|
US7964571B2
(en)
|
2004-12-09 |
2011-06-21 |
Egen, Inc. |
Combination of immuno gene therapy and chemotherapy for treatment of cancer and hyperproliferative diseases
|
|
US20120269886A1
(en)
|
2004-12-22 |
2012-10-25 |
Nitto Denko Corporation |
Therapeutic agent for pulmonary fibrosis
|
|
ES2900801T3
(es)
|
2004-12-22 |
2022-03-18 |
Nitto Denko Corp |
Portador de fármacos y kit de portador de fármacos para inhibir la fibrosis
|
|
DE102005039154A1
(de)
*
|
2005-08-17 |
2007-03-01 |
GÖPFERICH, Achim, Prof. Dr. |
Bioabbaubare Polymere für den Transport von Nukleinsäuren in Zellen
|
|
US9572886B2
(en)
|
2005-12-22 |
2017-02-21 |
Nitto Denko Corporation |
Agent for treating myelofibrosis
|
|
KR100825519B1
(ko)
*
|
2007-01-05 |
2008-04-25 |
주식회사 바이오폴리메드 |
키토산 기재 고분자 접합체 및 그 제조방법
|
|
KR101508621B1
(ko)
*
|
2007-02-28 |
2015-04-07 |
세리나 쎄라퓨틱스, 인코포레이티드 |
활성화된 폴리옥사졸린 및 이를 포함하는 조성물
|
|
TWI407971B
(zh)
|
2007-03-30 |
2013-09-11 |
日東電工股份有限公司 |
Cancer cells and tumor-related fibroblasts
|
|
WO2009009441A2
(en)
*
|
2007-07-06 |
2009-01-15 |
Cedars-Sinai Medical Center |
Self-assembling complex for targeting chemical agents to cells
|
|
US9144546B2
(en)
|
2007-08-06 |
2015-09-29 |
Clsn Laboratories, Inc. |
Nucleic acid-lipopolymer compositions
|
|
KR20100065190A
(ko)
|
2007-09-14 |
2010-06-15 |
닛토덴코 가부시키가이샤 |
약물 담체
|
|
US20090130752A1
(en)
*
|
2007-11-07 |
2009-05-21 |
University Of Utah Research Foundation |
Biodegradable poly(disulfide amine)s for gene delivery
|
|
WO2009061515A1
(en)
*
|
2007-11-09 |
2009-05-14 |
Northeastern University |
Self-assembling micelle-like nanoparticles for systemic gene delivery
|
|
US20090171455A1
(en)
*
|
2007-12-31 |
2009-07-02 |
Boston Scientific Scimed, Inc. |
Biodegradable polymers
|
|
US8110651B2
(en)
*
|
2008-01-11 |
2012-02-07 |
Serina Therapeutics, Inc. |
Multifunctional forms of polyoxazoline copolymers and drug compositions comprising the same
|
|
FR2928373B1
(fr)
*
|
2008-03-05 |
2010-12-31 |
Centre Nat Rech Scient |
Polymere derive de la polyethylenimine lineaire pour le transfert de gene.
|
|
CA2717370A1
(en)
*
|
2008-03-14 |
2009-09-17 |
Egen, Inc. |
Biodegradable cross-linked branched poly (alkylene imines)
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2010085665A2
(en)
|
2009-01-23 |
2010-07-29 |
Cedars-Sinai Medical Center |
Targeted delivery system
|
|
KR101132413B1
(ko)
*
|
2009-05-06 |
2012-04-03 |
서울대학교산학협력단 |
Sars 백신 나노전달체
|
|
WO2010132879A2
(en)
|
2009-05-15 |
2010-11-18 |
The Johns Hopkins University |
Multicomponent degradable cationic polymers
|
|
CN101585921B
(zh)
*
|
2009-06-18 |
2010-12-01 |
天津大学 |
温度敏感聚乙烯亚胺-接枝-聚丙烯酸寡乙二醇酯嵌段共聚物及制备方法和应用
|
|
CN102575204B
(zh)
*
|
2009-10-23 |
2015-02-25 |
荷兰联合利华有限公司 |
染料聚合物
|
|
CN101812178B
(zh)
*
|
2010-04-20 |
2012-07-04 |
武汉大学 |
还原敏感性聚乙烯亚胺衍生物及其制备方法和应用
|
|
RU2012147538A
(ru)
|
2010-05-14 |
2014-06-20 |
3Е Сан Продактс Корпорейшн |
Полимерсодержащие очищающие композиции и способы их получения и применения
|
|
RU2013103347A
(ru)
*
|
2010-06-25 |
2014-07-27 |
Торэй Индастриз, Инк. |
Водорастворимый полимер и водорастворимый комплекс наночастиц
|
|
WO2012019168A2
(en)
|
2010-08-06 |
2012-02-09 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
RU2013120302A
(ru)
|
2010-10-01 |
2014-11-20 |
Модерна Терапьютикс, Инк. |
Сконструированные нуклеиновые кислоты и способы их применения
|
|
CN102174184B
(zh)
*
|
2011-01-14 |
2012-11-21 |
中国科学院广州生物医药与健康研究院 |
一种生物可降解的聚合物及其制备方法以及核酸药物运输载体
|
|
EP2691101A2
(en)
|
2011-03-31 |
2014-02-05 |
Moderna Therapeutics, Inc. |
Delivery and formulation of engineered nucleic acids
|
|
US9464124B2
(en)
|
2011-09-12 |
2016-10-11 |
Moderna Therapeutics, Inc. |
Engineered nucleic acids and methods of use thereof
|
|
US20130071444A1
(en)
|
2011-09-16 |
2013-03-21 |
The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Healthcare System |
Amphiphilic Cationic Polymers and Methods of Use Thereof
|
|
RU2648950C2
(ru)
|
2011-10-03 |
2018-04-02 |
Модерна Терапьютикс, Инк. |
Модифицированные нуклеозиды, нуклеотиды и нуклеиновые кислоты и их применение
|
|
CN104114572A
(zh)
|
2011-12-16 |
2014-10-22 |
现代治疗公司 |
经修饰的核苷、核苷酸和核酸组合物
|
|
US9283287B2
(en)
|
2012-04-02 |
2016-03-15 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of nuclear proteins
|
|
US9572897B2
(en)
|
2012-04-02 |
2017-02-21 |
Modernatx, Inc. |
Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins
|
|
CA2868391A1
(en)
|
2012-04-02 |
2013-10-10 |
Stephane Bancel |
Polynucleotides comprising n1-methyl-pseudouridine and methods for preparing the same
|
|
US9254311B2
(en)
|
2012-04-02 |
2016-02-09 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins
|
|
AU2013243948A1
(en)
|
2012-04-02 |
2014-10-30 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of proteins associated with human disease
|
|
CA2820236C
(en)
|
2012-06-15 |
2022-07-19 |
The Royal Institution For The Advancement Of Learning/Mcgill University |
Non-viral nanoparticle-based delivery system
|
|
CA2881582A1
(en)
|
2012-08-03 |
2014-02-06 |
Cedars-Sinai Medical Center |
Isolating traffic-enhancing mutants of drug delivery protein
|
|
CN103305549B
(zh)
*
|
2013-06-19 |
2015-04-22 |
四川大学 |
具有多重氧化还原刺激响应的纳米粒子基因载体系统及其制备方法和应用
|
|
WO2014056414A1
(zh)
|
2012-10-10 |
2014-04-17 |
四川大学 |
一种还原刺激响应型基因载体系统及其制备和应用
|
|
KR101452819B1
(ko)
|
2012-11-01 |
2014-10-23 |
국립암센터 |
환원제 반응형 이황화물 연결자 함유 고분자-광감각제 결합체 및 이를 포함하는 형광 영상 진단 및 광역학 치료용 조성물
|
|
WO2014081507A1
(en)
|
2012-11-26 |
2014-05-30 |
Moderna Therapeutics, Inc. |
Terminally modified rna
|
|
US20140200261A1
(en)
|
2013-01-17 |
2014-07-17 |
Moderna Therapeutics, Inc. |
Signal-sensor polynucleotides for the alteration of cellular phenotypes
|
|
EP2968391A1
(en)
|
2013-03-13 |
2016-01-20 |
Moderna Therapeutics, Inc. |
Long-lived polynucleotide molecules
|
|
EP2971010B1
(en)
|
2013-03-14 |
2020-06-10 |
ModernaTX, Inc. |
Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions
|
|
US8980864B2
(en)
|
2013-03-15 |
2015-03-17 |
Moderna Therapeutics, Inc. |
Compositions and methods of altering cholesterol levels
|
|
SMT202100691T1
(it)
|
2013-07-11 |
2022-01-10 |
Modernatx Inc |
Composizioni 5 comprendenti polinucleotidi sintetici che codificano proteine correlate a crispr e sgrna sintetici e metodi d'uso
|
|
US20160194368A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Circular polynucleotides
|
|
US20160194625A1
(en)
|
2013-09-03 |
2016-07-07 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
JP2016538829A
(ja)
|
2013-10-03 |
2016-12-15 |
モデルナ セラピューティクス インコーポレイテッドModerna Therapeutics,Inc. |
低密度リポタンパク質受容体をコードするポリヌクレオチド
|
|
CN106061466A
(zh)
|
2013-12-19 |
2016-10-26 |
诺华股份有限公司 |
瘦蛋白mRNA组合物和制剂
|
|
EP3096773B1
(en)
|
2014-01-17 |
2020-07-01 |
Cedars-Sinai Medical Center |
Receptor targeting constructs and uses thereof
|
|
US9850293B2
(en)
|
2014-04-04 |
2017-12-26 |
Cedars-Sinai Medical Center |
Targeting trastuzumab-resistant HER2+ breast cancer with a HER3-targeting nanoparticle
|
|
CN104109248B
(zh)
*
|
2014-06-20 |
2017-02-01 |
南开大学 |
基于桥式双环糊精主客体诱导聚集构筑的聚集体及其应用
|
|
EP3169693B1
(en)
|
2014-07-16 |
2022-03-09 |
ModernaTX, Inc. |
Chimeric polynucleotides
|
|
WO2016014846A1
(en)
|
2014-07-23 |
2016-01-28 |
Moderna Therapeutics, Inc. |
Modified polynucleotides for the production of intrabodies
|
|
CN104356395B
(zh)
*
|
2014-11-12 |
2016-08-17 |
苏州大学 |
一种阳离子化丝素蛋白、制备方法及其应用
|
|
WO2016077625A1
(en)
*
|
2014-11-12 |
2016-05-19 |
Stayton Patrick S |
Stabilized polymeric carriers for therapeutic agent delivery
|
|
CN105012957B
(zh)
*
|
2015-07-03 |
2019-03-22 |
上海交通大学 |
一种交联型聚乙烯亚胺作为肿瘤蛋白抗原疫苗载体的用途
|
|
US20180256730A1
(en)
*
|
2015-09-16 |
2018-09-13 |
University Of Utah Research Foundation |
A polymeric carrier for delivery of a payload to a cell
|
|
DE102017003004A1
(de)
*
|
2017-03-23 |
2018-09-27 |
Friedrich-Schiller-Universität Jena |
Kationische Polymere mit D-Fructose-Substituenten
|
|
JP7285220B2
(ja)
|
2017-05-18 |
2023-06-01 |
モデルナティエックス インコーポレイテッド |
連結したインターロイキン-12(il12)ポリペプチドをコードするポリヌクレオチドを含む脂質ナノ粒子
|
|
WO2018213789A1
(en)
|
2017-05-18 |
2018-11-22 |
Modernatx, Inc. |
Modified messenger rna comprising functional rna elements
|
|
EP3638292A1
(en)
|
2017-06-14 |
2020-04-22 |
ModernaTX, Inc. |
Polynucleotides encoding coagulation factor viii
|
|
WO2019048645A1
(en)
|
2017-09-08 |
2019-03-14 |
Mina Therapeutics Limited |
STABILIZED COMPOSITIONS OF SMALL ACTIVATOR RNA (PARNA) FROM CEBPA AND METHODS OF USE
|
|
JP7423521B2
(ja)
|
2017-11-22 |
2024-01-29 |
モダーナティエックス・インコーポレイテッド |
フェニルケトン尿症の治療用のフェニルアラニンヒドロキシラーゼをコードするポリヌクレオチド
|
|
EP3714048B1
(en)
|
2017-11-22 |
2025-04-09 |
ModernaTX, Inc. |
Polynucleotides encoding ornithine transcarbamylase for the treatment of urea cycle disorders
|
|
US20220265856A1
(en)
|
2017-11-22 |
2022-08-25 |
Modernatx, Inc. |
Polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits for the treatment of propionic acidemia
|
|
MA51523A
(fr)
|
2018-01-05 |
2020-11-11 |
Modernatx Inc |
Polynucléotides codant pour des anticorps anti-virus du chikungunya
|
|
WO2019165583A1
(zh)
*
|
2018-02-27 |
2019-09-06 |
苏州大学张家港工业技术研究院 |
一种可逆自修复环氧树脂及其制备与回收重塑方法
|
|
EP3775211B1
(en)
|
2018-04-12 |
2023-04-05 |
MiNA Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
|
US20210148918A1
(en)
*
|
2018-04-17 |
2021-05-20 |
Purdue Research Foundation |
Modifying surface of a live cell and the uses thereof
|
|
KR101992236B1
(ko)
|
2018-05-16 |
2019-06-24 |
가톨릭대학교 산학협력단 |
디셀레노디프로피오네이트의 양 말단에 폴리(입실론-카프로락톤)이 공유결합된 환원분해성 폴리(입실론-카프로락톤) 고분자, 이를 포함하는 항암용 조성물 및 약물 전달용 조성물
|
|
WO2019226650A1
(en)
|
2018-05-23 |
2019-11-28 |
Modernatx, Inc. |
Delivery of dna
|
|
US20220184185A1
(en)
|
2018-07-25 |
2022-06-16 |
Modernatx, Inc. |
Mrna based enzyme replacement therapy combined with a pharmacological chaperone for the treatment of lysosomal storage disorders
|
|
EP3833762A4
(en)
|
2018-08-09 |
2022-09-28 |
Verseau Therapeutics, Inc. |
Oligonucleotide compositions for targeting ccr2 and csf1r and uses thereof
|
|
CN110859969B
(zh)
*
|
2018-08-28 |
2022-01-11 |
上海市第十人民医院 |
聚乙烯亚胺修饰的荧光素钠造影剂及其制备方法和应用
|
|
WO2020047201A1
(en)
|
2018-09-02 |
2020-03-05 |
Modernatx, Inc. |
Polynucleotides encoding very long-chain acyl-coa dehydrogenase for the treatment of very long-chain acyl-coa dehydrogenase deficiency
|
|
WO2020056147A2
(en)
|
2018-09-13 |
2020-03-19 |
Modernatx, Inc. |
Polynucleotides encoding glucose-6-phosphatase for the treatment of glycogen storage disease
|
|
US20220243182A1
(en)
|
2018-09-13 |
2022-08-04 |
Modernatx, Inc. |
Polynucleotides encoding branched-chain alpha-ketoacid dehydrogenase complex e1-alpha, e1-beta, and e2 subunits for the treatment of maple syrup urine disease
|
|
WO2020056239A1
(en)
|
2018-09-14 |
2020-03-19 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
|
EP3856233A1
(en)
|
2018-09-27 |
2021-08-04 |
Modernatx, Inc. |
Polynucleotides encoding arginase 1 for the treatment of arginase deficiency
|
|
EP3953473A1
(en)
|
2019-04-12 |
2022-02-16 |
MiNA Therapeutics Limited |
Sirt1-sarna compositions and methods of use
|
|
JP2022532078A
(ja)
|
2019-05-08 |
2022-07-13 |
アストラゼネカ アクチボラグ |
皮膚及び創傷のための組成物並びにその使用の方法
|
|
US20230000990A1
(en)
*
|
2019-12-17 |
2023-01-05 |
Universiteit Gent |
Non-viral vectors comprising polypropyleneimine
|
|
US20230235298A1
(en)
|
2020-06-01 |
2023-07-27 |
Modernatx, Inc. |
Phenylalanine hydroxylase variants and uses thereof
|
|
AU2021377895A1
(en)
|
2020-11-13 |
2023-06-15 |
Modernatx, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
WO2022204370A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles and polynucleotides encoding ornithine transcarbamylase for the treatment of ornithine transcarbamylase deficiency
|
|
WO2022204371A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding glucose-6-phosphatase and uses thereof
|
|
US20240207444A1
(en)
|
2021-03-24 |
2024-06-27 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding phenylalanine hydroxylase and uses thereof
|
|
US20240216288A1
(en)
|
2021-03-24 |
2024-07-04 |
Modernatx, Inc. |
Lipid nanoparticles containing polynucleotides encoding propionyl-coa carboxylase alpha and beta subunits and uses thereof
|
|
WO2022204369A1
(en)
|
2021-03-24 |
2022-09-29 |
Modernatx, Inc. |
Polynucleotides encoding methylmalonyl-coa mutase for the treatment of methylmalonic acidemia
|
|
EP4314292A1
(en)
|
2021-03-26 |
2024-02-07 |
MiNA Therapeutics Limited |
Tmem173 sarna compositions and methods of use
|
|
EP4355882A2
(en)
|
2021-06-15 |
2024-04-24 |
Modernatx, Inc. |
Engineered polynucleotides for cell-type or microenvironment-specific expression
|
|
WO2022271776A1
(en)
|
2021-06-22 |
2022-12-29 |
Modernatx, Inc. |
Polynucleotides encoding uridine diphosphate glycosyltransferase 1 family, polypeptide a1 for the treatment of crigler-najjar syndrome
|
|
US20250017867A1
(en)
|
2021-10-01 |
2025-01-16 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of fibrosis and/or cardiovascular disease
|
|
WO2023099884A1
(en)
|
2021-12-01 |
2023-06-08 |
Mina Therapeutics Limited |
Pax6 sarna compositions and methods of use
|
|
WO2023170435A1
(en)
|
2022-03-07 |
2023-09-14 |
Mina Therapeutics Limited |
Il10 sarna compositions and methods of use
|
|
WO2023183909A2
(en)
|
2022-03-25 |
2023-09-28 |
Modernatx, Inc. |
Polynucleotides encoding fanconi anemia, complementation group proteins for the treatment of fanconi anemia
|
|
CN114920859B
(zh)
*
|
2022-05-11 |
2023-09-26 |
宁夏医科大学总医院 |
5-氟尿嘧啶-1-丁酰基-β-环糊精第二面衍生物及制备方法及其应用
|
|
US20260035707A1
(en)
|
2022-07-26 |
2026-02-05 |
Modernatx, Inc. |
Engineered polynucleotides for temporal control of expression
|
|
WO2024103225A1
(zh)
*
|
2022-11-14 |
2024-05-23 |
林桂孜 |
一种阳离子聚酯及其制备方法和应用
|
|
WO2024125597A1
(en)
|
2022-12-14 |
2024-06-20 |
Providence Therapeutics Holdings Inc. |
Compositions and methods for infectious diseases
|
|
WO2024134199A1
(en)
|
2022-12-22 |
2024-06-27 |
Mina Therapeutics Limited |
Chemically modified sarna compositions and methods of use
|
|
WO2024197033A1
(en)
|
2023-03-21 |
2024-09-26 |
Modernatx, Inc. |
Polynucleotides encoding relaxin for the treatment of heart failure
|
|
EP4704816A1
(en)
|
2023-05-03 |
2026-03-11 |
ModernaTX, Inc. |
Polynucleotides encoding cystic fibrosis transmembrane conductance regulator for the treatment of cystic fibrosis
|
|
WO2025072482A1
(en)
|
2023-09-27 |
2025-04-03 |
Modernatx, Inc. |
Immunoglobulin a protease polypeptides, polynucleotides, and uses thereof
|
|
WO2025255199A1
(en)
|
2024-06-05 |
2025-12-11 |
Modernatx, Inc. |
Argininosuccinate synthase 1 and argininosuccinate lyase polypeptides and polynucleotides and uses thereof
|
|
CN119192568A
(zh)
*
|
2024-10-11 |
2024-12-27 |
湖北中烟工业有限责任公司 |
还原敏感型超分子基因载体、其制备方法及应用
|