JP2008518912A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008518912A5 JP2008518912A5 JP2007539053A JP2007539053A JP2008518912A5 JP 2008518912 A5 JP2008518912 A5 JP 2008518912A5 JP 2007539053 A JP2007539053 A JP 2007539053A JP 2007539053 A JP2007539053 A JP 2007539053A JP 2008518912 A5 JP2008518912 A5 JP 2008518912A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- piperazine
- sulfonyl
- carboxylic acid
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1(*)*C(C)(*)C*C1 Chemical compound CC1(*)*C(C)(*)C*C1 0.000 description 4
- HQHXPNTVFJCLNC-UHFFFAOYSA-N CC(C1)(Cc2c1cccc2)C(OC)=O Chemical compound CC(C1)(Cc2c1cccc2)C(OC)=O HQHXPNTVFJCLNC-UHFFFAOYSA-N 0.000 description 1
- XJWNCJRCHRYOBH-UHFFFAOYSA-N COC(C[n](ccc1c2)c1ccc2S(N(CC1)CCN1c1ccc(C(F)(F)F)cc1)(=O)=O)=O Chemical compound COC(C[n](ccc1c2)c1ccc2S(N(CC1)CCN1c1ccc(C(F)(F)F)cc1)(=O)=O)=O XJWNCJRCHRYOBH-UHFFFAOYSA-N 0.000 description 1
- KCCIMPCWFQONCQ-WLLUQGSSSA-N C[C@@H]([C@@H](C)N(CC1)/S(/c(cc2)cc3c2[s]cc3CC(O)=O)=C(/C)\O)N1c1ccc(C(F)(F)F)cn1 Chemical compound C[C@@H]([C@@H](C)N(CC1)/S(/c(cc2)cc3c2[s]cc3CC(O)=O)=C(/C)\O)N1c1ccc(C(F)(F)F)cn1 KCCIMPCWFQONCQ-WLLUQGSSSA-N 0.000 description 1
- IHSHHMUCAAABTK-QSVWIEALSA-N C[C@H](CN(CC1=C)c2ccc(C(C)(C)C)cc2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(CC1=C)c2ccc(C(C)(C)C)cc2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O IHSHHMUCAAABTK-QSVWIEALSA-N 0.000 description 1
- WKSXKTVBEURKJS-UUVAVEHKSA-N C[C@H](CN(C[C@@H]1C)c(c(Cl)c2)ccc2Cl)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c(c(Cl)c2)ccc2Cl)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O WKSXKTVBEURKJS-UUVAVEHKSA-N 0.000 description 1
- NRNHHHKZLQZYIO-MZBDJJRSSA-N C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(Cl)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(Cl)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O NRNHHHKZLQZYIO-MZBDJJRSSA-N 0.000 description 1
- VWEXFHTYXNUVEM-MZBDJJRSSA-N C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(F)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(F)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O VWEXFHTYXNUVEM-MZBDJJRSSA-N 0.000 description 1
- OCISQZLPSOHDDN-UUVAVEHKSA-N C[C@H](CN(C[C@@H]1C)c2ncc(C(F)(F)F)cc2)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ncc(C(F)(F)F)cc2)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O OCISQZLPSOHDDN-UUVAVEHKSA-N 0.000 description 1
- MDZAJWMNGMESHJ-MRXNPFEDSA-N C[C@H](CN(Cc(cc1)ccc1OC(F)(F)F)CC1=C)N1Sc(cc1)cc2c1[s]cc2CC(O)=O Chemical compound C[C@H](CN(Cc(cc1)ccc1OC(F)(F)F)CC1=C)N1Sc(cc1)cc2c1[s]cc2CC(O)=O MDZAJWMNGMESHJ-MRXNPFEDSA-N 0.000 description 1
- NYEPCYLVJPAFNE-MCPYQZEQSA-N C[C@H](CN(Cc1ccc(C(F)(F)F)cc1)C[C@@H]1C)N1S(c1c(CC(C2)C(O)=O)c2ccc1)(=O)=O Chemical compound C[C@H](CN(Cc1ccc(C(F)(F)F)cc1)C[C@@H]1C)N1S(c1c(CC(C2)C(O)=O)c2ccc1)(=O)=O NYEPCYLVJPAFNE-MCPYQZEQSA-N 0.000 description 1
- YDSABVFETOCXQR-UHFFFAOYSA-N Cc1cc(N)ccc1OC(F)F Chemical compound Cc1cc(N)ccc1OC(F)F YDSABVFETOCXQR-UHFFFAOYSA-N 0.000 description 1
- WRNXOOXIPSTAGJ-UHFFFAOYSA-N Cc1cc(OC(F)(F)F)ccc1 Chemical compound Cc1cc(OC(F)(F)F)ccc1 WRNXOOXIPSTAGJ-UHFFFAOYSA-N 0.000 description 1
- GTCFYVRPJAXCSZ-UHFFFAOYSA-N OC(C(Cc1ccc2)Cc1c2S(N(CC1)CCN1c1cccc(OCC(F)(F)F)c1)(=O)=O)=O Chemical compound OC(C(Cc1ccc2)Cc1c2S(N(CC1)CCN1c1cccc(OCC(F)(F)F)c1)(=O)=O)=O GTCFYVRPJAXCSZ-UHFFFAOYSA-N 0.000 description 1
- ZVBOVRZGOAXEHZ-UHFFFAOYSA-N OC(C1Cc2cc(S(N(CC3)CC=C3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2C1)=O Chemical compound OC(C1Cc2cc(S(N(CC3)CC=C3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2C1)=O ZVBOVRZGOAXEHZ-UHFFFAOYSA-N 0.000 description 1
- JEMYWYFOHSPFNM-UHFFFAOYSA-N OC(C[n]1c2cc(S(N(CC3)CCN3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2cc1)O Chemical compound OC(C[n]1c2cc(S(N(CC3)CCN3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2cc1)O JEMYWYFOHSPFNM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62325204P | 2004-10-29 | 2004-10-29 | |
| US60/623,252 | 2004-10-29 | ||
| US67981305P | 2005-05-11 | 2005-05-11 | |
| US60/679,813 | 2005-05-11 | ||
| PCT/US2005/038418 WO2006055187A1 (en) | 2004-10-29 | 2005-10-25 | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518912A JP2008518912A (ja) | 2008-06-05 |
| JP2008518912A5 true JP2008518912A5 (https=) | 2011-05-12 |
| JP5138377B2 JP5138377B2 (ja) | 2013-02-06 |
Family
ID=36071948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539053A Expired - Fee Related JP5138377B2 (ja) | 2004-10-29 | 2005-10-25 | Ｐｐａｒのモジュレータとしての置換スルホニル二環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7494999B2 (https=) |
| EP (1) | EP1805158B1 (https=) |
| JP (1) | JP5138377B2 (https=) |
| KR (1) | KR101404930B1 (https=) |
| AR (1) | AR052319A1 (https=) |
| AU (1) | AU2005307006B2 (https=) |
| BR (1) | BRPI0516435B1 (https=) |
| CA (1) | CA2585172C (https=) |
| DK (1) | DK1805158T3 (https=) |
| ES (1) | ES2682282T3 (https=) |
| HU (1) | HUE039584T2 (https=) |
| IL (1) | IL182427A (https=) |
| MX (1) | MX2007005205A (https=) |
| NZ (1) | NZ589748A (https=) |
| RU (1) | RU2384576C2 (https=) |
| WO (1) | WO2006055187A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| CA2521175A1 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| US20070208026A1 (en) * | 2003-04-07 | 2007-09-06 | Liu Kevin | N-Containing Heteroaromatic Compounds As Modulators Of Ppars And Methods Of Treating Metabolic Disorders |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| MX2007005205A (es) | 2004-10-29 | 2007-05-11 | Kalypsys Inc | Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma. |
| BRPI0614944A2 (pt) * | 2005-08-19 | 2011-04-26 | Elan Pharm Inc | inibidores sulfonamido n-bicìclicos ponte de gama-secretase |
| US8080579B2 (en) * | 2005-10-03 | 2011-12-20 | The Regents Of The University Of Michigan | Compositions and methods for treatment of inflammatory bowel disease |
| WO2007047432A1 (en) * | 2005-10-12 | 2007-04-26 | Kalypsys, Inc. | Sulfonamide derivatives as modulators of ppar |
| EP1940815B1 (en) * | 2005-10-25 | 2018-08-15 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN101379063A (zh) * | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| AU2007213671A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| EP2520567A3 (en) * | 2006-02-23 | 2012-12-12 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| WO2008043024A2 (en) * | 2006-10-04 | 2008-04-10 | Kalypsys, Inc. | Oral pharmaceutical formulation comprising a sulfonyl bicyclic modulator of ppar for the treatment of disease |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| US20100183696A1 (en) * | 2007-01-30 | 2010-07-22 | Allergan, Inc | Treating Ocular Diseases Using Peroxisome Proliferator-Activated Receptor Delta Antagonists |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| US20080242877A1 (en) * | 2007-02-26 | 2008-10-02 | Vinod Kumar Kansal | Intermediates and processes for the synthesis of Ramelteon |
| KR20100016620A (ko) | 2007-04-23 | 2010-02-12 | 얀센 파마슈티카 엔.브이. | 속해리성 도파민 2 수용체 길항제로서의 4-알콕시피리다진 유도체 |
| AU2008240729B2 (en) | 2007-04-23 | 2012-08-23 | Janssen Pharmaceutica N.V. | Thia(dia)zoles as fast dissociating dopamine 2 receptor antagonists |
| EP2098519A1 (en) | 2007-05-31 | 2009-09-09 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of ramelteon and its intermediates |
| RU2502734C2 (ru) | 2008-07-03 | 2013-12-27 | Янссен Фармацевтика Нв | Замещенные 6-(1-пиперазинил)-пиридазины в качестве антагонистов 5-нт6 рецептора |
| CA2730774C (en) | 2008-07-31 | 2016-09-13 | Janssen Pharmaceutica Nv | Piperazin-1-yl-trifluoromethyl-substituted-pyridines as fast dissociating dopamine 2 receptor antagonists |
| ES2390589T3 (es) * | 2008-10-09 | 2012-11-14 | Bayer Cropscience Ag | Procedimiento para la preparación de piridinas sustituidas con trihalometoxi funcionalizadas |
| WO2010121212A2 (en) * | 2009-04-17 | 2010-10-21 | H. Lee Moffit Cancer Center And Research Institute, Inc. | Indoline scaffold shp-2 inhibitors and method of treating cancer |
| RU2013114390A (ru) | 2010-08-31 | 2014-10-10 | СНУ Ар энд ДиБи ФАУНДЕЙШН | Применение фетального репрограммирования посредством ppar-дельта-агониста |
| EP3756661A1 (en) | 2013-09-09 | 2020-12-30 | vTv Therapeutics LLC | Use of a ppar-delta agonist for treating muscle atrophy |
| KR20250016494A (ko) | 2017-09-26 | 2025-02-03 | 테사로, 인코포레이티드 | 니라파립 제제 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN113880755B (zh) * | 2021-08-27 | 2024-06-18 | 成都药明康德新药开发有限公司 | 2-溴-5-(三氟甲氧基)吡啶的制备方法 |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929803A (en) * | 1974-05-28 | 1975-12-30 | Pfizer | Aryl carboxylic acids |
| US4237130A (en) * | 1979-06-21 | 1980-12-02 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids |
| DE3374408D1 (en) | 1982-10-22 | 1987-12-17 | Ciba Geigy Ag | Benzodioxole derivatives, process for their preparation and pharmaceutical compositions containing them |
| EP0158596A3 (de) | 1984-04-06 | 1986-08-13 | Ciba-Geigy Ag | Neue substituierte Benzodioxolderivate, Verfahren zu deren Herstellung und entsprechende pharmazeutische Zusammensetzungen |
| JPS6163671A (ja) | 1984-09-05 | 1986-04-01 | Shionogi & Co Ltd | ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 |
| JPH05255089A (ja) | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| GB9600464D0 (en) | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| PE86199A1 (es) | 1997-06-17 | 1999-09-24 | Schering Corp | Sulfonamida inhibidor de la enzima farnesilo transferasa |
| IL135177A0 (en) * | 1997-10-02 | 2001-05-20 | Sankyo Co | Amidocarboxylic acid derivatives and pharmaceutical compositions containing the same |
| TR200002182T2 (tr) | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| CA2342251A1 (en) | 1998-08-28 | 2000-03-09 | Scios Inc. | Use of piperidines and/or piperazines as inhibitors of p38-alpha kinase |
| ES2300151T3 (es) | 1998-09-22 | 2008-06-01 | Astellas Pharma Inc. | Derivados de cianofenilo. |
| WO2000056704A1 (en) | 1999-03-22 | 2000-09-28 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
| EP1236719A4 (en) | 1999-12-03 | 2003-06-25 | Kyoto Pharma Ind | NOVEL HETEROCYCLIC COMPOUNDS AND SALTS THEREOF, USE OF THESE COMPOUNDS IN MEDICINE |
| JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| GB0007907D0 (en) | 2000-03-31 | 2000-05-17 | Merck Sharp & Dohme | Therapeutic agents |
| AU2001292874B2 (en) * | 2000-09-27 | 2006-06-15 | Merck & Co., Inc. | Benzopyrancarboxylic acid derivatives for the treatment of diabetes and lipid disorders |
| CA2423744C (en) | 2000-09-29 | 2012-04-03 | Prolifix Limited | Hydroxamic acid compounds comprising a sulfonamide linkage as hdac inhibitors |
| WO2002051836A1 (en) | 2000-12-27 | 2002-07-04 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
| IL158590A0 (en) | 2001-06-11 | 2004-05-12 | Biovitrum Ab | Substituted sulfonamide compounds, process for their use as medicament for the treatment of cns disorders, obesity and type ii diabetes |
| US7456184B2 (en) | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| WO2003057145A2 (en) * | 2001-12-31 | 2003-07-17 | Guilford Pharmaceuticals Inc. | SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[imn]PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES |
| CA2479906C (en) | 2002-04-03 | 2011-02-08 | Topotarget Uk Limited | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors |
| US6875780B2 (en) | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| CN1181065C (zh) | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
| EP1511488B1 (en) | 2002-06-12 | 2013-05-22 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| DE10229777A1 (de) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
| WO2004048322A1 (en) * | 2002-11-25 | 2004-06-10 | Schering Corporation | Cannabinoid receptor ligands |
| DE10300099A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Indol-Phenylsulfonamid-Derivate |
| CN1751037A (zh) | 2003-02-14 | 2006-03-22 | 伊莱利利公司 | 作为ppar调节剂的磺酰胺衍生物 |
| CA2521175A1 (en) | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| US20070208026A1 (en) | 2003-04-07 | 2007-09-06 | Liu Kevin | N-Containing Heteroaromatic Compounds As Modulators Of Ppars And Methods Of Treating Metabolic Disorders |
| KR100762762B1 (ko) | 2003-04-17 | 2007-10-17 | 칼립시스, 인코포레이티드 | Ｐｐａｒ의 조절인자로서의 아릴 화합물 및 신진대사장애의 치료 방법 |
| MXPA06001202A (es) | 2003-07-29 | 2006-08-31 | Xenon Pharmaceuticals Inc | Derivados piridilo y su uso como agentes terapeuticos. |
| KR20060036106A (ko) | 2003-07-30 | 2006-04-27 | 제논 파마슈티칼스 인크. | 피리딜 유도체 및 그의 치료제로서의 용도 |
| CN101712653A (zh) | 2003-07-30 | 2010-05-26 | 泽农医药公司 | 哒嗪衍生物和它们作为治疗剂的用途 |
| CN1829701A (zh) | 2003-07-30 | 2006-09-06 | 泽农医药公司 | 哌嗪衍生物和它们作为治疗剂的用途 |
| DE10335449A1 (de) | 2003-08-02 | 2005-02-17 | Bayer Healthcare Ag | Bicyclische Indolinsulfonamid-Derivate |
| US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2005060958A1 (en) | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
| AR048523A1 (es) | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| CA2571881A1 (en) * | 2004-06-22 | 2006-01-26 | Andreas P. Termin | Heterocyclic derivatives for modulation of calcium channels |
| CA2573198A1 (en) | 2004-07-06 | 2006-02-09 | Xenon Pharmaceuticals Inc. | Nicotinamide derivatives and their use as therapeutic agents |
| EP1807085B1 (en) | 2004-09-20 | 2013-08-21 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-coa desaturase inhibitors |
| EP1827438B2 (en) | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| US7829712B2 (en) | 2004-09-20 | 2010-11-09 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives for inhibiting human stearoyl-CoA-desaturase |
| AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| JP5080256B2 (ja) | 2004-09-20 | 2012-11-21 | ゼノン・ファーマシューティカルズ・インコーポレイテッド | 二環式複素環誘導体およびステアロイル−ＣｏＡデサチュラーゼ（ＳＣＤ）のインヒビターとしてのそれらの使用 |
| EP2289510A1 (en) | 2004-09-20 | 2011-03-02 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives for the treatment of diseases mediated by stearoyl-coa desaturase enzymes |
| CA2580762A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as therapeutic agents |
| AR051091A1 (es) | 2004-09-20 | 2006-12-20 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de la estearoil-coa desaturasa |
| MX2007005205A (es) | 2004-10-29 | 2007-05-11 | Kalypsys Inc | Compuestos biciclicos sulfonilo-sustituidos como moduladores de receptores activados por el proliferador de la peroxisoma. |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| WO2007047432A1 (en) | 2005-10-12 | 2007-04-26 | Kalypsys, Inc. | Sulfonamide derivatives as modulators of ppar |
| US20090143396A1 (en) * | 2005-10-12 | 2009-06-04 | Malecha James W | Sulfonyl-Substituted Aryl Compounds as Modulators of Peroxisome Proliferator Activated Receptors |
| EP1940815B1 (en) * | 2005-10-25 | 2018-08-15 | Kalypsys, Inc. | Salts of modulators of ppar and methods of treating metabolic disorders |
| EP1996198A1 (en) * | 2006-03-17 | 2008-12-03 | Kalypsys, Inc. | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| TW200745059A (en) * | 2006-05-16 | 2007-12-16 | Kalypsys Inc | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US20080004281A1 (en) * | 2006-06-28 | 2008-01-03 | Kalypsys, Inc. | Methods for the modulation of crp by the selective modulation of ppar delta |
| WO2008043024A2 (en) | 2006-10-04 | 2008-04-10 | Kalypsys, Inc. | Oral pharmaceutical formulation comprising a sulfonyl bicyclic modulator of ppar for the treatment of disease |
| US20080287477A1 (en) * | 2006-10-11 | 2008-11-20 | Kalypsys, Inc. | Novel Compounds as Modulators of Ppar |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
-
2005
- 2005-10-25 MX MX2007005205A patent/MX2007005205A/es active IP Right Grant
- 2005-10-25 EP EP05851253.4A patent/EP1805158B1/en not_active Expired - Lifetime
- 2005-10-25 RU RU2007116039/04A patent/RU2384576C2/ru not_active IP Right Cessation
- 2005-10-25 US US11/258,463 patent/US7494999B2/en not_active Expired - Lifetime
- 2005-10-25 ES ES05851253.4T patent/ES2682282T3/es not_active Expired - Lifetime
- 2005-10-25 DK DK05851253.4T patent/DK1805158T3/en active
- 2005-10-25 NZ NZ589748A patent/NZ589748A/xx not_active IP Right Cessation
- 2005-10-25 CA CA2585172A patent/CA2585172C/en not_active Expired - Lifetime
- 2005-10-25 AR ARP050104470A patent/AR052319A1/es unknown
- 2005-10-25 AU AU2005307006A patent/AU2005307006B2/en not_active Ceased
- 2005-10-25 HU HUE05851253A patent/HUE039584T2/hu unknown
- 2005-10-25 BR BRPI0516435-4A patent/BRPI0516435B1/pt not_active IP Right Cessation
- 2005-10-25 JP JP2007539053A patent/JP5138377B2/ja not_active Expired - Fee Related
- 2005-10-25 KR KR1020077009519A patent/KR101404930B1/ko not_active Expired - Fee Related
- 2005-10-25 WO PCT/US2005/038418 patent/WO2006055187A1/en not_active Ceased
-
2007
- 2007-04-10 IL IL182427A patent/IL182427A/en active IP Right Grant
-
2008
- 2008-09-04 US US12/204,489 patent/US7834004B2/en not_active Expired - Lifetime
- 2008-09-04 US US12/204,459 patent/US7915253B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5138377B2 (ja) | Ｐｐａｒのモジュレータとしての置換スルホニル二環式化合物 | |
| JP2008518912A5 (https=) | ||
| US20090227599A1 (en) | Sulfonyl-substituted bicyclic compounds as modulators of ppar | |
| EP3157917B1 (en) | Compounds, compositions and methods of increasing cftr activity | |
| CN111787916B (zh) | 用于治疗疾病的二氢神经酰胺去饱和酶抑制剂 | |
| RU2669695C2 (ru) | Циклические амидные производные как ингибиторы 11-бета-гидроксистероид-дегидрогеназы и их применение | |
| AU2017217238A1 (en) | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| WO2009117421A2 (en) | Heterocyclic modulators of gpr119 for treatment of disease | |
| JPH072851A (ja) | ５員複素環化合物、それらの調製方法及びこれらの化合物を含む医薬組成物 | |
| JP2021510818A5 (https=) | ||
| HUT76062A (en) | Thiazolidines and oxazolidines substituted by a pyridine ring and pharmaceutical compositions containing the same | |
| KR20070084574A (ko) | 유도가능 산화질소 신타제 이량체화 억제제 | |
| WO2021107125A1 (ja) | リゾホスファチジン酸受容体作動活性を有する化合物およびその医薬用途 | |
| KR20120047960A (ko) | 글루코키나아제(ｇｋ) 활성화제로서 치환된 벤즈아미드 유도체 | |
| CN101421258B (zh) | 作为ppar调节剂的磺酰基取代的双环化合物 | |
| US7863276B2 (en) | Salts of modulators of PPAR and methods of treating metabolic disorders | |
| TWI386392B (zh) | 一種可作為過氧小體增生活化受體調控劑的磺酸基取代雙環化合物 | |
| WO2002006272A1 (fr) | Derives de polyfluoroalkyltriazole, leur preparation et leur utilisation en therapeutique | |
| JP2009517483A (ja) | 一酸化窒素シンターゼの二量化の抑制剤としてのイミダゾール誘導体 | |
| KR20240046553A (ko) | Sting 길항제로서의 소분자 우레아 유도체 | |
| BR112019018774A2 (pt) | composto tendo uma estrutura de acordo com a fórmula i, sal farmaceuticamente aceitável, composição farmacêutica, método para prevenir ou tratar uma doença ou afeção e método para imunomodulação, inibição ou prevenção de rejeição de enxertos de órgãos ou pele ou tratamento de tumores ou câncer |