JP2005529870A5 - - Google Patents
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- JP2005529870A5 JP2005529870A5 JP2003583402A JP2003583402A JP2005529870A5 JP 2005529870 A5 JP2005529870 A5 JP 2005529870A5 JP 2003583402 A JP2003583402 A JP 2003583402A JP 2003583402 A JP2003583402 A JP 2003583402A JP 2005529870 A5 JP2005529870 A5 JP 2005529870A5
- Authority
- JP
- Japan
- Prior art keywords
- kda
- polymer
- molecular weight
- range
- molecular
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US37179102P | 2002-04-11 | 2002-04-11 | |
| US41470502P | 2002-09-30 | 2002-09-30 | |
| PCT/US2003/010976 WO2003086382A1 (en) | 2002-04-11 | 2003-04-10 | Tnp-470 polymer conjugates and use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005529870A JP2005529870A (ja) | 2005-10-06 |
| JP2005529870A5 true JP2005529870A5 (https=) | 2006-04-13 |
| JP4514455B2 JP4514455B2 (ja) | 2010-07-28 |
Family
ID=29254460
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003583402A Expired - Fee Related JP4514455B2 (ja) | 2002-04-11 | 2003-04-10 | Ｔｎｐ−４７０ポリマー複合体及びその使用 |
Country Status (7)
| Country | Link |
|---|---|
| US (5) | US7332523B2 (https=) |
| EP (1) | EP1494662B1 (https=) |
| JP (1) | JP4514455B2 (https=) |
| AU (2) | AU2003230852B2 (https=) |
| CA (1) | CA2480666C (https=) |
| ES (1) | ES2398381T3 (https=) |
| WO (1) | WO2003086382A1 (https=) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030100605A1 (en) * | 2001-05-15 | 2003-05-29 | Grupp Stephan A. | Methods of treating cancer with angiogenesis inhibitors |
| AU2003226349B2 (en) * | 2002-04-11 | 2008-01-31 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| AU2003230852B2 (en) * | 2002-04-11 | 2008-07-10 | Children's Medical Center Corporation | TNP-470 polymer conjugates and use thereof |
| WO2006084054A2 (en) * | 2005-02-02 | 2006-08-10 | Children's Medical Center Corporation | Method of treating angiogenic diseases |
| NZ560712A (en) * | 2005-02-17 | 2010-12-24 | Synta Pharmaceuticals Corp | (3,4,5-trisubstituted-phenyl)isoxazole combretastin derivatives for the treatment of disorders |
| EP2170402B1 (en) | 2007-06-26 | 2015-03-25 | Children's Medical Center Corporation | Metap-2 inhibitor polymersomes for therapeutic administration |
| WO2009036108A1 (en) * | 2007-09-13 | 2009-03-19 | Children's Medical Center Corporation | Methods and compositions for inhibiting vascular leakage |
| EP2209420A4 (en) | 2007-10-09 | 2014-01-22 | Univ St Louis | PARTICULARS FOR IMAGING |
| US9468607B2 (en) | 2007-10-09 | 2016-10-18 | Washington University | Ligand directed toroidal nanoparticles for therapy and diagnostic imaging |
| EP2217283A2 (en) * | 2007-11-28 | 2010-08-18 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
| WO2009141826A2 (en) | 2008-05-22 | 2009-11-26 | Ramot At Tel Aviv University Ltd. | Novel conjugates of polymers having a therapeutically active agent and an angiogenesis targeting moiety attached thereto and uses thereof in the treatment of angiogenesis related diseases |
| CN102105157B (zh) * | 2008-05-22 | 2015-09-30 | 特拉维夫大学拉莫特有限公司 | 聚合物、抗血管生成剂和靶向部分的缀合物及其在制备用于治疗骨相关血管生成状况的药物中的用途 |
| EP2303288A4 (en) | 2008-05-22 | 2015-04-22 | Univ Ramot | CONJUGATES OF A POLYMER, A BISPHOSPHONATE AND AN ANTI-ANGIOGENESE MEDIUM AND ITS USE IN THE TREATMENT AND CONTROL OF ILLNESSES RELATED TO BONE |
| US8715685B2 (en) * | 2009-07-14 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides and their polymer conjugates for HIV disease |
| US8715986B2 (en) * | 2009-10-29 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides, ligand-targeted multi- stereoisomer peptide polymer conjugates, and uses thereof |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| JP2013514999A (ja) | 2009-12-17 | 2013-05-02 | ワシントン・ユニバーシティ | 抗血栓性ナノ粒子 |
| AU2011239414A1 (en) | 2010-04-15 | 2012-11-08 | The Washington University | Prodrug compositions, prodrug nanoparticles, and methods of use thereof |
| US20110294952A1 (en) * | 2010-05-25 | 2011-12-01 | SynDevRX | Optimized Drug Conjugates |
| DK2576638T3 (da) * | 2010-05-25 | 2021-03-15 | Syndevrx Inc | Polymerkonjugerede metap2-inhibitorer og terapeutiske fremgangsmåder til anvendelse deraf |
| US9895449B2 (en) * | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
| IN2014MN01819A (https=) | 2012-03-05 | 2015-07-03 | Univ Ramot | |
| CN105431426A (zh) | 2013-04-10 | 2016-03-23 | 新德发制药有限公司 | Metap2抑制剂和治疗肥胖症的方法 |
| US9954366B2 (en) | 2013-07-11 | 2018-04-24 | General Electric Company | Grid power factor control system |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| US9969722B2 (en) | 2015-12-10 | 2018-05-15 | Syndevrx, Inc. | Fumagillol derivatives and polymorphs thereof |
| CN108697807B (zh) | 2016-01-11 | 2021-11-26 | 辛德弗雷克斯公司 | 代谢功能障碍引起的肿瘤的治疗 |
| MX2020005836A (es) | 2017-12-06 | 2020-08-20 | Genentech Inc | Controles sinteticos para inmunohistoquimica. |
| CN113453721B (zh) | 2018-10-26 | 2025-09-16 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
| US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| KR0138530B1 (ko) | 1988-09-01 | 1998-05-15 | 우메모또 요시마사 | 푸마길롤 유도체 |
| US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| EP0889041B1 (en) | 1996-03-06 | 2002-07-24 | TSUMURA & CO. | Novel iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| US6225478B1 (en) | 1997-03-05 | 2001-05-01 | Tsumura & Co. | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| WO2001036002A1 (en) * | 1999-11-17 | 2001-05-25 | School Of Pharmacy, University Of London | Conjugates of hpma copolymer and ellipticin |
| AU2001274587A1 (en) * | 2000-06-22 | 2002-01-02 | Takeda Chemical Industries Ltd. | Polymer-containing drug composition |
| JP2004508411A (ja) * | 2000-09-13 | 2004-03-18 | プラエシス ファーマシューティカルズ インコーポレーテッド | 持続的薬物送達のための医薬組成物 |
| US6919307B2 (en) * | 2000-11-01 | 2005-07-19 | Praecis Pharmaceuticals, Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| US6548477B1 (en) * | 2000-11-01 | 2003-04-15 | Praecis Pharmaceuticals Inc. | Therapeutic agents and methods of use thereof for the modulation of angiogenesis |
| BR0115109A (pt) * | 2000-11-01 | 2005-10-18 | Praecis Pharm Inc | Agentes terapêuticos e métodos de uso dos mesmos para a modulação da angiogênese |
| US6858580B2 (en) | 2001-06-04 | 2005-02-22 | Nobex Corporation | Mixtures of drug-oligomer conjugates comprising polyalkylene glycol, uses thereof, and methods of making same |
| AU2003226349B2 (en) * | 2002-04-11 | 2008-01-31 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| AU2003230852B2 (en) * | 2002-04-11 | 2008-07-10 | Children's Medical Center Corporation | TNP-470 polymer conjugates and use thereof |
| WO2005066197A2 (en) * | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
-
2003
- 2003-04-10 AU AU2003230852A patent/AU2003230852B2/en not_active Ceased
- 2003-04-10 WO PCT/US2003/010976 patent/WO2003086382A1/en not_active Ceased
- 2003-04-10 EP EP03723958A patent/EP1494662B1/en not_active Expired - Lifetime
- 2003-04-10 ES ES03723958T patent/ES2398381T3/es not_active Expired - Lifetime
- 2003-04-10 US US10/511,009 patent/US7332523B2/en not_active Expired - Lifetime
- 2003-04-10 CA CA2480666A patent/CA2480666C/en not_active Expired - Lifetime
- 2003-04-10 JP JP2003583402A patent/JP4514455B2/ja not_active Expired - Fee Related
-
2004
- 2004-02-19 US US10/783,986 patent/US6949584B2/en not_active Expired - Lifetime
-
2005
- 2005-07-20 US US11/185,538 patent/US20060020024A1/en not_active Abandoned
-
2007
- 2007-12-18 US US11/958,688 patent/US20080112919A1/en not_active Abandoned
-
2008
- 2008-10-09 AU AU2008229857A patent/AU2008229857A1/en not_active Abandoned
- 2008-12-02 US US12/326,134 patent/US20090176874A1/en not_active Abandoned
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