JP2008518912A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2008518912A5 JP2008518912A5 JP2007539053A JP2007539053A JP2008518912A5 JP 2008518912 A5 JP2008518912 A5 JP 2008518912A5 JP 2007539053 A JP2007539053 A JP 2007539053A JP 2007539053 A JP2007539053 A JP 2007539053A JP 2008518912 A5 JP2008518912 A5 JP 2008518912A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- piperazine
- sulfonyl
- carboxylic acid
- trifluoromethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 0 CC1(*)*C(C)(*)C*C1 Chemical compound CC1(*)*C(C)(*)C*C1 0.000 description 4
- HQHXPNTVFJCLNC-UHFFFAOYSA-N CC(C1)(Cc2c1cccc2)C(OC)=O Chemical compound CC(C1)(Cc2c1cccc2)C(OC)=O HQHXPNTVFJCLNC-UHFFFAOYSA-N 0.000 description 1
- XJWNCJRCHRYOBH-UHFFFAOYSA-N COC(C[n](ccc1c2)c1ccc2S(N(CC1)CCN1c1ccc(C(F)(F)F)cc1)(=O)=O)=O Chemical compound COC(C[n](ccc1c2)c1ccc2S(N(CC1)CCN1c1ccc(C(F)(F)F)cc1)(=O)=O)=O XJWNCJRCHRYOBH-UHFFFAOYSA-N 0.000 description 1
- KCCIMPCWFQONCQ-WLLUQGSSSA-N C[C@@H]([C@@H](C)N(CC1)/S(/c(cc2)cc3c2[s]cc3CC(O)=O)=C(/C)\O)N1c1ccc(C(F)(F)F)cn1 Chemical compound C[C@@H]([C@@H](C)N(CC1)/S(/c(cc2)cc3c2[s]cc3CC(O)=O)=C(/C)\O)N1c1ccc(C(F)(F)F)cn1 KCCIMPCWFQONCQ-WLLUQGSSSA-N 0.000 description 1
- IHSHHMUCAAABTK-QSVWIEALSA-N C[C@H](CN(CC1=C)c2ccc(C(C)(C)C)cc2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(CC1=C)c2ccc(C(C)(C)C)cc2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O IHSHHMUCAAABTK-QSVWIEALSA-N 0.000 description 1
- WKSXKTVBEURKJS-UUVAVEHKSA-N C[C@H](CN(C[C@@H]1C)c(c(Cl)c2)ccc2Cl)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c(c(Cl)c2)ccc2Cl)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O WKSXKTVBEURKJS-UUVAVEHKSA-N 0.000 description 1
- NRNHHHKZLQZYIO-MZBDJJRSSA-N C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(Cl)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(Cl)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O NRNHHHKZLQZYIO-MZBDJJRSSA-N 0.000 description 1
- VWEXFHTYXNUVEM-MZBDJJRSSA-N C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(F)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ccc(C(F)(F)F)c(F)c2)N1S(c1cccc(C2)c1CC2C(O)=O)(=O)=O VWEXFHTYXNUVEM-MZBDJJRSSA-N 0.000 description 1
- OCISQZLPSOHDDN-UUVAVEHKSA-N C[C@H](CN(C[C@@H]1C)c2ncc(C(F)(F)F)cc2)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O Chemical compound C[C@H](CN(C[C@@H]1C)c2ncc(C(F)(F)F)cc2)N1S(c1ccc(CCC2C(O)=O)c2c1)(=O)=O OCISQZLPSOHDDN-UUVAVEHKSA-N 0.000 description 1
- MDZAJWMNGMESHJ-MRXNPFEDSA-N C[C@H](CN(Cc(cc1)ccc1OC(F)(F)F)CC1=C)N1Sc(cc1)cc2c1[s]cc2CC(O)=O Chemical compound C[C@H](CN(Cc(cc1)ccc1OC(F)(F)F)CC1=C)N1Sc(cc1)cc2c1[s]cc2CC(O)=O MDZAJWMNGMESHJ-MRXNPFEDSA-N 0.000 description 1
- NYEPCYLVJPAFNE-MCPYQZEQSA-N C[C@H](CN(Cc1ccc(C(F)(F)F)cc1)C[C@@H]1C)N1S(c1c(CC(C2)C(O)=O)c2ccc1)(=O)=O Chemical compound C[C@H](CN(Cc1ccc(C(F)(F)F)cc1)C[C@@H]1C)N1S(c1c(CC(C2)C(O)=O)c2ccc1)(=O)=O NYEPCYLVJPAFNE-MCPYQZEQSA-N 0.000 description 1
- YDSABVFETOCXQR-UHFFFAOYSA-N Cc1cc(N)ccc1OC(F)F Chemical compound Cc1cc(N)ccc1OC(F)F YDSABVFETOCXQR-UHFFFAOYSA-N 0.000 description 1
- WRNXOOXIPSTAGJ-UHFFFAOYSA-N Cc1cc(OC(F)(F)F)ccc1 Chemical compound Cc1cc(OC(F)(F)F)ccc1 WRNXOOXIPSTAGJ-UHFFFAOYSA-N 0.000 description 1
- GTCFYVRPJAXCSZ-UHFFFAOYSA-N OC(C(Cc1ccc2)Cc1c2S(N(CC1)CCN1c1cccc(OCC(F)(F)F)c1)(=O)=O)=O Chemical compound OC(C(Cc1ccc2)Cc1c2S(N(CC1)CCN1c1cccc(OCC(F)(F)F)c1)(=O)=O)=O GTCFYVRPJAXCSZ-UHFFFAOYSA-N 0.000 description 1
- ZVBOVRZGOAXEHZ-UHFFFAOYSA-N OC(C1Cc2cc(S(N(CC3)CC=C3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2C1)=O Chemical compound OC(C1Cc2cc(S(N(CC3)CC=C3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2C1)=O ZVBOVRZGOAXEHZ-UHFFFAOYSA-N 0.000 description 1
- JEMYWYFOHSPFNM-UHFFFAOYSA-N OC(C[n]1c2cc(S(N(CC3)CCN3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2cc1)O Chemical compound OC(C[n]1c2cc(S(N(CC3)CCN3c3ccc(C(F)(F)F)cc3)(=O)=O)ccc2cc1)O JEMYWYFOHSPFNM-UHFFFAOYSA-N 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62325204P | 2004-10-29 | 2004-10-29 | |
| US60/623,252 | 2004-10-29 | ||
| US67981305P | 2005-05-11 | 2005-05-11 | |
| US60/679,813 | 2005-05-11 | ||
| PCT/US2005/038418 WO2006055187A1 (en) | 2004-10-29 | 2005-10-25 | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008518912A JP2008518912A (ja) | 2008-06-05 |
| JP2008518912A5 true JP2008518912A5 (https=) | 2011-05-12 |
| JP5138377B2 JP5138377B2 (ja) | 2013-02-06 |
Family
ID=36071948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007539053A Expired - Fee Related JP5138377B2 (ja) | 2004-10-29 | 2005-10-25 | Ｐｐａｒのモジュレータとしての置換スルホニル二環式化合物 |
Country Status (16)
| Country | Link |
|---|---|
| US (3) | US7494999B2 (https=) |
| EP (1) | EP1805158B1 (https=) |
| JP (1) | JP5138377B2 (https=) |
| KR (1) | KR101404930B1 (https=) |
| AR (1) | AR052319A1 (https=) |
| AU (1) | AU2005307006B2 (https=) |
| BR (1) | BRPI0516435B1 (https=) |
| CA (1) | CA2585172C (https=) |
| DK (1) | DK1805158T3 (https=) |
| ES (1) | ES2682282T3 (https=) |
| HU (1) | HUE039584T2 (https=) |
| IL (1) | IL182427A (https=) |
| MX (1) | MX2007005205A (https=) |
| NZ (1) | NZ589748A (https=) |
| RU (1) | RU2384576C2 (https=) |
| WO (1) | WO2006055187A1 (https=) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| US20060258683A1 (en) * | 2003-04-07 | 2006-11-16 | Liu Kevin | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| WO2004092130A2 (en) * | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | N-containing heteroaromatic compounds as modulators of ppars and methods of treating metabolic disorders |
| CA2585172C (en) | 2004-10-29 | 2014-08-12 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
| US20070190079A1 (en) * | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| AU2006279312A1 (en) * | 2005-08-19 | 2007-02-22 | Elan Pharmaceuticals, Inc. | Bridged N-cyclic sulfonamido inhibitors of gamma secretase |
| US8080579B2 (en) * | 2005-10-03 | 2011-12-20 | The Regents Of The University Of Michigan | Compositions and methods for treatment of inflammatory bowel disease |
| WO2007047432A1 (en) * | 2005-10-12 | 2007-04-26 | Kalypsys, Inc. | Sulfonamide derivatives as modulators of ppar |
| HUE040020T2 (hu) * | 2005-10-25 | 2019-02-28 | Kalypsys Inc | PPAR modulátorok sói és eljárások metabolikus betegségek kezelésére |
| JO2769B1 (en) | 2005-10-26 | 2014-03-15 | جانسين فارماسوتيكا ان. في | Rapid decomposition of physiologically antagonistic agents of the 2-dopamine receptor |
| AU2007213670A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3,9-diazabicyclo[3.3.1]nonane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
| CN101379063A (zh) * | 2006-02-10 | 2009-03-04 | 神经研究公司 | 3,9-二氮杂双环[3.3.1]壬烷衍生物及其作为单胺神经递质再摄取抑制剂的用途 |
| WO2007090888A1 (en) | 2006-02-10 | 2007-08-16 | Neurosearch A/S | 3-heteroaryl- 3,9-diazabicyclo[3.3.1]nonane derivatives as nicotinic acetylcholine receptor agonists |
| EP2520567A3 (en) | 2006-02-23 | 2012-12-12 | Shionogi & Co., Ltd. | Nitrogen-containing heterocycle derivatives substituted with cyclic group |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| AR060937A1 (es) * | 2006-05-16 | 2008-07-23 | Kalypsys Inc | Compuestos biciclicos sustituidos con sulfonilo como moduladores de ppar |
| WO2008043024A2 (en) * | 2006-10-04 | 2008-04-10 | Kalypsys, Inc. | Oral pharmaceutical formulation comprising a sulfonyl bicyclic modulator of ppar for the treatment of disease |
| JO2642B1 (en) | 2006-12-08 | 2012-06-17 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
| WO2008094860A2 (en) | 2007-01-30 | 2008-08-07 | Allergan, Inc. | Treating ocular diseases using peroxisome proliferator-activated receptor delta antagonists |
| JO2849B1 (en) | 2007-02-13 | 2015-03-15 | جانسين فارماسوتيكا ان. في | Dopamine 2 receptor antagonists are rapidly hydrolyzed |
| US20080242877A1 (en) * | 2007-02-26 | 2008-10-02 | Vinod Kumar Kansal | Intermediates and processes for the synthesis of Ramelteon |
| MX2009011416A (es) | 2007-04-23 | 2009-11-05 | Janssen Pharmaceutica Nv | Tia(di)azoles como antagonistas del receptor de dopamina 2 de disociacion rapida. |
| RS52518B (sr) | 2007-04-23 | 2013-04-30 | Janssen Pharmaceutica N.V. | Derivati 4-alkoksipiridazina kao brzo disocirajući dopamin 2 receptorski antagonisti |
| EP2098519A1 (en) | 2007-05-31 | 2009-09-09 | Teva Pharmaceutical Industries Ltd. | Process for the synthesis of ramelteon and its intermediates |
| CA2729313C (en) | 2008-07-03 | 2016-08-30 | Janssen Pharmaceutica Nv | Substituted 6-(1-piperazinyl)-pyridazines as 5-ht6 receptor antagonists |
| ES2622161T3 (es) | 2008-07-31 | 2017-07-05 | Janssen Pharmaceutica, N.V. | Piridinas sustituidas con piperazin-1-il-trifluorometilo como antagonistas del receptor de la dopamina 2 de disociación rápida |
| ES2390589T3 (es) * | 2008-10-09 | 2012-11-14 | Bayer Cropscience Ag | Procedimiento para la preparación de piridinas sustituidas con trihalometoxi funcionalizadas |
| WO2010121212A2 (en) * | 2009-04-17 | 2010-10-21 | H. Lee Moffit Cancer Center And Research Institute, Inc. | Indoline scaffold shp-2 inhibitors and method of treating cancer |
| EP2612669A4 (en) | 2010-08-31 | 2014-05-14 | Snu R&Db Foundation | USING THE FÖTAL REPROGRAMMING OF A PPAR AGONIST |
| WO2015035171A1 (en) | 2013-09-09 | 2015-03-12 | High Point Pharmaceuticals, Llc | Use of a ppar-delta agonist for treating muscle atrophy |
| TWI843707B (zh) | 2017-09-26 | 2024-06-01 | 美商提薩羅有限公司 | 尼拉帕尼（ｎｉｒａｐａｒｉｂ）調配物 |
| BR112020018094A2 (pt) | 2018-03-08 | 2020-12-22 | Incyte Corporation | Compostos de aminopirazina diol como inibidores de pi3k-¿ |
| US11046658B2 (en) | 2018-07-02 | 2021-06-29 | Incyte Corporation | Aminopyrazine derivatives as PI3K-γ inhibitors |
| CN113880755B (zh) * | 2021-08-27 | 2024-06-18 | 成都药明康德新药开发有限公司 | 2-溴-5-(三氟甲氧基)吡啶的制备方法 |
| WO2023147309A1 (en) | 2022-01-25 | 2023-08-03 | Reneo Pharmaceuticals, Inc. | Use of ppar-delta agonists in the treatment of disease |
Family Cites Families (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3929803A (en) * | 1974-05-28 | 1975-12-30 | Pfizer | Aryl carboxylic acids |
| US4237130A (en) * | 1979-06-21 | 1980-12-02 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(substituted sulfonyl)benzofuran-2-carboxylic acids |
| ATE30722T1 (de) | 1982-10-22 | 1987-11-15 | Ciba Geigy Ag | Neue benzodioxolderivate, verfahren zu deren herstellung und entsprechende pharmazeutische zusammensetzungen. |
| EP0158596A3 (de) | 1984-04-06 | 1986-08-13 | Ciba-Geigy Ag | Neue substituierte Benzodioxolderivate, Verfahren zu deren Herstellung und entsprechende pharmazeutische Zusammensetzungen |
| JPS6163671A (ja) | 1984-09-05 | 1986-04-01 | Shionogi & Co Ltd | ２，３−ジヒドロベンゾフラン−５−スルホンアミド誘導体および降圧利尿剤 |
| JPH05255089A (ja) | 1991-12-18 | 1993-10-05 | Sanwa Kagaku Kenkyusho Co Ltd | 抗ウイルス剤 |
| US5464788A (en) | 1994-03-24 | 1995-11-07 | Merck & Co., Inc. | Tocolytic oxytocin receptor antagonists |
| GB9600464D0 (en) | 1996-01-09 | 1996-03-13 | Smithkline Beecham Plc | Novel method |
| AU8253698A (en) | 1997-06-17 | 1999-01-04 | Schering Corporation | Novel tricyclic sulfonamide inhibitors of farnesyl-protein transferase |
| WO1999018066A1 (en) * | 1997-10-02 | 1999-04-15 | Sankyo Company, Limited | Amidocarboxylic acid derivatives |
| TR200002182T2 (tr) | 1998-01-27 | 2000-12-21 | Aventis Pharmaceuticals Products Inc. | İkame edilmiş aksozaherosayklil faktör xa inhibitörleri |
| US7517884B2 (en) * | 1998-03-30 | 2009-04-14 | Kalypsys Inc. | Sulfonyl-substituted bicyclic compounds as modulators of PPAR |
| MXPA01002173A (es) | 1998-08-28 | 2003-07-14 | Scios Inc | Inhibidores de p38-alfa cinasa. |
| CN1129581C (zh) * | 1998-09-22 | 2003-12-03 | 山之内制药株式会社 | 氰基苯基衍生物 |
| CA2367963A1 (en) | 1999-03-22 | 2000-09-28 | Darwin Discovery Limited | Hydroxamic and carboxylic acid derivatives |
| WO2001040192A1 (en) | 1999-12-03 | 2001-06-07 | Kyoto Pharmaceutical Industries, Ltd. | Novel heterocyclic compounds and salts thereof and medicinal use of the same |
| JP2001261657A (ja) | 2000-03-17 | 2001-09-26 | Yamanouchi Pharmaceut Co Ltd | シアノフェニル誘導体 |
| GB0007907D0 (en) | 2000-03-31 | 2000-05-17 | Merck Sharp & Dohme | Therapeutic agents |
| JP2004513090A (ja) * | 2000-09-27 | 2004-04-30 | メルク エンド カムパニー インコーポレーテッド | 糖尿病及び脂質異常症の治療のためのベンゾピランカルボン酸誘導体 |
| JP4975941B2 (ja) | 2000-09-29 | 2012-07-11 | トポターゲット ユーケー リミテッド | （ｅ）−ｎ−ヒドロキシ−３−（３−スルファモイル−フェニル）アクリルアミド化合物及びその治療用途 |
| CA2433090A1 (en) | 2000-12-27 | 2002-07-04 | Kyowa Hakko Kogyo Co., Ltd. | Dipeptidyl peptidase iv inhibitor |
| CN1800185A (zh) | 2001-06-11 | 2006-07-12 | 比奥维特罗姆股份公司 | 取代的磺酰胺化合物、其制备方法及其作为治疗cns疾病、肥胖和ii型糖尿病的药物的应用 |
| US7456184B2 (en) * | 2003-05-01 | 2008-11-25 | Palatin Technologies Inc. | Melanocortin receptor-specific compounds |
| WO2003057145A2 (en) * | 2001-12-31 | 2003-07-17 | Guilford Pharmaceuticals Inc. | SUBSTITUTED 4,9-DIHYDROCYCLOPENTA[imn]PHENANTHRIDINE-5-ONES DERIVATIVES THEREOF AND THEIR USES |
| NZ536116A (en) | 2002-04-03 | 2007-01-26 | Topotarget Uk Ltd | Carbamic acid compounds comprising a piperazine linkage as HDAC inhibitors |
| US6875780B2 (en) * | 2002-04-05 | 2005-04-05 | Warner-Lambert Company | Compounds that modulate PPAR activity and methods for their preparation |
| CN1181065C (zh) * | 2002-05-08 | 2004-12-22 | 上海医药工业研究院 | 芳烷甲酰烷基哌嗪衍生物及其作为脑神经保护剂的应用 |
| EP2436676A1 (en) * | 2002-06-12 | 2012-04-04 | Symphony Evolution, Inc. | Human adam-10 inhibitors |
| DE10229777A1 (de) * | 2002-07-03 | 2004-01-29 | Bayer Ag | Indolin-Phenylsulfonamid-Derivate |
| WO2004048322A1 (en) * | 2002-11-25 | 2004-06-10 | Schering Corporation | Cannabinoid receptor ligands |
| DE10300099A1 (de) * | 2003-01-07 | 2004-07-15 | Bayer Healthcare Ag | Indol-Phenylsulfonamid-Derivate |
| ES2297382T3 (es) | 2003-02-14 | 2008-05-01 | Eli Lilly And Company | Derivados de sulfonamida como moduladores de ppar. |
| US20060258683A1 (en) * | 2003-04-07 | 2006-11-16 | Liu Kevin | Para-sulfonyl substituted phenyl compounds as modulators of ppars |
| WO2004092130A2 (en) | 2003-04-07 | 2004-10-28 | Kalypsys, Inc. | N-containing heteroaromatic compounds as modulators of ppars and methods of treating metabolic disorders |
| DE602004002394T2 (de) | 2003-04-17 | 2007-09-13 | Kalypsys, Inc., San Diego | (3-{3-'(2,4-bis-trifluormethyl-benzyl)-(5-ethyl-pyrimidin-2-yl)-amino]-propoxy}-phenyl)-essigsäure und verwandte verbindungen als modulatoren von ppars und verfahren zur behandlung von stoffwechselstörungen |
| MXPA06001202A (es) | 2003-07-29 | 2006-08-31 | Xenon Pharmaceuticals Inc | Derivados piridilo y su uso como agentes terapeuticos. |
| US7456180B2 (en) | 2003-07-30 | 2008-11-25 | Xenon Pharmaceuticals Inc. | Piperazine derivatives and their use as therapeutic agents |
| CA2533897A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridazine derivatives and their use as therapeutic agents |
| CA2533900A1 (en) | 2003-07-30 | 2005-02-10 | Xenon Pharmaceuticals Inc. | Pyridyl derivatives and their use as therapeutic agents |
| DE10335449A1 (de) | 2003-08-02 | 2005-02-17 | Bayer Healthcare Ag | Bicyclische Indolinsulfonamid-Derivate |
| US20050124625A1 (en) | 2003-10-21 | 2005-06-09 | Salvati Mark E. | Piperazine derivatives and their use as modulators of nuclear hormone receptor function |
| GB0325956D0 (en) | 2003-11-06 | 2003-12-10 | Addex Pharmaceuticals Sa | Novel compounds |
| WO2005060958A1 (en) | 2003-12-19 | 2005-07-07 | Kalypsys, Inc. | (5- (2-phenyl)-thiazol-5-ylmethoxy)-indol-1-yl) -acetic acid derivatives and related compounds as modulators of the human ppar-delta receptor for the treatment of metabolic disorders such as type 2 diabetes |
| AR048523A1 (es) | 2004-04-07 | 2006-05-03 | Kalypsys Inc | Compuestos con estructura de aril sulfonamida y sulfonilo como moduladores de ppar y metodos para tratar trastornos metabolicos |
| US7569604B2 (en) * | 2004-06-22 | 2009-08-04 | Vertex Pharmaceuticals Incorporated | Heterocyclic derivatives for modulation of calcium channels |
| ATE537830T1 (de) | 2004-07-06 | 2012-01-15 | Xenon Pharmaceuticals Inc | Nicotinamid derivate und ihre verwendung als therapeutika |
| MX2007003332A (es) | 2004-09-20 | 2007-06-05 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como inhibidores de estearoil-coa-desaturasa. |
| BRPI0515500A (pt) | 2004-09-20 | 2008-07-29 | Xenon Pharmaceuticals Inc | derivados piridazina para inibição de estearoil-coa-desaturase |
| AU2005286647A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
| EP1827438B2 (en) | 2004-09-20 | 2014-12-10 | Xenon Pharmaceuticals Inc. | Piperazin derivatives for inhibiting human stearoyl-coa-desaturase |
| CN101084211A (zh) | 2004-09-20 | 2007-12-05 | 泽农医药公司 | 杂环衍生物及其作为治疗剂的用途 |
| MX2007003318A (es) | 2004-09-20 | 2007-05-18 | Xenon Pharmaceuticals Inc | Derivados heterociclicos y su uso como agentes terapeuticos. |
| AU2005286728A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as mediators of stearoyl-CoA desaturase |
| AU2005286790A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Bicyclic heterocyclic derivatives and their use as inhibitors of stearoyl-CoA-desaturase (SCD) |
| CA2585172C (en) * | 2004-10-29 | 2014-08-12 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as modulators of ppar |
| US20070190079A1 (en) | 2004-10-29 | 2007-08-16 | Kalypsys, Inc. | Methods for the selective modulation of ppar |
| WO2007047431A2 (en) * | 2005-10-12 | 2007-04-26 | Kalypsys, Inc. | Sulfonyl-substituted aryl compounds as modulators of peroxisome proliferator activated receptors |
| WO2007047432A1 (en) | 2005-10-12 | 2007-04-26 | Kalypsys, Inc. | Sulfonamide derivatives as modulators of ppar |
| HUE040020T2 (hu) * | 2005-10-25 | 2019-02-28 | Kalypsys Inc | PPAR modulátorok sói és eljárások metabolikus betegségek kezelésére |
| WO2007109577A1 (en) * | 2006-03-17 | 2007-09-27 | Kalypsys, Inc. | Alkylamine-substituted bicyclic aryl compounds useful as modulators of ppar |
| US20070249519A1 (en) * | 2006-04-20 | 2007-10-25 | Kalypsys, Inc. | Methods for the upregulation of glut4 via modulation of ppar delta in adipose tissue and for the treatment of disease |
| AR060937A1 (es) * | 2006-05-16 | 2008-07-23 | Kalypsys Inc | Compuestos biciclicos sustituidos con sulfonilo como moduladores de ppar |
| US20080004281A1 (en) * | 2006-06-28 | 2008-01-03 | Kalypsys, Inc. | Methods for the modulation of crp by the selective modulation of ppar delta |
| WO2008043024A2 (en) | 2006-10-04 | 2008-04-10 | Kalypsys, Inc. | Oral pharmaceutical formulation comprising a sulfonyl bicyclic modulator of ppar for the treatment of disease |
| US20080287477A1 (en) * | 2006-10-11 | 2008-11-20 | Kalypsys, Inc. | Novel Compounds as Modulators of Ppar |
| WO2008091863A1 (en) * | 2007-01-23 | 2008-07-31 | Kalypsys, Inc. | Sulfonyl-substituted bicyclic compounds as ppar modulators for the treatment of non-alcoholic steatohepatitis |
-
2005
- 2005-10-25 CA CA2585172A patent/CA2585172C/en not_active Expired - Lifetime
- 2005-10-25 NZ NZ589748A patent/NZ589748A/xx not_active IP Right Cessation
- 2005-10-25 HU HUE05851253A patent/HUE039584T2/hu unknown
- 2005-10-25 BR BRPI0516435-4A patent/BRPI0516435B1/pt not_active IP Right Cessation
- 2005-10-25 ES ES05851253.4T patent/ES2682282T3/es not_active Expired - Lifetime
- 2005-10-25 DK DK05851253.4T patent/DK1805158T3/en active
- 2005-10-25 US US11/258,463 patent/US7494999B2/en not_active Expired - Lifetime
- 2005-10-25 AR ARP050104470A patent/AR052319A1/es unknown
- 2005-10-25 JP JP2007539053A patent/JP5138377B2/ja not_active Expired - Fee Related
- 2005-10-25 EP EP05851253.4A patent/EP1805158B1/en not_active Expired - Lifetime
- 2005-10-25 WO PCT/US2005/038418 patent/WO2006055187A1/en not_active Ceased
- 2005-10-25 RU RU2007116039/04A patent/RU2384576C2/ru not_active IP Right Cessation
- 2005-10-25 KR KR1020077009519A patent/KR101404930B1/ko not_active Expired - Fee Related
- 2005-10-25 MX MX2007005205A patent/MX2007005205A/es active IP Right Grant
- 2005-10-25 AU AU2005307006A patent/AU2005307006B2/en not_active Ceased
-
2007
- 2007-04-10 IL IL182427A patent/IL182427A/en active IP Right Grant
-
2008
- 2008-09-04 US US12/204,459 patent/US7915253B2/en not_active Expired - Lifetime
- 2008-09-04 US US12/204,489 patent/US7834004B2/en not_active Expired - Lifetime
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5138377B2 (ja) | Ｐｐａｒのモジュレータとしての置換スルホニル二環式化合物 | |
| JP2008518912A5 (https=) | ||
| US20090227599A1 (en) | Sulfonyl-substituted bicyclic compounds as modulators of ppar | |
| EP3157917B1 (en) | Compounds, compositions and methods of increasing cftr activity | |
| CN111787916B (zh) | 用于治疗疾病的二氢神经酰胺去饱和酶抑制剂 | |
| RU2669695C2 (ru) | Циклические амидные производные как ингибиторы 11-бета-гидроксистероид-дегидрогеназы и их применение | |
| AU2017217238A1 (en) | Haloallylamine indole and azaindole derivative inhibitors of lysyl oxidases and uses thereof | |
| WO2009117421A2 (en) | Heterocyclic modulators of gpr119 for treatment of disease | |
| JPH072851A (ja) | ５員複素環化合物、それらの調製方法及びこれらの化合物を含む医薬組成物 | |
| JP2021510818A5 (https=) | ||
| HUT76062A (en) | Thiazolidines and oxazolidines substituted by a pyridine ring and pharmaceutical compositions containing the same | |
| KR20070084574A (ko) | 유도가능 산화질소 신타제 이량체화 억제제 | |
| WO2021107125A1 (ja) | リゾホスファチジン酸受容体作動活性を有する化合物およびその医薬用途 | |
| KR20120047960A (ko) | 글루코키나아제(ｇｋ) 활성화제로서 치환된 벤즈아미드 유도체 | |
| CN101421258B (zh) | 作为ppar调节剂的磺酰基取代的双环化合物 | |
| US7863276B2 (en) | Salts of modulators of PPAR and methods of treating metabolic disorders | |
| TWI386392B (zh) | 一種可作為過氧小體增生活化受體調控劑的磺酸基取代雙環化合物 | |
| WO2002006272A1 (fr) | Derives de polyfluoroalkyltriazole, leur preparation et leur utilisation en therapeutique | |
| JP2009517483A (ja) | 一酸化窒素シンターゼの二量化の抑制剤としてのイミダゾール誘導体 | |
| KR20240046553A (ko) | Sting 길항제로서의 소분자 우레아 유도체 | |
| BR112019018774A2 (pt) | composto tendo uma estrutura de acordo com a fórmula i, sal farmaceuticamente aceitável, composição farmacêutica, método para prevenir ou tratar uma doença ou afeção e método para imunomodulação, inibição ou prevenção de rejeição de enxertos de órgãos ou pele ou tratamento de tumores ou câncer |