CA2480666C - Tnp-470 polymer conjugates and use thereof - Google Patents
Tnp-470 polymer conjugates and use thereof Download PDFInfo
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- CA2480666C CA2480666C CA2480666A CA2480666A CA2480666C CA 2480666 C CA2480666 C CA 2480666C CA 2480666 A CA2480666 A CA 2480666A CA 2480666 A CA2480666 A CA 2480666A CA 2480666 C CA2480666 C CA 2480666C
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- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
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- C07D303/18—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by etherified hydroxyl radicals
- C07D303/20—Ethers with hydroxy compounds containing no oxirane rings
- C07D303/22—Ethers with hydroxy compounds containing no oxirane rings with monohydroxy compounds
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
- C08F220/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and only one being terminated by only one carboxyl radical or a salt, anhydride ester, amide, imide or nitrile thereof
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
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- C08F220/02—Monocarboxylic acids having less than ten carbon atoms; Derivatives thereof
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| WO2009036108A1 (en) * | 2007-09-13 | 2009-03-19 | Children's Medical Center Corporation | Methods and compositions for inhibiting vascular leakage |
| EP2209420A4 (en) | 2007-10-09 | 2014-01-22 | Univ St Louis | PARTICULARS FOR IMAGING |
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| EP2217283A2 (en) * | 2007-11-28 | 2010-08-18 | Mersana Therapeutics, Inc. | Biocompatible biodegradable fumagillin analog conjugates |
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| CN102105157B (zh) * | 2008-05-22 | 2015-09-30 | 特拉维夫大学拉莫特有限公司 | 聚合物、抗血管生成剂和靶向部分的缀合物及其在制备用于治疗骨相关血管生成状况的药物中的用途 |
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| US8715986B2 (en) * | 2009-10-29 | 2014-05-06 | Lucia Irene Gonzalez | Stereoisomer peptides, ligand-targeted multi- stereoisomer peptide polymer conjugates, and uses thereof |
| US9808500B2 (en) | 2009-12-17 | 2017-11-07 | Washington University | Antithrombotic nanoparticle |
| JP2013514999A (ja) | 2009-12-17 | 2013-05-02 | ワシントン・ユニバーシティ | 抗血栓性ナノ粒子 |
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| US20110294952A1 (en) * | 2010-05-25 | 2011-12-01 | SynDevRX | Optimized Drug Conjugates |
| DK2576638T3 (da) * | 2010-05-25 | 2021-03-15 | Syndevrx Inc | Polymerkonjugerede metap2-inhibitorer og terapeutiske fremgangsmåder til anvendelse deraf |
| US9895449B2 (en) * | 2010-05-25 | 2018-02-20 | Syndevrx, Inc. | Polymer-conjugated MetAP2 inhibitors, and therapeutic methods of use thereof |
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| CN105431426A (zh) | 2013-04-10 | 2016-03-23 | 新德发制药有限公司 | Metap2抑制剂和治疗肥胖症的方法 |
| US9954366B2 (en) | 2013-07-11 | 2018-04-24 | General Electric Company | Grid power factor control system |
| TW201636342A (zh) | 2014-12-19 | 2016-10-16 | 武田藥品工業有限公司 | 煙黴醇衍生物 |
| US9969722B2 (en) | 2015-12-10 | 2018-05-15 | Syndevrx, Inc. | Fumagillol derivatives and polymorphs thereof |
| CN108697807B (zh) | 2016-01-11 | 2021-11-26 | 辛德弗雷克斯公司 | 代谢功能障碍引起的肿瘤的治疗 |
| MX2020005836A (es) | 2017-12-06 | 2020-08-20 | Genentech Inc | Controles sinteticos para inmunohistoquimica. |
| CN113453721B (zh) | 2018-10-26 | 2025-09-16 | 辛德弗雷克斯公司 | Metap2抑制剂的生物标志物及其应用 |
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| GB8500209D0 (en) | 1985-01-04 | 1985-02-13 | Ceskoslovenska Akademie Ved | Synthetic polymeric drugs |
| US5164410A (en) | 1988-01-09 | 1992-11-17 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
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| US5180738A (en) | 1988-09-01 | 1993-01-19 | Takeda Chemical Industries | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5166172A (en) | 1988-09-01 | 1992-11-24 | Takeda Chemical Industries, Ltd. | Fumagillol derivatives and pharmaceutical compositions thereof |
| US5290807A (en) | 1989-08-10 | 1994-03-01 | Children's Medical Center Corporation | Method for regressing angiogenesis using o-substituted fumagillol derivatives |
| US6017954A (en) | 1989-08-10 | 2000-01-25 | Children's Medical Center Corp. | Method of treating tumors using O-substituted fumagillol derivatives |
| EP0415294A3 (en) | 1989-08-31 | 1991-06-12 | Takeda Chemical Industries, Ltd. | Cyclohexanol derivatives, production and use thereof |
| EP0889041B1 (en) | 1996-03-06 | 2002-07-24 | TSUMURA & CO. | Novel iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| US6225478B1 (en) | 1997-03-05 | 2001-05-01 | Tsumura & Co. | Iridoid derivatives and neovascularization inhibitors containing the same as active ingredient |
| WO2001036002A1 (en) * | 1999-11-17 | 2001-05-25 | School Of Pharmacy, University Of London | Conjugates of hpma copolymer and ellipticin |
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| AU2003226349B2 (en) * | 2002-04-11 | 2008-01-31 | Children's Medical Center Corporation | Methods for inhibiting vascular hyperpermeability |
| AU2003230852B2 (en) * | 2002-04-11 | 2008-07-10 | Children's Medical Center Corporation | TNP-470 polymer conjugates and use thereof |
| WO2005066197A2 (en) * | 2003-12-29 | 2005-07-21 | Praecis Pharmaceuticals, Inc. | Inhibitors of methionine aminopeptidase-2 and uses thereof |
-
2003
- 2003-04-10 AU AU2003230852A patent/AU2003230852B2/en not_active Ceased
- 2003-04-10 WO PCT/US2003/010976 patent/WO2003086382A1/en not_active Ceased
- 2003-04-10 EP EP03723958A patent/EP1494662B1/en not_active Expired - Lifetime
- 2003-04-10 ES ES03723958T patent/ES2398381T3/es not_active Expired - Lifetime
- 2003-04-10 US US10/511,009 patent/US7332523B2/en not_active Expired - Lifetime
- 2003-04-10 CA CA2480666A patent/CA2480666C/en not_active Expired - Lifetime
- 2003-04-10 JP JP2003583402A patent/JP4514455B2/ja not_active Expired - Fee Related
-
2004
- 2004-02-19 US US10/783,986 patent/US6949584B2/en not_active Expired - Lifetime
-
2005
- 2005-07-20 US US11/185,538 patent/US20060020024A1/en not_active Abandoned
-
2007
- 2007-12-18 US US11/958,688 patent/US20080112919A1/en not_active Abandoned
-
2008
- 2008-10-09 AU AU2008229857A patent/AU2008229857A1/en not_active Abandoned
- 2008-12-02 US US12/326,134 patent/US20090176874A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005529870A (ja) | 2005-10-06 |
| EP1494662A1 (en) | 2005-01-12 |
| US20060020024A1 (en) | 2006-01-26 |
| ES2398381T3 (es) | 2013-03-15 |
| AU2008229857A1 (en) | 2008-10-30 |
| AU2003230852B2 (en) | 2008-07-10 |
| EP1494662B1 (en) | 2012-11-28 |
| WO2003086382A1 (en) | 2003-10-23 |
| JP4514455B2 (ja) | 2010-07-28 |
| AU2003230852A1 (en) | 2003-10-27 |
| EP1494662A4 (en) | 2006-07-19 |
| US20050169881A1 (en) | 2005-08-04 |
| US7332523B2 (en) | 2008-02-19 |
| US20080112919A1 (en) | 2008-05-15 |
| US6949584B2 (en) | 2005-09-27 |
| US20040229945A1 (en) | 2004-11-18 |
| CA2480666A1 (en) | 2003-10-23 |
| US20090176874A1 (en) | 2009-07-09 |
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