JP2008517924A5 - - Google Patents
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- Publication number
- JP2008517924A5 JP2008517924A5 JP2007538054A JP2007538054A JP2008517924A5 JP 2008517924 A5 JP2008517924 A5 JP 2008517924A5 JP 2007538054 A JP2007538054 A JP 2007538054A JP 2007538054 A JP2007538054 A JP 2007538054A JP 2008517924 A5 JP2008517924 A5 JP 2008517924A5
- Authority
- JP
- Japan
- Prior art keywords
- composition
- cerebrovascular
- ischemic event
- pharmaceutically acceptable
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 claims 19
- 150000001875 compounds Chemical class 0.000 claims 15
- 230000000302 ischemic effect Effects 0.000 claims 9
- -1 N- methyl - piperazine compound Chemical class 0.000 claims 6
- 230000002401 inhibitory effect Effects 0.000 claims 5
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 5
- 150000003839 salts Chemical class 0.000 claims 5
- 206010021143 Hypoxia Diseases 0.000 claims 4
- 241000406668 Loxodonta cyclotis Species 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004193 piperazinyl group Chemical group 0.000 claims 3
- 125000004195 4-methylpiperazin-1-yl group Chemical group [H]C([H])([H])N1C([H])([H])C([H])([H])N(*)C([H])([H])C1([H])[H] 0.000 claims 2
- 206010002660 Anoxia Diseases 0.000 claims 2
- 241000976983 Anoxia Species 0.000 claims 2
- 206010008111 Cerebral haemorrhage Diseases 0.000 claims 2
- 206010019196 Head injury Diseases 0.000 claims 2
- 208000010496 Heart Arrest Diseases 0.000 claims 2
- 206010061216 Infarction Diseases 0.000 claims 2
- 241000283080 Proboscidea <mammal> Species 0.000 claims 2
- 206010038669 Respiratory arrest Diseases 0.000 claims 2
- 230000001154 acute effect Effects 0.000 claims 2
- 230000007953 anoxia Effects 0.000 claims 2
- 125000004432 carbon atom Chemical group C* 0.000 claims 2
- 230000007213 cerebrovascular event Effects 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 125000005842 heteroatom Chemical group 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 230000007574 infarction Effects 0.000 claims 2
- 208000014674 injury Diseases 0.000 claims 2
- 230000007971 neurological deficit Effects 0.000 claims 2
- 230000004112 neuroprotection Effects 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- 230000009984 peri-natal effect Effects 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 210000000278 spinal cord Anatomy 0.000 claims 2
- 208000005809 status epilepticus Diseases 0.000 claims 2
- 230000001052 transient effect Effects 0.000 claims 2
- 230000008733 trauma Effects 0.000 claims 2
- 230000002792 vascular Effects 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 1
- YNAVUWVOSKDBBP-UHFFFAOYSA-N Morpholine Chemical group C1COCCN1 YNAVUWVOSKDBBP-UHFFFAOYSA-N 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- 230000002490 cerebral effect Effects 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 229910052739 hydrogen Inorganic materials 0.000 claims 1
- 239000001257 hydrogen Substances 0.000 claims 1
- 239000006207 intravenous dosage form Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229910052760 oxygen Inorganic materials 0.000 claims 1
- 230000035515 penetration Effects 0.000 claims 1
- 229920006395 saturated elastomer Polymers 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 230000008728 vascular permeability Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US62128004P | 2004-10-22 | 2004-10-22 | |
| PCT/US2005/037839 WO2006047262A1 (en) | 2004-10-22 | 2005-10-21 | 4 [(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-7-ethynyl-3-quinolinecarbonitriles for the treatment of ischemic injury |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2008517924A JP2008517924A (ja) | 2008-05-29 |
| JP2008517924A5 true JP2008517924A5 (enExample) | 2008-09-11 |
Family
ID=35784691
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2007538054A Withdrawn JP2008517924A (ja) | 2004-10-22 | 2005-10-21 | 虚血傷害を処置するための４−［（２，４−ジクロロ−５−メトキシフェニル）アミノ］−６−アルコキシ−７−エチニル−３−キノリンカルボニトリル |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US20060116375A1 (enExample) |
| EP (1) | EP1802581B1 (enExample) |
| JP (1) | JP2008517924A (enExample) |
| KR (1) | KR20070085413A (enExample) |
| CN (1) | CN101044117A (enExample) |
| AT (1) | ATE391122T1 (enExample) |
| AU (1) | AU2005299822A1 (enExample) |
| BR (1) | BRPI0516995A (enExample) |
| CA (1) | CA2581807A1 (enExample) |
| CR (1) | CR9072A (enExample) |
| DE (1) | DE602005005843T2 (enExample) |
| DK (1) | DK1802581T3 (enExample) |
| EC (1) | ECSP077385A (enExample) |
| ES (1) | ES2303287T3 (enExample) |
| IL (1) | IL182547A0 (enExample) |
| MX (1) | MX2007004833A (enExample) |
| NO (1) | NO20071708L (enExample) |
| PL (1) | PL1802581T3 (enExample) |
| PT (1) | PT1802581E (enExample) |
| RU (1) | RU2007111704A (enExample) |
| SI (1) | SI1802581T1 (enExample) |
| WO (1) | WO2006047262A1 (enExample) |
| ZA (1) | ZA200703275B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TW200829555A (en) * | 2006-11-10 | 2008-07-16 | Astrazeneca Ab | Chemical compounds |
| CN102952037A (zh) * | 2012-11-18 | 2013-03-06 | 大连九信生物化工科技有限公司 | 一种2-氰基-n-(2,4-二氯-5-甲氧苯基)乙酰胺的合成方法 |
| WO2014086284A1 (zh) * | 2012-12-04 | 2014-06-12 | 上海医药集团股份有限公司 | 一类氘代3-氰基喹啉类化合物、其药用组合物、制备方法及其用途 |
| CN114436851B (zh) * | 2022-01-17 | 2023-08-22 | 常州大学 | 一种n,n-二甲基苄胺及其衍生物的制备方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002008A (en) * | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
| US6297258B1 (en) * | 1998-09-29 | 2001-10-02 | American Cyanamid Company | Substituted 3-cyanoquinolines |
| US6521618B2 (en) * | 2000-03-28 | 2003-02-18 | Wyeth | 3-cyanoquinolines, 3-cyano-1,6-naphthyridines, and 3-cyano-1,7-naphthyridines as protein kinase inhibitors |
| TWI275390B (en) * | 2002-04-30 | 2007-03-11 | Wyeth Corp | Process for the preparation of 7-substituted-3- quinolinecarbonitriles |
| TW200423938A (en) * | 2003-02-21 | 2004-11-16 | Wyeth Corp | 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-alkoxy-3-quinolinecarbonitriles for the treatment of ischemic injury |
-
2005
- 2005-10-21 DK DK05820982T patent/DK1802581T3/da active
- 2005-10-21 AU AU2005299822A patent/AU2005299822A1/en not_active Abandoned
- 2005-10-21 PT PT05820982T patent/PT1802581E/pt unknown
- 2005-10-21 AT AT05820982T patent/ATE391122T1/de not_active IP Right Cessation
- 2005-10-21 RU RU2007111704/04A patent/RU2007111704A/ru not_active Application Discontinuation
- 2005-10-21 BR BRPI0516995-0A patent/BRPI0516995A/pt not_active IP Right Cessation
- 2005-10-21 CN CNA2005800360383A patent/CN101044117A/zh active Pending
- 2005-10-21 KR KR1020077011472A patent/KR20070085413A/ko not_active Withdrawn
- 2005-10-21 ES ES05820982T patent/ES2303287T3/es not_active Expired - Lifetime
- 2005-10-21 CA CA002581807A patent/CA2581807A1/en not_active Abandoned
- 2005-10-21 US US11/255,556 patent/US20060116375A1/en not_active Abandoned
- 2005-10-21 SI SI200530255T patent/SI1802581T1/sl unknown
- 2005-10-21 PL PL05820982T patent/PL1802581T3/pl unknown
- 2005-10-21 JP JP2007538054A patent/JP2008517924A/ja not_active Withdrawn
- 2005-10-21 WO PCT/US2005/037839 patent/WO2006047262A1/en not_active Ceased
- 2005-10-21 MX MX2007004833A patent/MX2007004833A/es active IP Right Grant
- 2005-10-21 EP EP05820982A patent/EP1802581B1/en not_active Expired - Lifetime
- 2005-10-21 DE DE602005005843T patent/DE602005005843T2/de not_active Expired - Lifetime
-
2007
- 2007-03-30 NO NO20071708A patent/NO20071708L/no not_active Application Discontinuation
- 2007-04-11 EC EC2007007385A patent/ECSP077385A/es unknown
- 2007-04-12 IL IL182547A patent/IL182547A0/en unknown
- 2007-04-20 CR CR9072A patent/CR9072A/es not_active Application Discontinuation
- 2007-04-20 ZA ZA200703275A patent/ZA200703275B/xx unknown