JP2008520739A - 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製および使用方法 - Google Patents

長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製および使用方法 Download PDF

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JP2008520739A
JP2008520739A JP2007543444A JP2007543444A JP2008520739A JP 2008520739 A JP2008520739 A JP 2008520739A JP 2007543444 A JP2007543444 A JP 2007543444A JP 2007543444 A JP2007543444 A JP 2007543444A JP 2008520739 A JP2008520739 A JP 2008520739A
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dpan
dihydroxy
oil
lcpufa
hydroxy
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JP2008520739A5 (enExample
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リンダ メアリー アーテルバーン
ウィリアム バークレー
ビンディ ダンギ
ジェームズ フラット
ユング リー
エルスウィク メアリー ヴァン
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マーテック・バイオサイエンシーズ・コーポレーション
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6436—Fatty acid esters
    • C12P7/6445—Glycerides
    • C12P7/6472—Glycerides containing polyunsaturated fatty acid [PUFA] residues, i.e. having two or more double bonds in their backbone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/10—Antioedematous agents; Diuretics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/42—Unsaturated compounds containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
    • C07D303/02—Compounds containing oxirane rings
    • C07D303/38—Compounds containing oxirane rings with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6432—Eicosapentaenoic acids [EPA]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/64—Fats; Fatty oils; Ester-type waxes; Higher fatty acids, i.e. having at least seven carbon atoms in an unbroken chain bound to a carboxyl group; Oxidised oils or fats
    • C12P7/6409—Fatty acids
    • C12P7/6427—Polyunsaturated fatty acids [PUFA], i.e. having two or more double bonds in their backbone
    • C12P7/6434—Docosahexenoic acids [DHA]

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  • Chemical & Material Sciences (AREA)
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  • Engineering & Computer Science (AREA)
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  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Rheumatology (AREA)
  • Diabetes (AREA)
  • Pain & Pain Management (AREA)
  • Hematology (AREA)
  • Psychiatry (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Cosmetics (AREA)
  • Epoxy Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2007543444A 2004-11-19 2005-11-21 長鎖多価不飽和脂肪酸由来のオキシリピンならびにその作製および使用方法 Pending JP2008520739A (ja)

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US62984204P 2004-11-19 2004-11-19
US72903805P 2005-10-21 2005-10-21
PCT/US2005/042462 WO2006055965A2 (en) 2004-11-19 2005-11-21 Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same

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JP2008520739A true JP2008520739A (ja) 2008-06-19
JP2008520739A5 JP2008520739A5 (enExample) 2009-01-15

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US (2) US7884131B2 (enExample)
EP (1) EP1824809A4 (enExample)
JP (1) JP2008520739A (enExample)
KR (1) KR20070090928A (enExample)
CN (1) CN101102988B (enExample)
AU (1) AU2005306320B2 (enExample)
BR (1) BRPI0516803A (enExample)
CA (1) CA2588166A1 (enExample)
EA (1) EA010802B1 (enExample)
IL (1) IL183246A0 (enExample)
MX (1) MX2007006049A (enExample)
NZ (1) NZ555394A (enExample)
WO (1) WO2006055965A2 (enExample)

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WO2012026106A1 (ja) * 2010-08-25 2012-03-01 国立大学法人 東京大学 光学活性な新規抗炎症性化合物及びその製造方法
JP2013500966A (ja) * 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
JP2015522535A (ja) * 2012-05-10 2015-08-06 ソルテックス エヌエー エルエルシー 天然の特異的炎症収束性メディエータおよびその前駆物質を含有する、抗炎症活性を有する油
JP2016505016A (ja) * 2013-01-11 2016-02-18 マサチューセッツ アイ アンド イヤー インファーマリー 炎症及び血管形成を減少させるｃｙｐ４５０脂質メタボライト
JP2016520612A (ja) * 2013-05-30 2016-07-14 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 新規ｎ−３イムノリソルベント：構造及び作用
JP2018506584A (ja) * 2015-02-09 2018-03-08 ボード オブ スーパーバイザーズ オブ ルイジアナ ステート ユニバーシティ アンド アグリカルチュアル アンド メカニカル カレッジ 炎症性、変性及び神経変性疾患の治療のための化合物、組成物及び方法
US10537541B2 (en) 2015-10-02 2020-01-21 Complexa Inc. Treatment of focal segmental glomerular sclerosis (FSGS) using therapeutically effective oral doses of 10-nitro-9(E)-octadec-9-enoic acid
US11608342B2 (en) 2015-07-07 2023-03-21 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
US12006319B2 (en) 2018-05-25 2024-06-11 Cardurion Pharmaceuticals, Inc. Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
US12213975B2 (en) 2018-08-31 2025-02-04 Cardurion Pharmaceuticals, Inc. PDE9 inhibitors for treating sickle cell disease

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US7893106B2 (en) * 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same
US20090318394A1 (en) * 2004-11-19 2009-12-24 Julie Nauroth Long Chain Polyunsaturated Fatty Acids and Methods of Making and Using the Same
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WO2007090162A2 (en) * 2006-01-31 2007-08-09 Martek Biosciences Corporation OXYLIPINS FROM STEARIDONIC ACID AND γ-LINOLENIC ACID AND METHODS OF MAKING AND USING THE SAME
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US20080161274A1 (en) * 2006-10-26 2008-07-03 Resolvyx Pharmaceuticals, Inc. Compounds and methods for inhibition of bone loss
WO2008070129A2 (en) * 2006-12-05 2008-06-12 Resolvyx Pharmaceuticals, Inc. Compositions and methods for the treatment of inflammatory disease
US20110190389A1 (en) * 2007-02-20 2011-08-04 Linda Arterburn Oxylipins from long chain polyunsaturated fatty acids and methods of making and using the same
PL2124973T3 (pl) * 2007-03-23 2015-10-30 Novartis Ag Kompozycja zawierająca kwasy tłuszczowe omega-3 oraz zamaskowane lub powleczone sole miedzi
WO2008118457A2 (en) * 2007-03-26 2008-10-02 University Of Medicine And Dentistry Of Nj Synthesis of resolvins and intermediates, compounds prepared thereby, and uses thereof
US8324277B2 (en) 2007-08-01 2012-12-04 University of Pittsburgh—of the Commonwealth System of Higher Education Nitrated-fatty acids modulation of type II diabetes
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KR20150115959A (ko) * 2007-10-12 2015-10-14 레솔빅스 파마슈티칼즈, 인코퍼레이티드 안과 질환의 치료를 위한 옥실리핀 화합물
US20110027841A1 (en) * 2007-12-21 2011-02-03 Martek Biosciences Corporation Method for preparation of oxylipins
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US20140024713A1 (en) 2008-06-19 2014-01-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
WO2009155439A2 (en) 2008-06-19 2009-12-23 University Of Utah Research Foundation Use of nitrated lipids for treatment of side effects of toxic medical therapies
US8927747B2 (en) * 2008-09-16 2015-01-06 The Brigham And Women's Hospital, Inc. 14-hydroxy-docosahexaenoic acid compounds
CA2742227C (en) * 2008-10-31 2017-01-24 Lipid Pharmaceuticals Ehf. The use of fatty acid compositions as laxatives
WO2010095706A1 (ja) * 2009-02-20 2010-08-26 国立大学法人東京大学 新規抗炎症性化合物
ES2345241B1 (es) * 2009-03-16 2011-09-08 Lipopharma Therapeutics Uso de 2-hidroxiderivados de acidos grasos poliinsaturados como medicamentos.
WO2010118761A1 (en) * 2009-04-17 2010-10-21 Eolas Science Limited Compositions rich in omega-3 fatty acids with a low content in phytanic acid
LT2443246T (lt) 2009-06-15 2018-03-26 Amarin Pharmaceuticals Ireland Limited Kompozicijos ir būdai, skirti trigliceridų sumažinimui, nepakeliant ldl-c lygio subjekte, kartu taikant statino terapiją
USRE46608E1 (en) 2009-09-01 2017-11-14 Catabasis Pharmaceuticals, Inc. Fatty acid niacin conjugates and their uses
SG178948A1 (en) 2009-09-01 2012-04-27 Catabasis Pharmaceuticals Inc Fatty acid niacin conjugates and their uses
US8686167B2 (en) 2009-10-02 2014-04-01 Complexa, Inc. Heteroatom containing substituted fatty acids
AU2010313249B2 (en) 2009-10-30 2016-05-19 Biojiva Llc Alleviating oxidative stress disorders with PUFA derivatives
WO2012023254A1 (ja) * 2010-08-19 2012-02-23 国立大学法人 東京大学 オメガ３系脂肪酸由来の新規抗炎症性代謝物
AU2011336856A1 (en) 2010-11-29 2013-07-04 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
US11712429B2 (en) 2010-11-29 2023-08-01 Amarin Pharmaceuticals Ireland Limited Low eructation composition and methods for treating and/or preventing cardiovascular disease in a subject with fish allergy/hypersensitivity
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US9416118B2 (en) 2011-06-10 2016-08-16 The Brigham And Women's Hospital, Inc. Docosahexaenoyl ethanolamides
WO2013028501A1 (en) 2011-08-19 2013-02-28 The University Of Utah Research Foundation Combination therapy with nitrated lipids and inhibitors of the renin-angiotensin-aldosterone system
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WO2017041094A1 (en) 2015-09-03 2017-03-09 Solutex Na Llc Compositions comprising omega-3 fatty acids, 17-hdha and 18- hepe and methods of using same
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EP3950649A1 (en) 2015-11-23 2022-02-09 Retrotope, Inc. Site-specific isotopic labeling of 1, 4-diene systems
WO2019104311A1 (en) * 2017-11-27 2019-05-31 Brown University Compositions and methods for suppressing neurological disease
WO2019104315A1 (en) * 2017-11-27 2019-05-31 Brown University Compositions and methods using lipids for treating neurological disease
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Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63238075A (ja) * 1987-03-24 1988-10-04 Mitsumaru Kagaku Kk 高度不飽和脂肪酸からのラクトン類の製造法
JPH05286956A (ja) * 1992-04-06 1993-11-02 Nippon Suisan Kaisha Ltd ドコサペンタエン酸モノエポキシ体、及びその製造法
JPH11209259A (ja) * 1998-01-20 1999-08-03 Noevir Co Ltd 皮膚化粧料
WO2002092540A1 (en) * 2001-05-14 2002-11-21 Martek Biosciences Corporation Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsatruated fatty acids from microbes, genetically modified plant seeds and marine organisms
JP2003525880A (ja) * 2000-02-16 2003-09-02 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド アスピリン誘発脂質メディエータ

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4866046A (en) * 1988-05-31 1989-09-12 Top Laboratories, Inc. Low-dosage sublingual aspirin
US5102670A (en) 1990-09-14 1992-04-07 Abraham Nader G Method for treating eye disorders by reducing 12(r)-hydroxyeicosatetraenoic acid and 12(r)-dihydroxyeicosatrienoic acid levels
US6887901B1 (en) 1993-06-15 2005-05-03 Brigham & Women's Hospital, Inc. Lipoxin compounds and their use in treating cell proliferative disorders
GB9403857D0 (en) * 1994-03-01 1994-04-20 Scotia Holdings Plc Fatty acid derivatives
CZ281096B6 (cs) * 1994-06-30 1996-06-12 Jindřich Mudr. Drsc. Mourek Tuková složka mléčné výživy a dětská výživa
US5955496A (en) 1996-08-13 1999-09-21 The Regents Of The University Of California Dihydroxy-oxy-eicosadienoates
DK0956013T3 (da) 1996-10-11 2003-08-04 Scarista Ltd Farmaceutisk præparat indeholdende eicosapentaensyre og/eller stearidonsyre
US6174695B1 (en) * 1997-08-12 2001-01-16 The Regents Of The University Of California Epoxide hydrolase inhibitor methods
DE19757414A1 (de) 1997-12-23 1999-07-01 Nutricia Nv Fettmischung
ES2286999T5 (es) 1999-03-04 2016-11-17 Suntory Holdings Limited Utilización de un material que contiene ácido docosapentaenoico
EP1197560A4 (en) 1999-07-07 2005-08-03 Kyowa Hakko Kogyo Kk PROCESS FOR PREPARING HYDROXILATED FATTY ACID AND DELTA LACTONE
BR0015404A (pt) 1999-11-09 2002-06-25 Alcon Inc Compostos relacionados com ácido 15-hidroxieicosatetraenóico e métodos de uso
DE10046541A1 (de) 2000-09-19 2002-03-28 Knoll Ag Mechanisch stabile darreichungsformen, enthaltend Ubichinone
WO2002029018A2 (en) 2000-10-06 2002-04-11 Michigan State University Divinyl ether synthase gene and protein, and uses thereof
WO2003053423A2 (en) * 2001-12-18 2003-07-03 The Brigham And Women's Hospital Inhibition or prevention of infection by bacteria with epa, dha or analogs
US7527935B2 (en) 2002-03-19 2009-05-05 Mitsubishi Tanabe Pharma Corporation G-protein coupled receptor having eicosanoid as ligand and gene thereof
SI2022775T1 (sl) 2002-04-01 2015-03-31 University Of Southern California Trihidroksi polinenasiäśeni eikosanoidi
US7582785B2 (en) 2002-04-01 2009-09-01 University Of Southern California Trihydroxy polyunsaturated eicosanoid derivatives
FR2843124B1 (fr) 2002-08-02 2004-10-15 Goemar Lab Sa Procede de preparation d'acides gras polyinsatures libres et de leurs metabolites d'oxydation
DK2216318T3 (en) * 2002-08-12 2018-12-10 Brigham & Womens Hospital Resolvins: Bio templates for therapeutic interventions
US20040166130A1 (en) 2002-12-23 2004-08-26 L'oreal Lanolin-free cosmetic composition comprising a hydroxylated fatty acid aromatic ester
US7893106B2 (en) 2004-11-19 2011-02-22 Martek Biosciences, Corporation Oxylipins from stearidonic acid and γ-linolenic acid and methods of making and using the same

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63238075A (ja) * 1987-03-24 1988-10-04 Mitsumaru Kagaku Kk 高度不飽和脂肪酸からのラクトン類の製造法
JPH05286956A (ja) * 1992-04-06 1993-11-02 Nippon Suisan Kaisha Ltd ドコサペンタエン酸モノエポキシ体、及びその製造法
JPH11209259A (ja) * 1998-01-20 1999-08-03 Noevir Co Ltd 皮膚化粧料
JP2003525880A (ja) * 2000-02-16 2003-09-02 ザ・ブリガーム・アンド・ウーメンズ・ホスピタル・インコーポレーテッド アスピリン誘発脂質メディエータ
WO2002092540A1 (en) * 2001-05-14 2002-11-21 Martek Biosciences Corporation Production and use of a polar lipid-rich fraction containing omega-3 and/or omega-6 highly unsatruated fatty acids from microbes, genetically modified plant seeds and marine organisms
JP2004536059A (ja) * 2001-05-14 2004-12-02 マーテック バイオサイエンシズ ボールダー コーポレーション 微生物、遺伝的に改変された植物種子および海洋生物由来のω−３および／またはω−６高度不飽和脂肪酸を含有する極性脂質の豊富な画分の生成および使用

Non-Patent Citations (7)

* Cited by examiner, † Cited by third party
Title
JPN6011060206; ＭＩＬＫＳ，Ｍ．Ｍ．　ａｎｄ　ＳＰＲＥＣＨＥＲ，Ｈ．: 'Ｍｅｔａｂｏｌｉｓｍ　ｏｆ　４，７，１０，１３，１６-ｄｏｃｏｓａｐｅｎｔａｅｎｏｉｃ　ａｃｉｄ　ｂｙ　ｈｕｍａｎ　ｐｌａｔｅｌｅｔ　ｃｙｃｌｏｏｘｙｇｅｎａｓｅ　ａｎｄ　ｌｉｐｏｘｙｇｅｎａｓｅ' Ｂｉｏｃｈｉｍｉｃａ　ｅｔ　Ｂｉｏｐｈｙｓｉｃａ　Ａｃｔａ，　Ｌｉｐｉｄｓ　ａｎｄ　Ｌｉｐｉｄ　Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．８３５，　Ｎｏ．１, 1985, ｐ．２９-３５ *
JPN6011060209; ＳＰＲＥＣＨＥＲ，Ｈ．　ａｎｄ　ＣＡＲＥＡＧＡ，Ｍ．Ｍ．: 'Ｍｅｔａｂｏｌｉｓｍ　ｏｆ　（ｎ-６）　ａｎｄ　（ｎ-３）　ｐｏｌｙｕｎｓａｔｕｒａｔｅｄ　ｆａｔｔｙ　ａｃｉｄｓ　ｂｙ　ｈｕｍａｎ　ｐｌａｔｅｌｅｔｓ' Ｐｒｏｓｔａｇｌａｎｄｉｎｓ，　Ｌｅｕｋｏｔｒｉｅｎｅｓ　ａｎｄ　Ｍｅｄｉｃｉｎｅ Ｖｏｌ．２３，　Ｎｏ．２-３, 1986, ｐ．１２９-１３４ *
JPN6011060211; ＯＬＩＷ，Ｅ．Ｈ．　ａｎｄ　ＳＰＲＥＣＨＥＲ，Ｈ．: 'Ｍｅｔａｂｏｌｉｓｍ　ｏｆ　ｐｏｌｙｕｎｓａｔｕｒａｔｅｄ　ｆａｔｔｙ　ａｃｉｄｓ　ｂｙ　ａｎ　（ｎ-６）-ｌｉｐｏｘｙｇｅｎａｓｅ　ａｓｓｏｃｉａｔｅｄ　ｗｉｔｈ　ｈｕｍａｎ　ｅｊａｃｕｌａｔｅｓ' Ｂｉｏｃｈｉｍｉｃａ　ｅｔ　Ｂｉｏｐｈｙｓｉｃａ　Ａｃｔａ，　Ｌｉｐｉｄｓ　ａｎｄ　Ｌｉｐｉｄ　Ｍｅｔａｂｏｌｉｓｍ Ｖｏｌ．１００２，　Ｎｏ．３, 1989, ｐ．２８３-２９１ *
JPN6011060212; ＧＵＥＲＲＩＥＲＯ，Ａ．　ｅｔ　ａｌ．: 'Ｈｙｄｒｏｘｙｅｉｃｏｓａｔｅｔｒａｅｎｏｉｃ，　ｈｙｄｒｏｘｙｅｉｃｏｓａｐｅｎｔａｅｎｏｉｃ，　ｈｙｄｒｏｘｙｄｏｃｏｓａｐｅｎｔａｅｎｏｉｃ，　ａｎｄ　ｈｙｄｒｏｘｙｄｏｃｏｓａｈｅｘａｅｎｏｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ｎａｔｕｒａｌ　Ｐｒｏｄｕｃｔｓ Ｖｏｌ．５３，　Ｎｏ．１, 1990, ｐ．５７-６１ *
JPN6011060213; ＫＡＲＡＮＩＡＮ，Ｊ．Ｗ．　ｅｔ　ａｌ．: 'Ｉｎｈｉｂｉｔｏｒｙ　ｅｆｆｅｃｔｓ　ｏｆ　ｎ-６　ａｎｄ　ｎ-３　ｈｙｄｒｏｘｙ　ｆａｔｔｙ　ａｃｉｄｓ　ｏｎ　ｔｈｒｏｍｂｏｘａｎｅ　（Ｕ４６６１９）-ｉｎｄｕｃｅｄ　ｓｍｏｏｔｈ　ｍｕｓｃｌｅ' Ｊｏｕｒｎａｌ　ｏｆ　Ｐｈａｒｍａｃｏｌｏｇｙ　ａｎｄ　Ｅｘｐｅｒｉｍｅｎｔａｌ　Ｔｈｅｒａｐｅｕｔｉｃｓ Ｖｏｌ．２７０，　Ｎｏ．３, 1994, ｐ．１１０５-１１０９ *
JPN6011060215; ＨＡＶＩＶ，Ｆ．　ｅｔ　ａｌ．: 'Ｓｔｒｕｃｔｕｒａｌ　ｒｅｑｕｉｒｅｍｅｎｔｓ　ｆｏｒ　ｔｈｅ　ｉｎｈｉｂｉｔｉｏｎ　ｏｆ　５-ｌｉｐｏｘｙｇｅｎａｓｅ　ｂｙ　１５-ｈｙｄｒｏｘｙｅｉｃｏｓａ-５，８，１１，１３-ｔｅｔｒａｅｎｏｉ' Ｊｏｕｒｎａｌ　ｏｆ　Ｍｅｄｉｃｉｎａｌ　Ｃｈｅｍｉｓｔｒｙ Ｖｏｌ．３０，　Ｎｏ．２, 1987, ｐ．２５４-２６３ *
JPN6011060216; ＭＡＮＣＩＮＩ，Ｉ．　ｅｔ　ａｌ．: 'Ｎｏｖｅｌ　１０-ｈｙｄｒｏｘｙｄｏｃｏｓａｐｏｌｙｅｎｏｉｃ　ａｃｉｄｓ　ｆｒｏｍ　ｄｅｅｐ-ｗａｔｅｒ　ｓｃｌｅｒａｃｔｉｎｉａｎ　ｃｏｒａｌｓ' Ｈｅｌｖｅｔｉｃａ　Ｃｈｉｍｉｃａ　Ａｃｔａ Ｖｏｌ．８２，　Ｎｏ．５, 1999, ｐ．６７７-６８４ *

Cited By (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
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JP2013500966A (ja) * 2009-07-31 2013-01-10 ユニバーシティー オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケーション 抗炎症剤としての脂肪酸
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JP2019163265A (ja) * 2013-05-30 2019-09-26 ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッドＴｈｅ Ｂｒｉｇｈａｍ ａｎｄ Ｗｏｍｅｎ’ｓ Ｈｏｓｐｉｔａｌ， Ｉｎｃ． 新規ｎ−３イムノリソルベント：構造及び作用
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US11608342B2 (en) 2015-07-07 2023-03-21 H. Lundbeck A/S PDE9 inhibitors with imidazo triazinone backbone and imidazo pyrazinone backbone for treatment of peripheral diseases
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US12006319B2 (en) 2018-05-25 2024-06-11 Cardurion Pharmaceuticals, Inc. Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
US12466832B2 (en) 2018-05-25 2025-11-11 Cardurion Pharmaceuticals, Inc. Monohydrate and crystalline forms of 6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-3-tetrahydropyran-4-yl-7H-imidazo[1,5-a]pyrazin-8-one
US12213975B2 (en) 2018-08-31 2025-02-04 Cardurion Pharmaceuticals, Inc. PDE9 inhibitors for treating sickle cell disease

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