449 A JP 2007543449A JP 2007543449 A JP2007543449 A JP 2007543449A JP 2008520741 A JP2008520741 A JP 2008520741A
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substituted
unsubstituted
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alkyl
heterocyclic ring
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JP2008520741A5 (enExample
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ウィリアム ジョセフ レノックス，
ホンヤン チ，
ダク−ヒュン リー，
スーンキュ チョウイ，
ヤン−チューン ムーン，
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ピーティーシー セラピューティクス， インコーポレイテッド
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
    • A61K31/343—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
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    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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  • Nitrogen Condensed Heterocyclic Rings (AREA)
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  • Plural Heterocyclic Compounds (AREA)
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JP2007543449A 2004-11-23 2005-11-23 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール Pending JP2008520741A (ja)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62988904P 2004-11-23 2004-11-23
US63373804P 2004-12-06 2004-12-06
US63928304P 2004-12-27 2004-12-27
PCT/US2005/042483 WO2006065480A2 (en) 2004-11-23 2005-11-23 Tetrahydrocarbazoles as active agents for inhibiting vegf production by translational control

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JP2008520741A true JP2008520741A (ja) 2008-06-19
JP2008520741A5 JP2008520741A5 (enExample) 2009-03-12

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JP2007543450A Pending JP2008520742A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体
JP2007543449A Pending JP2008520741A (ja) 2004-11-23 2005-11-23 翻訳制御によるｖｅｇｆ生成を阻害するための活性因子としてのテトラヒドロカルバゾール
JP2007543448A Pending JP2008520740A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール

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JP2007543450A Pending JP2008520742A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生の阻害に有用なカルバゾール誘導体、カルボリン誘導体およびインドール誘導体

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JP2007543448A Pending JP2008520740A (ja) 2004-11-23 2005-11-23 Ｖｅｇｆ産生を阻害する活性因子としての置換されたフェノール

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US (3) US8143257B2 (enExample)
EP (3) EP1817025A2 (enExample)
JP (3) JP2008520742A (enExample)
CA (3) CA2588384A1 (enExample)
MX (3) MX2007006179A (enExample)
WO (3) WO2006065479A2 (enExample)

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US8076353B2 (en) 2004-03-15 2011-12-13 Ptc Therapeutics, Inc. Inhibition of VEGF translation
JP2008520744A (ja) 2004-11-19 2008-06-19 ザ・レジェンツ・オブ・ザ・ユニバーシティ・オブ・カリフォルニア 抗炎症性ピラゾロピリミジン
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AU2007347115A1 (en) 2006-04-04 2008-10-23 The Regents Of The University Of California PI3 kinase antagonists
KR101433395B1 (ko) 2006-07-19 2014-08-26 이 아이 듀폰 디 네모아 앤드 캄파니 3-치환된 2-아미노-5-할로벤즈아미드의 제조 방법
ITMI20061581A1 (it) * 2006-08-04 2008-02-05 Univ Bari Ligandi del recettore beta-3 adrenergico e loro uso in terapia
UA98777C2 (en) 2006-11-20 2012-06-25 Эли Лилли Энд Компани Tetrahydrocyclopenta[b]indole compounds as androgen receptor modulators
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